Linear mentoring evolves into networks of scientists Janet Rubin Margaret Gourlay Maria Escolar.
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Transcript of Linear mentoring evolves into networks of scientists Janet Rubin Margaret Gourlay Maria Escolar.
![Page 1: Linear mentoring evolves into networks of scientists Janet Rubin Margaret Gourlay Maria Escolar.](https://reader036.fdocuments.us/reader036/viewer/2022062517/56649ed15503460f94bdf925/html5/thumbnails/1.jpg)
Linear mentoring evolves into networks of scientists
Janet Rubin Margaret Gourlay Maria Escolar
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Janet Rubin, MD
1. Research: Bone remodeling
2. Clinical: Metabolic bone disease and general endocrinology
Until 2006
• rose to Professor of Medicine, Division of Endocrinology, Metabolism and Lipids at Emory University
• Career Development path within the VA system
•?VA system as mentor
2006 + UNC, Professor Medicine
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transcription
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Mesenchymal stem cell
Noggin, Nodal
BMP 2,4,7
Hedgehog
Wnt10b, 3a
BMPs
Hedgehog
Low
High
Wnt 10b
Smad 1,4TAZ
Smad 1,4Shn
Pax3,7Sim1,Lbx1,Myf5
Runx2, Osx
PPAR. CEBPa Myogenin, MyoD
Osteoblast Adipocyte Myocyte
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Mentoring: Farming for the future
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Mentoring: general
• Directed– Your mentee’s work directly benefits your career
• Off-topic– Your contribution is
• Altruistic• Improves your local environment• Improves your global environment
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Mentoring: A case in point
• Direct: Margaret Gourlay
• Off-topic: Maria Escolar
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Direct mentoring: Margaret
JR: Expertise in clinical bone
Basic biology insights
MG: Epidemiology training
Brought together via recruitment &
insight of UNC Roadmap program
Translating biological insight:•Important question•Niche for MG career
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Off target mentoring: Maria
JR: Expertise in grant writing
ME: Turning great ideas into a viable RO1
Brought together via UNC mentoring initiative
Grant review
Need for clinical research expertise
Bring on MG
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Peer mentoring on an R01 application
• Preparation– My training and research
• An unlikely combination– Osteoporosis screening and Krabbe Disease?
• Peer mentoring in grant preparation– Reasons for success– Lessons learned
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Before 2002
• BS microbiology/English, University of Iowa
• DVM, Iowa State University; 4-1/2 years of veterinary practice
• MD, Rush Medical College
• Family Medicine residency, UCSD; Medical Editing fellowship, Georgetown University
2002-2004 Robert Wood Johnson Clinical Scholars Program, UNC
2004-2007 UNC K30 Program
2004-present, Assistant Professor, UNC Department of Family Medicine
Training and other preparation
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2005-07, UNC Program in Translational Science: Osteoporosis screening in younger postmenopausal women, Rubin is mentor.
2007-12, NCRR K23 Career Development Award: Selective screening for osteoporosis in younger postmenopausal women, Rubin is co-mentor.
Pending, NIAMS R03: FSH as a biomarker of bone strength in younger postmenopausal women, Rubin is key co-investigator.
Research on osteoporosis screening0.
000.
250.
500.
751.
00S
ensi
tivity
0.00 0.25 0.50 0.75 1.001-Specificity
ostopp ROC area: 0.768 orai ROC area: 0.7504
score ROC area: 0.7571 Reference
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Some topic overlap
• Clinical research
• Studies of diagnostic imaging tests
• Diagnostic accuracy analysis
Important differences
• Common vs. rare disease
• Population health vs. approach to high-risk subgroups
Osteoporosis screening and Krabbe Disease?
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Peer mentoring in grant preparation
• What a peer could contribute– Knowledge of Maria’s past proposals (K30 and
Translational Science Programs)– Writing and editing experience– Recent experience with two NIH submissions– Shared belief that Maria could finish grant on time
• What didn’t matter– Medical specialty and research emphasis– No prior work on an R01
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Peer mentoring in grant preparation
• Reasons for success– Fascinating, clinically important topic– Outstanding preliminary studies – Highly motivated writing team
• Challenges– Compressed time frame– Different work styles
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Lessons learned
• You can and should mentor at an early stage of your career.
• Knowledge of cross-cutting disciplines (editing, epidemiology, biostatistics) can make you an “expert” at any stage.
• For peer mentor, exhaustive knowledge of content area is less important than sound logic and enthusiasm.
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UCBT
0
12
24
36
48
60
72
0 12 24 36 48 60 72
Calendar Age (months)
Dev
elo
pm
enta
l Ag
e (m
on
ths)
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Mentor # 1
• Dr. Joanne Kurtzberg, Pediatric Bone Marrow Transplantation at Duke University Medical Center
Contracts a small percentage of my clinical time
Encourages clinical research
Meets regularly with me
I observe her grow as a leader in her field
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Mentor # 2
• Dr. Mel Levine, Director for the Center of Development and Learning at UNC
Provides space and initial resources
Recognizes the importance of my work
Challenges me to become independent
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The NFRD
• Where is the funding?
• Multidisciplinary team
• Clinical service
• No time for research
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Krabbe Disease
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August 2006 –Newborn Screening for Krabbe Disease is implemented in New York State
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Mentor # 3
Dr. Joseph Piven, Director of the Neurodevelopmental Research Center (NDRC) at UNC
Common research interests
Has experience with NIH grants
Identifies key resources within UNC
Serves as a role model
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Mentor # 4
• Dr. Eugene Orringer
Provides funding to protect research time
Identifies mentors at different levels
Supports all aspects of my work (clinical, research, academic)
Available when crisis strikes!
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My first NIH grant – R01
DTI as a tool to identify babies with Krabbe Disease in need of urgent treatment
In a prospective study of 100 babies with low GALC enzyme, determine if DTI can identify which newborns will develop infantile Krabbe Disease
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Mentor # 5
• Dr. Janet Rubin
“Don't despair. IT"S ALL GOOD.
No one can take away SIGNIFICANCE, NOVELTY and IMPACT away from you.
You go girl”.
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Mentor # 6
• Dr. Margaret Gourlay
“Today I had to see patients until late, and work on some issues we had with the budget. I still need to send drafts of letters, look at the abstract, environment and data dissemination. Grrrrrr” Maria
I can put in a few hours of work after 8:30 tonight. Overall, you are in great shape. I will be on call on Friday night and in clinic on Saturday. Although I might have to take a nap first, I can help you late Saturday PM. On Sunday, you can do the page count on the full file so we know how close it is to 25 pp. Then you can trim and refine.” Margaret
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R01 Funded!