LOCAL AND INTERNATIONAL COMMITTEES

Chairs: Eduardo Richardet, Argentina; Norma Pilnik, Argentina International Chair: Christian Rolfo, Belgium Educational & IASLC School of Thoracic Oncology Chair: Luis E. Raez, USA Scientific Chair: Edgardo S. Santos, USA INTERNATIONAL COMMITTEE Paul Bunn, USA David Gandara, USA Fred R. Hirsch, USA Giorgio V. Scagliotti, Italy Marileila Varella-Garcia, USA Ignacio I. Wistuba, USA

LOCAL ARGENTINA COMMITTEE

Santiago Bella Nestor Bustamante Eduardo Cazap Liliana Dalurzo Gustavo Ferraris Diego Kaen Daniel Maldonado Claudio Martin Ignacio Magri Martin Paradelo Martin Richardet Gonzalo Recondo Silvia Zunino LATIN AMERICAN COMMITTEE

Alfredo Aguilar, Peru Osvaldo Aren, Chile Oscar Arrieta, Mexico Carlos Barrios, Brazil Monica Campos, Chile Andrés Cardona, Colombia Luis Corrales, Costa Rica Mauricio Cuello, Uruguay Jaime De La Garza, Mexico Lucia Delgado, Uruguay Christian Caglevic, Chile Graciela Gomez, Paraguay Roberto Ivan Lopez, Panama Jorge Madrid, Chile Manuel Magallanes, Mexico Luis Mas, Peru Clarissa Mathias, Brazil Francisco Orlandi, Chile Moises Russo, Chile Ricardo Santos, Brazil Luis Ubillos, Uruguay Carlos Vallejos, Peru Mario Varangot, Uruguay Tatiana Vidaurre Rojas, Peru Nise Yamaguchi, Brazil

SPONSORED BY: INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER ORGANIZING PARTNER: FEDERACIÓN LATINOAMERICANA DE SOCIEDADES DE CANCEROLOGÍA

7:30 AM - 6:00 PM Registration [SALÓN URITORCO]

9:00 AM - 4:45 PM IASLC SCHOOL OF THORACIC ONCOLOGY PROGRAM AGENDA Chairs Luis E. Raez, USA Luis Corrales-Rodríguez, Costa Rica Eduardo Richardet, Argentina

9:00 AM - 9:05 AM Welcome and Introductions Luis E. Raez, USA Eduardo Richardet, Argentina

9:05 AM - 9:30 AM Pre-meeting test 9:30 AM - 10:00 AM Pulmonary Medicine Susana Vanoni, Argentina 10:00 AM - 10:30 AM Pathology Fred R. Hirsch, USA Marileila Varella-Garcia, USA 10:30 AM - 11:00 AM Thoracic Surgery Francisco Tarrazzi, USA 11:00 AM - 11:15 AM Break 11:15 AM - 11:45 AM Radiation Oncology Ana Botero, USA Berta Roth, Argentina 11:45 AM - 12:15 PM Medical Oncology Christian Rolfo, Belgium 12:15 PM - 12:30 PM Questions and Answers Norma Pilnik, Argentina 12:30 PM - 1:30 PM Working Lunch – Biostatistics Eduardo Cuestas, Argentina 1:30 PM - 2:00 PM Workstation 1 – Pulmonary Viviana Moyano, Argentina Susana Vanoni, Argentina

WEDNESDAY, AUGUST 15, 2018

2:00 PM - 2:30 PM Workstation 2 – Pathology Ignacio I. Wistuba, USA 2:30 PM - 3:00 PM Workstation 3 – Thoracic Surgery Daniel Maldonado, Argentina 3:00 PM - 3:15 PM Break

3:15 PM - 3:45 PM Workstation 4 – Radiation Oncology Ana Botero, USA Gustavo Ferraris, Argentina 3:45 PM - 4:15 PM Workstation 5 – Medical Oncology Luis E. Raez, USA 3:45 PM - 4:15 PM Workstation 5 – Medical Oncology Eduardo Richardet, Argentina

4:15 PM - 4:45 PM Post-meeting test 4:45 PM Wrap-up and adjourn

Workshop: LATM Molecular Pathology Working Group

[SALÓN LUGONES B-C]

10:15 AM - 11:40 AM PATIENT ADVOCACY 1 – FLASCA SYMPOSIUM Chairs Nise Yamaguchi, Brazil Eduardo Cazap, Argentina

10:15 AM - 10:20 AM Welcome Nise Yamaguchi, Brazil 10:20 AM - 10:30 AM Tumor Molecular Profile: A New Challenge Luis Mas, Peru 10:30 AM - 10:40 AM Learning from Patients To be announced 10:40 AM - 10:50 AM Our Body Helping to Cure Cancer: Immunotherapy Diego Kaen, Argentina

10:50 AM - 11:00 AM Celebrating the Survivors To be announced

THURSDAY, AUGUST 16, 2018

11:00 AM - 11:10 AM Communication Skills Martin Richardet, Argentina

11:10 AM - 11:20 AM Is it Easy to Get New Drugs in Latin America? Open Discussion Lucía Delgado Pebe, Uruguay

11:20 AM - 11:40 AM Round Table

Nise Yamaguchi, Brazil Lucía Delgado Pebe, Uruguay Eduardo Cazap, Argentina

12:00 PM - 1:00 PM OPENING CEREMONY Chairs Eduardo Richardet, Argentina Norma Pilnik, Argentina Christian Rolfo, Belgium 12:00 PM - 1:00 PM Welcome and Introduction to the IASLC Latin America Conference on Lung Cancer 2018 Eduardo Richardet, Argentina

12:00 PM - 1:00 PM The Future of Lung Cancer Management in Latin America Norma Pilnik, Argentina 12:00 PM - 1:00 PM Welcome from the IASLC President Giorgio V. Scagliotti, Italy 12:00 PM - 1:00 PM Welcome from the IASLC CEO Fred R. Hirsch, USA 1:00 PM - 2:00 PM CANCER CONTROL PROGRAM AND TOBACCO FORUM

Chairs Nise Yamaguchi, Brazil Lucía Delgado Pebe, Uruguay

1:00 PM - 1:15 PM Importance of Smoking Cessation in the Treatment of Lung Cancer

Patients Raquel Pendito, Argentina 1:15 PM - 1:30 PM WHO Framework Convention on Tobacco Control in Latin America Nise Yamaguchi, Brazil 1:30 PM - 1:45 PM Panel Discussion Eduardo Cazap, Argentina Jaime De La Garza, Mexico 2:15 PM - 3:15 PM INDUSTRY SUPPORTED SYMPOSIUM (TO BE ANNOUNCED)

2:15 PM - 3:15 PM INDUSTRY SUPPORTED SYMPOSIUM (TO BE ANNOUNCED)

3:30 PM - 4:30 PM LUNG CANCER SCREENING Chairs Edgardo S. Santos, USA Lucía Delgado Pebe, Uruguay

3:30 PM - 3:50 PM Lung Cancer Screening: Clinical Practice and Guidelines Luis Corrales-Rodriguez, Costa Rica 3:50 PM - 4:10 PM Lung Cancer Screening: Impact on Survival and Economics Ignacio Magri, Argentina 4:10 PM - 4:30 PM Lung Cancer Screening in Latin America: Challenges and Progress Carlos Barrios, Brazil [SALÓN LUGONES B]

4:45 PM - 5:45 PM DIAGNOSTIC IMAGING INNOVATION Chairs Jose Maria Lastiri, Argentina Jorge Alatorre, Mexico

4:45 PM - 5:00 PM PET CT Scan as a Tool for Lung Cancer Management: Utility Marcelo Claria, Argentina 5:00 PM - 5:15 PM EBUS and Navigation System to Yield a Diagnosis Francisco Tarrazzi, USA 5:15 PM - 5:30 PM Stereotactic Body Radiotherapy in NSCLC with Oligometastatic Disease Ana Botero, USA 5:30 PM - 5:45 PM Role of Interventional Radiology in the Modern Era of Lung Cancer Carlos Rojas, Peru

[SALÓN LUGONES C]

4:45 PM - 5:45 PM YOUNG INVESTIGATORS SESSION Chairs Christian Caglevic, Chile Martín Richardet, Argentina

4:45 PM - 5:05 PM How to Write a Manuscript and a Research Grant Carlos Ferreira, Brazil 5:05 PM - 5:25 PM How to Incorporate Research in Latin America Roberto Ivan Lopez, Panama

5:25 PM - 5:45 PM The Role of Medical School to Promote Basic and Clinical Research Obstacles, Resources and Policies

Ada Blidner, Argentina

[SALÓN LUGONES B] 6:00 PM - 7:00 PM OPEN INDUSTRY SUPPORTED SYMPOSIUM

[SALÓN LUGONES C]

6:00 PM - 7:00 PM OPEN INDUSTRY SUPPORTED SYMPOSIUM

7:00 PM - 9:00 PM WELCOME RECEPTION

7:00 AM - 7:00 PM Registration

[SALÓN LUGONES A]

7:00 AM - 8:00 AM IASLC BUSINESS MEETING

[SALÓN LUGONES B-C]

8:00 AM - 9:15 AM PRESIDENTIAL SYMPOSIUM Chairs Eduardo Richardet, Argentina Norma Pilnik, Argentina Giorgio V. Scagliotti, Italy 8:00 AM - 8:15 AM

8:15 AM - 8:30 AM 8:30 AM - 8:45 AM 8:45 AM - 9:00 AM

9:00 AM - 9:15 AM

FRIDAY, AUGUST 17,2018

9:30 AM - 10:30 AM GENERAL SESSION 1 INNOVATIVE CLINICAL TRIAL DESIGN FOR NSCLC Chairs

Carlos Vallejos, Peru Christian Rolfo, Belgium

9:30 AM - 9:45 AM Bringing Opportunities in Clinical Research to Latin America Lucia Delgado Pebe, Uruguay

9:45 AM - 10:00 AM Master Protocols David Gandara, USA 10:00 AM - 10:15 AM Lung MAP Roy Herbst, USA 10:15 AM - 10:30 AM Bringing Research to the Patient: Remote Consenting for a Novel

Trial: Genomics of Young Lung Cancer Fred R. Hirsch, USA

[FOYER]

10:30 AM - 11:00 AM NETWORKING BREAK AND POSTER VIEWING [POSTER SESSION 1]

[SALÓN LUGONES B]

11:00 AM - 12:00 PM GENERAL SESSION 2 LUNG CANCER PATHOLOGY IN THE ERA OF TARGETED THERAPY Chairs Marileila Varella-Garcia, USA Liliana Darluzo, Argentina

11:00 AM - 11:15 AM The Importance of Histologic Diagnosis in Lung Cancer: Clinical Implications Martín Paradelo, Argentina 11:15 AM - 11:30 AM Tissue Quality Control for Molecular Testing Ignacio I. Wistuba, USA 11:30 AM - 11:45 AM Gene Expression Profile for Role in the Era of Targeted Therapy Maria Arcila, Colombia 11:45 AM - 12:00 PM Questions and Answers [SALÓN LUGONES C]

11:00 AM - 12:00 PM GENERAL SESSION 3 DIAGNOSTIC AND STAGING ISSUES IN THE CONTEMPORARY PULMONARY MEDICINE Chairs David Smith, Argentina Claudia Poleri, Argentina

11:00 AM - 11:15 AM Assessment of the Pulmonary Nodule Sergio Lucino, Argentina 11:15 AM - 11:30 AM Potential and Limitations of EBUS for Diagnosis and Staging Francisco Tarrazzi, USA

11:30 AM - 11:45 AM Optimization of Bronchoscopic Samples in the Era of Molecular

Pathology Mark Block, USA 11:45 AM - 12:00 PM Roadmap for Liquid Biopsy in Lung Cancer Christian Rolfo, Belgium [SALÓN LUGONES B]

12:15 PM - 1:15 PM GENERAL SESSION 4 MOLECULAR MARKERS IN LUNG CANCER

Chairs Marileila Varella-Garcia, USA Mario Varangot, Uruguay

12:15 PM - 12:30 PM Molecular Markers in Lung Adenocarcinomas Rafael Rosell, Spain

12:30 PM - 12:45 PM Molecular Markers in Squamous Cell Carcinoma David Gandara, USA 12:45 PM - 1:00 PM Molecular Diagnosis Guidelines Recommended Internationally Fred R. Hirsch, USA 1:00 PM - 1:15 PM Molecular Testing in Lung Cancer: Efforts and Perspectives in Latin

America Oscar Arrieta, Mexico [SALÓN LUGONES C]

12:15 PM - 1:15 PM GENERAL SESSION 5 NEW DEVELOPMENTS IN SURGERY Chairs Francisco Tarrazzi, USA Nestor Bustamante, Argentina

12:15 PM - 12:30 PM Mediastinum Surgical Staging

Gustavo Lyon, Argentina 12:30 PM - 12:45 PM Invasive Mediastinal Staging: Mediastinoscopy, EBUS and EUS William William, Brazil

12:45 PM - 1:00 PM VATS, Robot-Assisted or Thoracotomy for Lung Cancer Surgery Ricardo Terra, Brazil

1:00 PM - 1:15 PM Sublobar Resection for Stage I NSCLC Mark Block, USA [SALÓN LUGONES B-C]

1:30 PM - 2:30 PM INDUSTRY SUPPORTED SYMPOSIUM Treatment Updates in NSCLC: Translating Evidence into Clinical Practice

[SALÓN LUGONES B-C]

2:45 PM - 4:00 PM GENERAL SESSION 6 ADJUVANT THERAPY IN THE MOLECULAR ERA Chairs Gonzalo Recondo, Argentina Clarissa Mathias, Brazil

2:45 PM - 3:00 PM Adjuvant Chemotherapy for NSCLC: Where Are We Now? Norma Pilnik, Argentina 3:00 PM - 3:15 PM Role of Targeted Agents in the Adjuvant Setting Luis E. Raez, USA 3:15 PM - 3:30 PM Is There a Role for Immunotherapy in the Lung Cancer Adjuvant Setting? Edgardo S. Santos, USA

3:30 PM - 3:45 PM Prognostic and Predictive Makers for Adjuvant Therapy in NSCLC Osvaldo Arén, Chile 3:45 PM - 4:00 PM Questions and Answers [FOYER]

4:00 PM - 4:30 PM NETWORKING BREAK AND POSTER VIEWING [POSTER SESSION 1]

[SALÓN LUGONES B]

4:30 PM - 5:30 PM GENERAL SESSION 7 STAGE IIIA/B NON-SMALL CELL LUNG CANCER

Chairs Santiago Bella, Argentina Jorge Gallardo, Chile

4:30 PM - 4:45 PM Optimal Radiation Dose and Schedule Gustavo Ferraris, Argentina 4:45 PM - 5:00 PM Optimal Combined Modality Therapy for Locally-Advanced NSCLC Alberto Chiappori, USA

5:00 PM - 5:15 PM Is There a Role for Neoadjuvant Therapy for N2 Disease?

Federico Albrecht, USA 5:15 PM - 5:30 PM Integration of Molecular Imaging and Agents in Locally-Advanced NSCLC Claudio Martin, Argentina [SALÓN LUGONES C]

4:30 PM - 5:30 PM GENERAL SESSION 8: SQUAMOUS CELL CARCINOMA Chairs Giorgio V. Scagliotti, Italy Luis Ubillos, Uruguay

4:30 PM - 4:45 PM Biological Insights of Squamous Cell Carcinoma: Novel Targets Jorge Gómez, USA 4:45 PM - 5:00 PM Maintenance Therapy in Squamous Cell Carcinoma Gilberto Castro, Brazil

5:00 PM - 5:15 PM Checkpoint Inhibitors and Vaccines in Squamous Cell Carcinoma Ticiana Leal, USA 5:15 PM - 5:30 PM How to Approach Second-line Therapy in Squamous Cell Carcinoma David Gandara, USA [SALÓN LUGONES B-C]

5:45 PM - 6:45 PM INDUSTRY SUPPORTED SYMPOSIUM (TO BE ANNOUNCED)

[SALÓN LUGONES B-C]

7:00 PM - 8:00 PM INDUSTRY SUPPORTED SYMPOSIUM (TO BE ANNOUNCED)

8:15 PM - 11:00 PM FACULTY DINNER [BY INVITATION ONLY]

7:00 AM - 5:00 PM Registration

[SALÓN LUGONES B]

8:00 AM - 9:15 AM POSTER DISCUSSION [SESSION 1] Chairs Giorgio Scagliotti, Italy Eduardo Richardet, Argentina

SATURDAY, AUGUST 18, 2018

8:00 AM - 8:05 AM PD.1.01 8:05 AM - 8:10 AM PD.1.02

8:10 AM - 8:15 AM PD.1.03 8:15 AM - 8:30 AM Discussant 8:30 AM - 8:35 AM Questions & Answers 8:35 AM - 8:40 AM PD.1.04 8:40 AM - 8:45 AM PD.1.05

8:45 AM - 8:50 AM PD.1.06 8:50 AM - 9:05 AM Discussant 9:05 AM - 9:15 AM Questions & Answers [SALÓN LUGONES C]

8:00 AM - 9:15 AM POSTER DISCUSSION [SESSION 2] Chairs Fred R. Hirsch, USA Norma Pilnik, Argentina

8:00 AM - 8:05 AM PD.2.01 8:05 AM - 8:10 AM PD.2.02 8:10 AM - 8:15 AM PD.2.03 8:15 AM - 8:30 AM Discussant 8:30 AM - 8:35 AM Questions & Answers

8:35 AM - 8:40 AM PD.2.04 8:40 AM - 8:45 AM PD.2.05 8:45 AM - 8:50 AM PD.2.06 8:50 AM - 9:05 AM Discussant 9:05 AM - 9:15 AM Questions & Answers

[SALÓN LUGONES B]

9:30 AM - 10:30 AM GENERAL SESSION 9 MANAGEMENT OF ADVANCED STAGE NON SQUAMOUS-NSCLC Chairs Christian Rolfo, Belgium Norma Pilnik, Argentina

9:30 AM - 9:45 AM Front-line Therapy for EGFR/ALK/ROS-1 Genomic Aberrations Rafael Rosell, España 9:45 AM - 10:00 AM Dealing with ALK Resistance: How Far to Go? Christian Rolfo, Belgium 10:00 AM - 10:15 AM Selecting Patients for Maintenance Therapy Giorgio V. Scagliotti, Italy 10:15 AM - 10:20 AM Molecular Targeted Therapy for Brain Metastases and

Leptomeningeal Disease Ignatious Ou, USA

10:20 AM - 10:30 AM Questions & Answers

[SALÓN LUGONES C]

9:30 AM - 10:30 AM GENERAL SESSION 10 IMMUNOTHERAPY IN NON-SMALL CELL LUNG CANCER Chairs Ana Oton, USA Eduardo Richardet, Argentina

9:30 AM - 9:40 AM Immunotherapy: Putting it in a Simple Language Ada Blidner, Argentina 9:40 AM - 9:50 AM Predictive Assays for Immunotherapy Fred R. Hirsch, USA 9:50 AM - 10:00 AM Clinical Trials with Anti-PD-1 Inhibitors Luis E. Raez, USA 10:00 AM - 10:10 AM Trials with Anti-PD-L1 Inhibitors Clarissa Mathias, Brazil 10:10 AM - 10:20 AM Other Immunotherapy Pathways: CTL4 and Others David Carbone, USA 10:20 AM - 10:30 AM Questions & Answers

[FOYER] 10:30 AM - 11:00 AM NETWORKING BREAK AND POSTER VIEWING

[POSTER SESSION 2]

[SALÓN LUGONES A-B] 11:00 AM - 12:30 PM ROUND TABLE DISCUSSIONS

Chairs Diego Kaen, Argentina Martín Richardet, Argentina

[ROUND TABLE 1] LOCALLY-ADVANCED LUNG CANCER: SURGERY AND ADJUVANT TREATMENT Coordinators: Norma Pilnik, Argentina; Edgardo Santos, USA Secretary: Ignacio Magri, Argentina

Members Jorge Arcuri, Argentina Emilio Batagelj, Argentina Luis Corrales-Rodríguez, Costa Rica

Fernanda Díaz Vázquez, Argentina Diego Fernandez, Argentina Alejandra Ibero, Argentina Diego Insaurralde, Argentina Manuel Magallanes, Mexico Luis Medina, Argentina Juan Muñoz, Argentina Patricia Murina, Argentina Viviana Paez, Argentina

[ROUND TABLE 2] NOVELS APPROACHES IN SURGERY: ROBOTIC SURGERY, VATS, NAVIGATION SYSTEM Coordinators: Gustavo Lyons, Argentina; Francisco Terrazzi, USA Secretary: Bernardo Pasteris, Argentina

Members Sebastián Avalos, Argentina Diego De Bernardi, Argentina Ricardo Luengo, Argentina Daniel Maldonado, Argentina José A. Menéndez, Argentina Hugo Moreno, Argentina Federico Santander, Argentina Saúl Seput, Argentina

David Smith, Argentina

[ROUND TABLE 3] TREATMENT OF WILD TYPE LUNG CANCER TUMORS: FIRST AND SECOND LINE Coordinators: Paul Bunn USA; Adrián Hannois, Argentina Secretary: Carlos Brocca, Argentina

Members Luciana Acosta, Argentina Lucas Carranza, Argentina Rubén Kowalyszyn, Argentina Carlos Medina, Argentina Alberto Prino, Argentina José Yugdar, Argentina

[ROUND TABLE 4] THERAPY OF TUMORS CARRYING EGFR MUTATIONS Coordinators: Eduardo Richardet, Argentina; Rafael Rosell, Spain Secretary: Aldo Riso, Argentina

Members Ricardo Armisen, Chile Gisela Germán, Argentina Patricia Hernández, Argentina Jorge Madrid, Chile Eugenia Pacher, Argentina

[ROUND TABLE 5] ALK-POSITIVE TUMORS: THERAPIES Coordinators: Oscar Arrieta, Mexico; Giorgio V. Scagliotti, Italy Secretary: Matías Molina, Argentina

Members Jorge Alatorre, Chile Jean Arevalo Rojas, Argentina Mónica Campos, Chile Nicolás Castagneris, Argentina Marcelo Fogtman, Argentina Vanina Giraudo, Argentina Clelia Lazaris, Argentina Luis Mas, Peru Mariano Paolasso, Argentina Laura Perelli, Argentina Gonzalo Recondo, Argentina

[ROUND TABLE 6]

HOW TO STUDY MOLECULAR BIOLOGY AND TUMOR MARKERS Coordinators: Fred R. Hirsch, USA; Ignacio I. Wistuba, USA Secretary: Mónica Ahumada, Chile

Members Verónica Bengió, Argentina Norma Canals, Argentina Liliana Dalurzo, Argentina Cristina Fernandez Ferradas, Chile Andrés Guidi, Argentina Martín Paradelo, Argentina Claudia Poleri, Argentina

[ROUND TABLE 7] NEW MOLECULES AND THERAPIES FOR LUNG CANCER Coordinators: David Gandara, USA; Mario Varangot, Uruguay Secretary: Carmen Pupareli, Argentina

Members Alejandro Ahualli, Argentina Romina Brombin, Argentina Claudio Martín, Argentina Francisco Olivari, Argentina Sergio Rodríguez, Argentina Andrea Sosa, Argentina

[ROUND TABLE 8] OLIGOMETASTASIC LUNG CANCER Coordinators: Nestor Bustamante, Argentina; Berta Roth, Argentina Secretary: Claudio Sole, Chile

Members Gerardo Arroyo, Argentina Pablo Carmignani, Argentina Silvia Zunino, Argentina Darío Llanos, Argentina

[ROUND TABLE 9] DIAGNOSIS AND STAGING IN LUNG CANCER Coordinators: Mark Block, USA; Luis Ubillos, Uruguay Secretary: Sergio Lucino, Argentina

Members Carlos Capellino, Argentina Marcelo Claria, Argentina Pedro Garcia, Argentina Marcelo Lavarda, Argentina Viviana Moyano, Argentina Harold Sommerville, Argentina

[ROUND TABLE 10] LOCALLY-ADVANCED LUNG CANCER Coordinators: Claudia Bagnes, Argentina; Mauricio Cuello, Uruguay Secretary: Tatiana Vidaurre Rojas, Peru

Members Alfredo Aguilar, Peru Cristian Caglevic, Chile Pablo Companys, Argentina Jorge Gallardo, Chile Graciela Gomez, Paraguay Ignacio Jerez, Argentina

[ROUND TABLE 11] INMUNOTHERAPY IN NON-SMALL LUNG CANCER Coordinators: Osvaldo Aren, Chile; Luis E. Raez, USA Secretary: Juan Cundom, Argentina

Members Enrique Aman, Argentina Santiago Bella, Argentina Maximiliano Canigiani, Argentina Matías Cortes, Argentina Gonzalo Etcheverria, Argentina Gustavo Ferraris, Argentina Betania Mascheroni, Argentina

[ROUND TABLE 12] LIQUID BIOPSY Coordinators: Marileila Varella-Garcia, USA; Christian Rolfo, Belgium Secretary: Ruben Salanova, Argentina

Members Carlos Barrios, Brazil Vanina Denninhof, Argentina Marisa Dinardi, Uruguay Hernan Juarez, Argentina Daniel Lerda, Argentina Clarissa Mathias, Brazil Martin Pairola, Argentina Yanina Posniak, Argentina

[SALÓN LUGONES B] 12:45 PM - 1:45 PM GENERAL SESSION 11

SMALL CELL LUNG CANCER & NEUROENDOCRINE TUMOR (NET) Chairs Oscar Arrieta, Mexico Nise Yamaguchi, Brazil

12:45 PM - 1:00 PM Small Cell Cancer Biology: Are There New Targets? Ruben Salanova, Argentina 1:00 PM - 1:15 PM Systemic Therapy for SCLC Brian Hunis, USA

1:15 PM - 1:30 PM Successes and Challenges of Radiation Therapy for SCLC Berta Roth, Argentina 1:30 PM - 1:45 PM Management of Well-Differentiated NET Luis Zunino, Peru [SALÓN LUGONES C]

12:45 PM - 1:45 PM GENERAL SESSION 12 ADVANCED RADIATION TECHNOLOGY

Chairs Berta Roth, Argentina Claudio Sole, Chile

12:45 PM - 1:00 PM Radiation Oncology Challenges in Latin America Hugo Marsiglia, Chile

1:00 PM - 1:15 PM Role of SBRT in Early-Stage NSCLC Moises Russo, Chile 1:15 PM - 1:30 PM Role of SBRT in Advanced NSCLC Silvia Zunino, Argentina 1:30 PM - 1:45 PM Role of Proton Therapy in Lung Cancer Ana Botero, USA

[SALÓN LUGONES B-C]

2:00 PM - 3:00 PM INDEPENDENT SATELLITE SYMPOSIUM Individualizing the Treatment of Advanced NSCLC

[SALÓN LUGONES B]

3:15 PM - 4:15 PM GENERAL SESSION 13 NOVEL THERAPIES TARGETING LUNG CANCER PATHWAYS Chairs Paul Bunn, USA Carlos Ferreira, Brazil

3:15 PM - 3:25 PM RET/BRAF

Paul Bunn, USA 3:25 PM - 3:35 PM MET and MET Exon 14 Skipping Mutations Rafael Rosell, Spain 3:35 PM - 3:45 PM DNA Repair Inhibitors David Gandara, USA 3:45 PM - 3:55 PM NF-1 Mutation David Carbone, USA 3:55 PM - 4:05 PM NTRK Mutation Giorgio V. Scagliotti, Italy

[SALÓN LUGONES C]

3:15 PM - 4:15 PM GENERAL SESSION 14 MESOTHELIOMA, THYMOMA AND THYMIC CARCINOMA

Chairs

Brian Hunis, USA Jorge Madrid, Chile

3:15 PM - 3:30 PM VATS and Robotic Surgery in Thymic Surgery Ricardo Santos, Brazil 3:30 PM - 3:45 PM Biological Insights and Novel Therapy for Malignant Mesothelioma Luis Corrales-Rodriguez, Costa Rica 3:45 PM - 4:00 PM Current Standard of Care for the Treatment of Thymoma: What’s New? Manuel Magallanes, Mexico

4:00 PM - 4:15 PM Innmunotherapy Rationale in Small Cell Lung Cancer and Miscellaneous Francisco Orlandi, Chile [FOYER]

4:15 PM - 4:45 PM NETWORKING BREAK AND POSTER VIEWING [POSTER SESSION 2]

[SALÓN LUGONES B]

4:45 PM - 5:45 PM GENERAL SESSION 15 EPIDERMAL GROWTH FACTOR RECEPTOR, MUTATION AS TARGETED THERAPY Chairs Clarissa Mathias, Brazil Luis Mas, Peru

4:45 PM - 5:00 PM Actual Status of First and Second Generation EGFR TKIs in the Treatment of NSCLC

Fred R. Hirsch, USA 5:00 PM - 5:15 PM Targeting T790M Mutation in Lung Cancer Carlos Barrios, Brazil 5:15 PM - 5:30 PM New Insights of EGFR Inhibition: EGF816, ASP8273 and Others Rafael Rosell, Spain 5:30 PM - 5:45 PM EGFR TKIs with Central Nervous System Penetration for Management

of Lung Cancers Paul Bunn, USA

[SALÓN LUGONES C]

4:45 PM - 5:45 PM GENERAL SESSION 16 ALK/EML4 TRANSLOCATION AS TARGETED THERAPY Chairs Alfredo Aguilar, Peru Osvaldo Arén, Chile

4:45 PM - 5:00 PM ALK Inhibitors: Where Are We Now? Ana Oton, USA 5:00 PM - 5:15 PM Novel Molecular Mechanisms of Resistance to ALK Inhibition Brian Hunis, USA 5:15 PM - 5:30 PM ALK Inhibitors with Central Nervous System Penetration for

Management of Lung Cancers Jorge Alatorre, Mexico

5:30 PM - 5:45 PM ALK Inhibitors in Combination with Other Targeted Therapies

and Radiotherapy in Patients with ALK+ NSCLC Luis Ubillos, Uruguay [SALÓN LUGONES B-C]

6:00 PM - 6:30 PM CLOSING CEREMONY Chairs Eduardo Richardet, Argentina Norma Pilnik, Argentina Christian Rolfo, Belgium

6:00 PM - 6:30 PM Award Presentations

Norma Pilnik, Argentina

6:00 PM - 6:30 PM Closing Remarks

Eduardo Richardet, Argentina

6:00 PM - 6:30 PM Closing Remarks Giorgio V. Scagliotti, Italy

6:00 PM - 6:30 PM Introducing the Latin America Conference on Lung Cancer 2019: Mexico City

Fred R. Hirsch, USA