C146-E141E

Liquid Chromatograph Mass Spectrometer

LCMS-8030

Next-Generation Ultra Fast LC/MS/MS

Fully Compatible with HPLC and UHPLC

Triple quadrupole mass spectrometer plays very important role in trace analysis of complex matrices such as residual pesticide

in foods, contaminants in environment, drug concentration in blood and screening of abused drugs. In recent years, UHPLC

system has been developed realizing high speed and high resolution, however, analysis speed of mass spectrometer has

bottlenecked in combination of UHPLC and triple quadrupole mass spectrometer. Our LCMS-8030 meets your requirement by

combining Ultra Fast MRM Acquisition and Ultra Fast Polarity Switching. LCMS-8030 enjoys maximum benefit of UHPLC

performance and offers analytical speed beyond comparison.

U l t r a F a s t L C p e r f o r m a n c eWith a pressure range up to 130 MPa, high-speed injection, overlapping injection and highly efficient gradient mixing, Nexera UHPLC enables ultra-high speed and ultra-high resolution analysis.

U l t r a F a s t M S S p e e d● Fastest multiple reaction monitoring (MRM) transition

times available today (dwell times of 0.8 msec and pause times of 1 msec)

● High speed multi-analyte detection with 555 MRM transitions in one second

● Unsurpassed polarity switching speed (polarity switching time of 15 msec)

S y s t e m I n t e g r a t i o nBy bringing together the world’s highest performance LC system and the fastest triple quadrupole mass spectrometer available today, Shimadzu delivers a new approach to ultra fast mass spectrometry detection. Robust, simple and Ultra Fast.

GCMS-QP2010 UltraGCMS-QP2010 SE

LCMS-IT-TOF iMScope MALDI-7090GCMS-TQ8030 LCMS-8030 LCMS-2020LCMS-8040 LCMS-8050

Figure1. Standard Chromatogram of 226 Pesticides in Two Minutes

Figure 2

0.25 0.50 0.75 1.00 1.25 1.50 1.75 min0

0.5

1.0

1.5

×105

Inte

nsi

ty

Low speed

Product Ion scanMRM

scan startthreshold

High speed

01.00 1.25 min

2.0

4.0

6.0

8.0

×105

Inte

nsi

ty

×105

0.0100 200 300 m/z

1.0

2.0

3.0

108.9 218.1

261.1

399.3

Inte

nsi

ty

N

N

H

C

OOCH3

OCH3

N

N O O CH2 CH3

H

S

O

O

Compound Name m/z Time (0.885 min – 1.462 min)

Fusion of Ultra Fast MRM Acquisition and Ultra Fast Polarity Switching

U l t r a F a s t M a s s S p e c t r o m e t r y D e t e c t i o n

An Ultra Fast Scan Speed of 15,000 u/sec Results in a Wealth of Information

With high-resolution, high peak capacity

separations, mass spectrometry detection needs

to be Ultra Fast to acquire sufficient data points

across a peak to deliver accurate and reliable

quantitation. Coupled with Nexera, the

LCMS-8030 not only delivers the fastest MRM

acquisition times available today, with dwell

times of 1 msec, it also acquires data with a

polarity switching time of just 15 msec.

Figure 1 illustrates a 2-minute elution of 226

pesticides using the LCMS-8030 with the

Nexera UHPLC system. Ultra Fast polarity

switching and Ultra Fast MRM analysis times

deliver reliable and accurate quantitation.

Figure 2 illustrates a 1.5-minute elution of 29 pesticides using the LCMS-8030 with the Nexera UHPLC

system. Ultra Fast polarity switching and Ultra Fast MRM transitions deliver reliable and accurate

quantitative results. Furthermore, Synchronized Survey Scan technology, utilizing a high-speed scanning

rate of 15,000 u/sec, allows full spectrum scans within a series of MRM measurements, providing

confirmation of target compounds with information-rich product ion spectra.

Introducing the Next Generation of Triple Quadrupole Technology

To provide best-in-class performance for Ultra Fast data acquisition rates in MS/MS detection, we have developed UFsweeper technology. This technology efficiently accelerates ions out of the collision cell, dramatically minimizing cross talk and shortening MRM analysis time to the lowest possible level. Simply put, the LCMS-8030 delivers higher data quality at higher data acquisition speeds.

4

UFsweeper Technology Effectively Accelerates Ions Out of the Collision Cell

555 MRM Transitions in One Second is Now Possible!

patent pending

UFsweeper is a unique technology created by

Shimadzu that delivers unparalleled

efficiency and speed. UFsweeper accelerates

ions out of the collision cell by forming a

pseudo-potential surface. The result is higher

CID efficiency and Ultra Fast ion transport to

reduce the sensitivity losses and cross-talk

that are observed on other systems.

UFsweeperConventional

design

UFsweeper efficiently acceleratesions out of the collision cell without losing momentum.

Ions lose momentum due to collision with gas.

Dwell time

100 msec

10 msec

1 msec

%RSD

0.48

0.79

1.92

×104

00 0.5 1.0 1.5 2.0 2.5 3.0 3.5 min

0.5

1.0

1.5

Alprazolam m/z 309 >281, FWHM = 3 sec, Pause time 1 msec, n = 6

Dwell time1 msec

Dwell time10 msec

Dwell time100 msec

In the UFsweeper collision cell, there is no ion loss

even at 1 msec dwell times as ions are accelerated

from the pressurized collision cell without losing

momentum. In addition, higher RF power

capability exceptionally minimizes the pause time

between each MRM transition. For

the first time, true high-

throughput analysis without

sacrificing ion intensity is a reality.

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Atmospheric ionization source

Shimadzu engineering results in the rapid transfer of the wide m/z range of ions from the Qarray to the octopole region, enabling Ultra Fast MRMs and product ion scans.

Ion opticsOur unique Qarray ion guide was designed to effectively focus ions over a wide m/z range by overlapping multiple electric fields (Patent pending).

Qarray

The transmission efficiency between octopoles is dramatically improved with a larger aperture size, supported by a triple inlet turbo molecular pump.

Octopole

Desolvation line: Easy maintenance without breaking vacuum

U l t r a F a s t M a s s S p e c t r o m e t r y D e t e c t i o n

Delivering Results – Quickly and Accurately

The ion optics on the LCMS-8030 have been

fully optimized for ion transport to the

detector using a series of RF and DC ion

guides before Q1. This design has a

significant impact on challenging matrices.

For example, in the case of a 10 ppb

pesticides mixture spiked into tomato

extract, 1400 individual 1μl aliquots were

injected over a period of 2 days. The result is

an outstanding 2.19% reproducibility.

00

0.5

1

1.5

2

2.5

3

200 400 600 800 1000 1200

Rel

. I

nte

nsi

ty

Injection

Chromafenozide 10ng/mL in tomato

1400 analyses (47 hours)

Internal standard %RSD 2.19%

Ultra Fast Speed Combined with Femtogram Detection

Drawing on our groundbreaking research and hands-on experience, the LCMS-8030 has been designed to achieve outstanding performance quicker than ever before. Bringing together advanced ion acceleration technology and high-sensitivity detection systems, we have created one of the most advanced triple quadrupole mass spectrometry systems currently available.

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Detector

UFsweeper collision cell

Utilizing over 30 years experience in quadrupole research, development, and manufacture, Shimadzu delivers high-performance hyperbolic mass filters to its current LC/MS products. Even at the maximum scan rate (15,000 u/sec), excellent sensitivity and resolution are maintained.

Quadrupole rods

01.00 1.25 1.50 1.75 2.00 min

0.5

1.0

1.5

2.0×106

In

ten

sity

Dummy transition

m/z 700.0 >165.0

01.00 1.25 1.50 1.75 2.00 min

0.5

1.0

1.5

2.0×106

Verapamil 1 μg/mL

m/z 455.2 >165.0

Pause Time 3msec

Dwell Time 3msec

In

ten

sity

100

50

01.50 1.75 min

×10,000

Below 0.003%

Area%RSD(n=6)

7.75

3.36

3.11

1.43

0.79

1.29

0.31

0.70

0.58

0.40

Accuracy%

116.35

109.37

95.38

90.55

94.15

97.02

99.98

96.92

99.83

100.48

Conc.ng/mL

0.0058

0.0108

0.0477

0.0907

0.4708

0.9702

4.9995

9.6907

49.9108

100.4682

Std. Conc.ng/mL

0.005

0.01

0.05

0.1

0.5

1

5

10

50

100

Malachite greenm/z 329.2 > 313.15

R2= 0.99990530.005 –100ng/mL

Are

a

0.00.0

1.0

2.0

3.0

4.0

5.0

×106

25.0 50.0Concentration, ng/mL

75.0 100

UFsweeper Technology

Linearity - Dynamic Range with Ultra Fast Mass Spectrometry

UFsweeper technology is a unique approach to

accelerating MRM and ion fragmentation. Even at

high-speed data acquisition rates, cross talk and background

noise are eliminated.

Equipping a true high-speed pulse-counting detector and conversion dynode system has resulted in

astonishing data acquisition rates even with polarity switching. The development of a unique semi-floating

high-voltage power supply realizes ultra-high speed polarity switching (15 msec).

7

Easy Maintenance Identical to the LCMS-2020

22

33

11

DL（Desolvation Line）

Optimizing System Performance

U l t r a F a s t M a s s S p e c t r o m e t r y D e t e c t i o n

The LCMS-8030 heated ion source works with the most challenging samples, delivering robust,

high-sensitivity detection using ESI, APCI or our dual probe ionization interface.

System maintenance for the ion source is simplicity itself. Cleaning the heated desolvation capillary is quick

and maintains system vacuum to provide greater uptime and usability.

Simplicity

The LCMS-8030 achieves best-in-class performance for ultra fast mass spectrometry

detection and opens new opportunities for all application areas.

Using LabSolutions software to optimize the power of the Nexera UHPLC and

LCMS-8030 accelerates results, simply.

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MRM Synchronization optimizes MRM cycle times for overlapping retention time windows and helps to simplify method

development and routine analysis with multiple MRM experiments. MRM retention time windows can partially or

completely overlap; however, the cycle time for each analyte is constant, ensuring high-speed data sampling across a peak.

MRM Synchronization delivers optimized peak sampling and quantitative data for each retention time window even with

high-resolution chromatography.

MRM Synchronization

Quantitation Browser for Effective Multianalyte Quantitation

Single-vendor Solution Provides Seamless Operation

The combination of Shimadzu’s LCMS-8030 and Nexera UHPLC brings together the latest hardware on a

single platform for the next generation of Ultra Fast technology.

The unified platform provides

unmatched qualitative and quantitative

analysis, increased productivity, and

accelerated workflows for high-

throughput data analysis. Also, all

software operations are handled

seamlessly, reducing PC conflicts and the

need for user intervention.

The Quantitation Browser in

LabSolutions LCMS software

provides intuitive functionality

that contributes to more efficient

data processing. With the

Quantitation Browser, peak

information, quantitative results,

and statistical calculations of a

series of data can be rapidly

viewed in a single window.

9

When performing quantitation, system parameters must first be optimized. Shimadzu offers

various method packages to eliminate the need for MRM determination and chromatographic

method development.

Open Access Sample Logging for Triple Quadrupole LCMS

With sample logging now

made easy, Quan Solution

allows users unfamiliar

with LCMS software the

capability to perform

LC/MS/MS analysis using

pre-set methods. Simple

screens allow users to

access the power of a

triple quadrupole LCMS

without extensive

training.

Residual PesticidesNo. of compounds: 167

Veterinary DrugsNo. of compounds: 42

Water Quality AnalysisNo. of compounds: 44 (Golf Course Pesticides), 32 (Pesticides Targeted for Water Quality Control)

Drugs of AbuseNo. of compounds: 286

Rapid Toxicology Screening SystemNo. of compounds: 106

Primary MetabolitesNo. of compounds: 55

Lipid MediatorsNo. of compounds: 130

Po w e r f u l Wo r k f l o w S o l u t i o n s

Sample registration by selecting the standard samples, unknown samples, and QC samples at the specified positions

Login

Quantitative Reports Received Via E-mail

Sample Vial Selection

Analysis

Quan Solution SoftwareOptional Open Solution Series Software

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Changing between ESI, APCI and DUIS interface is a completely tool-free operation.

APCI-8030 DUIS-8030

Corona needle

ESI probe

Sample injection

Corona needle

Profiling Solution software analyzes a huge amount of data from chromatograms, extracting every peak

from multiple data files and creating a data table, which is required for multivariate analysis. Profiling

Solution supports both LC/MS and GC/MS instruments and allows multivariate analysis with various

analytical methods.

Profiling Solution Ver. 1.1

Optional Ion Source

Data Processing Software for Profiling

Detected

Peak

An

alyticalin

strum

ent

Mu

ltiple d

ataD

ata table

Mu

ltivariatean

alysis softw

are

Data file

11

LCM

S-8030

Printed in Japan 3655-07305-50ANS

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