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The members of the ISC organizing committee would like to take the oppor-

tunity to say thank you to all the professors who supported us in the plan-

ning and realization of the congress. Special thanks go to the rector of the

Medical University of Graz, Univ.-Prof. Dr. Josef Smolle, who has been our

biggest supporter from the beginning. Furthermore, we would like to thank

Univ.-Prof. Dr. Freyja Smolle-Jttner, Univ.-Doz. Dr. Cord Langner, and

Univ.-Prof. Dr.phil. Peter Holzer for their active support, guidance, and re-

sources. We would also like to thank MMag. Gerald Auer, Mag. Thomas

Moretti, and Mag. Maria Friedl for their assistance. Last but not least we

want to express our gratitude to Kathrin Eller, Robert Fuchs, Nassim Ghaf-

fari Tabrizi-Wizsy, Ursula Hiden, Grazyna Kwapiszewska, Eva Sturm, Peter

Tomazic, Wolfgang Sattler, and Evelyn Jantscher-Krenn for much appreci-

ated advises as well as their scientific support.

A big thank you also goes to our ambassadors all over the world who

helped spread the word and advertised this years International Student

Congress in their home countries.

International Student CongressMedical University of Graz

Auenbruggerplatz 2, 8036 Graz,[email protected] www.medunigraz.at/isc

Ida AringerThomas Georgi

Robert FreiKatharina Jandl

Carina Hasenhrl


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WELCOME - VITAJ - FOGADTATS - - BIENVENIDO - -

DVZLET BUNVENIT - - ACCUEIL - VELKOMMEN - BENVENUTO -

WILKOMMEN - SERVUS- WELCOME - VITAJ - FOGADTATS - - BIENVENIDO -

DVZLET BUN VENIT - - ACCUEIL - VELKOMMEN

BENVENUTO - - WILKOMMEN - SERVUS - WELCOME - VITAJ - FOGADTATS -

BIENVENIDO - - DVZLET BUN VENIT -

ACCUEIL - VELKOMMEN - BENVENUTO - - WILKOMMEN - SERVUS - WELCOME - VITAJ

FOGADTATS - - BIENVENIDO - - DVZLET BUNVENIT

- ACCUEIL - VELKOMMEN - BENVENUTO - - WILKOMMEN - SERVUS



WILKOMMEN - SERVUS - WELCOME - VITAJ - FOGADTATS - - BIENVENIDO -

DVZLET BUNVENIT - - ACCUEIL - VELKOMMEN- BENVENUTO

- WILKOMMEN - SERVUS - WELCOME - VITAJ - FOGADTATS - - BIENVENIDO

- DVZLET - BUN VENIT - - ACCUEIL

VELKOMMEN - BENVENUTO - - WILKOMMEN - SERVUS - WELCOME - VITAJ


- ACCUEIL - VELKOMMEN - BENVENUTO - - WILKOMMEN - SERVUS




DVZLET - BUN VENIT - - ACCUEIL - VELKOMMEN -


BIENVENIDO - - DVZLET BUN VENIT - -



- ACCUEIL - VELKOMMEN - BENVENUTO - - WILKOMMEN - SERVU




DVZLET - BUN VENIT - - ACCUEIL - VELKOMMEN


BIENVENIDO - - DVZLET BUN VENIT - -



- ACCUEIL - VELKOMMEN - BENVENUTO - - WILKOMMEN - SERVU




DVZLET BUN VENIT - - ACCUEIL - VELKOMMEN -


BIENVENIDO - - DVZLET BUN VENIT -



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We would like to welcome you to the third edition of the International Stu-

dent Congress, which is taking place at the Medical University of Graz June

4th - 6th, 2015.

This congress is organized by students for students and aims at giving

young scientists the opportunity to get familiar with scientific congresses, to

present and discuss their research in a friendly international atmosphere.

This years ISC takes place under the slogan You Define Tomorrows Re-

search, which is exactly what we encourage you to do be pro-active,

communicate your ideas, and share your excitement with others!

Enjoy the ISC 2015!


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We would like to welcome you to the third edition of the International Student Congress, which is taking

place at the Medical University of Graz on June 4th

- 6th

, 2015.

Science and research are essential to the future of every society. For this reason education and training in

scientific research are of great significance to academic institutions around the world.

In the spirit of promoting interest in research, the International Student Congress aims to be a platform for:

presenting ideas and results

acquiring knowledge and skills

introducing students to research fields and career opportunities

discussing current topics in medical research with leading experts

networking and interdisciplinary exchange of knowledge

The congress aims to bring together students from Bachelor, Master, PhD as well as Diploma studies of

medicine and related life sciences. Participants will be offered a chance to present the results of their scien-

tific work and discuss them with their colleagues as well as leading experts.

This years ISC takes place under the slogan You Define Tomorrows Research, which is exactly what we

encourage you to dobe pro-active, communicate your ideas, and share your excitement with others!

A total of seven awards will be granted to the best performances. The prize money is provided by Steier-

mrkische Sparkasse and will be awarded as follows:

2 awards of 300.- each will be granted to the best plenary presentation

2 awards of 200.- each will be granted to the best oral presentation

2 awards of 200.- each will be granted to the best poster presentation

1 awards of 100.- will be granted to the best abstract submission

We wish you the best of luck with your presentation!


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Keynotes 13

Plenaries 14

Precourses 15

Workshops 17

Congress Guide 20

About the medical University 21

About Graz 22

Congress Etiquette 23

How to find your way to the ISC 24

Overview 25

Partner-Congresses 28

30

Oral Presentations Overview 31

Poster Presentations Overview 32

Plenary I 33

Plenary II 34

Dentistry I (Oral) 35

Endocrinology I (Oral) 37

Technical Innovations (Oral) 39

Public Health (Oral) 41

Surgery I (Oral) 43

Oncology I (Oral) 44

Cardiology I (Oral) 46

Gynecology I (Oral) 48

Immunology I (Oral) 50

Cell-& Molecular-Biology I (Oral) 52

Cardiology II (Oral) 54

Biochemistry/Pharmacology (Poster) 56

Case Reports I (Poster) 58

Case Reports II (Poster) 60

Dentistry II (Poster) 62

Gynecology II (Poster) 64

Internal Medicine I (Poster) 66


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Microbiology/Infectiology I (Poster) 68

Neurology/Psychiatry I (Poster) 70

Oncology II (Poster) 72

Public Health II (Poster) 74

Public Health III 76

Case Reports III (Oral) 78

Dermatology/Opthalmology (Oral) 80

Gastro-Oncology (Oral) 82

Internal Medicine II (Oral) 83

Microbiology/Infectiology II (Oral) 85Mixed Session (Oral) 87

Immunology II (Oral) 89

Neurology/Psychiatry II (Oral) 91

Nephrology I (Oral) 93

Cardiology III (Poster) 95

Case Reports IV (Poster) 97

Cell-& Molecular-Biology I (Poster) 99

Dentistry III (Poster) 101

Endocrinology II (Poster) 104

Immunology III (Poster) 106

Nephrology II (Poster) 108

Public Health IV (Poster) 110

Surgery II (Poster) 112


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9:00 - 10:00am KW Second Floor Precourse Registration

10:00 - 10:30am SZ.KW21 Precourse Opening Ceremony

10:30 - 11:30am various locations Precourse Part I

11:30 - 12:00pm Coffee Break

12:00 - 1:00pm various locations Precourse Part II

1:00 - 2:00pm Lunch Buffett

2:00 - 3:00pm various locations Precourse Part III


3:30 - 4:30pm various locations Precourse Part IV

8:00 - 10:30pm FeierlauneHarrachgasse 22 Pub Quiz

8:00 - 9:00am HSZ Registration

9:009:15am HS D Opening Ceremony

9:15 - 10:15am HS D

Keynote "Blood sugar control in type 1 diabetes" &Meet the SpeakerJeffrey I Joseph, D.O.- Thomas Jefferson University,Philadelphia, USA

10:15 - 10:45am Coffee & Networking

10:45 - 11:45am UR KW.11Dentistry IOral Presentations

10:45 - 11:45am SR KW.11Endocrinology IOral Presentations

10:45 - 11:45am UR KW.12 Technical InnovationsOral Presentations

10:45 - 11:45am SR KW.12Public Health IOral Presentations

10:45 - 11:45am SR KW.13Surgery IOral Presentations

10:45 - 11:45am SR KW.14Oncology IOral Presentations

10:45 - 11:45am SZ KW.21Cardiology IOral Presentations

10:45 - 11:45am UR KW.21 Gynecology IOral Presentations


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10:45 - 11:45am UR KW.22Immunology IOral Presentations

10:45 - 11:45am SR KW.32Cell- & Molecular-Biology IOral Presentations

10:45 - 11:45am SR KW.31 Cardiology II

Oral Presentations

11:45 - 12:15pm Coffee & Networking

12:15 - 1:45pm various locations Workshops


2:45 - 3:30pm HS DPlenary IPlenary Presentation Session


3:45 - 4:45pm HS D

Keynote "Nanotechnologies" & Meet the Speaker"Nanotechnologies"Univ. Prof. Dr. Albert Duschl- Paris Lodron UniversitySalzburg


5:00 - 6:00pm HSZ HS E1Biochemistry & PharmacologyPoster Presentations

5:00 - 6:00pm HSZ HS E1 Case Reports IPoster Presentations

5:00 - 6:00pm HSZ HS E1Case Reports IIPoster Presentations

5:00 - 6:00pm HSZ HS E1Dentistry IIPoster Presentations

5:00 - 6:00pm HSZ HS E1Gynecology IIPoster Presentations

5:00 - 6:00pm HSZ HS E1Internal Medicine IPoster Presentations

5:00 - 6:00pm HSZ HS E2 Microbiology & Infectiology IPoster Presentations

5:00 - 6:00pmHSZ HS E2 Neurology & Psychiatry I

Poster Presentations

5:00 - 6:00pm HSZ HS E2Oncology IIPoster Presentations

5:00 - 6:00pm HSZ HS E2Public Health IIPoster Presentations

5:00 - 6:00pm HSZ HS E2Public Health IIIPoster Presentations

6:15 - 6:45pm HS D Award and Closing Ceremony


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8:00 - 9:15am HSZ Registration

9:15 - 10:15am UR KW.11Case Reports IIIOral Presentations

9:15 - 10:15am

SR KW.11

Dermatology & OphthalmologyOral Presentations

9:15 - 10:15am SR KW.12Gastro-oncologyOral Presentations

9:15 - 10:15am SR KW.13Internal Medicine IIOral Presentations

9:15 - 10:15am SR KW.14Microbiology & Infectiology IIOral Presentations

9:15 - 10:15am

UR KW.21

Mixed SessionOral Presentations

9:15 - 10:15am UR KW.22Immunology IIOral Presentations

9:15 - 10:15am SR KW.32Neurology & Psychiatry IIOral Presentations

9:15 - 10:15am SR KW.31Nephrology IOral Presentations

10:15 - 10:45am Coffee & Networking

10:45 - 11:45am HS DKeynote "New aspects of allergology" & Meet theSpeakerProf. Dr. Erika Jensen-Jarolim - AllergyCare, Vienna, Austria


12:00 - 12:45pm HS DPlenary IIPlenary Presentations


1:45 - 2:45pm

HSZ HS E1

Cardiology IIIPoster Presentations

7:45 - 8:00pmMeeting Point: Main SquareWear something traditional from your home country.

8:00 - 10:30pm

Official Welcome in the Mayors Hall Show off your internationality! Wear something typical

from your home country and enjoy the wonderful MayorsHall overlooking the Maine Square!


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1:45 - 2:45pm HSZ HS E1Case Reports IVPoster Presentations

1:45 - 2:45pm HSZ HS E1Cell- & Molecular-Biology IIPoster Presentations

1:45 - 2:45pm HSZ HS E1Dentistry IIIPoster Presentations

1:45 - 2:45pm HSZ HS E1Endocrinology IIPoster Presentations

1:45 - 2:45pm HSZ HS E2Immunology IIIPoster Presentations

1:45 - 2:45pm HSZ HS E2Nephrology IIPoster Presentations

1:45 - 2:45pm HSZ HS E2Public Health IVPoster Presentations

1:45 - 2:45pm HSZ HS E2 Surgery IIPoster Presentations


3:15 - 3:35pm HS D Award and Closing Ceremony

3:35 - 5:00pm HSZ Scientific Wine Time

6:45 - 7:00pm Main SquareMeeting Point: Main SquareWe'll meet up at the Main Square for our Scientific CityTour.

7:00 - 8:00pmScientific City TourStarting at the Main Square, you'll get the opportunity notonly to get to know the beautiful city of Graz but also toget some insight in those places of scientific significance.

8:00 - 11:59pmTam TamKeesgasse 3

ISC Farewell PartyDon't miss our Farewell Party.


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Jeffrey I Joseph, D.O. - Thomas Jefferson University, Philadelphia,USA

June 5th9:1510:15am

Jeffrey I Joseph is a Professor of Anesthesiology at Thomas Jefferson Uni-versity in Philadelphia, Pennsylvania. He is the director of both the Jeffer-son Artificial Pancreas Center and the Anesthesiology Program for Transla-tional Research. Aside from his research, for which he is renowned andrespected in the diabetes technology community, he is a very successfulentrepreneur and founder of three companies: RTM Vital Signs(implantable vital sign sensor), Capillary Biomedical (implantable CGMdevice, insulin delivery and artificial pancreas) and Animas Corporation(insulin pump therapy; was sold to Johnson and Johnson in 2006).

Univ. Prof. Dr. Albert Duschl - Paris Lodron University

Salzburg

June 5th2:303:45pm

The NanoDiode Multi-Stakeholder Dialogue engages Stakeholders into thediscussion on nanotechnologies. The KeyNote presents an overview onNanotechnologies & Nanomaterials, give insights in their risk & benefits

and their potential for the future. The talk intends to enable transfer ofknowledge and to further discuss public engagement to address societallydesired fields of innovation. The key message is: Get to know and discussimportant societal and ethical challenges and together identify desiredfields of innovation in nanotechnology.

Prof. Dr. Erika Jensen-Jarolim - Messerli Research Institute, Vi-enna, Austria

June 6th 10:4511:45 am

Erika Jensen-Jarolim, MD is immunologist and has a double appointmentas professor for Comparative Medicine between the Medical UniversityVienna and University of Veterinary Medicine Vienna. Before that sheserved as professor and head of the Institute of Pathophysiology and Al-lergy Research at the Medical University of Vienna. Her research is dedi-cated to the improvement of immunological diagnosis and therapies in al-lergy. She introduced the term allergooncology where focus is given onallergic mechanisms in cancer. Jensen-Jarolim is engaged in national andinternational boards and societies such as the Collegium InternationaleAllergologicum.


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Significance of prognostic factors in patients with non-Hodgkin lymphoma (DLBCL) of

gastrointestinal tract

Sran Nikolovski

The role of integrin 111 in adhesion and migration in synovial fibroblasts under in-

flammatory conditions

Kerstin Katharina Rauwolf

Impact of stem cell co-transplantation and chemical caspase blocker modulation in

cartilage tissue repair

Rokhsareh Rohban

HER2 gene copy number and breast cancer specific survival

Giovanni Battista Biserni

MiR-96-5p level influences cellular growth and survival in colorectal cancer.

Anna Ress

Poor short-term outcome in patients with ischemic stroke and active cancer

Markus Kneihsl


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This pre-course will take you through the important firststages of scientific writing, including planning your timeand understanding your assignment, through to starting towrite, editing and proofreading your work.

Have you ever tried to write a paper in extenso? For agood career in science you have to be able to communi-cate your research results. Our Colleges from Serbia offeryou hands-on tips & tricks to use on your journey fromliterature search to the writing of the final version of a pa-per. What are the chances for a student to get his re-search published? How to choose the right journal andwhat is the impact factor? What is data fabrication andplagiarism and how it is detected? And much more! En-hance your scientific skills with the lecturers from theEuropes oldest student scientific journal, MedicinskipodmladakMedical Youth.

1: Pain management in patients with concomitant diseasescan be challenging. Based on a case from our pain clinicwe will discuss pharmacological treatment options, opioidrotation, rescue medication, and typical problems whichmay occur in pain management.

2: A 30 year old patient was referred to hospital becauseof recurrent fever up to 39C. A big abscess (5x8x5cm) in

the neck was suspected as a focus for the fever and ele-vated C-reactive protein (CRP) levels. Nevertheless, differ-ent antibiotic regimen failed and the fever as well as highCRP levels persisted. Within the course of the hospitalstay he developed painful skin lesions on the hands andlegs, thoracic pain as well as decreased kidney function.Together we will work on the differential diagnosis of thiscase and what diagnostic procedures are necessary fordiagnosing his disease and starting specific therapy.

In this course the participants are going to learn and rein-force the practical skill of abdominal sonography. It is im-portant for us to teach structured procedures with a highlypractical component in small groups of max. 5 students.Per group, there will be two tutors of the peer-teaching-group Sono4you helping the attendees to reach the

learning target.

Students will be acquainted with the basic principles offlow cytometry and the potential uses thereof. Using sim-ple protocols, the participants will learn how to design andperform experiments and to acquire and analyze anddocument the data.

Objectives:

Setup the flow cytometer

Plan experimental setups for flow cytometry

Isolate and label cellsPerform data acquisition and analysis

Which career choices do you face when you finish yourstudies? Which area of research is advisable for your ca-reer? Is going abroad a must-do? How do you apply for aposition, what is important in your CV?

There are a lot of questions, when it comes to career pos-sibilities, especially for young motivated scientists. To-gether in an international group we will discuss and giveadvices. We will talk about the hearing procedure for aPHD position. At the end of the day we invite people whohave chosen science as a career path.

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Sample size calculation is a vital part at the planning stageof a trial. For example, the involvement of too many partici-pants puts unnecessarily participants at risk, wastesmoney, time, and effort; on the other hand, enrolling toofew participants may lack statistical power and miss ascientifically important response to the intervention,wastes resources, and is therefore unethical. In this work-shop, the concept of sample size calculation will be pre-sented for the situation of randomized controlled trials.Emphasize will be put on practical issues which will beillustrated with examples.

In academic medicine funding of scientific research pro-jects is becoming increasingly important. Basically twomain sources of funding exist: funding bodies and busi-nesses. Funding bodies are organizations that supportscientific activities by providing research grants. Theseorganizations typically offer standardized application formsthat need to be submitted by certain deadlines. Fundingbodies may also have calls for proposals. Funding bodiesinclude scientific societies, charitable funds or national orinternational research councils. Commercial companiesare another option. Companies might be interested in pro-viding financial support for projects related to the area oftheir product portfolio. This workshop offers an overview ofthe basics of fund raising covering national and interna-

The medical university of Graz was one of the first institu-tions in Europe to establish a compression chamber. Eventoday Graz is one of two hospitals in Austria, which canperform hyperbaric medicine in this way. The compressionchamber is not only used for decompression, but also fortherapy of lifethreatening infections like gangrene, tubercu-losis or for curing of intoxications. In this workshop you willbe able to visit the compression chamber at the hospital ofGraz and hear about the most important facts of hyper-baric medicine.

Every healthcare professional should be proficient in per-formance of advanced cardiac life support. This workshopwill focus on emergency assessment and management ofcritically ill patients through high-fidelity simulator training.

Airway management skills are essential both during rou-tine and critical clinical situations. This workshop will pro-vide participants with several skills relevant for the man-agement of difficult airway situations through part-task andsimulation training.

Sample size calculation is a vital part at the planning stageof a trial. For example, the involvement of too many partici-pants puts unnecessarily participants at risk, wastesmoney, time, and effort; on the other hand, enrolling toofew participants may lack statistical power and miss ascientifically important response to the intervention,wastes resources, and is therefore unethical. In this work-shop, the concept of sample size calculation will be pre-sented for the situation of randomized controlled trials.

Emphasize will be put on practical issues which will beillustrated with examples.


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Cardiopulmonary examination is a central clinical skill. Inthis workshop, participants will learn structured perform-ance of cardiopulmonary bedside assessment and get totrain diagnosis of common cardiac diseases in "Harvey -The cardiopulmonary patient simulator".

.

Sonography offers many advantages in examining traumapatients. In this workshop, participants will be able to learnand perform structured real-life examination using modernsonography according to the E-FAST approach.

Palliative care as an interdisciplinary medical specialityaims to prevent and relieve physical suffering as well asemotional, spiritual and social distress in patients withserious life-threatening illnesses in order to achieve the

best possible quality of life for patients and their families.However, scientific evidence to guide palliative care prac-tice is still inadequate. Hence, current research in the fieldof Palliative Care is strongly needed to provide an evi-dence-based approach to everyday palliative care prac-tice.

Be prepared for your residency - in this workshop we willpresent you some information on the symptoms and his-tory of several patients and you have to find the right diag-nosis and should also propose the appropriate treatment.Some cases will be simple, some will be similar to those

Dr. House and his team are dealing with.

.

According to Dubben and Beck-Bornholdt, millions of arti-cles are published every year in scientific journals; most ofthem worthless, since quantity of publications seems to bemore important than quality nowadays. Therefore, criticalreading of scientific papers ist an important skill for scien-tists and physicians. The workshop will provide a shortintroduction in how to read and to interpret articles criticallyin medicine and natural sciences. Principal points for effi-ciently reading of studies and assessing the quality of sci-entific publications will be discussed on the basis of exam-

ples and demonstrations. The main goal of this workshopis to raise awareness for misinformation and misinterpreta-tion in scientific studies, since paper is proverbial knownfor being patient.


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Delegates will learn the fundamental skills of plastic sur-gery at an early career stage in a supportive environment.There is a balanced mix of practical and theoretical mate-rial taught on the course with demonstrations and softtissue models for practise. The course provides delegateswith the confidence required to perform the basic skill re-quired in plastic surgery.

.

In this workshop we will discuss the problem of overdiag-nosis. It happens when people get a diagnosis they dontneed. Although hard to believe, theres growing scientificevidence suggesting many people are overdiagnosedacross a lot of different conditions, including asthma,breast cancer and high blood pressure. Participantsshould have a curios und critical attitude and be open fordebate.

Medical students have to face many challenges while theirtheoretical an practical training at med school. Bigamounts of learning materials, difficult exams and the han-dling of real life situations with patients and colleagues canbe very tough. In this workshop you will hear about actualstudies and background information about the health ofmedical students and their biopsychosocial burden. Wealso want to discuss about problems at your faculties andways to face them.

Nanomedicine employs converging technologies to im-prove human health. Nanomedicine includes the develop-ment of nanoparticles for therapeutic and diagnostic appli-cations and the design of nano-sized tools for tissue engi-neering and regenerative medicine. The workshop willprovide an overview on the status quo, promises and pit-falls in nanomedicine with special focus on nanopharma-ceuticals.

.

The workshop "Acute Coronary Syndrome" deals with oneof the most important reasons for death in developedcountries. Pathogenesis, clinical features, ECG and labfindings as well as current guidelines concerning diagno-sis, risk stratification and treatment will be presented. Sev-eral cases shall be discussed by the audience.

The number of standardized laparoscopic techniques ingeneral surgery is increasing worldwide. The aim of thisworkshop is to train practical and theoretical skills in lapa-roscopy. In the first part of this workshop, these standardi-zed techniques are presented theoretically in a short lectu-re. In the second part, all participants get the possibility totrain practical skills in laparoscopy using a spezializedpelvitrainer.


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A young university with a long standing tradition

As early as 1863 much emphasis was laid on medical research and the education of new physicians, both

of which proved to be very successful.In January 2004, the former Faculty of Medicine was replaced byan autonomous university. The core competences of the Medical University of Graz are high-

standard training and education, research at an international level and continuous improvement of

top-quality-medicine. Additionally, the orientation toward the bio-psycho-social model is one of the main

concerns of the university.

According to the bio-psycho-social model, patients and their ailments are the main focus and tended

to by specialists. In the field of education the Medical University of Graz breaks new grounds due to a new

curriculum for medicine that was introduced in 2002. Students start their education with a practical trai-

ning and medical knowledge will be taught in different specialized modules. For the students this

means practical experience at a very early stage of their studies, many seminars and small study

groups. Furthermore, emphasis is laid on both medical knowledge and social competence and Medical Uni-

versity of Graz. In the fall of 2004, the program Nursing Science was introduced. It is the only one in

Austria and accounts for all the new needs and challenges in health care.

The Medical University of Graz has a long tradition of successful and internationally renowned re-

search, which is obvious by the fact that three Nobel Prize winners have conducted research in its

institutes and clinics:

Fritz Pregl, Nobel Prize in Chemistry (1923)Julius Wagner von Jauregg, Nobel Prize in Medicine (1927)Otto Loewi, Nobel Prize in Medicine (1936)

We at the Medical University of Graz also focus on the utilization of research results. Next to providing me-

dical education and first-class medical treatment, research is the core task and competence of the medical

schools. It provides the basis for all progress in medicine, be it by exploring physiological processes and

decoding genes and their functions, or by developing new operation techniques and testing new

ingredients for pharmaceutical products. The Medical University of Graz is highly committed to scientific

medical research and has been throughout its long history. In its university clinics and pre-clinical institutesand centers, researchers employ state-of-the-art scientific methods to search for answers and new ap-

proaches, thus contributing continuously to the progress in medicine and biotechnology.


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Graz has a long and eventful history. The tracks of first buildings and fortresses date back to the early sto-

ne age. The Celts, who lived not only in Gallia (like Asterix) but also in the region of today's Austria, left

their traces in Graz too. You can find them, for instance, in the small forest directly behind the University

Hospital, the Leechwald. During the time of the Roman Empire the area of Graz was a busy area foragriculture; the antique city Flavia Solva near the city of Leibnitz, south of Graz is witness of it. They

even found a Roman villa underneath the airport of Graz.

The word Graz originates from the Slavic word Gradec, meaning small fortress. This fortress,

which was uilt on the hill in the city center, the Schlossberg, didn't remain small for long. For nearly 300

years Graz was the residence of the Habsburgs, the Austrian Imperial dynasty. In the time of the war

against the ottomans, the fortress was captured for the last time in history, as the next great enemy who

tried to occupy the city, Napoleon, was never able to do so. Graz remains the only city that the inge-

nious general from Corsica could never conquer. He got so furious; he forced the Austrian Emperor to let

him destroy the city without fight. No sooner said than done, the fortress as blown up and half of

the Schlossberg with it. The only other two buildings that survived the destruction, apart from some resi-dues of the fortress, were the clock tower (Uhrturm) and the bell tower (Liesl).

A second good reason to visit Graz is the exceptional living quality. According to an inquiry, 92% of the citi-

zens are very satisfied with living in the city. This is quite a high number, dont you think? Maybe it's becau-

se of the many parks, the forests inside and outside the city or its manageable size (300.000 inhabitants on

127.6 km) which you can easily discover by public transportation and by bicycle. Perhaps it's the southern

flair (Graz is known as the Austrian city with the most Italian flair) in the small alleys of the city center, with

its hidden places where you can just drop inside a bar or a caf for a drink or a cup of coffee, read a good

book, watch the scenery and enjoy life. Moreover, lets not forget the friendly citizens of Graz. They, too,

are the reason why so many just love to visit or, even, stay forever.

The rooftop landscape of Graz, which you can look at from every elevated spot around the city center, has

been a UNESCO world's cultural heritage since 1999. In 2003, the city was given the honor of being

Cultural Capital of Europe.

Whether you are interested in architecture or the fine arts, there are numerous options you can choose

from: the opera house, the many theaters, the museums, open air and indoor concert venues and our

castle in the district of Eggenberg are all sports worth visiting. During summertime the street artists of

La Strada fill the streets with a special atmosphere while the Jazz Summer brings great artists to town.

As Graz is a university city, there is a large number of students living here. Where there are students, there

are bars and parties. In the Uni Quarter along and around Elisabethstrae the bars are lined up for your

choice, and the Bermuda Triangle in the city center got its name from one or the other getting lost

there until the break of dawn. As our 40,000 students are not only partying but also studying, they

can do so at 4 universities, 2 universities of applied sciences and 2 pedagogical colleges.

A lot of famous people were born in Graz or lived here. Leopold Auenbrugger, whom you may know as the

inventor of medical percussion, Hans Gross, the founder of criminology (yes, he kind of invented CSI),

emperors of the Habsburgs dynasty, Arnold Schwarzenegger, Nicola Tesla, Otto Loewi, Erwin

Schrdinger, Nicolaus Hanoncourt, Karlheinz Bhm, and so on.


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First and most importantly: You are at a student congress. Dont be afraid to get in touch with each other. It

might seem difficult at first as there are so many people from different countries with different cultures,

speaking different languages. However, a nice conversation is the first step to getting to know each other

and to exchange knowledge.

1. Be on time for sessions as a visitor and arrive at least 10 minutes in advance

when you are the presenter.

2. Each session is guided by a chairperson who introduces the presenters and asks

questions to start a discussion. If you are a presenter it is an unwritten rule to

introduce yourself before your session begins.

3. Respect the presenter by listening to him/her quietly. If you want to ask something

there is a scheduled discussion time after each presentation.

4. At the registration you will receive a patch with your name on it. Please wear it

visibly at all times (especially lunch and coffee breaks), so everybody you talk to

can easily remember your name.

5. Consider the dress code which, depending on the host country, might be elegant

or casual. The ISC does not ask you to wear a suit but dress nicely nonetheless.

6. Last, but not least, be nice and friendly to each other, respect your counterpart

and enjoy yourself!


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The ISC takes place at the lecture hall center of the Medial University of Graz which is located at

the university hospital (Univ.-Klinikum LKH Graz, Auenbruggerplatz 1, 8036 Graz). Follow our signs!

You can get there by public transportation or by foot, depending where you are staying.

Tram line 7 (final station)

Bus line 41 (final station)

Bus line 64 (direction Stiftingtal)

Bus line 77 (final station)

Find us at the Meeting Point (Main Square) at 07:45pm on Friday and at 6:45pm on Saturday, this way you

will find your way to the Official Welcoming Ceremony at City Hall, the Scientific City Tour and the ISC

Farewell Party more easily.

Thursday, 4thof June: Pub Quiz at the Bar Feierlaune in Harrachgasse 22 (basement).

Friday, 5thof June: Official Welcome at City Hall. Take tram line 7 to the main square (Hauptplatz).

Saturday, 6thof June: Scientific City Tour and following ISC Farewell Party at Tam Tam in Keesgasse

3. Take tram line 7 to Jakominiplatz or Hauptplatz and walk from there.

Public transport:Youll find information about public transport in Graz at the website of Holding-Graz

(http://www.holding-graz.at/linien.html). You can get tickets at the ticket machine in the tram, at the driver of

the bus or in every newspaper kiosk. A one hour ticket costs 2.1 , 24h 4.80 and a 7-day-pass 13.40.

Bicycle:If you want to rent a bike, visit the homepage www.grazbike.at


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Main Station

Main Square:Official Welcome

Farewell-PartyTAM TAM, Keesgasse 3


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Pub-QuizFeierlaune, Harrachgasse 22

ISC 2015LKH Graz/St. Leonhard


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Dentistry I Case Reports III

(SR KW.11) (SR KW.11)

Endocrinology I Dermatology/Opthalmology

(SR KW.11) (SR KW.11)

Technical Innovations Gastro-oncology

(UR KW.12) (SR KW.12)

Public Health I Internal Medicine II

(SR KW.12) (SR KW.13)

Surgery I Microbiology/Infectiology II

(SR KW.13) (SR KW.14)

Oncology II Mixed Session

(SR KW.14) (UR KW.21)

Cardiology I Immunology II

(SZ KW.21) (UR KW.22)

Gynecology I Neurology/Psychiatry II

(UR KW.21) (SR KW.32)

Immunology I Nephrology I

(UR KW.22) (SR KW.31)

Cell-& Molecular-Biology I

(SR KW.32)

Cardiology II

(SR. KW.31)


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Biochemistry/Pharmacology Cardiology III

(HSZ HS E1) (HSZ HS E1)

Case Reports I Case Reports IV


Case Reports II Cell- & Molecular-Biology II


Dentistry II Dentistry III


Gynecology II Endocrinology II


Internal Medicine I Immunology III


Microbiology/Infectiology I Nephrology II


Neurology/Psychiatry I Public Health IV


Oncology II Surgery II


Public Health II

(HSZ HS E2)

Public Health III

(HSZ HS E2)


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Sran Nikolovski

Medical Faculty Belgrade, Serbia;

Introduction: Non-Hodgkin lymphomas of gastrointestinal tract are the most frequent form of all extranodal lymphomas. The most significant risk factors

which have influence on their occurrence are age, gender, immunosupression, autoimmune and immunodeficient conditions, microorganisms, expositionto toxic chemicals, lifestyle and genetic factors.

Aim: Determination of significance and influence of basic prognostic factors in survival of patients with diffuse large B-cell lymphoma of gastrointestinaltract.

Materials and ethods:The survey included 97 patients treated against non-Hodgkin lymphoma of gastrointestinal tract in the period 2001-2013 onInstitute of Hematology, Clinical Center of Serbia in Belgrade. We analyzed clinical characteristics in these patients which are compared with the length ofsurvival time. Used statistical methods were univariate and multivariate analysis.

Results: There was significant difference in relation between five year overall survival and Ann Arbor stadium 2, ECOG performancestatus 2, interna-tional prognostic index 2, high levels of thrombocytes and C reactive protein, hypoalbuminemia and newly defined inflammato ry stage-modified interna-tional prognostic index (p


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Giovanni Battista Biserni1, Monica Jernberg Engstrm2, Anna Mary Bofin2

1School of Medicine, University of Bologna, Alma Mater Studiorum, Bologna, Italy; 2Department of Laboratory Medicine, Childrens and Womens Health,Norwegian University of Science and Technology, Trondheim, Norway

HER2 amplification occurs in 10-15 % of breast cancers. It is associated with poor breast cancer specific survival (BCSS) and is an important prognostic

and predictive marker. HER2 status is determined by immunohistochemistry (IHC) and/or in situ hybridization (ISH).While it has been generally acceptedthat the ratio between HER2 and CEP17 determines HER2-status, the most recent guidelines for interpretation of HER2 ISH acknowledge the signifi-cance of HER2 copy number alone.

The aims of this study were to assess BCSS according to absolute HER2 copy number and HER2-status expressed as a HER2/CEP 17 ratio with andwithout and increased CEP17 copy number.

The study population comprised breast cancer patients treated with surgery only and with long-term follow-up. ISH for HER2/CEP17 was done on tissuemicroarrays and was successful in 680 cases. These were included in the study. Kaplan-Meier methods were used to estimate BCSS.

Results show that 47 cases had >=4=6 copies of HER2 and only two ofthese were HER2 negative by ratio. The risk of death from breast cancer was increased among those with >=6 HER2 (HR 2.84; CI 1.95-4.13(unadjusted)). After adjusting for stage, there was a slight increased risk of death from breast cancer in cases that were HER2 negative by ratio but with>=4


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Asana Vali Sichani1, Mohhamad Monirifard2, Ava Vali Sichani3

1Dentist, Students' Research Committee, School of Dentistry, IsfahanUniversity of Medical Sciences, Isfahan, Iran.; 2Dentist, department oforthodontics, School of Dentistry, Isfahan University of Medical Sciences,

Isfahan, Iran.;3

Dentist, pediatric department, School of Dentistry, khoras-gan University of Medical Sciences, Isfahan, Iran.

Introduction:Malocclusion and dental caries are two of most frequent dental conditions.The prevalence of malocclusion in increasing in many countries. The aimof this study is evaluating the association between DMFS index and differ-ent types of malocclusion in 11-14 year old Iranian children.

Method and Materials: A cross sectional study was done on 281 iranian11-14 years old children (162 female, 119 male) that selected by Multi-stage Stratified Sampling among Isfahan school .DMFS index, overjet (mm) overbite (mm) anterior crowding (mm) andanterior spacing (mm) were measured. The results were analyzed, linearregression and pearson correlation test, and significanc level of 0.05.

Results: DMFS index showed significant relationship with crowding in inwhole (male and female) group (P=0.002, R=0.183) also, in female group(P=0.000, R=0.274) but not in male group. Other types of malocclusionhavent significant relationship with DMFS.

Conclusion: This study has shown positive significant relationship be-tween DMFS and crowding, but it doesn't mean a cause and effect rela-tionship.

Abbas Haghighat1, Mehdi Mehdikhani2, Alireza Reihany Mohammadi1

1Isfahan University of Medical Sciences, Iran, Islamic Republic of; 2IsfahanUniversity, faculty of Engineering, Iran

Background: Biodegradable membranes have been used to regeneratebone defects, especially in dental implants use for lost teeth. Therefore,many studies have been fulfilled on physical, chemical, mechanical, andbiological properties enhancement of such membranes.

Methods: 45S bioactive glass(BG) nanoparticles were prepared by sol-geltechnique. BG nanoparticles were characterized by X-ray diffraction(XRD), scanning electron microscopy (SEM), X-ray fluorescence (XRF),Fourier transformed infrared spectroscopy (FTIR), and transmission elec-tron microscopy (TEM). The composition of materials was verified with X-ray fluorescent (XRF) and the morphology and particles size were evalu-ated with transmission electron microscopy(TEM). Chitosan-45S BG nano-composite membrane was prepared by solvent casting technique. Theamount of BG nanoparticles in the nanocomposite membrane was 30 wt%.Membrane was characterized by SEM, XRD, FTIR, and TEM. Mechanicalproperties of the membrane were determined by standard tensile test. Invitro antibacterial activity and degradation of the prepared membrane was

evaluated.

Results: Results showed uniform distribution of BG nanoparticles andsome BG aggregates in the prepared nanocomposite membrane. Suitablemechanical properties of the membrane were observed. It showed antibac-terial activity against E.Coli bacteria. Inhibition zone was observed aroundthe Degradation studies illustrated gradual weight loss of the membrane.During degradation test membrane maintained its configuration and uni-formity.

Conclusion: According to the mechanical, degradation, and antibacterialactivity tests, it was concluded that Chitosan-45S BG nanocompositemembrane could be used as a good candidate for guided tissue regenera-tion.

Parinaz Mahdavian, Elham Shadmehr

Isfahan University of medical sciences, Iran

Background: Pain control after root canal treatment is important in endo-dontic practice. The purpose of the present study was to investigate theefficacy of orally administered clonidine on postoperative pain and the useof analgesics after root canal treatment.

Methods: In a randomized double-blinded clinical trial, 60 patients (30 pergroup) having first or second mandibular molars with irreversible pulpitisrandomly received either 0.2 mg/kg clonidine or placebo one hour before

treatment. All patients received standard IANB of 2% lidocaine with1:100000 epinephrine. After single-visit root canal treatment, each patientrecorded their pain score on a Heft Parker visual analogue scale at 3, 6,12, 24, 36, 48, and 72 hours after treatment. Data were analyzed by Mann-Whitney, c2, Cochrane Q, and t tests as well as Pearson correlation analy-sis (p < .05).

Results: The results indicate that patients who received clonidine hadsignificantly lower pain scores at 3, 6 and 12 hours after root canal treat-ment compared with the patients who received placebo (P < .05). The useof analgesics in the clonidine patients was significantly lower than in theplacebo group (P< .05).

Conclusion: Patients who received orally administered clonidine beforesingle-visit endodontic treatment of irreversible pulpitis in mandibular mo-lars had significantly less early postoperative pain and used fewer analge-sics than those who had lidocaine as the anesthetic.

Magdalena Czeryska1, Paulina Orow1, Magdalena Choromaska2,Anna Justyna Milewska3

1Restorative Dentistry Scientific Circle next to Department of Restorative

Dentistry; Scientific Circle next to Department of Statistics and MedicalInformatics, Medical University of Bialystok; 2Department of RestorativeDentistry, Medical University of Bialystok; 3Department of Statistics andMedical Informatics, Medical University of Bialystok

Introduction: Oral cavity hygiene treatment includes systematic toothbrushing (min. twice a day), using dental floss, rinsing oral cavity withspecial dental rinses and extra accessories eg. irrigator, toothpicks.

Aim: The aim of the study was to got to know what kind of oral cavityhygiene procedures are the most often made by patients.

Materials and Methods: The information were obtained with a authorssurvey. 331 questionnaire forms were filled in by patients of SpecialistClinics in University Hospital in Bialystok. First of all authors received apermission from Bioethical Commission. Data was analyzed with Statistica10.0 (Ch^2 Pearson Test; p


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Stefanie Schnbacher, Elisabeth Santigli, Barbara KlugUniversity Clinic of Dentistry and Maxillofacial Surgery, Department ofOrthodontics and Maxillofacial Orthopaedics, Medical University of Graz,

Austria

Background: Dental work implies exposition to potential health hazardsdue to pathogen aerosols or blood exposure. The aim of this study was toinvestigate the seroprevalence of hepatitis B virus (HBV), hepatitis C virus(HCV) and Legionella in dental health care workers (DHCW).

Methods: Questionnaires were completed by 240 volunteers at dentalmeetings in Austria in 2010. Blood samples were analyzed with permissionof the ethical commission, Medical University of Graz. Questions werebased on barrier methods and vaccination status. ELISA was performedfor Legionella, HBV and HCV detection. HCV was confirmed by PCR.SPSS 21.0 was applied for statistical analysis.

Results: Fourteen (5,8%) persons were tested positive for Legionella IgG.HCV was detected in two (0,8%) participants and nine (3,8%) had experi-enced a HBV infection in the past. Immunization protection was testedpositively in 200 (83,3%) subjects while reported by 215 (89,6%). 173

(84%) DHCWs reported wearing always gloves and 137 (66,5%) the con-stant usage of face masks. Women reported a more frequent use of glovesthan man (p=0,018), dentists a more frequent use of face masks thandental assistants (p=0,002).

Discussion: HCV prevalence comes close to the reported prevalence ingeneral population (1%). Generalization of the results is restricted by theparticipation of volunteers only.

Conclusion: More attention to HBV immunization and barrier methodsshould be paid in dental education. This study serves as baseline for thedesign of a representative survey based upon DHCWs from 80 randomlychosen dental offices compared with a control group.

Gal IvancicMedical University of Graz, Austria

Material and Methods: The retrospective study was carried out at thedepartment of oral and maxillofacial surgery at the University Clinic Graz. Itwas required that all patients for this study had undergone a tumor surgerywith microvascular tissue transfer and had received a dental and prostheticrehabilitation with implants in the years between 2006 and 2010.

Results:Between 2006 and 2010, 42 cancer patients, who underwent atumor surgery in the oral and maxillofacial region with microvascular tissuetransfer, had received a dental rehabilitation through implants with a suc-cess rate of 96,1 % after a 12-months follow-up.

The average time between the tumor surgery and the implantation was 13months, with the iliac crest graft used as the most common microvasculartissue.65,1 % of these patients had to be treated with a vestibuloplasty, whichwas with 55 % the most common pr-prosthetic procedure. More than half(55,8 %) of all patients were able to receive a subsequent prosthetic care.

Discussion and Conclusion: Dental rehabilitation with implants andsubsequent prosthetic care at the department of oral and maxillofacialsurgery at the University Clinic Graz provides an effective type of therapyfor certain patients without contraindications improving the patient's qualityof life, masticatory function as well as the aesthethic aspect of the patient'sappearance and is conform to the current, internatinal literature of otherUniversities.


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Julian Augustin Zedler, Harald Sourij, Norbert Tripolt

Medical University of Graz, Austria

Background: Patients with Diabetes type 2 have 2-4 fold higher risk of

cardiovascular events compared to the non-diabetic population. Athero-sclerosis and plaque formation is strongly influenced by different arms ofthe immune system, including B lymphocytes. Recent investigations sug-gest combined free serum light chains (cFLC) as a potential biomarker forcardiovascular events. Our aim was therefore to assess the association ofcFLC with carotid atherosclerosis measured by ultrasound, a well-established surrogate parameter cardiovascular events.

Methods:We performed a crossectional analysis in data from a a prospective singlecenter 2-year study of 97 pa-tients with type 2 diabetes and insufficientlycontrolled cardiovascular risk factor. Complete data on cFLC, high sensi-tive C-reactive protein (hsCRP) was available for 75 subjects. Carotidintima media thickness (CIMT) and a B-score to quantify plaque burdenwas determined according to the Asymptomatic Carotid Artery PlaqueStudy protocol (ACAPS). The data was compared using explorative statis-tical analysis.

Results: The preliminary results showed no significant correlation betweencIMT and cFLC (spearman rho, p=0,071). However, a significant correla-tion between cFLC and the B-score (spearman rho, p=0,001) as well ashsCRP (spearman rho, p=0,02) were observed.

Conclusion:In this small study, cFLC was associated with carotid atherosclerosis,measured by the B-score. However, further larger datasets need to confirmthis association and determine whether cFLC could be used as a potentialbiomarker for atherosclerosis and cardiovascular risk, since regular surro-gate parameters are not yet accurate enough to detect atheroscleroticprogression.

Anna Krentowska1, Anna Skoneczny1, Klaudyna Noiszewska2, ArturBossowski2

1Students' Scientific Association at the Department of Pediatrics, Endocri-nology, and Diabetology with Cardiology Division, Medical University ofBiaystok, Poland; 2Department of Pediatrics, Endocrinology, and Diabe-tology with Cardiology Division, Medical University of Biaystok, Poland

Background: Growth hormone deficiency (GHD) is associated with cardio-vascular abnormalities. The condition of blood vessels may be reflected bycentral arterial pressure (CAP), so its assessment seems to be useful inmonitoring cardiovascular results of growth hormone (GH) treatment. Theaim of the study was to evaluate the influence of GH replacement therapy

on CAP parameters in children with GHD.

Methods: The study group included 53 patients with GHD (mean age 12.6years) treated in Endocrinology Outpatient Clinic and the Department ofPediatrics, Endocrinology, and Diabetology, Medical University of Bialy-stok. The patients were divided into subgroups: qualified for GH therapy(group 1; n=28) and undergoing GH therapy (group 2; n=25). The controlgroup consisted of patients with no cardiac irregularities or endocri-nopathies (mean age 13.2 years). Three measurements of CAP wereperformed using a Central Blood Pressure Meter (cBP01) and averagevalues were calculated. Statistical analysis was performed using Statistica10.0.

Results: Group 1 presented significantly lower CAP (p


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.

Mirna Dzubur, Azra Bahtic, Edin Begic, Semir Hrvo

Medical faculty, University of Sarajevo, Bosnia and Herzegovina

Background: One of the main complications of radioiodine (I-131) therapyin patients with thyrotoxicosis is the occurrence of hypothyroidism up to afew years after treatment. Various factors can determine patient's re-sponse to radioiodine therapy (RAI therapy). The aim of this study was toevaluate the influence of thyroid gland volume and dose of radioactiveiodine on the occurrence of hypothyroidism one year after radioiodinetreatment.

Methods: The medical records of 120 patients, who underwent radioiodinetreatment between January 2004 and September 2014, were retrospec-tively analyzed. The administered dose of radioactive iodine, thyroid glandvolume and thyroid hormone levels before treatment and one year aftertreatment, were evaluated.

Results: 83% of patients were female. Mean age was 55,5 (31-81, SD-10,66) years. 19 (15,8%) patients had positive autoantibodies (Gravesdisease) and 101 (84,2%) had negative autoantibodies. Thyroid glandvolume was estimated by use of ultrasound and hypothyroidism was found

in 28% of patients with a volume 35 ml (Pearson coefficient r-0,51, p20mCi, hypothyroidism was found in 66,6% ofpatients (RR-2,29, p


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Milad Alimohammadi, soheyla Honary

Mazandaran University Of medical science, Iran

Introduction: Biofabrication by using fungi is an exciting recent interest to

develop an eco-friendly production of metallic nanoparticles for pharma-ceutical applications. This study aimed to synthesize and characterize Aunanoparticles by using Penicillium talaromycose.

Methods: The fungus Penicillium talaromycose was grown in fluid czapekdox broth on shaker at 28 C and 200 rpm for ten days. Then the super-natant was separated from the mycelia to convert AuCl4 solution into nano-gold particles. After 24 hours, synthesized gold nanoparticles were char-acterized by using UV-Visible Spectroscop, PCS (Photon CorrelationSpectroscopy), Zeta potential, SEM (Scanning Electron Microscopy), AFM(Atomic Force Microscopy) and FT-IR (Fourier transformed infrared spec-troscopy).

Results: The UV-Visible Spectroscopy analysis revealed a plasmon bondpeak around 560nm suggesting formation of nanoparticles. The SEM, AFMand PCS showed that the gold nanoparticles were formed fairly uniformwith spherical shape and good monodispersity with the average diameterunder 100nm. Besides, a negative zeta potential were found for nanoparti-cles indicating their stability in solution. The FT-IR spectra revealed thepresence of different functional groups to gold nanoparticles which werepresent in the fungal extract.

Conclusion: The current approach suggests that the rapid synthesis ofnanoparticles would be proper for developing a biological process for massscale production. We believe that development of eco-friendly process forthe formulation of metallic nanoparticles is an important step in the field ofapplication of nanotechnology.

Andreea Maria Pascutoi1, Rares Georgescu2, Adina Cristina Friciu2

1University of Medicine and Pharmacy of Targu Mures,Targu Mu-

res,Romania;

2

The First Surgical Clinic, The Mures County Clinical Hospi-tal,Targu Mures,Romania

Background (aim of study): This study aimed to assess the need forcombining the two techniques (blue dye and radionuclide technique) todetect sentinel lymph nodes (SLN) and to compare the accuracy of thesetwo methods.

Methods: This study comprises 67 patients with early breast cancer whounderwent sentinel node biopsy by combining the two methods: radionucli-de and blue dye technique. We conducted a prospective non-randomizedstudy by comparing the results of the two techniques: the total number ofexcised lymph nodes and the number of positive lymph nodes in order todetermine the accuracy of the two methods.

Results: When using the radionuclide method we managed to detect anaverage number of 2.21 lymph nodes and 0.84 lymph nodes with methylenblue technique, which represents a statistically significant difference(p=0.0001). We also achieved a significant difference regarding the avera-

ge number of positive lymph nodes that was of 0.33 for the radionuclideand 0.07 for the methylen blue technique (p=0.0156). Therefore we obtai-ned the following results: sensitivity=91.80%, specificity=87.06% andaccuracy of the two methods=33.77%.

Conclusions: Sentinel lymph node biopsy using the radionuclide techni-que has significantly higher accuracy in terms of total number and numberof positive lymph nodes than the methylen blue technique. The combineduse of both techniques presents no major advantages and is indicatedonly during the learning curve. The exclusive use of vital dye is not recom-mended because of the risk of understaging.

Clarina Wieser

Medical University Graz, Austria;

Background: On ultrasound Intima-media-thickness (IMT) of the carotidartery serves a parameter for cardio-vascular disease. Since functionalchanges occur earlier than morphological alterations, there is the hypothe-sis that a decrease in vessel flexibility could occur before IMT starts toincrease.

The purpose of the study was to assess and compare IMT by carotid arteryultrasound as well as the vessel flexibility in normals and volunteers withcardio-vascular riskfactors (CVR-F).

Methods: 30 people (18 to 35y) - 15 healthy and 15 with CVR-F. On Ultra-sound IMT was measured by B-Mode-Ultrasonography and from colordoppler transversal carotid artery sequences the minimal cross-sectional(Min-Area) as well as the maximum one (Max-Area) were obtained and thevessel flexibility index (VFI) calculated in the following way: Min-Area*100/Max-Area.

Results: In healthy volunteers mean and standard deviation of IMT:0.420.046mm and VFI: 0.220.039% could be estimated as compared tothose with CVR_F IMT: 0.490.06mm VFI: 0.180.038% IMT and VFI inboth groups statistically significant p


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Ramona Baumgartner1, Birgit Teubl2, Carolin Tetyczka2, Eva Roblegg2

1Research Center Pharmaceutical Engineering Graz GmbH, Aus-

tria;2Institute of Pharmaceutical Sciences, Department of Pharmaceutical

Technology, University of Graz, Austria

The oral cavity displays an attractive route in drug administration that is notassociated with gastric transit and hepatic first pass metabolism. However,physicochemical properties such as poor water solubility of pharmaceuticalactive ingredients often result in low permeability and thus, poor bioavail-ability. Hence, an ample body of research exists to enhance solubility,such as salt formation or particle size reduction into the nanometer scale.Specifically, the latter one has attracted much research interest in the pastdecade.

This study aimed at developing a stable aqueous nano-suspension of themodel compound phenytoin via wet media milling using various stabilizers.The nano-suspensions were carefully characterized regarding hydrody-namic particle sizes, crystallinity and dissolution characteristics. The per-meability of bulk- and nano-phenytoin through a buccal in-vitro as well asex-vivo model was investigated and the apparent permeability coefficientswere determined. Moreover, cell viability and cytotoxicity studies wereconducted. The addition of Tween 80 (used as stabilizer) resulted in astable crystalline nano-suspension with a mean hydrodynamic particle sizeof 330 nm. Dissolution studies revealed an improved solubility behavior

compared to the bulk material. The enhanced solubility characteristicsfurther impacted the permeability, as the diffusion coefficient (dQ/dt, g/s)of nano-sized phenytoin was 1.4-fold higher. Cytotoxicity and cell viabilitystudies demonstrated that bulk- and nano-phenytoin exhibited no harmfuleffects on buccal cells.

It can be concluded that crystalline nano-suspensions are a promising toolfor safe drug administration via the oral cavity.

Lukas Stastny1, Markus Kofler1, Sebastian Johannes Reinstadler2,Thomas Schachner1, Juliane Kilo1, Margaretha Rammer1, GuyFriedrich2, Dominik Wiedemann3, Ludwig Mller1, Michael Grimm1,Johannes Bonatti4, Nikolaos Bonaros11Department of Cardiac Surgery, Medical University of Innsbruck, Austria; 2UniversityClinic of Interna l Medicine III, Cardiology and Angiology, Medical University of Inns-bruck;3Department of Cardiac Surgery, Medical University of Vienna, Vienna,

Austri; 4Heart and Vascular Insti tute, Cleveland Clinic Abu Dhabi , Abu Dhabi, UnitedArab Emirates

ABSTRACT NOT TO BE PUBLISHED

Rebekka Prokschi, Liudmila Nikitina, Gottfried Dohr, Herbert Juch

Medical University of Graz, Austria

Introduction: Nanotechnology provides novel perspectives for severalfields including the pharmaceutical industry. Dendritic polyglycerols haveemerged as novel polymeric scaffolds and have demonstrated a greatpotential for various biomedical applications. In the study the charge-dependent uptake of dendritic polyglycerol nanoparticles (NPs) as well astheir potential toxic effect on early human placenta were investigated.

Materials and methods: Placental explants from early pregnancy werecultivated according to standard procedures in culture medium with 10%FBS. Additionally, cultivation and exposure to NPs was performed in hu-man AB serum to model a physiological protein environment. Neutral,

negatively and positively charged polyglycerol NPs (~5nm, fluorescent/biotinylated) were applied. Paraffin sections of exposed placentas wereanalysed by fluorescent and light microscopy. LDH concentration in culturemedium was measured by ELISA.

Results: Biotinylated NPs showed higher sensitivity for evaluation of NPslocalisation. Positively and negatively charged polyglycerol NPs revealed asignificant uptake at a 10-3M concentration, although we did not observethe transfer of NPs towards the placental villi. The uptake of NPs wasdramatically decreased by cultivating in pure human AB serum. We did notreveal any acute cytotoxicity in exposed placental explants or cells, basedon LDH measurements.

Conclusion: Polyglycerol NPs do not seem to cross the placental barrierof early human placenta, in detectable amounts, although negatively andpositively charged NPs are able to enter outer layer of placental barrierwithout signs of acute cytotoxicity. Presence of serum proteins in con-centrations closer to physiological seems to modify NPs and significantly

decrease their uptake.


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Bianca Raffaelli1, Jrgen Gallinat2

1Charit Universittsmedizin Berlin, Germany; 2University Medical CentreHamburg-Eppendorf (UKE), Germany

The proper interpretation of emotions is essential for an adequate sociallife. The ability to recognize facial expressions develops gradually in thecourse of life and shows age- and sex-related differences. While previousresearch focused mainly on adult cohorts, we examined sex differences inface recognition during adolescence, a phase of life characterized by veryhigh emotional reactivity.

We examined 1617 14-year-old adolescents, recruited as part of the IMA-GEN study, a European multicenter research project on mental being ofyoung people. The ability of face emotion detection was measured with theMorphed Faces Task (IDENT); thereby, the subjects were shown picturesof faces expressing happiness, sadness, fear and anger with varyingdegree of severity. For each picture, subjects were asked to indicate be-tween two given emotions which one they found most suitable.

We detected that boys opted significantly more often for fear and sadness

than girls, when they had to choose between one of those emotions andhappiness. On the contrary, when the choice was between two negativeemotions, we could not find any sex-related difference.

On the one hand, the more frequent detection of negative emotions infaces by boys could explain their higher aggressiveness rates in this agegroup. On the other hand, it might mean that girls identify more often posi-tive emotions, which may correlate with their higher rates of optimism,presented in other studies. Further research is needed in order to verifythese explanatory approaches and to understand the biopsychosocialreasons for those sex-related differences.

Hannah Deborah Schnitzlein1, Eva Maria Trapp. MD. PhD1, BenceCsapo. MD2, Josef Wilhelm Egger. Prof. PhD1

1University Clinic of Medical Psychology and PsychotherapieResearch

Unit of Behavioral Medicine, Health Psychology and Empirical Psychoso-matics Medical University of Graz;2University Clinic of Obstetrics and

Gynecology Medical University of Graz

Objective: In light of the biopsychosocial model, our aim was to describethe effect of physical activity during pregnancy as well as other psychoso-cial resilience factors on the psychological system level. We investigatedstress coping strategies and the social support profile, for relevance ofphysical activity in pregnancy to stress-related variables.

Methods: In our pilot study we examined 36 healthy women in the 2ndtrimester using a stress coping strategy questionnaire in a standardizedtesting procedure and non-standardized variables of social support throughan interview and questionnaire.

Results: Of the 36 women we could categorize 22 as high and 14 as lowphysically active women. We found that women with low physical activitytended to see their partner support more positively than their physicallyactive counterparts (p=0.01). In addition our research showed a positivitybias among all women in the individual reflection of their personal socialsupport, which demonstrated itself through a leftward shift of the distribu-tion of answers on the social support questionnaire. Additional analysis ofthe population portrayed interactions of age, parity, gravity, time in gesta-tion and complications in pregnancy with improved stress coping.

Conclusions: Though we could not confirm the hypothesis that physicalactivity in pregnancy is accompanied by a positive perception of socialsupport we found that low physically active pregnant women in our re-search show a higher satisfaction of their partner support. All women in theindividual interview had a tendency to rate emotional support as the mostimportant form of support for pregnant women.

Boonsub Sakboonyarat1, Monai Meesaeng1, Kritchaporn Chokcharo-ensap1, Nattapong Jaisue1, Dusit Janthayanont2, Phutsapong Srisa-wat3

1th yr. Medical Cadet, Phramongkutklao College of Medicine, Thailand;

2Department of Family Medicine, Phramongkutklao College of Medicine,

Thailand; 3Department of Orthopedic surgery, Phramongkutklao Collegeof Medicine, Thailand

Low back pain (LBP) is one of musculoskeletal problems in adolescentaround the world including Thailand. The symptom affects their daily life ifthey are left untreated. The information of LBP in Thailand was limited. Apreliminary survey in a Ayutthaya province by the Department of FamilyMedicine, Phramongkutklao College of Medicine revealed that LBP wascommon in this community too. The present study was aimed to determinethe prevalence and the associated factors of LBP in this population. Thefindings from this study are crucial for planning and developing the strategyand intervention for proper managements of LBP in adolescent.

A Cross-sectional study was conducted at Phra Nakhon Si AyutthayaProvince, Thailand between 30 November- 4 December 2014. Standard-ized questionnaires were used to collect the demographic data and associ-ated factors from students.

4,162 valid questionnaires were received including 2,445 (58.7%) frommale respondents and 1,717 (41.3%) from female respondents. The sec-ondary school students in this study showed LBP rates of 26.6% respec-tively, and the prevalence was influenced by the students grade, use ofdigital products, and daily activities, these factors affected the rates of LBPto varying degrees. The multivariate logistic regression analysis revealedthat gender, age, grade, smartphone use, history of accident related LBP,

transportations to school, desk height, frequency of weekly exercise andseat in class.

ASTRIT M. Gashi1, FEHMI ZEQIRI2

1University Clinical Center of Kosovo, Kosovo; 2Obstetrician and Gyneco-logical Clinic (OGC) Prishtina

Aim: The awareness rate among women in Kosovo on Pap test screeningfor cervical cancer should be determined.

Material and Methods: The research was a cross-sectional study, whichwas framed based on a questionnaire, which was completed by the partici-pants in this research. The sample of the research is composed by 500women of ages 21 to 65 years old, divided into categories as: womeninstructed for Pap test; teachers; students; women from rural and urban

areas who had only elementary education.

Results: 354 women (n=500) or 70.8 % did not know what Pap test isabout, whereas 146 women, or 29.2% did not know it at all. Out of allcategories of women that knew about Pap test, the most informed wereteachers, with 30.14%, students, with 25.34%, women instructed for Paptest, with19.17%, women with elementary education from cities with14.38%, and women with elementary education from villages with 10.97%.302 women (n=500), or 60.4% declared that they had not never taken Paptest before, whereas 198 women, or 39.6% had taken the Pap test at leastonce in their life.434 women (n=500), or 86.8 % declared that they had nothad any information about Pap test from their doctor, whereas 66 women,or 13.2% were informed in details about the importance of Pap test.

Conclusions: From our research, we conclude that the rate of awarenessamong women in Kosovo, on Pap test screening for cervical cancer, is low.

Around 70.8% of women in Kosovo do not know what Pap test is about.


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Alexander Sanders, Celia Taylor

University of Birmingham, United Kingdom, United Kingdom

ABSTRACT NOT TO BE PUBLISHED


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Dora Csengeri1, Katharina Marsoner1, Langeder Rainer1, SchllnastHelmut2, Mischinger Hans-Joerg1, Kornprat Peter1

1Division of General Surgery, Department of Surgery,Medical University ofGraz, Austria; 2Divison of General Radiological Diagnostics,Medical Uni-versity of Graz, Austria

Aim: To review the outcome of resected IPMNs of the pancreas and iden-tify clinical and pathological prognostic features.

Methods: Prospectively collected, retrospective review of a single centercohort of 54 patients with IPMN who underwent pancreatic resection be-tween January 2000 and December 2013 at the Department of GeneralSurgery of the Medical University of Graz. The patients were grouped intononinvasive and invasive IPMN and compared for demographics, clinico-pathological findings and outcome.

Results: Twenty-four of the patients exhibited noninvasive and thirty aninvasive IPMN. Mean age was 67 (11) years, 43% female. Surgicalstrategies included pancreaticoduodenectomy (n=30), distal pancreatec-tomy (n=13) or total pancreatectomy (n=11).The median follow up was 42

(range 0127) months; 1-, 5- and 10-year overall survival was 87%; 84%and 51%, respectively. The overall survival rates for noninvasive IPMNwere significantly better than those for invasive IPMN (p=0.008).Significantpredictors of poor outcome included positive lymph nodes, perineural andlympovascular invasion (p60 U/l had worse survival compared with those with nor-mal level (p=0-009 and p=0-018; respectively).

Conclusion: Long-term outcome after pancreatic resection for noninvasiveIPMN is excellent. While the main duct IPMNs should be resected, thebranch duct neoplasms may be maintained under observation, in absenceof the worrisome features.

Andre Alexander Barth, Christina Forstner, Elisabeth Presterl, GeraldIhra, Gabriela Muschitz, Chieh-Han Tzou, Thomas Rath, AlexandraFochtmann, Vera Vorstandlechner, Michael Bollinger

Allgemeines Krankenhaus der Stadt Wien, Klinische Abteilung fr Plasti-sche und Rekonstruktive Chirurgie

Background: Acinetobacter baumannii and Staphylococcus aureus causemore blood stream infections in intensive- care burn units than any otherpathogen. The target of this survey is to identify risk factors of Acinetobac-ter- related bacteraemia of intensive- care burn patients.

Methods: The study included all patients, who were treated between 2003and 2014 at the intensive- care burn unit at the Medical University of Vi-enna. Non- intensive-care patients were excluded from this survey, as wellas those with an ABSI-Score 3, a TBSA lower than 10% and Patientsyounger than 12 years. To identify possible risk factors, microbiologicalculture results of blood samples, tip of the central venous catheter, woundswab, urine and bronchial secretion were analyzed using regression analy-sis.

Results: 472 Patients have been included in this study. Acinetobacter spp.has been proven contaminating the samples of 7/472 (1,5%) patients. The

ABSI- score (7 vs. 10, p=0.029) and TBSA (25% vs. 55%, p=0,024) ofAcinetobacter- positive patients were significantly higher. Acinetobactercolonized the CVC- tip in 4 out of 7 patients (57% vs. 2%, p=


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Sran Nikolovski

Medical Faculty Belgrade, Serbia

Introduction: Chronic lymphocytic leukemia is malignant proliferation ofpatologic lymphocytes with variable expression of surface molecules.Manifestations are usually consequence of accumulation of pathologiccells and suppression of function of residual normal cells.

Aim: Determination of significance and influence of comorbidity indexes oncourse and outcome of disease in patients with chronic lymphocytic leuke-mia.

Material and methods: The survey included 115 patients with chroniclymphocytic leukemia treated at Clinic of Hematology, Clinical center ofSerbia, in the period 2001-2011. Parameters as clinical stadiums, levels oflactat-dehidrogenase and 2-microglobulin, percentage of CD38+ cells,bone marrow infiltration and comorbidity indexes are compared with periodof survival and outcome of disease by using univariate, multivariate andCox regression analyses.

Results: Values of 2-microglobulin 3 mg/dL or larger and ACE -27 comor-bidity index larger of 1 showed high significance by showing larger percentof deaths. New 2M-ACE-27 score was determined as good prognosticfactor with statistically significant differences in comparison with courseand outcome of disease and with statistically significant connection of highvalues of that score with larger percent of deaths in patients with chroniclymphocytic leukemia.

Conclusions: Factors with significant predictive value on course andoutcome of disease of patients with chronic lymphocytic leukemia arevalues of 2-microglobulin and ACE-27 score, use of fludarabine in firsttherapy line as well as new defined 2M-ACE-27 score.

Ines Anders1, Martin Asslaber1, Nicole Golob-Schwarzl1, IrisHalbwedl1, Margit Gogg-Kamerer1, Mohamed Al Effah1, Jens Hoff-mann2, Jana Rolff2, Helmut Popper1, Johannes Haybaeck1

1

Institute of Pathology, Medical University of Graz, Graz, Aus-tria; 2Experimental Pharmacology & Oncology Berlin - Buch, Germany

Background: Regulation of mRNA translation mainly occurs at the initia-tion step, which requires the interaction of many eukaryotic initiation fac-tors (eIFs). Dysregulation may lead to abnormal gene expression possiblyresulting in uncontrolled cell growth and cancer formation. Due to few dataon the role of eIFs in lung carcinogenesis we evaluated the eIF proteinexpression profile in lung carcinomas.

Methods:The protein expression levels of eIFs and several members ofthe mammalian Target of Rapamycin (mTOR) pathway were determinedusing Western Blot analysis on 18 Xenograft mouse models, representingthe main entities of lung carcinomas (adenocarcinoma, squamous cellcarcinoma, large cell carcinoma, pleomorphic carcinoma, small cell lungcancer). Immunohistochemistry for the eIF subunits 2, 3p110, 3h, 3m, 4eand 6 was performed on tissue micro arrays (TMAs), containing primarylung cancer and metastasis cases of a total of 718 patients.

Results: Western Blot analysis of xenograft tumor specimen revealed asignificant up-regulation of p70S6K, phospho-PTEN, eIF 3j and 4E-BP1compared to control. We observed an expression of phospho-mTOR, eIF3A, eIF 3B, eIF 3p110, eIF 3k and eIF 4G compared to no signal in con-trols. Western Blot analysis confirmed the results of immunohistochemistrywith eIF4e being upregulated at least 1, 5-fold and variable expressionpatterns of eIF 3p110.

Conclusion: Our findings indicate a major contribution of eIFs to lungcancer. Specific eIF subunits are differentially expressed in various lungcancer entities which might explain their biological behaviour.

Pavle Zoran Banovi

Medical Faculty University Novi Sad, Serbia

Introduction: Cell culture -21/13 today is used for production vac-cines against rabies, because of characteristics like spontaneous tumoro-genesis it may present reliable model for research in experimental oncol-ogy. Mebendazole has been recently proved to be effective against sometypes of tumors in vivo as in vitro.

The Aim: The aim of this experiment is studying fibrosarcoma inducted byinoculation of cell culture BHK-21/C13 as a model of local tumor for testingantitumor drugs, and investigating potential antitumor effects of mebenda-zole on inducted fibrosarcoma.

Materials and methods: Adult Syrian golden hamsters were inoculatedwith a suspension of tumorogenic baby hamster kidney (BHK) cells bysubcutaneous injection. On day 5 after inoculation, 30% of LD50 doses forsmall rodents of mebendazole were given orally for 6 days, and the samedose of mebendazole suspended in 10% dimethyl sulfoxide were injectedintraperitoneally into the one group of hamsters for 3 days. 19 days afterinoculation of BHK cells animals were sacrificed and samples of tumorwere excised, processed, described and analyzed.

Results: Experimental groups with oral application of mebendazole wereshown regressive changes in tumor volume, tumor cell structure and or-ganization, while named characteristic of experimental group with intraperi-toneal application of mebendazole showed smallest differences from tu-mors in control group.

Conclusion: Model of inducted fibrosarcoma has been shown as highlyreproducible, with local infiltration and high level of expression and viru-

lence. Mebendazole has been showed clear antitumor effect via oral appli-cation.

Angelika Babuskov

Medical University of Novi Sad, Serbia

Hypercalcemia is the major metabolic complication of the malignancy andoften it requires urgent treatment. We examined the influence of sex, age,histopathological diagnosis, receptor status in breast cancer patients, thesignificance of clinical and laboratory parameters on outcome of patients.The study included 60 patients who had a total of 72 episodes of hypercal-cemia, treated with the combination of parenteral hydration, diuretic ther-apy and Zoledronic acid. The examination included patients with diag-nosed malignant disease who has serum calcium levels over 3mmol/L.Response to therapy was defined as lowering serum calcium levels below3mmol/L within 5 days with a patients survival rate for more than 10 days.

We used the standard statistical analysis: median, range of values, stan-dard deviation, Pearsons correlation coefficient and Kaplan Meier curveswith Log Rang test. Correlation between characteristics two survival curveswas shown using the method. We notes a positive correlation that existsbetween elevated levels of creatinine values (ANOVA: F = 7.801, p =0.001), alkaline phosphatase (ANOVA: F = 5.455, p =0.023) , negativecorrelation hemoglobin level (ANOVA: F = 5.135, p = 0.027) level of cal-cium in the blood. The percentage of complete response to therapy wasachieved in 71.2 % of patients. Median survival from the diagnosis ofhypercalcemia is 31 days. Patients with level of lactate dehydrogenasebelow 480 IU/L (p


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Georgina Isabell Alber, Thomas Huber, Jan Bauer, Claus Zimmer

Klinikum rechts der Isar, Technische Universitt Mnchen, Germany

Glioblastoma (GBM) is the most common malignant primary braintumor.Mean-age at diagnosis is 64 years, survival is about 15 months. Standardtherapy of GBM includes surgery, radiation- and chemotherapy. Postop-

erative monitoring of tumor volume using MRI is a critical factor to detectrecurrent disease. Semi-automated volumetric measurements of contrast-enhancing-tissue and tumor-associated-edema could be an objectivequantity in tumor-treatment.The main objective was to determine the reproducibility. A second aim wasto assess the relationship of contrast enhancement to tumor edema inrecurring disease.

This on-going, retrospective study includes patients with GBM and mini-mum three follow-up-MR-scans performed in 2013/2014. We analysed 30patients (8, mean age=58 15, mean scans=5 1,7). Semi -automatedvolumetric measurements were performed by using the toolSmartbrush(Brainlab, Feldkirchen). Interreader variability was assessedby three different observer groups (neuroradiologists, medical students,non-medicals) with 4 observers each, everyone segmenting 8 MR-scans(including contrast enhancements and perifocal changes). Reproducibilityerrors were assessed using inter-class-correlation coefficients. In eachfollow-up-scan, contrast-enhancing tumor volume was measured in a T1-

weighted-MP-Rage-sequence (isotropic 1mm, -/+contrast agent) andassociated edema in an isotropic FLAIR-(fluid-attenuated-inversion-recovery)-sequence.

Preliminary statistics showed inter-class-correlation coefficients were 0,99for each group. The relative-root-mean-square-error was 19% in associ-ated edema and 10% in contrast enhancement. In general an increase ofcontrast-enhancement goes along with an increase of the associated-edema-changes. In at least 6/30cases associated-edema-changes couldbe detected earlier than contrast-enhancement.

Semi-automated volumetry provides a reproducible volumetric assess-ment. This could be a helpful tool to detect recurrences earlier and moreprecise than pure visual evaluation.

Tamara Ivkovska

Institute of Patgology, Macedonia,

Introduction: Carcinoma of the breast is the most common malignancy ofwomen in Macedonia. The current study was conducted with the objectiveof assessing estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu status of mammary cancers for correlation with histological grade,tumor size and lymph node metastasis.

Materials and methods: One hundred and fifty mastectomy specimenswith invasive breast carcinomas were analyzed.

Results:Tumor size ranged from 0.3 to 8.0 cm; 12% were 2.0 and 35.3%were 5.0 cm in diameter. The predominant morphology was infiltratingductal carcinoma (85.3%). The majority of the cases presented as grade II(55.3%) and lymph node involvement (60.3%). ER and PR were positive in73.7% and 65.3% cases respectively. HER-2/neu was positive (3+) in20.7%. ER and PR expression were decreased significantly in HER-2+tumors compared with HER-2tumors (ER, 46.1% vs 74.1%; PR, 26.3%vs 55.3%). HER-2 was positive in 11.7% of grade 2 and 28.4% of grade 3ductal carcinomas and negative in all grade 1 ductal carcinomas. HER-2over-expression or amplification essentially was limited to grades 2 and 3ductal carcinomas and correlated inversely with ER or PR expression.

Conclusion:ER and PR expression in breast cancers in the current studywas found to be comparable to published international data. Assessmentof prognostic markers for the clinical management of breast cancer pa-tients is strongly advocated to provide best therapeutic options.


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Mostafa Jafari1, Naseh Pahlavani2, Masoud Rezaei Rezaei3, HamidRasad2, Omid Sadeghi2, Hossein Ali Rahdar4, Mohammad HasanEntezari51Student Research Committee, Arak University of Medical Science, Arak, Iran; 2Food Security ResearchCenter, Department of Clinical Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran; 3Facultyof Nursing and Midwifery, School of

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