• Vitiligo is an acquired pigmentary anomaly of the skin manifested by depigmented white patches surrounded by a normal or a hyperpigmented border which may slowly enlarge with concurrent development of new lesions.

Theories• autoimmune, • cytotoxic, • biochemical,• oxidant-antioxidant, • neural, and • viral

GENETICS

MELASMA

Treatment options

• Sun screen• Depigmenting agentsHydroquinone 4% Azelaic acid 20% Tretinoin 0.05 %

Combination Therapy

• Mild steroid(0.1% H.cort)

• Tretinoin 0.05%

• Hydroquinine 4%