LymphoidOrganogenesi s

F. Melchers

List of Contributors : XI

I Stem Cells - Hematopoietic, Epithelial, Others

M.F. Pittenger, J.D. Mosca and K .R. McIntoshHuman Mesenchymal Stem Cells : Progenitor Cells for Cartilage ,Bone, Fat and Stroma 3

R.L. Phillip sInvestigating the Genetic Control of Stem Cell Behavior 1 3

A.G. Rolink and F . MelchersPrecursor B Cells from Pax-5-deficient Mice - Stem Cell sfor Macrophages, Granulocytes, Osteoclasts, Dendritic Cells, Natural Kille rCells, Thymocytes and T Cells 2 1

U. Just, D. Boettiger, O . Kan, T.M. Dexter and E. SpooncerInsertional Mutagenesis as a Route to Identifying Genes Involvedin Self Renewal of Haemopoietic Stem Cells 27

Y. Yokota, S . Mori, S .-I. Nishikawa, A . Mansouri, P . Gruss, T. Kusunoki ,T. Katakai and A . ShimizuThe Helix-Loop-Helix Inhibitor Id2 and Cell Differentiation Control 3 5

A.J . PotocnikRole of 131 Integrin for Hemato-Lymphopoiesis in Mouse Development 43

J. Liippo, K .-P . Nera, P. Kohonen, M. Lampisuo, K . Koskela, P . Nieminenand O. LassilaThe Ikaros Family and the Development of Early Intraembryoni cHematopoietic Stem Cells 5 1

M. Kondo and I .L. WeissmanFunction of Cytokines in Lymphocyte Development 59

P.W. Kincade, K.J . Payne, K.-S . Tudor, Y . Yamashita, K .L. Medina,M.I.D. Rossi and T . KouroRe-evaluation of B Lymphocyte Lineage Differentiation Schemes 67

II Vessel Development

A. Lymboussaki, M.G. Achen, S .A. Stacker and K. AlitaloGrowth Factors Regulating Lymphatic Vessels 75

A. Eichmann, C . Corbel, L. Pardanaud, C . Brdant, D. Moyon and L . YuanHemangioblastic Precursors in the Avian Embryo 8 3

M.A. Aurrand-Lions, L. Duncan, L. Du Pasquier and B .A. ImhofCloning of JAM-2 and JAM-3 : an Emerging Junctional Adhesion MolecularFamily? 9 1

III Thymus Development

H.-R . Rodewal dThymus Epithelial Cell Reaggregate Grafts 10 1

M. Naspetti, F. Martin, A . Biancotto, F. Malergue, P . Mansuelle ,F. Galland and P . NaquetA Novel Anti-Ep-CAM Antibody to Analyze the Organizatio nof Thymic Medulla in Autoimmunity 109

M. Schorpp, W. Wiest, C . Egger, M . Hammerschmidt, T . Schlakeand T . BoehmGenetic Dissection of Thymus Development 11 9

W. van Ewijk, H . Kawamoto, W .T.V. Germeraad and Y. KatsuraDeveloping Thymocytes Organize Thymic Microenvironments 12 5

J .J .T. Owen, D .E. McLoughlin, R.K. Suniara and E .J . JenkinsonThe Role of Mesenchyme in Thymus Development 13 3

B. Kyewski, B . Röttinger and L. KleinMaking Central T-Cell Tolerance Efficient : Thymic Stromal Cells Sampl eDistinct Self-Antigen Pools 13 9

IV Lymphoid Tissue Development

Y.-J . Liu, N. Kadowaki, M .-C. Rissoan and V . Soumeli sT Cell Activation and Polarization by DC1 and DC2 14 9

M. Cella, H . Nakajima, F . Facchetti, T. Hoffmann and M. ColonnaILT Receptors at the Interface Between Lymphoid and Myeloid Cells 161

F. Sallusto, A . Langenkamp, J . Geginat and A. LanzavecchiaFunctional Subsets of Memory T Cells Identified by CCR7 Expression 167

M. Lipp, R. Burgstahler, G. Müller, V. Pevzner, E . Kremmer, E . Wol fand R. FörsterFunctional Organization of Secondary Lymphoid Organs by the Chemokin eSystem 17 3

C. Schaniel, F . Melchers and A .G. RolinkThe Cluster of ABCD Chemokines which Organizes T Cell-dependent B Cel lResponses 18 1

B .A. de Boer, I . Voigt, H .-J . Kim, S .A. Camacho, M . Lipp, R . Förste rand C. BerekAffinity Maturation in Ectopic Germinal Centers 19 1

R. Mebius and K . Akash iPrecursors to Neonatal Lymph Nodes : LTß+CD45+CD4 +CD3- Cell sare Found in Fetal Liver 197

R. EttingerThe Role of Tumor Necrosis Factor and Lymphotoxin in Lymphoid Orga nDevelopment 20 3

Subject Index 211