ANNUAL REPORT

ANNUAL REPORT

2

3

1. Presentation 5

2. Organogram 8

3. Hospital Committees 10

4. Healthcare activity 16Patients treated 17Distribution pathology 18Outpatient activity 19Hospitalization 21Overall indicator of activityd 23Radiation oncology activity 24Central services activity 25

5. Early Diagnosis Unit - II Marqués del Turia 30Breast Screening 31Gynaecological Screening 31

6. Early Diagnosis Unit - IELCAP 32Diagnosis of asymptomatic lung cancer 33

7. Opportunistic Screening Program for Early Diagnosis of Prostate Cancer 34

Opportunistic screening program for early diagnosisof prostate cancer 35

Index

4

PRESENTATION1.

6

Specialist cancer centers such as the IVO Foundation, constitute one of the best ways to approach the fight against cancer. This model streamlines diagnosis, facilitates personalized therapy and allows follow up of the disease by multidisciplinary teams, with a broad view, and without doubt, greater efficiency.In recent years we have advanced our knowledge about cancer and the ways to fight it. In the most common diseases, such as breast cancer, cure rates are currently between 80% and 85%, demonstrating that the efforts made in healthcare, teaching

and research produce results, and enable us to continue the fight against cancer.

Reviewing 2016, once again at the IVO we have accomplished one of our most important objectives, that is to provide our patients with a quality, comprehensive healthcare service, personalized, and flexible, responding to patients’ needs, working as a team with one single objective, ‘the patient’.

Specifically:

• We have maximized access to care• We have adapted our resources• We have opted for quality and seen an increase in the number of certifications and

accreditations.• In short, we have managed to provide the best care for our patients, prioritizing response

times, managing delay, and offering personal treatment, all thanks to the coordination between the professionals.

The Institute works on the premise that people who suffer from this disease require an individualized response; people, who along with their families, bear an enormous psychological burden. Therefore, thanks to the coordination of a team of over 600 professionals, including medical, nursing and auxiliary staff, we are able to offer exactly that, complete care for the cancer patient, 24 hours a day, covering all the physical and emotional aspects arising during the disease process.

7

Among the fundamental pillars of the IVO, we can highlight our direct, personal approach, something that is inherent in the Institution and our great distinction, and something of increasing value that we reinforce day by day, conscious of the great benefit it brings to the patients and their families.

The staff are the most important asset of our Institution, the professionals and their teamwork are of vital importance, and for which I thank you all for your efforts and dedication, as well as expressing my deep regard for the patients for the trust they place daily in the center.

This is one of the reasons why this Institution is so deeply respected, together with the social aims to which we are dedicated.

Our objective remains that of continued improvement, seeking to provide an answer to new challenges to control the disease. It is therefore necessary to continue our efforts, using the best resources available in the areas of prevention, application of new techniques and treatments, and in research and teaching, that enable us to proceed along the path toward excellence.

I herewith present the Scientific and Healthcare report for the year 2016.

Dra. Asunción Perales General Director

Fundación IVO

ORGANOGRAM2.

9GENERALDIRECTOR

LEGAL DEPARTMENT

COMMUNICATION

MEDICALDIRECTOR

DIRECTOR OF MANAGEMENT

FINANCE DEPARTMENT

NURSINGDEPARTMENT

MEDICAL SERVICES

ANATOMICPATHOLOGY A.R.T.D.

MOLECULAR BIOLOGY

LABORATORY

GENERAL AND DIGESTIVE SURGERY

DERMATOLOGY

GYNAECOLOGY

INTERNAL MEDICINE

MEDICAL ONCOLOGY

PSYCHOLOGY

RADIOLOGY

UROLOGY

THORACICSURGERY

CONSULTANTS

ORTHOPEDIC TRAUMA SURGERY

PNEUMOLOGY CARDIOLOGY NEUROSURGERY PLASTIC SURGERY NEPHROLOGY

DIGESTIVE DISEASE

LABORATORY

NUCLEAR MEDICINE

ENTEAR, NOSE

AND THROAT

RADIOLOGICAL PHYSICS

RADIOTHERAPY

MEDICAL RECORDS

EMERGENCY DEPARTMENT

HUMAN RESOURCES

DEPARTMENTSYSTEMS

MANAGEMENT PHARMACY

ASSISTANT DIRECTOR OF

MANAGEMENT

EXTERNAL CONTRACTORS

MAINTENANCE

PURCHASING

WORKPLACE HEALTH AND

SAFETY

HOSPITAL COMMITTEES3.

11

NAME JOB TITLE

Chairperson Asunción Perales Marín General Director

Secretary Belén Bolás Calduch Communication

Members

Cristina Bordils Montero Director of Management

Ángela Palacios Llopis Assistant Director of Management

Mª Carmen Ortega Blázquez Finance Director

Pedro Gómez Gómez Humans Resources Director

Javier Díaz Llopis Systems Management Director

Amparo Montemayor Bustamante Head of Nursing

Rosa Iñiguez Ramón Head of Hospital Admissions

Carlos J. Andrés Blasco Head of Pharmacy Department

Eduardo Aznar Oroval Head of Clinical Analysis and Microbiology Department

Ana Calatrava Fons Head of Pathology Department

Mª Ángeles Martínez Navarrete Head of Anaesthesiology, Reanimation, Critical care Therapeutics Department

Rafael Estevan Estevan Head of General and Digestive Surgery Department

Juan Carlos Peñalver Cuesta Head of Thoracic Surgery Department

Carlos Guillén Barona Head of Dermatology Department

Lucas Minig Head of Gynaecology Department

Vicente Guillem Porta Head of Medical Oncology Department

Leoncio Arribas Alpuente Head of Radiation Oncology Department

Juan B. Vendrell Marqués Head of Otolaryngology Department

Vicente Crispín Contreras Head of Radiophysics and Radiological Protection Department

José Cervera Deval Head of Radiology Department

José Rubio Briones Head of Urology Department

Andrés Poveda Velasco Coordinator of the Gynaecological Oncology Clinical Area

José A. López Guerrero Head of Molecular Biology Laboratory Department

Carmen Martínez Lapiedra Attending Physician Digestive Diseases Unit

Adoración Egido GonzálezElena Contel Ballesteros

Attending Physicians Internal Medicine Unit

Francisco J. Pascual Plá Coordinator of the Emergency Unit

Antonio Mancheño Alvaro Coordinator of the Home Hospitalization Unit

Rocío Romero Retes Psychologist Psycho-Oncology Unit

MANAGEMENT AND MONITORING COMMITTEE

12

NAME JOB TITLEChairperson Asunción Perales Marín General DirectorSecretary Ángela Palacios Llopis Assistant Director of Management

Members

Amparo Avaria Navalón Responsible for Transfusion ServiceAmparo Montemayor Bustamante Head of Nursing

Francisco Pascual Plá Coordinator of the Emergency UnitJuan Carlos Peñalver Cuesta Head of Thoracic Surgery Department

Head of Anaesthesiology, Reanimation, Critical care Therapeutics Department

TRANSFUSION COMMITTEE

NAME JOB TITLE Chairperson Asunción Perales Marín Medical DirectorSecretary Ángela Palacios Llopis Assistant Director of Management

Members

Eduardo Aznar Oroval Head of Clinical Analysis and Microbiology Department

Agustín Iranzo Tatay Attending Physician of Clinical Analysis and Microbiology Department

Tomás García Lozano Attending Physician of Clinical Analysis and Microbiology Department

Adoración Egido González Attending Physician Internal Medicine Unit

Elena Contel Ballesteros Attending Physician Internal Medicine Unit

Javier Ortega Giménez Attending Physician of A.R.C.T. Department

Francisco Pascual Plá Coordinator of the Emergency UnitYolanda Colomer Nieves Specialized PharmacistAmparo Montemayor Bustamante Head of NursingCarmen Juárez Martí Nursing Supervisor of Surgical Services

INFECTIONS AND PROPHYLAXIS COMMITTEE

13

NAME JOB TITLEChairperson Asunción Perales Marín General DirectorVice chairman Sergio Miguel Almenar Medina Medical PathologistSecretary Carlos J. Andrés Blasco Specialized Pharmacist in Hospital Pharmacy

Members

Vicente Guillem Porta Medical OncologistCarlos Fernández-Martos Soriano Medical OncologistIsmael Pastor Climente Specialized Pharmacist in Hospital PharmacyDiego Cano Blanquer Primary Care PharmacistCarmen Arce Martínez NurseLourdes Bello Luna Bachelor in lawCarlos Llombart Fuertes Bachelor in lawEsteban Morcillo Sánchez Clinical PharmacistMilagros Ardid Encinar PediatricianIgnacio Martín Domenech Family and Community Medicine PhysicianVicente Moya Sahorí Health Information Management Physician

CLINICAL RESEARCH ETHICS COMMITTEE

NAME JOB TITLE

Company Representatives

Asunción Perales Marin General DirectorCristina Bordils Montero Director of ManagementÁngela Palacios Llopis Assistant Director of Management

Vicente Crispin Contreras Head of Radiophysics and Radiological Protection Department

Prevention Delegates

Rosario Valero Valero Radiation Oncology technicianLucas Valero Corraliza Pathology technician Inmaculada Atance Pallarés Radiation Oncology nurseAmparo Devís Gamir Administrative Officer

HEALTH AND SAFETY COMMITTEE

14

NAME JOB TITLEChairperson Onofre Sanmartín Jiménez Clinical Head of Dermatology DepartmentSecretary Lourdes Bello Luna Lawyer

Members

Joaquín Gavilá Gregori Tutor and Attending Physician Medical OncologyMª Luisa Chust Climent Tutor and Attending Physician Radiation OncologyCelia Requena Caballero Tutor and Attending Physician Dermatology

Vicente Crispin Contreras Head of Radiophysics and Radiological Protection Department

Carlos J. Andrés Blasco Head of Pharmacy Department Pilar Ferrer Peñaranda Valencia Heath Department Representative Sol Castaño Lerena Administrative OfficerM.I.R. Resident Intern Specialist Training Representative

TEACHING COMMITTEE

NAME JOB TITLE

Workers' Representatives

Amparo Devís Gamir CC.OO.María Dolores Solís Moreno CSIFRosario Valero Valero CC.OO.

Company Representatives

Ángela Palacios Llopis Assistant Director of ManagementJosé Benet Aguilar LawyerPedro Antonio Gómez Gómez Humans Resources Director

COMMISSION

NAME JOB TITLEChairperson Asunción Perales Marín General DirectorVice chairman Miguel Ángel Muñoz Quintana Clinical Head of Oncology MedicalSecretary Carlos J. Andrés Blasco Head of Pharmacy Department

Members

Cristina Bordils Montero Director of ManagementYolanda Colomer Nieves Specialized Pharmacist Amparo Montemayor Bustamante Head of NursingCarlos Guillén Barona Head of Dermatology DepartmentJosé Rubio Briones Head of Urology DepartmentAdoración Egido González Attending Physician Internal Medicine UnitCelia López de Briñas Monfort Clinical Head of A.R.C.T. Department

PHARMACY COMMITTEE

15

NAME JOB TITLEAmparo Devís Gamir AdministrativeInmaculada Atance Pallarés NurseGemma Dobón González Pathology technicianAna Ferrer Rafael Radiology technicianAna Pérez Balaguer AdministrativeRosario Valero Valero Clinical AssistantAmparo Alcina Núñez Clinical AssistantMª José Pérez Llopis Clinical AssistantIsabel Catalá Navarro AdministrativeEduardo Ferrandis Perepérez Clinical Head of Otolaryngology DepartmentMaría Dolores Solís Moreno Clinical AssistantAna Perales Vila NurseJosefina Larrosa Moya NurseAmparo Almagro Herrero NurseLucas Valero Corraliza Pathology TechnicianJuan Andrés Calvet Sánchez Computer EngineerRafael Martínez Dolz Pathology Technician

WORKS COUNCIL

NAME JOB TITLEChairperson Asunción Perales Marín General Director

Secretary Eduardo Aznar Oroval Head of Clinical Analysis and Microbiology Department

Members

Ángela Palacios Llopis Assistant Director of Management

Amparo Martínez Tejedor Administrative assistant Clinical Analysis and Microbiology Department

Agustín Iranzo Tatay Attending Physician Clinical Analysis and Microbiology Department

Marina Sánchez Yepes Attending Physician Clinical Analysis and Microbiology Department

Nuria Casani Turégano Nursing Supervisor Clinical Analysis and Microbiology Department

Amparo Ferrándiz Martínez Nurse Clinical Analysis and Microbiology Department

QUALITY MANAGEMENT LABORATORY COMMISSION

HEALTH CARE ACTIVITY4.

17

NUMBER OF PATIENTS TREATED

2015 2016 DIFFERENCE % DEVNew Patients 4.994 4.759 -235 -4,7

Prevalent Patients 31.788 31.692 -96 -0,3

TOTAL 36.782 36.451 -331 -0,9

ORIGIN NEW PATIENTS

2015 2016 DIFFERENCE % DEV

ARAGÓN 13 1 -12 -92,3

CASTILLA LA MANCHA 269 304 35 13,0

MURCIA 87 88 1 1,1

OTROS 131 210 79 60,3

ALICANTE 598 589 -9 -1,5

CASTELLON 136 134 -2 -1,5

VALENCIA 3.760 3.433 -327 -8,7

TOTAL 4.994 4.759 -235 -4,7

NEW PATIENTS

Health Care ActivityPatients treated

18

Distribution Pathology

DISTRIBUTION PATHOLOGY

MALIGNANT PATHOLOGY DISTRIBUTION

Malignant Pathology

Bening Pathology

19

Outpatient Activity2015 2016 DIFFERENCE % DEV

ANAESTHESIOLOGY Outpatient Consultations 4.518 4.389 -129 -2.9

RADIOTHERAPY Valencia 12.291 11.106 -1.185 -9,6

Alcoy 3.077 3.076 -1 0,0

Cuenca 2.021 2.444 423 20,9

MEDICAL ONCOLOGY

Outpatient Consultations 18.383 18.481 98 0,5

Genetic Counselling 1.196 1.210 14 1,2

Day Hospital Consultations 12.367 12.827 460 3,7

GynaecologicalOncolologyClinicalArea

Outpatient Consultations 1.433 1.397 -36 -2,5

Day Hospital Consultations 1.159 1.280 121 10,4

DERMATOLOGY 16.624 15.997 -627 -3,8

SURGERY 19.882 19.031 -851 -4,3

UROLOGY 17.213 18.104 891 5,2

GYNAECOLOGYOutpatient Consultations 8.337 6.792 -1.545 -18,5

Cervical Pathology Unit 2.533 2.061 -472 -18,6

Gynaecological Oncology Clinical Area 2.266 2.192 -74 -3,3

OTOLARYNGOLOGY 6.486 6.003 -483 -7,4

HAEMATOLOGYOutpatient Consultations 1.790 1.723 -67 -3,7

Day Hospital Consultations 189 248 59 31,2

PSYCHOLOGY 2.461 2.446 -15 -0,6

NUCLEAR MEDICINE 285 196 -89 -31,2

INTERNAL MEDICINE 1.622 1.429 -193 -11,9

PNEUMOLOGY 1.653 1.547 -106 -6,4

DIGESTIVE DISEASE 4.601 4.446 -155 -3,4

THORACIC SURGERY 1.452 1.535 83 5,7

RECONSTRUCTIVE PLASTIC SURGERY 1.127 1.079 -48 -4,3

CONSULTANTS

ORTHOPEDIC TRAUMA SURGERY 870 1.049 179 20,6

NEUROSURGERY 129 136 7 5,4

NEUROLOGY 511 555 44 8,6

CARDIOLOGY 547 544 -3 -0,5

TOTAL 147.023 143.323 3.700 -2,5

OUTPATIENT CONSULTATIONS ACTIVITY

20

DAY HOSPITAL

2015 2016 DIFFERENCE % DEV.

Medical Oncology 13.561 14.161 600 4,4

Haematology 452 551 99 21,9

Urology 654 846 192 29,4

Nuclear Medicine 14 28 14 100,0

TOTAL 14.681 15.586 905 6,2

EMERGENCY VISITS FOR DEPARTMENT

2015 2016 DIFFERENCE % DEV.Medical Oncology 4.682 4.562 -120 -2,6

Urology 871 795 -76 -8,7

Surgery 534 490 -44 -8,2

Gynaecology 215 177 -38 -17,7

Radiotherapy 199 201 2 1,0

Otolaryngology 117 168 51 43,6

Home Hospitalization Unit 422 375 -47 -11,1

Internal Medicine 151 180 -29 19,2

Others 353 319 -34 -9,6

OVERALL TOTAL 7.544 7.267 -277 -3,7

OVERALL NUMBER OF EMERGENCIES

2015 2016 DIFFERENCE % DEV.Emergencies attended 7.544 7.267 -277 -3,7

Emergencies admitted 1.811 1.899 88 4,9

% Admissions 24,0 26,1 2,1 -

21

HOSPITAL STAYS

2015 2016 DIFFERENCE % DEV.

SURGERY 4.477 3.871 -606 -13,5ORTHOPEDIC TRAUMA SURGERY 59 124 65 110,2THORACIC SURGERY 219 352 133 60,7DERMATOLOGY 340 238 -102 -30,0RECONSTRUCTIVE PLASTIC SURGERY 278 320 42 15,1GYNAECOLOGY 838 1.086 248 29,6HAEMATOLOGY 157 275 118 75,2NEUROSURGERY 0 0 - -MEDICAL ONCOLOGY 10.403 11.059 656 6,3A.B.M.T 159 96 -63 -39,6OTOLARYNGOLOGY 1.530 1.177 -353 -23,1RADIOSURGERY 83 61 -22 -26,5BRACHYTHERAPY 387 280 -107 -27,6RADIOTHERAPY 2.667 2.122 -545 -20,4UROLOGY 4.154 3.974 -180 -4,3INTERNAL MEDICINE 3.380 3.255 -125 -3,7DIGESTIVE DISEASES 173 107 -66 -38,2INTENSIVE CARE UNIT 5.341 4.782 -559 -10,5TOTAL HOSPITAL 34.645 33.179 -1.466 -4,2EMERGENCY UNIT 103 125 22 21,4HOME HOSPITALIZATION UNIT 29.324 27.887 -1.437 -4,9

Hospitalization

22

SURGERY ACTIVITY

2015 2016 DIFFERENCE % DEV.

SURGERY 1.390 1.281 -109 -7,8ORTHOPEDIC TRAUMA SURGERY 46 46 - -RECONSTRUCTIVE PLASTIC SURGERY 166 150 -16 -9,6THORACIC SURGERY 197 188 -9 -4,6DERMATOLOGY 957 967 10 1,0GYNAECOLOGY 507 458 -49 -9,7NEUROSURGERY 0 1 1 -OTOLARYNGOLOGY 439 390 -49 -11,2ANAESTHESIOLOGY AND REANIMATION 107 123 16 15,0RADIOTHERAPY - BRACHYTHERAPY 363 341 -22 -6,1UROLOGY 1.002 1.018 16 1,6TOTAL 5.174 4.963 -211 -4,1

23

AVERAGE HOSPITAL STAY FOR DEPARTMENT

2015 2016 DIFFERENCE % DEV.

SURGERY 3,1 3,0 -0,1 -3,2ORTHOPEDIC TRAUMA SURGERY 2,5 4,1 1,6 64,0RECONSTRUCTIVE PLASTIC SURGERY 2,3 2,7 0,4 17,4THORACIC SURGERY 1,7 1,7 - -DERMATOLOGY 1,5 1,6 0,1 6,7DIGESTIVE DISEASES 2,5 2,3 -02 -8,0GYNAECOLOGY 1,5 2,2 0,7 46,7HAEMATOLOGY 4,8 5,7 0,9 18,8INTERNAL MEDICINE 8,5 8,1 -0,4 -4,7MEDICAL ONCOLOGY 10,9 10,6 -0,3 -2,8OTOLARYNGOLOGY 3,8 3,3 -0,5 -13,2RADIOSURGERY 1,8 1,7 -0,1 -5,6BRACHYTHERAPY 2,7 2,3 -0,4 -14,8RADIOTHERAPY 9,5 7,4 -2,1 -22,1A.B.M.T 22,7 19,2 -3,5 -15,4UROLOGY 3,6 3,4 -0,2 -5,6INTENSIVE CARE UNIT 2,3 2,3 - -TOTAL HOSPITAL 4,2 4,1 -0,1 -2,4

HOME HOSPITALIZATION UNIT 16,6 16,5 -0,1 -0,6

Overall Indicator of Activity

HOSPITAL OVERALL INDICATOR

2015 2016 DIFFERENCE % DEV.

Occupancy rate 82,7 78,2 -4,5 -5,4

Turnover rate 72,3 68,4 -3,9 -5,4

Average hospital stay 4,2 4,1 -0,1 -2,4

24

RADIOTHERAPY TREATMENTS

2015 2016 DIFFERENCE % DEV.GROUP I: SIMPLE TREATMENT 189 235 46 24,3GROUP II: PALLIATIVE TREATMENT 392 396 4 1,0GROUP III: ADJUVANT TREATMENT 470 423 -47 -10,0GROUP IV: RADICAL TREATMENT 267 301 34 12,7GROUP V: COMPLEX TREATMENT 285 311 26 9,1IGRT/IMRT 246 298 52 21,1RADIOSURGERY 46 36 -10 -21,7HIGH RATE DOSE BRACHYTHERAPY 215 232 17 7,9PROSTATE BRACHYTHERAPY 114 110 -4 -3,5OCULAR BRACHYTHERAPY 26 11 -15 -57,7OVERALL TOTAL 2.250 2.353 103 4,6

Radiation Oncology Activity

25

HAEMATOLOGY: BLOOD BANK

2015 2016 DIFFERENCE % DEV.Red cells concentrate 2.864 3.173 309 10,8Platelets 311 362 51 16,4PFC 163 144 -19 -11,7Irregular Antibodies Scrutiny 2.012 2.024 12 0,6Direct antiglobulin tests 27 35 8 29,6Antibodies Identification 17 56 39 229,4Studies of transfusion reactions 2 3 1 50,0ABO and RH groups 2.005 2.120 115 5,7

HAEMATOLOGY: DIAGNOSTIC ACTIVITY INDICATORS

2015 2016 DIFFERENCE % DEV.Studies of bone marrow (aspirate / biopsy) 68 90 22 32,4Cytochemistry (PERLS/PAS) 13 18 5 38,5Morphological study of peripheral blood 136 145 9 6,6

Central Services ActivityClinical Analysis, Microbiology and Haematology

OVERALL INDICATOR OF ACTIVITY

2015 2016 DIFFERENCE % DEV.

BIOCHEMISTRY

PATIENTS 25.088 24.087 -1.001 -4,0

REQUESTS 74.075 74.869 794 1,1

DETERMINATIONS 2.438.322 2.510.440 72.118 3,0

MICROBIOLOGY (Bacteriology + Serology) 30.238 33.448 3.210 10,6

TUMOR MARKERS 39.024 39.936 912 2,3

26

BIOPSIES

2015 2016 DIFFERENCE % DEV.NUMBER OF PATIENTS 8.922 8.246 -676 -7,6NUMBER DE BIOPSIES 26.593 28.133 1.540 5,8NUMBER DE BLOCKS 40.705 37.081 -3.624 -8,9

CYTOLOGIES

2015 2016 DIFFERENCE % DEV.

I.V.O.Vaginal 2.913 2.508 -405 -13,9Non vaginal 3.080 3.071 -9 -0,3

Calle de la Estrella 8.138 6.436 -1.702 -20,9OVERALL TOTAL 14.131 12.015 -2.116 -15,0

IMMUNOHISTOCHEMISTRY

2015 2016 DIFFERENCE % DEV.Number 18.302 15.405 -2.897 -15,8

S.I.S.H.

2015 2016 DIFFERENCE % DEV.Number 151 105 -46 -30,5

NECROPSIES

2015 2016 DIFFERENCE % DEV.

Number of Necropsies 2 1 -1 -50,0

Pathology

27

TYPE OF ANALYSIS 2015 2016 DIFF. % DEV.Translocation t(14;18) or fusion gene Bcl-2-IGH for diagnosis of Follicular Lymphoma or Hodgkin large B-cell 14 21 7 50,0

Translocation t(14;18) or fusion gene BCL1-IGH for diagnosis of lymphoma mantle 4 1 -3 -75,0

Gene rearrangement for clonality studies of B-cell lymphomas 34 29 -5 -14,7TCR gene rearrangements range for clonality studies of T-cell lymphomas 36 31 -5 -13,9

Sequence of BRCA1 or 2 breast cancer and hereditary ovarian index case 408 355 -53 -13,0

Sequence of BRCA1 or 2 breast cancer and hereditary ovarian familial cases 174 114 -60 -34,5

Microsatellite study intensity (BAT25, BAT26, D5S346, D17S250, D2S123) sporadic colon cancer and colon cancer hereditary nonpolyposis

98 86 -12 -12,2

Study hypermethylation of the promoter region of gene MLH1 nonpolyposis colon cancer and sporadic colon cancer hereditary

8 3 -5 -62,5

Study of c-Kit mutations (exons 9,11,13 and 17) and PDGFR (exons 12 and 18). Gastrointestinal stromal tumor (GIST), in response to TREATMENT with Gleevec and as indicator in case TREATMENT C-Kit negative

93 65 -28 -30,1

Study of different types of fusion between COL1A1-PDGFB genes. Differential diagnosis of dermatofibrosarcoma protuberans and as an indicator of TREATMENT with Gleevec in advanced cases

12 4 -8 -66,7

Study of the sequencing of any specific mutation. Sequencing of a known mutation or a particular region of 400 bp 425 431 6 1,4

Study mutations CDKN2A (exons 1-alpha, 1-beta 2). Genetic predisposition to melanoma and pancreatic cancer 30 27 -3 -10,0

MLPA BRCA1. Multiple linkage analysis to detect loss or gain of genetic material associated with hereditary breast cancer 194 190 -4 -2,1

Molecular Biology

NUMBER OF SAMPLES REVIEW BY PROCESS

28

TYPE OF ANALYSIS 2015 2016 DIFF. % DEV.MLPA BRCA 2. Multiple linkage analysis to detect loss or gain of genetic material associated with hereditary breast cancer 195 188 -7 -3,6

Analysis of mutations in JAK2 (V617F) 3 8 5 166,7Factor V Leiden (G1691A) 0 1 1 -Hemochromatosis: S65C 2 1 -1 -50,0Hemochromatosis: C282Y 2 1 -1 -50,0Prothrombin 1 1 0 0,0MTHFR: C&/T y A1298C 0 1 1 -Mutations in the gene K-ras 41 61 20 48,8PCA3 expression determination in prostate cancer 419 520 101 24,1Determination of EGFR mutations 62 48 -14 -22,6Analysis of MC1R gene polymorphism 116 100 -16 -13,8Quantitative determination of the expression BCR-ABL(9;22) en CML y ALL 11 19 8 72,7

Determination of microsatellite instability in endometrial and ovarian cancer 79 30 -49 -62,0

Typing Human Papilloma Virus 11 9 -2 -18,2PCA3 expression determination in prostate cancer urine sample sent from other hospitals 127 120 -7 -5,5

TOTAL 2.599 2.465 -134 -5,2

29

ACTIVITY INDICATORS

2015 2016 DIFFERENCE % DEV.VENTRICULAR EJECTION FRACTION (VEF) 413 429 16 3,9SCINTIGRAPHY 165 178 13 7,9SENTINEL NODE 385 363 -22 -5,7TREATMENTS WITH I131 9 5 -4 -44,4BONE TRACKING 1.527 1.433 -94 -6,2ISOTOPE RENOGRAM 34 24 -10 -29,4

PET 494 411 -83 -16,8OVERALL TOTAL 3.027 2.843 -184 -6,1

ACTIVITY INDICATORS

2015 2016 DIFFERENCE % DEV.

COMPUTED AXIAL TOMOGRAPHY 26.623 27.447 824 3,1MAGNETIC RESONANCE 4.847 4.592 -255 -5,3ULTRASOUNDS 9.784 10.011 227 2,3DOPPLER 291 286 -5 -1,7MAMMOGRAMS 9.463 9.039 -424 -4,5CONVENTIONAL RADIOLOGY 10.577 10.108 -469 -4,4RADIOLOGY WITH CONTRAST 182 112 -70 -38,5INTERVENTIONAL RADIOLOGY 2.916 2.771 -145 -5,0DENSITOMETRY 2.596 2.582 -14 -0,5OVERALL TOTAL 67.279 66.948 -331 -0,5

Radiology

Nuclear Medicine

EARLY DIAGNOSIS UNIT II MARQUÉS DEL TURIA

5.

31

ACTIVITY INDICATORS

2015 2016 DIFFERENCE % DEV.

Women screened 20.291 19.006 -1.285 -6,3Pathological women 5.681 5.711 30 0,5Non pathological women 14.610 13.295 -1.315 -9,0Surgical pathological women 226 200 -26 -11,5

ACTIVITY INDICATORS

2015 2016 DIFFERENCE % DEV.

Women screened 9.080 7.430 -1.650 -18,2Pathological women 943 899 -44 -4,7Non pathological women 8.137 6.531 -1.606 -19,7Surgical pathological women 265 147 -118 -44,5

BREAST AND GYNECOLOGICAL PATHOLOGY

Breast Screening

Screening ginecológico

Breast Cancer

Gynecological cancer

EARLY DIAGNOSISUNIT IELCAP

6.

33

ACTIVITY INDICATORS

ACCUMULATED SINCE THE BEGINNING OF ACTIVITY IN JUNE 2008 TO DECEMBER

Number of inclusions 7.930

Number of reviews 28.714

Number of computed axial tomography 36.644

Number of lung cancer detected 142

Diagnosis of asymptomatic lung cancer

OPPORTUNISTIC SCREENING PROGRAM FOR EARLY DIAGNOSIS OF PROSTATE CANCER

7.

35

ACTIVITY INDICATORS

ACCUMULATED SINCE THE BEGINNING OF ACTIVITY IN JULY 2010 TO DECEMBER 2016

Number of inclusions 7.006

Number of reviews 4.265

Number of cancer detected 259

Opportunistic Screening Program for Early Diagnosis of Prostate Cancer

PROFESOR BELTRÁN BÁGUENA, 8 46009 VALENCIATEL. +34 96 111 40 00 - FAX +34 96 111 43 41