Local and Global Gating of Synaptic Plasticity
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Transcript of Local and Global Gating of Synaptic Plasticity
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Local and Global Gating of
Synaptic PlasticityManuel A. Sanchez-Montañes
Hannes Schulz
University of Osnabrück, Department of Cognitive Science
Action and Cognition II / May 2nd 2005
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Learning on Global vs. Local Scale
Mechanisms for learning in neuronal nets:
Local
Hebb’s Rule & modifications
Forms representations on
cortex
Global
Signals to the whole network
Modifies local learning
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Learning Goals
Local Learning:
Representation of all
stimuli
Possibility to add new
stimuli later on
Independence from
presentation frequency
Global Learning:
Influence size of
representation
(→ experimental
evidence on basal
forebrain)
◮ How to connect both?
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The Neuronal Model Experimental Results Discussion
Outline
1 The Neuronal Model
The Cell
The Network
The Inputs
2 Experimental Results
3 Discussion
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Outline
1 The Neuronal Model
The Cell
The Network
The Inputs
2 Experimental Results
3 Discussion
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
The Cell Model
∑
integrate-and-fire
refractory period
delayed transmission
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Nucleus Basalis
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Nucleus Basalis
Layers 1&2, 3&2 fully connected
Random weight initialization
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Nucleus Basalis
Layers 1&2, 3&2 fully connected
Random weight initialization
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Retrograde Signal Inhibition
Retrograde Signal
Dendrit
Firing
Cell
Inhibitory Signal
◮ Retrograde signal
of firing cell
blocked by
inhibitory inputs
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Heterosynaptic Long Term Depression
Presynaptic Cell Postsynaptic Cell
“Normal” Condition
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Heterosynaptic Long Term Depression
Presynaptic Cell Postsynaptic Cell
“Normal” Condition
LTD
Heterosynaptic LTD:
postsynaptic cell
active
presynaptic cell
inactive in time
window
◮ Synaptic efficacy
decrease
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Relative Timing in Hebb Learning
Sample interpretations of “Synchronous activity”:
Symmetric coincidence
window.
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Relative Timing in Hebb Learning
Sample interpretations of “Synchronous activity”:
Symmetric coincidence
window.
Asymmetric
coincidence window.
Used in this study.
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Input
Trial I
Ten different stimuli
pseudorandom order
500 examples shown to
network
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Input
Trial I
Ten different stimuli
pseudorandom order
500 examples shown to
network
Trial II
9+1 different stimuli
pseudorandom order
500 examples shown to
network
One stimulus paired with
stimulus in basal-neuron
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Input
Trial I
Ten different stimuli
pseudorandom order
500 examples shown to
network
Trial II
9+1 different stimuli
pseudorandom order
500 examples shown to
network
One stimulus paired with
stimulus in basal-neuron
Both run 40 times with random start parameters
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion
Outline
1 The Neuronal Model
The Cell
The Network
The Inputs
2 Experimental Results
3 Discussion
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion
Formed Representations – Trial I
Neuron Specificity
44.8% unspecific
50.5% specific to 1 stimulus
4.7% intermediate
Stimuli shown more often
to network not better
represented
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion
Formed Representations – Trial II
Number of neurons
representing
paired stimulus
increases
Number of neurons
representing other
stimuli stay the
same
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion
Role of the Global Mechanism
1 Basal ganglion neuron fires
2 Inhibitory neurons have a
prolonged refractory period
3 Inhibitory neurons do not fire
4 Excitatory neurons can fire
and shorten refractory period
again
Network Topology
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion
Role of the Global Mechanism
◮ Unchanged mean activity of
inhibitory neurons
◮ Delay of inhibitory activity relative to
excitatory activity
◮ Retrograde APs invade dendritic
tree
Network Topology
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion
The Same, in Graphs
Delay of inhibitory
activity relative to
excitatory activity
Number of neurons
representing paired
stimulus increases
Number of neurons
representing other stimuli
stay the same
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion
Outline
1 The Neuronal Model
The Cell
The Network
The Inputs
2 Experimental Results
3 Discussion
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion
Comparison of Results to Goals
New stimuli can be trained w/o loss
Optimally activated neurons inhibit othersUnspecific neurons are result
Frequency invariance, variable representation size
Invariance due to mechanism described aboveStimulus representation enhanced by globalmechanism
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The Neuronal Model Experimental Results Discussion
Predictions for Experimentors
During basal forbrain stimulation:
Delayed inhibitory activity
Invasion of dendritic tree by more retrograde APs
Hannes Schulz Local and Global Gating of Synaptic Plasticity
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The End