By: Aditya Singh, Sereene Bebwan, Caswell Wyatt, Gabby Hofmeister, Drew Oppong.
Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of...
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Transcript of Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of...
![Page 1: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/1.jpg)
Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998
Harvey Guthrey
University of North Texas
Instructor: Dr. Joseph Oppong
![Page 2: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/2.jpg)
Reasons To Study Texas
Texas ranked second in the nation in 2003 for incidence of kidney and renal pelvic cancers.
Texas had the seventh highest age-adjusted mortality rate for kidney and renal pelvic cancers from 2000-2004. The mortality rate is also increasing at the fourth highest rate in the country.
![Page 3: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/3.jpg)
Background
Studies of Balkan Endemic Nephropathy (BEN) suggest links between Pliocene Lignite deposits and kidney related cancers.
Possible contamination of groundwater due to the leaching of nephrotoxic substances.
A study in Northwest Louisiana exposed high levels of nephrotoxic substances in water samples taken from wells.
Nephrotoxic substances can include: Polycyclic Aromatic Hydrocarbons, Arsenic, Mercury, Lead
![Page 4: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/4.jpg)
Hypotheses to be tested
The presence of Lignite deposits is a risk marker for above average mortality rates.
More males suffer mortality from kidney and renal pelvic cancers than females.
Race/ethnicity is a risk marker for above average mortality rates.
Socioeconomic Status (SES) is a risk marker for above average rates.
![Page 5: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/5.jpg)
Methodology
Used GIS to investigate the spatial relationship between Lignite deposit location and counties with above average mortality rates for kidney and renal pelvic cancers
Correlations for race/ethnicity and SES
Comparison of age-adjusted mortality rates for males
and females
![Page 6: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/6.jpg)
Data Sources
Used county level mortality data for 1980-1998.
Mortality data from the Bureau of Vital Statistics at the Texas Department of Health was accessed through the vitalweb database.
Lignite and arsenic data obtained from the USGS seamless data distribution system.
![Page 7: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/7.jpg)
Lignite Locations
With the exceptionof a small lignite depositin Presidio county in westTexas, the lignites in Texasare located from South Central Texas extending Northeast to the Louisianaborder.
![Page 8: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/8.jpg)
Arsenic Concentrations
South-central Texas as well as parts of the southern panhandle and western Texas experience arsenic concentrations in the groundwater that exceed 10 micrograms per liter.
![Page 9: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/9.jpg)
Age-Adjusted Death Rates for Kidney and Renal Pelvic Cancers
State Average:
4.268 deaths per 100,000
![Page 10: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/10.jpg)
Above Average AADRfor Kidney and Renal Pelvic Cancer
State Average:
4.3 deaths per 100,000
49 of the 117 counties with
Above average rates contain
Lignite deposits
![Page 11: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/11.jpg)
Above Average AADRfor Renal Pelvic Cancer
State Average:
0.05 deaths per 100,000
Counties with high rates
restricted to the Eastern
portion of the state
![Page 12: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/12.jpg)
Above Average AADRfor Kidney Cancers
State Average:
4.2 deaths per 100,000
Highest density occurs in
South-central Texas and
Extends Northeast to the
Louisiana border
![Page 13: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/13.jpg)
Male and Female Mortality Rates
Male State Average
5.3 deaths per 100,000
Female State Average
2.6 deaths per 100,000
0
1
2
3
4
5
6
Females Males
![Page 14: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/14.jpg)
Mortality Rates for differentRace/Ethnicity GroupsState Averages:
For Blacks
4.4 deaths per 100,000
(r=0.147,p=0.019)
For Whites
4.3 deaths per 100,000
For Hispanics
4.4 deaths per 100,0000
1
2
3
4
5
Blacks Whites Hispanics
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Variations Through Time
The mortality rates
increased by a little
more than one death
per 100,000 during
study period.
2
2.5
3
3.5
4
4.5
5
1980-1984 1985-1989 1990-1994 1995-1998
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Results
There appears to be a relationship between Lignite deposits and areas that have a high density of counties with above average mortality rates.
![Page 17: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/17.jpg)
Results
Age-adjusted mortality rates are higher for males by a factor of 2.
There was a positive correlation between median income and mortality rates. (r=0.150,p=0.017)
There was a positive correlation between percent Black and mortality rates. (r=0.147,p=0.019)
![Page 18: Lignite Deposits and Kidney and Renal Pelvic Cancers in Texas 1980-1998 Harvey Guthrey University of North Texas Instructor: Dr. Joseph Oppong.](https://reader030.fdocuments.us/reader030/viewer/2022032702/56649ce55503460f949b2178/html5/thumbnails/18.jpg)
Further Research
Take Water samples to determine the concentrations of toxic compounds associated with Lignite deposits
Need to determine the location of lignite deposits with more precision.
It would be beneficial to examine data on what sources people use to obtain their water.
(bottles, wells, tap water)