Lecture 2 August 3, 2005 Lehninger (4 th Edition), Chapter 6,
Lecture 12 August 26, 2005 Lehninger (4 th Edition), Chapter 17.
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Transcript of Lecture 12 August 26, 2005 Lehninger (4 th Edition), Chapter 17.
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Lecture 12
• August 26, 2005
• Lehninger (4th Edition), Chapter 17
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FATTY ACID DEGRADATION (OXIDATION)
LNC Chapter 17
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LNC 10-1
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LNC 10-6
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LNC 10-8
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LNC 10-15
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LNC 10-16
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UPTAKE and DISTRIBUTION in Mammals
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LNC 17-1
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LNC 21-40
ADIPOSE TISSUE
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LNC 17-2
Chylomicron
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LNC 21-39a
Structure of an LDL particle
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LNC 21-39b
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Breakdown/Oxidation of Fatty Acids
-Oxidation
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Activation
LNC 17-5
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LNC 17-6
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C14 fatty acid 7 acetyl CoA
6 rounds of oxidation
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LNC 17-7
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LNC 19-8
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LNC 17-9
How to deal with unsaturated fatty acids:
cis 3 - ordouble bond between
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LNC 17-10
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LNC 17-11
How to deal with a fatty acid
containing an
uneven number of carbons
C3
C4
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LNC box 17-1
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LNC box 17-2
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catalase
Degradation ofvery long chainfatty acids in the
peroxisome
LNC 17-12
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Glyoxalate Cycle inPlants
LNC 17-13
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Ketone Bodies
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LNC Fig 17-18
Conditions favoringketone body formation:
depletion of OAfor gluconeogenesis
acetyl-CoA becomesavailable forketone body synthesis
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Metabolic Biochemistry
FATTY ACID SYNTHESIS
LNC Chapter 21
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LNC Fig. 21-1
the enzyme has threefunctional regions:
- biotin carrier protein- biotin carboxylase- transcarboxylase
acetyl-CoA + CO2 ==> malonyl-CoA
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LNC Fig. 21-4
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acyl carrier protein
LNC Fig. 21-2
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End of lecture 12
August 26, 2005