IS bx - USDA-APHIS€¦ · ANIMAL AND PLANT HEALTH INSPECTION SERVICE ANNUAL REPORT OF RESEARCH...

Thrs report IS required by law (7 USC 2143). Fa~lure to report according to the regulat~ons can resui ~n an order to cease and des~st and to be subject to penalties as provided for in Section 21 50

See reverse side for additional information

Interagency Report Control No 01 80-DOA-AN /

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REGISTRATION NO. CUSTOMER NO. 4

I

[ 3. REPORTING FACILITY (List all locations where animals were housed or used in actual research. testing, teaching, or experimentation. or held for these purposes. Attach additional I

ANIMAL AND PLANT HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY (TYPE OR PRINT)

FACILITY LOCATfONS(&es)

BIOLOGICAL STATION PELLSTON. MI 49769

\ .

2. HEADQUARTERS RESEARCH FACIUM (Name and Address, as regsterect wrth USDA, L' include zip code)

UNNERSrrY OF MICHIGAN 1301 CATHERINE STREET ANN ARBOR, MI 48109

I ANN ARBOR CAMPUS

34-R-0001 109

ANN ARBOR. MI 481 09-0614 I

FORM APPROVED OMBNO. MISMUG bx

I

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY (Attach ad&bnal sheets flnecessary w use APHIS FORM 7 0 2 3 J 1

ASSURANCE STATEMENTS I

A.

Antmals Covered By The Animal

Welfare Regulations

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-Human Primates

10. Sheep

1 1. Pigs

12. Other F a n Animals

13. Other Animals

Oppassum

Weasel

1 ) Professionally aaeptable standards governing the care. treatment, and use of animals. including appropriate use of anesthetic, analgesic, and tranquilizing drugs, prior to. during. and following actual research. teaching, testing. surgery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

6. Number of an~mals being bred. conditioned, or heldfor use in teaching. testing. experiments. research. or surgery but no( yet used for such PWO-.

3) This facility is adhering to the standards and regulations under the Act. and it has required that exceptions to the standards and regulations be speufied and explained by the princ~pal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all the exceptions is attached to this annual report. In addition to identi&mg the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

F.

TOTAL NO. OF ANIMALS

(Cots. C + D + E)

505

27

2994

1467

1 34

1 94

230

3

s 1

C. Number of animals upon which teaching. research, experiments. or tests were conducted involving no pain, distress, or use of pain- relieving drugs.

5

4

1256

293

42

101

2

3

1

4) The attending vetermarian for this research faality has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

0. Number of animals upon which experiments. teach~ng, research, surgery, or tests ware conducted involving accompanying pain or distress to the animals and for which appropriate anesthebc. analgesic. or tranquilizing drugs were used.

500

23

1738

1174

7 1

93

228

J

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible Institutional official)

1 certify that the above is true. correc!, and complete (7 U.S.C. Section 2143)

E. Number of animals upon which teaching. experiments. research, surgery or tests were conduded involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic.analgesic or tranquiluing drugs would have adversely affected the procedures. results, or interpretation of the teaching, research. experiments. surgery. or tests. (An explanation of the plocedures producing pain or distres in these animals and the reams such drugs were not used must be attached to this repod)

2 1

APHIS FORM 7023 (Replaces VS FORM 18-23 (Oct 88), which is obsolete PART 1 - HEADQUARTERS (AUG 91)

DATE SIGNED

1 112 1 I2002

SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL

NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Print)

This report is required by law (7 USC 2143). Fatlure to report according to the regulat~ons can See reverse side for Interagency Report Control No result ;rl an order to cease and des~st and to be subjed to penalt~es as provided for ~n Section 2150. add~t~onal information. 01 80-DOA-AN

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REGISTRATION NO. CUSTOMER NO. ANIMAL AND PLANT HEALTH INSPECTION SERVICE 34-R-0001 109 FORM APPROVED

OMB NO. 0579-0036 b 2 HEADQUARTERS RESEARCH FACILITY (Name and AWress, as registered wrth USDA

CONTINUATION SHEET FOR ANNUAL REPORT WudeZlp Code)

OF RESEARCH FACILITY UNlVERSrrY OF MICHIGAN 1301 CATHERINE STREET

(TYPE OR PRINT) ANN ARBOR, MI 481 09

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY (Attach addibonal sheets if necessaw or use this tbt7n.J I r A 8. Number of C. Number of D. Number of animals upon E, Number of animals upon *~ch teaching. F.

animals bang animals upon With experiments. experiments. research, surgery or tests were Animals Covered bred. which teaching. teaching. research. conducted involving accompanying pain or distress TOTAL NO. By The Animal conditioned. or research, surgery, or tests were to the animals and for which the use of appropnate OF ANIMALS

Welfare Regulations held for use in experiments, or conducted involving anesthetii,analgesic, or tranquilizing drugs would teachng, testing, tests were accompanying pain or have adversely affeded the procedures. results. or (Cob. C + experiments. conducted distress to the animals interpretation of the teaching. research. D+E) research, or involving no and for which appropriate experiments, surgery. or tests. (An explanabbn of surgery but not pain, distress, of anesthetic, analgesic, or the procedures pmd-ng pain or distress in these yet used for s u d ~ use of pain- tranquilizing drugs were animals and the re8sons such drugs were not used P'JrPoses relieving drugs. used. must be attached to this repoR)

Degu 337 173 -- - -- 510 - -

Ferret 175 175

Gerbil 12 12

Shrew - 307 307 *

Wild Mouse 48 1 48 1

Chipmunk 62 62

Vole n 77

Squirrel 6 6

Lemming 3 3

1 ASSURANCE STATEMENTS f 1) Professionalty acceptable standards governing the care, treatment. and use of animals, includii appropriate use of anesthetic. analgesic, and tranquilizing dngs, p ~ w to, during,

and following adwl research, teaching, testing, surgery. or experimentation were followed by this research facility.

2) Ea& principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Ad. and it has required thal exceptions to the standards and regulations be speufied and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all the exc~ t lons is attached to this u r n d mpofi In addrtion to identifying the IACUC-approved exceptions. this summary indudes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropnate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

t CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible Institutional official)

I certify that the above is true, correct, and complete (7 U.S.C. Section 2143) SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL NAME 8 TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (7'ype or Print) DATE SIGNED

1 1/21/2002

APHIS FORM 702319 (Replaces VS FORM 18-23 (Oct 88). which is obsolete PART 1 - HEADQUARTERS (AUG 91)

APHIS Form 7023 Column E Explanation

This form is intended as an aid to completing the APHIS Form 7023 Column E explanation. It is not an official form and its use is voluntary. Names, addresses, protocols, veterinary care programs, and the like, are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.

1. Registration Number: 34- R-000 1

2/3. Species (common name) & Number of animals used in this study:

Non-Human Primates (21)

4. Explain the procedure producing pain andlor distress.

21 monkeys were used to study the analgesic effects of drugs with a warm water tail-withdrawal procedure. These monkeys have their tails immersed in 40-50C water. The tail is not constrained and the monkeys can remove their tails without restriction.

5. Provide scientific Gstification why pain and/or distress could not be relieved. State methods or means used to determine that pain andlor distress relief would interfere with test results. (For Federally mandated testing, see Item 6 below)

. - A variety of opioid and non-opioid analgesics are being studied with this procedure. Administration of analgesics would alter normal responses and interfere with the results of the study.

6. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations (CFR) title number and the specific section number (e.g., APHIS, 9 CFR 11 3.102):

Agency: CFR:

This r- IS r w r d by In (7 U S C 2143). Fdure 10 r W m i n o to the ~ ' W J I ~ ~ O ~ S N 0 v 2 2 2002 ~,~~~~~~ can

- -

UNITED STATES DEPARTMEKT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVlCE

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRINT )

Telephone: (3 1 3) -577-1 629

- 1. CERTIFICATE NUMBER: 34-R-00 1 4

CUSTOMER NUMBER: 120

I

REPORTING FACILJTY ( bst all locabons where an~nrals wtrt h a r s c d or used In actual research. tesbng. or expenmentation, or hdd for these purpcua. Anach ad&hmJ sheets 11 ncccuary ) I

- --

FORM APPROVED OM6 NO. 0519-0036

-- -

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A \ 1

Wayne State University I

Division Of Laboratory Animal Resources 540 E. Canfield Detroit. MI 48201

B. maof - a n i d s bang- bred. conditioned. or hdd for use In teaching. testing. =P"-tt. rcxsnh. or surgery but not ye

N m e r of animals upon vrhich upcnments. tcachtng. -ch, surgefy. or t-b were conducted invdwng acconpanying pain or distress to the antmals and for which appropriate anesthetic. a

E. Number of an~rnafis upon wh~ch teaching. utpcnmcnts. nsearrh. surgery a tests were conducted irrvdwng acconpanying pain or distress to the animals and for Mich the use of approwte anesthetic. analgesic or tranquilizing drugs would ha* adversely affected the procedures. resultt. a interpretation of the teaching. nseardr. ex~enmmts. surgery. or tests. ( A n orplanation of the procedures producing pain or distress In these anfrrcals and the reasons such drugs were not used mwt be attached to

TOTAL NUMBER OF ANIMALS

( COLUMNS C + D + E )

4. clogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabtnts

9. Non-human Primate

10. Sheep

11. Pigs

1 2 . 6 8 8 ?arm Animals

f ASSURANCE STATEMENTS I

0

0

0

Goats 13. Other Animals

Ferrets

Gerbils

N BY HEADQUARTERS RESEARCH FAClLllY OFFICIAL

tive Officer or Legally Responsible Institutional Omdal )

30

0

0

0

5

0

DATE SIGNED

AP olete.

0

10

24

0

0

0

0

0

0

0

0

0

47

22

145

0

0

0

401

17

0

0

179 I

0

0

52

3

6

18

47

32

22 1

0

0

0

0

0

401

17

0

0

179

0

0

0

2 2

3

6

18

0

Wayne State University 34-R-0014

Gordon H. Scott Hall 540 E. Canfield Detroit, MI 48201

Applebaum College of Pharmacy and Health Sciences @ 259 Mack Avenue Room 5116 Detroit, MI 48201

Institute of Environmental Health '. Sciences

2727 Second Avenue Detroit, MI 48201

C.S. Mott Center 275 E. Hancock Detroit, MI 48201

Biological Science Building 5047 Gullen Ma11 Detroit, MI 48201

Lande Medical Research Building 550 E. Canfield Detroit, MI 48201

Kresge Eye Institute 4717 St. Antoine Blvd. Detroit, MI 48201

Vaitkevicius Magnetic Imaging 3990 John R Street Detroit, MI 48201

Elliman Clinical Research Building 421 E. Canfield Detroit, MI 48201

Life Science Building 5000 Gulien Mall Detroit, MI 48201

John Dingell Veteran's Administration Medical Center 4646 John R Street Detroit, MI 48201

Meyer L. Prentis Building Barbara Ann Karmanos Cancer Institute 110 East Warren Avenue Detroit, MI 48201

Attachment

Wayne State University, Registration No. 34-R-0014

Fifty Two Guinea Pigs Reported Under Reporting Code E:

Guinea pigs are utilized to evaluate the efficacy and toxicity of investigational antifungal agents for the treatment of pulmonary aspergillosis. The advent of sophisticated life saving medical procedures, such as organ transplantation, intensive cytotoxic chemotherapy against cancer, and the prevalence of HIV infection in recent years have dramatically altered the immune status of the patient

I _ - - population during the past ten years. Consequently, the incidence of Aspergillus infection has increased significantly among cancer patients, organ transplant recipients and AIDS patients. Although fungal infection due to A. fumigatus has emerged as a serious clinical problem in immunocompromised patients, the choice of antifungal agents highly effective against A. fumigatus is unfortunately very limited. In this guinea pig model, a variety of novel antifungal agents are evaluated in the treatment of pulmonary aspergillosis. Clinical symptoms of this infection are treated with antifungal agents (except in control animals) and both dietary and fluid supplementation. Animals which do not respond to treatment (and control animals) are euthanized a t the onset of anorexia, fever, dyspnea, or body weight loss greater than 20%.

Th~s reporr is requtred by law (7 USC 2143). Fatlure to report according to the regulations can

See attached form for additional mformation

Interagency Repon Control NO!

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE I 1. CERTIFICATE NUMBER: 34-R-0015

CUSTOMER NUMBER: 124 I FORM APPROVED OMB NO. 0579-0036

I Pharmacia & Upjohn 301 Henrietta Street Kalamazoo, MI 49007


I

. REPORTING FACILITY ( List all locabons where animals were housed or used in actual research. testing, or experimentation. or held for these purposes. Attach additional sheets if necessary )

FACIUIY LOCATIONS ( Sites ) - See Atached Listing

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if neceasarv or use APHIS Form 7023A 1 I 6. Numberof

animls beingz bred. conditioned, or held for use In teaching. testing. expenments. research. or surgery but not ye

C. Number of animals upon which teaching. research. experiments, or tests were conducted involving no p a n distress. or use of pain- relieving drugs.

E. Number of animals upon which teaching, experiments, research. surgery or tests were conducted invohnng actompartying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures, results, or interpretation of the teaching. research. expenments, surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

D. Number of animals upon which experiments, teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a


Anlmals Covered By The Animal

Welfare Repulatlons ( COLUMNS C + D + E )

4. Dogs I

5. Cats

6. Guinea Pigs I

7. Hamsters

10. Sheep I 11. Pigs I 12. Other F a n Animals I

G e r b i l s

Ferrets

I 1) Professiondw acceptable standards governing the cam, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following

adual research, teaching, testing, surgery, or e&mentation were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Ad, and it has required that exceptions to the standards and regulations be speufied and explained by the principal investigator and approved by the lnstiknional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to thls annual repoR In addition to idenwing the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions. as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFlClAL ( Chief Executive Officer or Legally Responsible Institutional Offiaal)

UTIONAL OFFICIAL NA

es VS FORM 18-23 (OCT 88). which is obsolete. (10)

APHIS Form 7023 Site List

The following sites have been reported by the facility.

Registration Number: 34-R-0015 Customer Number: 124 Facility: PHARMACIA & UPJOHN

301 HENRlEnA STREET KALAMAZOO, MI 49007

PHARMACIA & UPJOHN 301 HENRlETiA STREET KALAMCZOO. MI 49007

Explanation of Animal Use Listed in Column E

4. Dogs:

Attachment to USDA Annual Report Registration No. 34-R-00 1 5

November 2002

These sixty-one (61) animals were used in safetyltoxicity evaluations, the results of which will be used to support registration of Pharmacia proprietary compounds. Many of these compounds are being developed for the treatment of critical diseases in humans, primarily central nervous system (CNS) disorders and infectious diseases. Studies to characterize the toxicity of new phamaceuticals are required in non-rodent species by all regulatory agencies that review and approve new human medications, and alternative methodologies alone are not sufficient. [Title 2 1, Code of Federal Registry (CFR) 58 (Good Laboratory Practice for Non-clinical Laboratory Studies), 3 12 (.Investigational New Drug Applications), CFR 3 14 (Applications for FDA Approval to Market A New Drug...), CFR 5 1 1 (New Animal Drugs for Investigational Use), CFR 5 14 (New Animal Drug Applications); numerous sections apply in each of these.] In a safety evaluation, administration of analgesics is not possible as analgesics may alter the animals' response to the test compound or otherwise confuse interpretation of the study, which would result in a need to repeat studies, using additional animals. However, other nursing and supportive care is provided by the veterinary staff, as indicated.

6. Guinea Pigs: ----- --- ------ ---------- ------ ------ --- -- -------- --- ------------------------ --- ---------- ---- ---------- --- ------- -------------- -------------- ---- ---- ------------ --- --------- ----- ------ --------- -------------- ------ ---------- This experimentally induced condition was necessary to provide an ---------- -------- --- -------- --- ---- -------------- ----------- --- --------- -------- utic benefit. ---- ---- --------- ------------- ------ ----- -------- -- -------- --- ------------------------ administration of analgesic drugs would not provide relief and they could alter the animals' response to the test compounds or otherwise confuse interpretation of the study. However, animals that experience severe distress are removed from the study conditions, and this always relieves the reaction within minutes.

The remaining thirteen (1 3) animals experienced unanticipated adverse reactions to drug -------------- on --- ----- --- -- ------- ------------- ---- ---------------- --- -- ----- ------ --- ------ .'

--------------- Animals found to be experiencing these adverse reactions were euthanized immediately. These animals represented 4% of the total animals involved in the study.

8. Rabbits: ----- --- ------ ---------- ------ ---------- --- -- ------- ----------- --- ------------ ---- ---------- --- ------- -------------- -------------- ---- ---- ------------ --- ----------- ---------------- ------ -- -- ----- -------------- ------------ --- ---------- ----- --- ---------- ----- ------- -------- ---------- ----- ---------- ------ --- --- -- ------- --- ------------ ------ ---- ----------- -------- --------- ---------- ------- --- --------- ------------ ------ ----- ------ --- ---------- ------ ----- ----------- . As with other studies designed to provide data to support registration of new clinical entities, administration of analgesics or other anti-inflammatory drugs is not possible as they may alter the animals' response to the test compound or otherwise confuse interpretation of the study, invalidating the ----------- ----- ----- ---------- -- ------ --- -------- --------- ------ ------------ ---------- ----- ----------- ---- ----------- ---------------- -- -------------- -- ---------- --- ------------ --------- --------- -------- ---------- --- --------- ------ ------ ----- ----------- --- ---------------------- ------- ----- --------- ------

USDA Report 2002 - Attachments Pharmacia & Upjohn - Registration No. 34-R-0015

'Page 1

(b)(4)

(b)(4)

(b)(4)(b)(4)

(b)(4)

(b)(4)

-------------- --- ---- -------- ----------- ------------ --- ----- --- ---- -------- ------ ---------- ---- -------- ------ ------------ ---------------- ------- ----- ------ --- ---------- ------------ --- ----- ------------ Supportive and nursing care is provided as indicated, and animals not responding to treatment are euthanized promptly.

The remaining four (4) animals were used in safety/toxicity evaluations, the results of which will be used to support registration of Pharmacia proprietary compounds. (See regulations listed under Dogs, above.) In this type of evaluation, administration of analgesics is not possible as they may alter the animals' response to the test compound or otherwise confuse interpretation of the study, invalidating the resulting data and creating a need to repeat studies using additional animals. However, other nursing and supportive care is provided, as indicated.

9. Non-human Primafes:

These ten (10) animals were used in safetyltoxicity evaluations, the results of which will - - be used to support registration of Pharmacia proprietary compounds. (See regulations

listed under Dogs, above.) Studies to characterize the toxicity of new pharmaceuticals are required in both rodent and non-rodent species by all regulatory agencies that review and approve new human medications; primates are used as the non-rodent species only when metabolism, kinetics or some other factor precludes the use of purpose-bred beagles in pre-clinical toxicology studies. In this type of evaluation, administration of analgesics is not possible as they may alter the animals' response to the test compound or otherwise confuse interpretation of the study, invalidating the resulting data and creating a need to repeat studies using additional animals. However, other nursing and supportive care is provided by the veterinary staff, as indicated.

13. Other Species

Gerbils: 1463 of these animals ------ ------ --- ---- ---------------- ----- ------------------- --- -- -------- --- --------- ---- ----------- --- ---------- ---- ---------- ----- --------------------- --- ------- ---------------- -------- --- -------------- --------- ------ ----------- ----------- -------- ----- ------- --- ------- ---- ----- ----- -------------- --------- --- ----------- ---------- ---------- ------ ------ ------- --- ------------ ------- ------ --------- -------------- ----- ------------ ----- ------------ ------ ---- ---- ----- ------ --- ---------- ------ ----- ------------- As with other studies designed to provide data to support registration of new clinical entities, administration of analgesics is not possible as they may alter the animals' response to the test compound or otherwise confuse interpretation of the study, invalidating the resulting data and creating a need to repeat studies using additional animals. The potential for confused interpretation is particularly a concern in infectious disease studies, where masking of clinical signs with pain relievers or anti-inflammatory drugs may provide false information on test article efficacy. However, in these situations, other supportive and nursing care is provided as indicated.

----- ------------ -------- - - --- ---------- ------ ------ --- -- ------------ ------- --- -------- -------------- ------ --- ------ --------------- --------- ---- --- ------------ ---- --- -------------- ------ --- -------- --- ---- ------- ----- ---------- ------- ----- -------- ------ -------- -------------- -------- --- -- -------- ---- ---------- ----- ------ ---------------- ---------- ----- ------------- --------- --- ----------- --- ------------ ------ -- ----- --------- -------- ------ ---------- ---- ------------- ------------ ---------- ----- ------ ------ -------- ---------- --- ------ --- ------------ --- -- ------- --- ------ ---------- --------- ------- ---------- ---- ----- ------------- ------------

(b)(4)

(b)(4)

(b)(4)

Chinchillas:

These four (4) animals ------ ------ --- -- -------------------- -------- --- --------- ---- ----------- --- ---------- ---- ---------- ----- --------------------- --- ------- ---------------- -------- --- -------------- --------- ------ ----------- ----------- -------- ----- ------- --- ------- ---- ----- ----- -------------- --------- --- ----------- ---------- ---------- ------ ------ ------- --- ------------ ------- ------ --------- -------------- ----- ------------ ----- ------------ ------ ---- ---- ----- ------ --- ---------- ------ ----- ------------- As with other studies designed to provide data to support registration of new clinical entities, administration of analgesics is not possible as they may alter the animals' response to the test compound or otherwise confuse interpretation of the study, invalida----- ---- ----------- ----- ----- ---------- -- ------ --- -------- --------- ------- ------------ ---------- ----- ----------- ---- ---------- ---------------- -- -------------- -- ---------- --- ------------ --------- --------- -------- ---------- --- --------- ------ ------ ----- ----------- --- ---------------------- ------- ----- --------- ------ -------------- --- ---- -------- ---------- However, in these situations, other supportive and nursing care is provided as indicated.


Page 3

(b)(4)

(b)(4)

Exceptions to Standards and Regulations

Attachment to USDA Annual Report Registration No. 34-R-00 1 5

November 2002

The following exceptions to standards and regulations under the Act were approved by the IACUC during this reporting period:

The use of complete Freund's adjuvant (CFA) as part of an immunogen in horses was approved. The immunization process is required in the outline of manufacture for a biological that is the drug of choice for treatment of aplastic anemia and which is also an important part of adjunct therapy in transplant patients. This protocol was not utilized during the current reporting year and therefore impacted zero (0) animals. The IACUC closely monitors this protocol when it is active and is kept current on all efforts

: to refine the procedure by the investigators.

Under one protocol, the IACUC has approved an exemption such that cat enclosu---- ---- ---- --------- ----- ----------- ------- ----- --------- ------ ----------- ------ ----- -------- ----- ----------- --------- ------- ----- ------ --- --------- ------------ -------------- ----------- --- ------------ ------ ------------ ------- -------- . Because of the risk of contaminating other rooms if the cats were moved during sanitization, the rooms were only sanitized between studies (every 6-12 weeks). Granting an exception from the two-week sanitization schedule had little effect on the living conditions of the animals. The rooms and runs were washed down each day. WhiIe the washing proceeds, the cats jump onto perches within the runs and do not get wet. This allows the lower part of the runs and floors to be cleaned daily. During inspections, there have been no concerns about cleanliness. This regimen does allow a small deposit of dust and dander to accumulate on the top rails of the runs, but this is minimal. When a study is completed, runs are washed and disinfected before new animals enter the space.

Under another protocol, the IACUC approved an increase in the sanitization interval for dog runs from 14 days to up to 28 days, total. This impacted 35 dogs during this reporting period. These dogs were on studies where food consumption data was critical, and this was markedly disrupted by moving the animals out of the room in order to clean, adding an additional variable to the study. Granting this exception from the two-week sanitization schedule has had little effect on the living conditions of the animals. The runs are washed down each day (which seems minimally disruptive to the animals' food consumption), and during inspections, there have been no concerns about cleanliness. At the end of each 4-week study, runs are washed and sanitized per usual.

Under two protocols, dogs and nonhuman primates (NHPs) were occasionally housed in stainless steel metabolism cages for the collection of urine andlor feces (providing at least 1 X space) for pharrnacokinetic studies and studies involving radiolabeled compounds, necessitating limited exemptions from the enrichment plans for these species. This impacted thirty-six (36) dogs and twenty- seven (27) NHPs during this reporting period. The dogs were housed in metabolism cages for 1-3 days. They did not have access to manipulata or exercise outside of the cage during this time, due to the need for total urine collection and the use of radioactivity. The NHPs were housed in metabolism cages for 1- 3 days. They did not have access to manipulata throughout this study period, but received fruit treats daily.

USDA Report 2002 - Attachments Pharmacia & Upjohn - Registration No. 34-R-00 15

Page 3

(b)(4)

Short-term exemptions from exercise for post-surgical recovery were granted by the IACUC as follows: Eight (8) dogs underwent surgical procedures required to prepare them for participation in cardiovascular monitoring studies. These animals were exempted from exercise for a 14-day recovery period, after which time they were able to resume normal activity.

The IACUC has authorized the Attending Veterinarians to grant very short-term exemptions to the mandatory sanitization intervals under exceptional circumstances, providing that they personally view and evaluate the housing situation and determine that there would be no compromise to animal welfare standards by allowing the cage change to wait for one or two additional days. In these situations, the Attending Veterinarian must observe the room in question, then annotate the room maintenance record (RMR), stating that the exception has been granted. A copy is made of the RMR and a separate file documenting these exceptions is maintained in the Attending Veterinarian's office as well. Seven exemptions of this nature were granted this reporting period, each involving a 24-hour extension. Two of these involved a-total of -50 rabbits; three involved a total of 36 dogs; and huo involved a total of 32 nonhuman primates.


Page 5

C UNITED STATES DEPARTMENT OF AGRICULTURE

ANIMAL AND PUWT HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY ( TVPE OR P R I M )

13. REPORllNG FACnrrY ( List aU IcicaIons Mw ani- w m housed or used in actual research. t@s

M P I Reseatrh, lnc. 54943 N. Main Street Mattawan, MI 49071

Telephone: &/ -6684336

u

N O V 2 2 2002

REPORT OF ANlMALS USED BY OR UNDER CON7ROL OF RESEARCH FAClLJTY I Attach additlanrl .hwtr W numsam or ~ru APHIS Form 7023A ) I

4. ~ o g s 137 5. cats 28

C. rsrmaerd -upon whkh tceching. rrseenh emelmmts. or tssts~lere

COndllCtCd hvdving no psin. d~s-ss, or use of pain- rdiewng dmgs.

D. Numbcroraninatr upan- mrtwtr.-ng. ms-ch. tugay.a t c r t t ~ c o n d u d e d invdving ocanrpanVinopain~ &tress to the d s and for Mi& appmpdato aneslhetic. a

E ~unkrd .nkr r t ruponmlach~ . F. -rs#ueh.suww-- ~ k n r d v l n g # m r r p n y i n g ~ ~ ~ TOTAL NUMBER t e t h a . n b r r d r m d f o r M t h a u s r d ~ OF ANIMALS a m m t k ~ o r ~ d n r g r w a J d h . v b ~ ~ t h e ~ ~ o r i~uondtt#tslddngrsPbVdLsrq#imarr ( COLUMNS wrgwy,a- ( A n o r p l M l t i o n d b V C + D + E ) p r o d u d n g p o h o r ~ i n ~ s r r k r p l r ~ ~ ~ s u c h Q u g l w e m n o t w s d ~ b e s t E a c t K d t 0

1 2 2 ,760 0 4 4

1 I I I f

7. Hamsters 1 1 4 0 1 1 8 8 I 212 1 0 1 4 0 0

- 6. Guinea Pigs

1 I I 1

9. Nonhuman Primate 1 2 2 6 I I 2 6 4 I 0 . I 439

1 2 5

8. Rabbii 3 2 0

91. pigs 1 1 8 1 1 26 I 275 I 0 1 301

406

10. Sheep

13. Other Animals

I

I ASSURANCE STATEMENTS I

0

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chiat Executh Ontcer or Legally Responsible lnstihrtional Omdal )

1 3 1 537

T p or Rht

DATE SIGNED

AP (AUG 91 )

Column E Explanation

Registration Number: 34-R-0031

STUDY 1

Number of Animals: 4 Species : Dog

Explanation of Procedure Producing Pain and/or Distress

The test and control articles were administered by I.V. Infusion. All personnel administering the materials were thoroughly trained to avoid potential injury to the animals. Specifically, animals were closely monitored by technicians and veterinarians for general signs of toxicity, inappetance, and stool. (General clinical findings were considered toxicity findings. Three dogs were euthanized and one died at first dose.)

Scientific Justification

The route of administration was considered the most appropriate by the Sponsor and FDA to meet the objectives of this cardiovascular safety evaluation study.

Regulations

International Conference on Harmoniation (ICH) Harmonized Tripartite Guidelines

STUDY 2

Number of Animals: 131 Species : Guinea Pig


Skin sensitization studies were conducted to determine the potential for the test articles to produce allergy in human beings. The Maximization method used requires intradermal injection of Freund's Complete Adjuvant that typically produces localized skin ulcers at the injection site. The animals remained active, alert, and good appetites with no overt signs of pain.


The nature of these test articles required the use of the Maximization method. The FDA requires skin sensitization testing.

Regulations d

FDA Guidelines for Preclinical Toxicity Testing of Investigational Drugs for Human Use as well as generally accepted procedures for the testing of pharmaceutical compounds.

The United States Environmental Protection Agency (EPA), OPPTS 870.2600

The Organization for Economic Cooperation and Development (OECD). Guideline 406, Skin Sensitization.



STUDY 3

STUDY 4

Number of Animals: 4 Species : Rabbit


The potential for the test article gel to produce ocular irritation was evaluated. A small amount of gel (0.lmL) was placed in 1 conjunctival sac and the other eye served as an undosed control. A topical anesthetic was immediately available if pain was detected. The ocular reaction was mild and topical anesthetic was used.


The EPA requiresthis testing.

Regulations

The US Environmental Protection Agency (EPA) Toxic Substances Control Act (TSCA), Health Effect Test Guidelines, 798.4500.

FDA Guidelines for Preclinical Toxicity Testing of Investigational Drugs for Human Use as well as generally accepted procedures for the testing of pharmaceutical compounds,

Federal Hazardous Substances Act, Consumer Product Safety Commission, Method of Testing Toxic Substances, 16 CFR 1 1, Method of Testing Toxic Substances, Sec.1500.42, 1993.

The EPA, Office of Prevention, Pesticides and Toxic Substances, Health Effects Test Guidelines, 870-2400.

The Organization for Economic Cooperation and Development (OECD), Guideline 405, Acute Eye Irritation/Corrosion.

Number of Animals: 2 Species: Rabbit


A dermal study required the dermal application of test article that resulted in a moderate to severe skin reaction. The dosing and subsequent washing procedures were closely monitored by the investigator and staff veterinarian. By Study Day 15, the skin reactions had disappeared.


The EPA requires this testing.

Regulations

Guidelines entitled Detection of Toxicity to Reproduction for Medicinal Products, Federal Register, Vol. 59, No. 183, September 22, 1994, Guideline No. 4.1.3. Study for effects on embryo-fetal development.

The US Environmental Protection Agency (EPA), Toxic Substances Control Act (TSCA), Health Effect Test Guidelines, 798.4470

The EPA, Office Prevention, Pesticides, and Toxic Substances (OPPTS), Health Effects Test Guidelines, 870.2500.

The Organization for Economic Cooperation and Development (OECD), Guideline 404, Acute Dermal Irritation/Corrosion.



STUDY 5

Number of Animals: 8 Species: Dog

Explanation of Procedure Producing Pain andlor Distress

An Oral (Capsule dose) toxicity study resulted in marked weight loss. Dosing was continued in these animals with the objective of the dogs developing histological lesions similar to that observed on an earlier study. The animals were closely monitored by technicians and veterinarians and supportive treatment provided.


The FDA requiresthis testing

The FDA requested this study design to clarify lesions that were detected on a previous study. The FDA also placed the the sponsor's on-going clinical trial on indefinite hold pending the findings of this study.

Regulations

Direct communication between Sponsor and FDA.

This study is based on the FDA's Current View on Safety Evaluations of Drugs as well as generally acce~ted ~rocedures for the testina of ~harrnaceutical com~ounds.

Registration Number:

Summary of Exceptions

Summary of Exceptions to the Regulations and Standards

There were no exceptions to the regulations and standards.

Thrs report is requ~red by law (7 uSC 2143). Fa~lure to report according to the regulations 0 C T 0 8 2002 See Interagency Report Control No.:

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE


. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, te:

additional information

Stanwood, MI 49346 a j 1 + Please nore Q ~ O code- Telephone: -) -823-2392

1. CERTIFCATE NUMBER: 34-R-0004


1, or experimentation. or held for these purposes. Attach additional sheets if necessary )

---

FORM APPROVED

FAClLrrY LOCATIONS ( Sites ) - See Atached L~stmg Please see awdched. i

b

Cheri-Hill Kennel & Supply 171 90 Polk Road

5. Cats

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets i f necessarv o r u s e APHIS Fo rm 7023A \

6. Guinea Pigs I I

k

Animals Covered By The Anlmal

Welfare Rqjulatlonr

7. Hamsters

8. Rabbits

6. Number of - animals being - bred. conditioned, or held for use in teaching. testing. experiments. research. or surgery but not ye

I


10. Sheep

11. Pigs ! 12. Other Farm Animals I p- -

13. Other Animals

c. Number of animals upon which teaching. research, experiments, or tests were conduded involving no pain, distress, or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching. research, surgery. or tests were conducted involving accompanying pain or distress to the animals and for which appropnate anesthetic, a

E. Number of animals upon which teaching. experiments. research, surgery or tests were conducted involving accompanying pain or distress to the anirnals and for which the use of appropriate anesthetic. analgesic, or tranquilizing drugs would have adversely affected the procedures, results. or interpretation of the teaching, research, experiments. surgery. or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to



m


1) Professionally acceptable stadads governing the cam, treatment. and use of animels, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, dwing, and following &t.A researcf~, teaching, testing, surgery, or experimentation were followed by this reseadl facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to Vte standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (LACUC). A summary of all such exceptlons is attached to this annual report. In addition to idmtfying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptiw, as well as the species and number of animals Meded.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision d adequate veterinary care and to oversee the adequacy of other aspeds of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFlCVIL ( Chief Executive Officer or Legally Responsible Institutional Official )

S 1 DATE SIGNED

/0°7-oa AP

Licensee/Registrmt Nanle: d b a - C h e r i - n i l 1 K e n n e l

I p leaee list below all sites tnac houee>egulated anbale under the above number. De sure to i n c l u d e a l l requested information. If the line doee not apply, p ~ e a ~ e mark it N/A. If you have more than t k e e ( 3 ) sites copy t h i s tom as many times as needed before f illins in t h e s i tee .

S i t e

Addrese: 1 7 2 9 0 Polk Rd.

Stanwood, Hi 6 9 3 1 6

B u i l d i n g : S e e a t t a c h e d d i a g r a m

~Loor/~oom: F A W I T T Y SOUARE FOOTGE, 1 . 9 . 6 8 d -

Contactperson: phone no.: 231-823-2392

Fax No. 231-823-2925

S i t e No. : ~ a m e / ~ e p r t m e n t :

Addreea :

Building :

Floor /Room:

Contact Person: Phone No. :

S i t e Ho. : Name/Department : - 0 - Addream :

Building :

Floor/Room:

Contact Person : Phone No, : -

CHK Facilities RESEARCH

b .)

TOTAL SQUARE FOOTAGE, KENNELS / q! 5 q d

TOTAL SQUARE FOOTAGE, OFFICE COMPLEX 5. o ~ Y

TOTAL SQUARE FOOTAGE, ENTIRE RESEARCH FACILITY 9: b %

This report is required by law (7 USC 2143). Failure to repact according lo the regulattons can additional infotmation

interagency Report Conlrd NO.:

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVlCE

ANNUAL REPORT OF RESEARCH FACILITY ( TVPE OR PRINT )

I 1. CERTIFICATE NUMBER: 34-R-0008

CUSTOMER NUMBER: 1 15 I FORM APPROVED OM8 NO. 05790036

Dow Chemical Company H d t h & € ~ w ~ 8 e a f e r e b f - Toxicology and '1803 Building Environmental Midland, MI 48674 Research and

Telephone: (5U) -636-1 509 . . Consulting

I

3. REPORTING FACIUrV ( hl all locations where animals were housed or used in actual research, test@. or expE?fimefltati~n. or held for these purpores. Attach additional she& if n w )

FACILllY LOCATIONS ( Sitsr ) - See Abched Listing

1 REPORT OF ANIMALS USED BY OR UNOER CONTROL OF RESEARCH FACIlJlY I Attach additional sheets if necessarv or use APHIS Form 7023A 1

4. Dogs

B. N r n e r d -

animals being- bred, condioned, or held for use in - testing. qmimnts. research. or surgery but nd yt

6. Guinea Pigs

7. Hamsten

8. Rabbits

9. Non-hurnan Primate

.lo. Sheep

11. PIgs

12 Other Fann Animals

13. Omer Animals 1

C. Number of aninrals upon whicb Wc9Iing. research. eqmiments, or ledswere conduded imrdving no pain, distress, of use of pain- relieving drugs.

ID. Nwnbcrdanmals upon which apaimenk. teaching. -. surgery,a testswercconduc(cd involving aampanying pain a d i i lo the animals and f a which appropriate anesthdc. a

E. Numbs d animals upon which teaching, ~ . - . s w g e r y o r t e s b m n conducied irnrdving acconpany(ng pain or &stress lo the aninralt and for which the use d appmpriate

surgery, or tests. ( An eypbnaC0n.d the pcocedwes producing pain or diitnss in these animals and the reasons such drugs were not used mal be alBched to

TOTAL NUMBER OF ANIMALS.

ATTACHMENT 1

FACILITY LOCATIONS (SITE LISTINGS)

ACTIVE SITE

Toxicology and Environmental Research and Consulting Laboratory 1 803 Building Midland, Michigan 48674

LIST OF DELETED SITES LSites Permanentlv Closed)

Central Research Materials and Development Laboratory 170 1 Building Midland, MI 48674

Site Deleted (permanently closed) on May 20, 1996

Dow Chemical Company Toxicology Research Laboratory - Indianapolis 9550 N. Zionsville Road Indianapolis, IN 46268

Site Deleted (permanently closed) on December 3 1, 1995

Health & Environmental Sciences Lake Jackson Research Center Freeport, TX 77541

Site Deleted (permanently closed) on November 19, 1994

The Dow Chemical Company Midland. Michigan 48674

1 803 Building November 2 1, 2002

Elizabeth Goldentyer, D.V.M. Regional Director - Animal Care Eastern Region United States Department of Agriculture Marketing and Regulatory Programs Animal and Plant Health Inspection Service 920 Main Campus Drive Suite 200 Unit 3040 Raleigh, NC 27606-52 13

Dear Dr. Goldentyer,

Please find enclosed the original and one copy of the completed USDA Annual Report (APHIS form 7023 only) for the reporting facility of The Dow Chemical Company (registration number 34-R-0008, Customer Number 115). This facility has adhered to the standards and regulations under the Animal Welfare Act, as indicated on the Annual Report form.

As note the AHPIS form 7023 has been corrected to reflect the current telephone area code, which is 989, and the correct facility name, whch should be the Toxicology and Environmental Research and Consulting Laboratory. These changes were made on Animal Welfare Registration form submitted in June 2002.

Also enclosed are two copies of the list of former sites, previously listed under USDA . registration number 34-R-0008, which have been permanently closed and are no longer in operation. There are no animal numbers to report from these facilities, as no animals were present in the permanently closed facilities during this reporting period.

The only site that listed animals on this Annual Report is:

Site 1 : Toxicology and Environmental Research and Consulting Laboratory 1 803 Building Midland, MI 48674

Status: Active

The Institutional Animal Care and Use Committee of the Dow Chemical Company also inspects the Environmental Toxicology Laboratory which houses fresh water aquatic species only.

Elizabeth Goldentyer, D.V.M. November 2 1,2002 Page 2

The deleted sites and the dates of permanent closure are as follows:

Central Research Materials and Development Laboratory (formerly Central Research Bioproducts Laboratory) 170 1 Building Midland, MI 48674

Status: Deleted, Permanently closed May 20, 1996

~bxicology Research - Indianapolis 9550 N. Zionsville Road Indianapolis, IN 46268

Status: Deleted, Permanently closed December 3 1, 1995 (building has been demolished)

Health and Environmental Sciences Lake Jackson Research Center Freeport, TX 77541

Status: Deleted, Permanently closed November 19, 1994 (building has been demolished)

If you require additional information or clarification, please contact me.

Sincerely , --

-- ---- ------ --------- ---------- -------------- ----- ------------------ ----------- ----- ------------- ----------- ---- -------- ------- ------------

Enclosures

All redactions on this page are pursuant to (b)(6) & (b)(7)(c).

?us rcpor( is required by law (7 USC 2143). Fatlure lo report acwrding to the regulations --

See attached f m for additional informalion

hlwagency R e w l Catrd No.:

UNITED STATES DEPARTMENT' OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTKIN SERVICE



CUSTOMER NUMBER: 1 1 6 I FORM APPROVED OM6 NO. 05190036 I

I Providence Hospital 16001 W. Nine Mile Road Southfield, MI , 48075

I Telephone: (248) 849-33 26

1 I REPORTlNG FAClUrY ( Lid dl locations where animals wen hwsed or used in adwl research, lesting. or qmimntation. or held for these pwpwct. Attach additional sheets if ne#ssary )

FAClUTY LOCATIONS ( s i i ) - See AtacM Listing

tEWRT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClUrY I Attach additional sheets if nccszwrv or use APHIS Form 7023A \ I B. Nwnberof

animals being : bred. conditioned, or held for use in t-ng. testing. ucperimts. research. or surgery but no( yr

Number d animals upon w4lidI teaching. mearch. ocpcrimenls, or testswere amduaed imrdving no pain, distress, or use of pain- retiewng drugs.

D. Number d animals upon which' expe8imenb. Icaching. -, svrgery,or tests were ccnduded invdwng accwrpanying pain or d i s m to the animals and for which appropriate anesthetic a

E. Number d animals upon which teaching, eqwximenls. research. surgery or tests w e cwduded involving accompanying pain or distress to the animals and for Wch the use d appropriate aneslhetic. analgesic or tranquilizing drugs would

m, or tests. ( kr apbation d the procedures pcoducing pain or distress in these animals and the masons such dfugs wen not used must be attached to



9 9 Guinea P i i

CERTIFICATION BY HEADQUARTERS RESEARCH FAClUTY OFFCHL ( Chief Executive Omcer or Legally Responsible Institutional Omcial )

Rabbib

Norrhuman Primate

Sheep

piol,

other Farm Animals

Other Anirnab

DATE SIGNED

( AUG 91 )

65 65

-- - - --

SEP-29-1998 13:33 FROM USDR QPHIS RERC NE SECTOR TO

FACILITY SX!l%S LrS'PfNa

~icenee/lbgistration Number: 34-R-009

Please list below all sites that houae regulated anixnale under the above number. Be eure to inc lude all requested information. If the line doee not apply, please mark it Hi&. It you have more than three ( 3 ) s i tes c o n t h i s fom as many t h e e a8 needed before -f illina Ln the. sites.

Addrege: 540 East Canfield

Detroit, Mi. 48201

Site Ne.: ~ame/Department:

Address :

Contact Person: Phone No. : I

Site No. t . Name/Departrnent:

Address :

Building:

Floor/Rom:

Contact Pereon: Phone No. :


n ~ o r t W r e d by law (7 USC 2143). Fatlure to repat according to the rqpktions -an

UNITED STATES DEPARTMENT OF AGRICULTURE A N W AND P L M HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRIM )

See attached form for additid W m U o n

lnlera~eocy Report cuwd No.:

I FORM - o m NO. OSfQ0036

Providence Hospital 1 6001 W. Nine Mile Road Southfield, MI , 48075

Telephone: (248) 849-3326

- - - - -

FAClUM LOCATIONS ( Sites ) - See Atachcd UsUng

tEPORT OF ANIMALS USED BY OR UNDER COHTROL OF RESEARCH FACIUTY 1 Altach additional sheets If n-w or use APHIS Form 7023A b 1 L I

B. Nwnberd anirnalsbdng I b d . anditioned. or hdd for use in teaching. testing. epuirnents. research. or = m w k n ~ y c

Nurrbefd anirrrals upon whid, teaching. nsearch. ucpaiments. or tests weft amduckd immlving no pain, distress. or use d pain- relieving dnrgs.

Guinea Pigs I I . I

' o c p c r i m c n b . ~ t w ~ e r y o r t e s t t m n cmducted invdving accompMying pain or distress L o t h e a ~ a n d lorwhichtheusedaplpropriale m e s t k k analgesic. or tranquilldng drugs wadd

produdng pain or distress In these animals and the reasons such drugs wen not used mJsl be attactled b I

I TOTAL NUMBER OF ANIMALS


SURAEtCE STATEMENTS 1

Norrhwnan Primate

Sheep

Pm

Olher Farm Animafs

OthsrAnhals

CERTlFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFlCIAL ( Chief ExecuWe Omcer or Legally Responsible Institutional Omdal )

i

DATE SIGNED

SEP-29-1998 13: 33 FROM USDR QPHIS REAC NE SECTQF? T O

~ i c e n a e t z / ~ e g i ~ t ~ d n e N-: Providence Hospital . Animal .Lab

Pleame l ist below a l l aites that house regulated animals under t h e above num4er. Be *

oure to include all requested information. If the line does not apply, please mark it N/A. xf you have more than thzee ( 3 ) sites copy t h i e form as many t h e s as needed before _f i l l i n c t Fn the. site.9.

Sltca No. r 1 Name/Depattm.ent : D i v b j ov ,,.&spurrpa W- -

J e

Address: 540 East Canfield

Detroit, Mi. 48201

Address :

Building:

Floor/Room:

Contact Person: Phone No. : Y

5

Name/Department: S i t e No.; - Address :

Building :

Floor/Room:

Contact Pereon: Phone No. :


Thts repon .s mpured .y law (7 USC 2143). Farlure to rrport aaordIng to the regulatmns -CI

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTlON SERVICE I FORM APPROVED

OMB NO. 05790036

ANNUAL REPORT OF RESEARCH FACILITY ( TVPE OR PRINT ) I Henry Ford Hospital

2799 W Grand Blvd Detroit, MI 48202

Telephone: (31 3) -876-2024 2 6 2002

I rn

3. REPOR~NG F A C m ( st art laanonr whew anrrals were housed or utcd in actual reseam. tesbng, or orgcnmntanon. or h a for these pwposes. Attam adational sheers if ncarstry ) 1 FACnrrY LOCATIONS ( sit# ) - ~ e s ~ t a ~ ~ t d bsting

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Atbch additional shoots If n- or us. APHIS Form 7023A \ I C. NWtwof

anmars upon wtnm teacmng. raeanh. utpcnmnts. or tcrb wcrs conduaed ~nvdwng no pain, dlsIresS. or use of pan- rdtewnq drugs.

5. Cats I 8. Guinea Pigs 1 7. Hamsters I 8. Rabbits I

10. Sheep

3. Other An~mals I

ASSURANCE STATEMENTS

ucpcnmcnts. -. surgery or tests wen conducted hdwng acconpanylng pam or distrcu lo the antrnds and for whuh the us8 of appropriate anesmttic arulgcwC or tranqutlizing drugs ulrould have adwndy affected the procedures, results. or interpretation d the teadung. research, expeftmenb. surgcry, or tests. ( An exolanabon of Me procedures


( COLUMNS C+D+E)

produang patn or drslreu a these antrrels and the reasons such drugs were not used must be attamed to I

4) ma enenglng velmnm.n tor IS mseud! taoltty has sppmpnate ruthonty to wurs the provlsm of adequate vstmnery cam and to oversw the adequacy of other %SfmCU of ~ 1 ~ 1

ERTlFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Omcer or Legalty Responsible institutional Oftidal )

DATE SIGNED

1 1 11 5102 8). wnlb, IS obsolete.

( AUG 91

FACILIlY SITES LISTING

LicenseelRegistrant Name: Henw Ford Health Svstern (HFHS)

LicenseeIRegistrant Number: 34-R-0010

Please list below all sites that house regulated animals under the above number. Be sure to indude all requested information. If the line does not apply, please mark it N/A. If you have more than three (3) sites. COPY this form as manv times as needed before fillinq in the sites.

Site No.: 1 Name/Department: HFHS. Bioresources Department

Address: 2799 West Grand Boulevard

Detroit. MI 48202

Building: Education and Research.

FfoorlRoom: 4Ih floor. room 4002

Contact Person: ---------- ------------- Phone--------------- ----

Site No.: 2 NamelDepartrnent: William Beaumont Hospital

Address: 3601 West Thirteen Mile Road

Royal Oak, MI 48073

Building: Research Institute

Floor/Room: NIA

Contact Person: ----------- ---------- Phone- ---------- ------

C

Site No.: 3 Name/Department: HF HS. Bioresources F,

Address: One Ford Place

Detroit, MI 48202

Building: One Ford Place

FlooriRoom: 3 0

Contact Person- ---------- -------------- Phone: -----------------


FAClLlTY SITES LISTING

LicenseelRegistrant Name: Henw Ford Hospital d/b/a H e n ~ Ford Health System

Licensee/Registrant Number: 34-R-00 10

Please list below all sites that house regulated animals under the above number. Be sure to indude all requested information. If the line does not apply, please mark it N/A. I f you have more than three (3) sites. CODV this form as rnanv times as needed before fillinq in the sites.

Site No.: 4 Narne/Departrnent: Wayne State University. Division of Laboratow Animal Resources

Address: 259 Mack Avenue

Detroit. MI 48201

Building: Applebaum d

Floor/Room: 5" floor, room 5420

Contact Person- ------- --------------- Phone- --- ------------ --

Site No.: NarnefDepartment:

Address:

Building:

Fioor/Room:

Contact Person: Phone:

Site No.: Name/Department:

Address:

Building:

Fiood Room:

Contact Person: Phone:


NOV 2 9 2002 Thrs report IS requrred by law (7 USC 2143) Fallure to report accordrng to the regulations can result tn an order to cease and des~st and to be subject to penalt~es as provided for In Section 2150

See reverse stde for add~tlonal ~nfonnation

Interagency Report Control No 01 80-DOA-AN /


I I \ 2 HEADQUARTERS RESEARCH FACILITY (Name and Address, as regrstered wrth US&

ANNUAL REPORT OF RESEARCH FACILITY rnclude fip code)

(TYPE OR PRINT) MICHIGAN STATE UNIVERSITY OFFICE OF RESEARCH & GRADUATE 246 ADMINISTRATION BUILDING EAST LANSING, MI 48824 (5 17) 353-5064

) 3. REPORTING FACILITY (List all locations where animals were housed or used in actual research. testing, teach~ng, or expenmentation. w held for these purposes. Attach additional J sheets d necessary.) J

FACILITY LOCATIONSIsitesl

See Attached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY (Attad, awibbnal sheets i f necessary or use APHIS FORM 7023A )

A. B. Number of C. Number of D. Number of animals upon E. Number of animals upon whch teaching. F. animals being animals upon which experiments, experiments, research. surgery or tests were

Animals Covered bred. which teaching. teaching, research. conduded i n w t v i i accompanying pain or distress TOTAL NO. By The Animal conditioned. or research. surgery, or tests were to the animals and for which the use of appropriate OF ANIMALS

Welfare Regulations heldfor we in experiments, or conduded involving anesthetic,analgesic, or tranqu~ling drugs would teaching. testing, tests were accompanying pain or have adversely affected the procedures. results, or (Cols. C + experiments. conducted distress to the animals interpretation d the teaching, research, D+E) research, or involving no and for which appropriate experiments, surgery. or tests. (An explanation of surgery but not pain. distress. or anesthetic, analgesic. or the pnxedun?s producing pain or distress in these yet used for such use of pain- tranquilizing drugs were animals and the reasons such drugs were not used PUrPOseS relieving drugs. used. must be attached to thrs reporf)

4. ~ o g s 96 8 7 325 4 1 2

5. Cats 1 0 66 92 158

5. Guinea Pigs 48 48

7. Hamsters 159 "369 528

3. Rabbits 8 9 132 221

9. Non-Human Primates 6 6

10. Sheep 5 5 55

11. Pigs 6 6

M i n k 660 660

Ferret 1 3 1 3

Cow 25 7 257

1 9 6 2 Horse 8 1

vena 120 27 r 4 7

White Footed 50 50 -CE STATEMENTS

1) Professionally acceptable standards governing the care, treatment, and use of animals. including appropriate use of anesthetic, analgesic, and tranquilizing drugs, prior to, during. and following actual research. teaching, testing. surgery. or experimentation were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be spaofied and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all the exceptions is attached to this annual report In additton to identifying the IACUC-approved exceptions. this summary includes a brief explanation of the exceptions. as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL tive Officer or Legally Responsible lnstitutional official)

the above is true. correct. and complete (7 U.S.C. Section 2143) ATE SIGNED

88). which i s obsolete PART 1 HEADQUARTERS

Th~s report is required by law (7 USC 2143). Failure to report -ding to the regulat~ons can See reverse side for Interagency Report Control No result in an order to cease and desist and to be subject to penalties as provided for in Section 21 50. additional information. 01 80-DOA-AN

EAST LANSING, MI 48824 (517) 353-5064

UNITE0 STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE

CONTINUATION SHEET FOR ANNUAL REPORT OF RESEARCH FACILITY

(TYPE OR PRINT)

1. REGISTRATION NO. CUSTOMER NO. 34-R-00 1 7 129 FORMAPPROVED

OMB NO. 05794036 r I n

2 HEADQUARTERS RESEARCH FACILITY (Name and Address, as regfstered wrth mnc~ude~p Code)

MICHIGAN STATE UNIVERSITY OFFICE OF RESEARCH 8 GRADUATE 246 ADMINISTRATION BUILDING

. .


REPORT OF ANIMALS USED BY

A .

Animals Covered By The Animal

Welfare Regulations

Wild Caught e

Grass Rat

Prairie Vole

O~ossums

- -

1) Prof8s~iolally acceptable standards governing the care, treatment and use of animals, induding appropriate use of anesthetic, analgesic. and tranquilizing drugs, prior to. during. and follow^^ actual research. teaching, testing. surgery, or experimentation were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be speufied and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all the exceptions is attached to this annual report. In addition to identtfying W IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

F.


(Cols. C + D+E)

36

770

50

5

OR UNDER CONTROL

B. Number of animals being bred. conditioned. or held for use in teaching. testing. experiments, research, or surgery but not yet used for such PWP-S.

I

4) The attending veterinarian for thts research facil~ty has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of anlmal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible lnstitutional official)

OF RESEARCH FACIUTY

C. Number of animals upon which teaching. research. experiments, or tests were conducted involving no pain, distress. or use of pain- relieving drugs.

36

115

50

5

88). which is obsolete

I certify that the above is true. correct, and complete (7 U.S.C. Section 2143)

PART 1 HEADQUARTERS

(Attach additional sheets if necessary

D: Number of animals upon which experiments, teaching. research. surgery, or tests were conduded involving accompanying pain or distress to the animals and for w h i appropriate anesthetic. analgesic. or tranquilizing drugs were used.

105

or use this Ibmr.)

E, Number of an~mals upon which teaching. experiments. research, surgery or tests were conducted invohri accompanying pain or distress to the animals and for which the use of appropriate anesthetic,analgesic, or tranquiliing drugs would have advenely affected the procedures. results. or interpretation of the teaching. research. experiments. surgery, or tests. (An explanation of the pnxedures producing pain or distress in these animals and fhe reasons such drugs were not used must be attached lo this report)

TE SIGNED

L 4

This report 1s requrred by law (7 USC 2143). Fa~lure to report according to the reg -- &EFEIYED DEC 2 s ~ a q o r m m additional in ormation Interagency Report Control No.:

--- -




CUSTOMER NUMBER: 195 I FORM APPROVED

I Eastern Michigan University 433 Mark Jefferson Eastern Michigan Univ Ypsilanti, MI 481 97

I Telephone: (734) -487-3090

I f 3. REPORTlNG FACILITY ( List all locations where animls were housed or used in actual research, testing, or expenmentation, or held for these purposes. Attach additional sheets if necessary )

-- --

FAC lLm LOCATIONS ( Sites ) - See Atached Listing

I REPORT OF ANIMALS USED BY OR UNDER

Anlrnals Covered By The Animat

Welfare RqgulaUons

4. Dogs

B. Numberof anirnals berng bred, conditioned. or held for use In teaching. testing. expenments. research, or surgery but not ye

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits


10. Sheep I 11. Pigs I 12. Other Farm Animals I 13. Other Animals Fj=

1 ASSURANCE STATEMENTS

- - - -- - - --

'ROL OF RESEARCH FACILrrV I Attach additional sheets if neceuarv or use APHIS Form 7023A \ I Number of animals upon which teaching. research. experiments, or tests were conduded invdving no pain. distress. or use of pan- relieving drugs.

D. Number of aninrals upon which ucperiments. teaching. research, surgery. or tests were conducted involving accompanying pain or distress to the anltnais and for which appropnate anesthetic. a

E. NuMer of anirnals upon which teaching. expenments. re~earrh, surgery or tests were conducted involving accompanying pain or distress lo the animals and for which the use of appropnate anesthetic. analgesic. or tranquilizing drugs would have advenely affected the procedures. results. or interpretation of the teaching, research. expenmts. surgery, or tests. (An explanation of the procedures produang pain or distress in these an~mals and the reasons such drugs were not used must be attached to


( COLUMNS C+D+E)

I 290 (this study was conducted in "290

Puerto Rico) L - -

1 ) Profssdonally W l e standards governing the cam, trement. and use of animals. induding appropriate use of anestetic, analgesic. and tranquilking drugs, prior to, during. md following actual &, t h i n g , testing. swgery, or qxxirrtentation wefa followed by this mseadl facility.

2) Each principd irnrsstigator has considered alternatives to painful pmcedures.

3) This fa&y is adhering to the standads and regulations under the Ad, and it has required that exceptions lo the ttandards and regulatim be speafied and explained by the principal i n v e s t i w and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report In addition to identrtying the IACUCspproved exceptions. this summary includes a brief explanation d the exceptions, as well as the species and number of animals effected.

4) The attmdha veterinarian for this research facility has appropriate authority to ensum the provision of adequate veterinsry care and to oversee the adequacy of other aspects d animal Cafu and

CERTlFlCAllON BY HEADQUARTERS RESEARCH FACILITY OFFICWL ( Chief Executive Officer or Legally Responsible Institutional Official )

( AUG 91 )

DATE SIGNED

. .2/18/02

APHIS FORM 7023 (Replaces VS FORM 18-23 (OCT 88). whlch 1s obsolete.

Th~s report is required by law (7 USC 2143). Failure to report according to the regulat~ons can



. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, test

Ferris State University 220 Ferris Drive Big Rapids, MI 49307

1. CERTIFICATE NUMBER: 34-R-0019


Telephone: (61 6) -592-2246

-- --

FORM APPROVED OMB NO. 0579-0036

1. or experimentation, or held for these purposes. Attach additional sheets if necessary )

FAClLm LOCATIONS ( Sites ) - See Atached Listing

( REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY ( Attach additional sheets if necessanr or use APHIS Form 7023A 1 I


Welfare Regulations

B. Number of - anirnals being - bred. conditioned, or held for use in teaching. testing. experiments. research. or surgery but not ye

5. Cats


10. Sheep

11. Pigs

12. Other Farm Animals

13. Other Animals m 1 ASSURANCE STATEMENTS

C. Number of animals upon which teaching. research. experirnents, or tests were conducted involving no pain, distress, or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching, research, surgery. or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. experiments. research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic. analgesic, or tranquilizing drugs would have adversely affected the procedures. results, w interpretation of the teaching, research, experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to



1) Professionally acceptable stendards governing the care, treatment, and use d animals, including ~ppropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following actual resewch, teaching. testing, surgery, w eqwimenlation were followed by this research facility.

2) Each principal investigator has considered attemativer to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and rqulations be specir~ed and explained by the prindpal investigator and approved by the InstiMional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report. In addiion to identrfying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary can, and to oversee the adequacy of other aspects of animal care and --

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL e Officer or Legally Responsible Institutional Official )

ete.

DATE SIGNED

DEC-19-2002 11:01 USDQ RPHIS QC 919 716 5696 P.02/02

UNITED !STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERWCE

ANNUAL REPORT OF RESEARCH FACILITY ( TVPE OR P R I M )

I FORM APPROVED OME NO. 0579-00.36

I Dow Coming Corporation Health & Environmental Sciences Dc-3 2200 W. Salzburg Road Auburn, Mi 4861 1

. . I . REPORT~NG FACILITY ( LiSl JI lomtlans whera anirruk worn housd or used In -1 reaeorch, tesung, or expenmentauon, w nde for tneae purpoees. l ~ t a e n 8 d d l w maeta lf neceosery )

I REPORT OF A N W USED BY OR UNDER CONTROL OF RESEARCH FAClUN I Attach additional shoots If n-w or u w APHIS Form 7023A f Number of a n i d upon whid, teaching, ercpertmenu. r w c h . surgery or tests wrc conducted lnwlvlng eccompanylng petn a to the enimels end for &ch Lhe uhe of approvialet anetheat, srulguic or LrpnquilMng drugs would nave adveaeJy 3ffeud the procedures. results, or hterpretatlon of the teaming. resesreh. apdmmk surgery, or tests. ( An explanatrosl d me procedures producing pain or distress In these animals and me r-ns sum mgs were not used nust be 3lbChtd 10


( COLUMNS C+D+E)

5. Cats I I

10. sheep I I

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( chsdt h-8 oflaw at ~qpi ly ~errpwltwe IN- omcia1 )

TOTQL P. 02

This report 1s required by law (7 USC 2143). Failure to report according to the regulations can See reverse side for result ~n an order to cease and desist and to be subject to penalties as provided for in Sedion 2150 additional informabon.

Interagency Report Control No 0 180-00A-AN


OMB NO 0579-0036 I

2. HEADQUARTERS RESEARCH FACIUTY (Name and Address, as regtstered wrlh USOA. ANNUAL REPORT OF RESEARCH FACILITY rndude ~p Code)

(TYPE OR PRINT) HOPE COLLEGE 35 EAST 12TH STREET HOLLAND, MI 49422

1

3. REPORTING FACILITY (List all locations where animals were housed or used in a w l research, testing, teaching, or experimentation. w held for these purposes. Attach additional sheets if necessary.)

HOPE COLLEGE HOLLAND, MI 49422-9000

1

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY (Attach addrtiond sheets if necessary or use APHIS FORM 7023A) 1 A. 8. Number of C. Number of D. Number of an~mals upon E, Number of a n i d s upon which teaching, F.

animals being animals upon which experiments, axperiment~, nrsearch, surgery or tests were An~mals Covered bred. which teaching. teaching. research. conducted involving accompanying pain or distress TOTAL NO.

By The Animal conditioned, or research. surgery. or tests were to the animals and for which the use of appropriate OF ANIMALS Welfare Regulations held for use in experiments, or conduded involving a m a n a l g e s i c , or tranquilizing drugs would

teaching. testing. tests were ==wanying pain have adversely affected the procedures. results. or (COIS. C + experiments, conducted distress to the annnals intetpmbbon of the teaching, research. D+E) research. or involving no and for which appropriate experiments, surgery, or testa (An explanation of surgery but not pain, distress, or anesthetic, analgesic, or the procedures pmduchg pain or distress in these yet used for such use of pain- tranquilizing drugs were animals and the reasons such drugs were not used PUrpOses. relieving drugs. used. must be attached to ths report)

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters 1

8. Rabbits

9. Nan-Human Primates

10. Sheep

1 1. Pigs


13. Other Animals

graycheeked thrush 1 1

cedar waswings 6 6 . swainson's thrush 3 3 ASSURANCE STATEMENTS I

t) Professionally acceptable standards governing the care, treatment. and use of animals, including appropriate use of anesthetic, anaigeslc, and tranquiliing drugs. prior to, during. and following actual research. teaching, testing, surgery. or experimentation were followed by this research facility.

2) Each prinapal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act. and it has required Vlat exceptions to the standards and regulations be specffied and explained by the principal investigator and approved by the Institutional Animal Care end Use Committee (IACUC). A summary of all the excoptiom is attached to this annual report. In addition to identfying the IACUC-approved exceptions. this summary includes a brief explanation of the exceptions. as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other asDeds of anmal care and use.

I CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL I (Chief Executive Officer or Legally Responsible Institutional official)

I cerbfy that the above is true, correct, and complete (7 U.S.C. Section 2143) SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL NAME 8 TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (7ype or Print) DATE SIGNED

1 11/05/2002 1 I 1 APHIS FORM 7023 (Replaces VS FORM 18-23 ( ~ c t 88). which is obsolete PART I - HEADQUARTERS

(AUG 91)

Th~s report IS requtred by law (7 USC 2143) Failure to report according to the regulations can result in an order to cease and des~st and to be subject to penalties as provided for in Section 2150.

See reverse side for additional ~nfwmation.

Interagency Report Contrcl No 01 80-DOA-AN

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REGISTRATION NO. CUSTOMER NO. ANIMAL AND PLANT HEALTH INSPECTION SERVICE 34-R-0035 199

Animals Covered By m e Animal

Welfare Regulations


CONTINUATION SHEET FOR ANNUAL REPORT . OF RESEARCH FACILITY

(TYPE OR PRINT)

I 2 HEADQUARTERS RESEARCH FACILITY (Name and Address, as registered wrth USDA.

indudeZipCodeJ HOPE COLLEGE 35 EAST 12TH STREET HOLLAND, MI 49422

hermit thrush 1 1 1 1 1 ! 1

)R UNDER CONTROL OF RESEARCH FACIUTY (Altach acWMnd sheets i f necessary or use this fwm.)


1) Professionally acceptable standards govemlng the care. treatment, and use of animals, including appropriate use of anesthetic, analgesic, and tranquilking drugs, prior lo, during. and following actual research, teaching, testing. surgery. w experimentation were followed by this research faality.

F.


(Cots. C + D + E)

I 1 6. Number of animals being bred, conditioned, or held for use in teachmg, testing, experiments. research, or surgery but not yet used for such purposes.

arnerican robm

gray catb~rd


3) This facility is adhenng to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specifiad and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all the exceptions is altached to this annual repoh In addition to identifying the IACUC-approved exceptions. this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

' C. Number of animals upon which teaching. research. experiments, or tests were cmduded involving no pain. distress, or use of pain- relieving drugs.

9

3

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision d adequate veterinary care and to oversee the adequacy of other asoeds of animal care and use.

9

3

- - r - - - - -


D. Number of animals upon which experiments. teaching. research, surgery, or tests were conduded involving accompanying pain or distress to the animals and for which appropriate anesthetic, analgesic, or tranquilizing drugs were used.

E, Number of animals upon which teaching. experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic,analgesic, or tranquilizing drugs would have adversely affected the pmcedures, results. or interpretation of the teachii, research. experiments, surgery, or tests. (An expranatbn of the pmcedures producing pain or distress in these animals and the reasons such drugs were not used must be attached b this report)

I certify that the above is true, correct. and complete (7 U.S.C. Section 2143) DATE SIGNED

1 110512002

SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL

APHIS FORM 7023A (Replaces VS FORM 18-23 (Oct 88). which is obsolete PART 1 - HEADQUARTERS

(AUG 91)

NAME 8 TITLE OF C.E.O. OR lNSTlTUTIONAL OFFICIAL (Type or Pnnt)

mls repo? IS requrd by law (7 USC 2143). Fallwe lo report accotdng to the regulat~ms

can .

UNKED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY ( n p E OR PRIM )

3. REPORTING FAClUTY ( List 4 locations where arwnrals w e n housed or used In aclual r e , testinQ

William Beaumont Hospital Research Institute 381 1 West 1 3 Mile Road Royal Oak, MI 48073

Telephone: (81 0) -551-0666

Anhnab C d By TheAninvl

Wetfare Reguhtions

4. Dogs

B. Nuherd -- animds being bed. cmditioned. o held f a use k, lcachinQ M n g * arpcrimenb -, or =rgcry M nd F

5. Cats

7. Hamsten

8. Rabbits

8. Non-hwnan Primate

10. Sheep

11. Pigs .

12 Other Farm Animals

13. Other Anknals

Ferrets

E. w a d vlimab upor, which W n g . ~ ~ , s w g e r y a t c s t s m r c andvded imrdving ?aonFpnying pain or distress toIheanim&ndfor~ihUleuxdappropriate anaVKLiS anal- a tranquilking drugs would have adversdyallected theproccdurrr. rcsub, a inkrpmbtim d me teaching. mstwch. experimenls. turgay. a ksts. ( k, aphation d the proccdwtt Pcoducing pain a d i m in these and the masons aKh drugs were nol used must be attached to

I TOTAL NUMBER OF ANIWLS


4) rn. a t d i vdainarin for this re+such hcjlity has su(hority to aswe h a provirion of ahqmle rdsrinuy c m d to mmao rho adbguaq d other as- of a n h ~ cam d

RTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFJCW hief Exewtive Omcer w Legally Responsible InstiMional Official )

-

APHI which is obsolete.



Registration Number: 34-R-0037 Customer Number: 200 Facility: WILLIAM BEAUMONT HOSPITAL

3601 WEST 13 MlLE ROAD ROYAL OAK, MI 48073 (81 0) 551 -0666

3601 WEST 13 MlLE ROAD ROYAL OAK, .MI 48073

4% 1.' Ths -e:.ort IS required by law (7 USC 2143). Fatlure to report accordtng to the regulations -2n

-.* T f i L "ict See attached form for

additional tnformation Interagency Report Control 4

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE I 1. CERTlFlCATE NUMBER: 34-R-0033

CUSTOMER NUMBER: 522 I FORM APPROVED OM6 NO. 05794036

' I ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

Western Michigan University Research & Sponsored Programs Kalamazoo, MI 49008

3 b9 Telephone: (W) -387-3670

13. REPORTING FACIUTY ( List all locations where animals were housed or used in actual research. testing, or experimentation. or held for these purposes. Attach additional sheets if necessary ) 1

FACILITY LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if neeessarv or use APHIS Form 7023A 1 I k I 6. Number of I c. Number of I D. Number of animals I E. Number of animals upon which teaching. I F.


Welfare Regulations

animals being - bred. conditioned, or held for use in teaching. testing. experiments. research. or surgery but not ye

animals upon which teaching. research. experiments. or tests were conducted involving no patn. distress. or use of pain- relieving drugs.

upon which experiments, teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the animls and for which appropriate anesthetic, a

experiments. research. surgery ar tests were conducted involving accompanyng pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures. results. or interpretation of the teaching, research. experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to



4. Dogs

5. Cats I 6. Guinea Pigs I I I I I

8. Rabbits I 7. Hamsters

9. Non-human Primate I I I I I 10. Sheep

11. Pigs

I

-- -- -

( ASSURANCE STATEMENTS I

143

-


13. Other Animals

- -- -

1) Professionally acceptable standards governing the care, treatment and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing d n r g ~ o , d ~ n g , andfollowing actual research, teaching, testing, surgery, or experimentation were followed by this research facility.

143


- - - - -

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be speufied and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

1

4) The attending veterinarian for this research facility has appropriate authority to ensure the~ provision of adequate veterinary care and to oversee the adequacy of other aspeds of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legalty Responsible Institutional Official )

( AUG 91 )

Print

DATE SIGNED

10/28/02 IS

Thts repgn IS rea~ired by :aw (7 USC 2113) Farlure :o report accordmg to !he regulat~ons See attached form for Interagency Report Control No-: pan addttlcinal tnf0rtTWOn

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PUNT HEALTH INSPECTION SERVICE



CUSTOMER NUMBER: 202 I FORM APPROVED OtAB NO. 05790036

Central Michigan University Brooks Hall Mount Pleasant, MI 48859

Telephone: (51 7) -774-3227

I . REPORTING FACILITY ( L~st all locations where anlmals were housed or used in actual research. testing, or expenmentation. or held for these purposes. Attach additional sheets ~f necessary )

FAClLlM LOCATIONS ( Sites ) - See Alached Listing Rowe Hal 1 Brooks Hall

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH F A C l L l N I Attach additional sheets if necessaw o r use APHIS Form 7023A \ 1

Animals Covere4 By The Animal

Welfare Regulations

4. Dogs

- --

8. Number of - antmls betng - bred. c;ndt!iwed, 6;

held for use In teachmg. testtng. expenments, research. or surgery but not ye

-

C. Number of antmals upon whtch teachmg. resear;\. experiments, or

I tests were conducted ~nvolvlng no

I p a n d~stress. or use of pam- reltevmg drugs.

-

D. Number of anmils upon whtch expenments. teachtng. research, surgery. or tests were conducted tnv0lvlng accompanymg paln or d~stress to the animals and for whtch appropnale anesthettc. a

E. Number of antrnals upon which teaching. experiments, research. surgery or tests were conducted invdving accompanymg pain or distress to the animals and for which the use of appropnate anesthetic. analgesic, or tranqu~lizlng drugs would have adversely affected the procedures. results. or interpretation of the teachtng. research. experiments. surgery. or tests. ( An explanat~on of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

TOTAL YUMBER OF ANIMALS


5. Cat5

5. Guirlea Pigs --

7. Hansters

8. Rabbits


12. Other Farm Animals r

r*

0

0

10. Sheep

1 1. Pigs

ASSURANCE STATEMENTS I 1) Professimalty acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following

0

0

0

10

0

actual research. teaching, testing, surgery, or experimentation were followed by this research facility.

0

0

2) ~ a c h principal investigator has considered alternatives to painful procedures.

10

0

3) This facility is adhering to the standards and regulations under the Ad, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the IACUC-approved exceptions. this summary includes a brief explanalion of the exceptions, as well as the species and number of animals affected.

I I 10 l o

4) The attending vetefinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILIM OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Official )

-- - -

DATE SIGNED

d*;6 h 1s obsolete.

NAME 8 TITLE OF CEO. OR INSTITUTIONAL OFFICIAL ( Type or Pnnt

Ths rep00 is requ~red by law (7 USC 2143). Fa~lure to repon accord~ng to the regulations 0 CT Zoo2 Seeattached formfor Interagency Report Control No.:

can additional infomt~on m



I FORM APPROVED I OMB NO. 05794036 nv ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

Foundation For Behaviorial Resource 600 S. Lincoln Street Augusta, MI 49012

I I

)3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing. or experimentation. or held for these purposes. Attach additional sheets if necessary )

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A \ I I

knimals Covered By The Animal

Welfare Regulations

B. Number of animals being _ bred, conaitioned. or held for use in teaching. testing. experiments. research. or surgery but not ye

5. Cats

6. Guinea Pigs

9. Non-human Primate I -0- 10. Sheep I 1 1. Pigs I 12. Other Farm Animals r 13. Other Animals 0

C. Numberof animals upon which teaching. research. experiments. or tests were conducted involving no pain, distress, or use of pain- relieving drugs.

D. Number of animls upon which experiments, teaching, research. surgery, or tests were conduded involving accompanying pain or distress to the animals and for which appropriate anesthetic. a

Number of animals upon which teaching. experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for whicil the use of appiopriaie anesthetic. analgesic. or tranquilizing drugs would have adversely affected the procedures. results. or interpretation of the teaching, research. experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to



I ASSURANCE STATEMENTS

I 1) Professionally acceptable standards governing the care, treatment, and use of wimals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and follawing

actual research, teaching, testing, surgery, or experimentation were follawed by this rerearch f aa l i .

2) Each principal i nvwa to r has considered alternatives to painful procedures.

3) This facility b adhering to the standards and regulations under the Act and it has required that exceptions to the standards and regulations be speufied and explained by the principal inwtigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptlons Is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the species and number of animals Mected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oven- the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFlClAL ( Chief Executive Officer or Legally Responsible Institutional Official )

DATE SIGNED

(AUG91)

Interagency Repal Control No.:

--- -- -


CUSTOMER NUMBER: 2 1 5 I FORM APPROVED 0.8 NO. C%)OoO36 mJ

\


- J

Macomb Community College Veterinary Technician Program 44575 Garfield Road Clinton Township, MI 48038

1. REPORTING FAClUrY ( List all locations where anirnals were housed or used in a d w l research. testing. or experimentation. or held for these purposes. Attach additional sheets if necessary ) I

3) This facility is adhering to the standads and reOufatiom under the Act, and it has required that exceptioru to the standards end regulations be specif~ed and eaplained by the prindpal invedigator and approved by the I- Animal Cars end Use Cumnittee (IACUC). A summary of all such exceptlons Is attached to this annual report In adddim to i d e n t w ~ the LACUC+qmved exceptions, this indudes a brief eq9anation of the exceptions, as well as the speck and number of animals affeded.

REPORT OF ANIWLS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessaw or use APHIS Form 7023A 1 1

4) The attending veterinarian for this research facility hes -ate euthority to ensure the provision d adequate veterinary care and to oversee the adequacy of other as* of animal Cam and L

CERTlFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legalty Responsible Institutional Official )

E. Number of animals upon h i c h teaching. experiments, research. surgery or tests were conducted involving acconpanying pain or distress lo the animals and for which the use of appropriate anesthetic. analgesic. or lranquililing drugs would have advenely affected the procedures. results. or interpretation of the teaching. research, experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

k


Wetfan Regulations

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. R a b b i

9. Nonhuman Primate

F.



84

78

1 2

16

7

- - 0

C. Numberof animals upon which teaching. rerearch. experiments. or tests were conducted invdving no pain. distress, or use of pain- dieving drugs.

6. Number of animals being bred. conditioned. or- held for use in- teaching. testing. o~periments. reseam, or surgery but not ye

84

78

12

16

7

0

DATE SIGNED

0

0

0

10

20

12

0. Number of animals upon which experiments. teaching. research, surgery, or tests were umduded involving accarrpanying pain or distress to me animals and for which appropriate anesthetic. a

84

78

1 2

16

7

0 10. Shriep

11. P i i

12 Othtc Farm Animals

13. Other Animals

G e r b i l s Mice

Rats

NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL ( Type or Print

1) W e s s h a i l y eccepLaMe skxhfds governing lhe care. bwtmmt, and use of animals, M i m e use d enestetic, analgesic, and tranquiring bugs, prior to, during. and following achrel mseap3, t e s c h i . testing. surgery, or were followed by this rewar& facility.

2) Each principal investigator has contidered alternaths to painful pmcdures.


0

0

0

10

20

12

0

0

- 0

10

20

12

Thls report is re7utred by law (7 USC 2143). Fatlure to report accordtng to the regulations I ;- I , See attached form for 7-

Interagency Report Control No.:

can :I,-. : - 2 2 32 addibonal mfo-tton


ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRINT ) I Borgess Medical Center

Borgess Research Institute 1521 Gull Road Kalamazoo, MI 49048


CUSTOMER NUMBER: 21 8

I Telephone: (269) -226-5407


REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing. or experimentation. or held for these purposes. Attach additional sheets if necessary )

FAClLm LOCA ON ( Sites Se Ata ed listing

Borgess Research Instttute, 1521 ~ u l l toad; RaTamazoo, MI 49048 I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrPl I Attach additional sheets if necessarv or use APHIS Fann 7023A \ I


Welfare Regulatlom

4. Dogs

5. Cats

B. Number of ' animals being -

bred. conditioned, or held for use in teaching. testing. experiments, research, or surgery but not ye

C. Numberof animals upon which teaching. researcft. experiments, or tests were conducted involving no pain, distress. or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching, research. surgery. or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. experiments. research. surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic. or tranquilizing drugs would have adversely affected the procedures, results. or interpretation of Vle teaching, research, expenments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to



I I I 6. Guinea Pigs I 7. Hamsters

8. Rabb i


10. Sheep

11. Pigs


13. Other Animals I

1 ASSURANCE STATEMENTS 1 1) Professionally acceptable standards governing the care, treatment, and use of animals. including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following

actual research, teaching, testing, surgery, or =qwimentation were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to thls annual report. In addition to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.


BY HEADQUARTERS RESEARCH FACILITY OFFICLAL ve Officer or Legally Responsible Institutional Official )

DATE.SIGNED

L

AP lete.

Th~s report is requmd by law (7 USC 2143). Fatlure to report according to the regulations 0 C T 2 2002eeattached form for Interagency Report Control NO.: c-n additional information



I Michigan Dept. Of Natural Resources Wildlife Division



I P.O. Box 30028 Lansing, MI 48909

FORM APPROVED OM0 NO. 05794036

I Telephone: (51 7) -373-1 263

I I I. REPORTING FAClUM ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )


4. Dogs

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY i Attach additional sheets if necessaw or use APHIS Form 7023A 1



k


Welfare Regulations

5. Cats

C. Numberof animals upon which teaching. research. experiments. or tests were conducted involving no pan. distress. or use of pain- relieving drugs.

B. Number of animals being bred. conditioned. or held for use in teaching, testing, experiments. research, or surgery but not ye

6. Guinea Pigs

7. Hamsters

- I I I 8. Rabbits I

D. Number of animals upon which experiments, teaching. research. surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic. a

- I -- -

9. Non-human Primate 1 1 - - I

E. Number of animals upon which teaching. experiments. research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which !he use of appropriate anesthetic, analgesic. or tranquilizing drugs would have adversely affected the procedures. results, or interpretation of the teaching. research. experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

10. Sheep

I 11. Pigs 1

- -- 1 ASSURANCE STATEMENT^ a nutritional or behavioral studies involvins no pain I


white- tailed. a%& ~n imab

1) F'fuf~uioMlly acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquiliicg drugs, prior to, during, and following adual research. teaching, testing, swgery, or exphmtation were followed by this research facility.

2) Each prindpal investigatw has considered alternatives to painful procedures.

5a

3) This facility is adhering to the standads and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptlons Is attached to this annual report. In addion to identrfying the IACUC-approved exceptions, this summary includes a brief eaplanation of the exceptions, as well as tho species and number of animals affected

5


CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFlClAL

DA7E SIGNED

1 0/08/ A

(AUG 91 )

Site: 001 Status: Inactive

Site: 002 Status: Inactive

Site: : 003 Status: Active

Cusino WildIife ---------- --------- Research Station ----- ------------ Highway M-28 Shingleton, MI 49884 ----------------- County: Alger

Houghton Lake Wildlife ---------- --------- Research Area ---------- --- ------- 1759 S. Jeffs Road Menitt, MI 49667 -- ------------ ---County: Missaukee

Rose Lake WiIdlife ---------- --------- Research Center ---------- ---- ---------- 8562 E. Stoll Road East Lansing, MI 45823 -- ---------------- County: Ingham


ran

DEC 2002 See attached form for Thls report is requ~red by law (7 USC 2143). Fa~lure to report accordrng to the regulations - - additional mformation



- .

I Northern Michigan University 1401 Presque Isle Avenue Marquette, MI 49855


I

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, w experimentation. or held for these purposes. Attach additional sheets if necessary ) --

Biology Department FAClLlM LOCAIIONS ( sites ) - See Atached Listrng

Psychology Department REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLllY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 1

1. CERTIFICATE NUMBER: 34-R-0 1 2 1 CUSTOMER NUMBER: 424


Welfare Regulations

FORM APPROVED OMB NO. 0579.0036

B. Number of animals being - bred. conditioned, or held for use in teaching. testing, experiments. research, w surgery but not ye

I

4. Dogs

5. Cats I r

6. Guinea Pigs

7. Hamsters

8. Rabbits

10. Sheep


I


-- -

Number of animals upon which teaching. research. experiments, or tests were conducted involving no pain. distress. oc use of pain- relieving drugs.

D. Number of animals upon which experiments. teaching. research. surgery. or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic. a

1 E. Number of animals upon which teaching. experiments. research. surgery or tests were 1 conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic. analgesic, w tranquilizing drugs would have adversely affected the procedures. results, w interpretation of the teaching, research, experiments, surgery. or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

1 TOTAL NUMBER OF ANIMALS


t 1) Professionally acceptable standards ~overning the care, treatment, and use of animals, including appropriate use of anesteitic, analgesic, and tranquilizing drugs, prior to, dwing, and following

actual research, teaching, testing. uugery, or experimentation were followed by thin research facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Cam and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and m b e r of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspeds of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Ofikial )

DATE SIGNED

11-26-02,

(AUG 91 )

0 E C 0 2 2002 SFe attached form for This report IS requtred by law (7 USC 2143). Fatlure to report according to the regulabons - +-,- additional information





CUSTOMER NUMBER: 423 I FORM APPROVED OM8 NO. 0579-0036

\. Jl Michigan Technological University Vice President For Research 1400 Townsend Drive Houghton, MI 49931

Telephone: (906) -487-3043

3. REPORTING FACILITY ( bst all locations where animals were housed or used in actual research. testing, or experimentation, or held for these purposes. Attach additional sheets if necessary ) 1 FACILITY LOCATIONS ( Sies ) - See Atached Listing

A. B. Number of animals being - bred,

Animals Covered conditioned. or By The Animal held for use in

Welfare Regulations teaching.

testing. experiments. research. or surgery but not ye

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Ra~bits


10. Sheep

C. Nurrberof animals upon which teaching. research, experiments, or tests were conducted involving no pain, distress, or use of pain- relieving drugs.

0. Number of animals upon which experiments. teaching. research. surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. . experiments. research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic. analgesic. or tranqurlizing drugs would have adversely affected the procedures. results, or interpretation of the teaching, research, experiments, surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used ms t be attached to



6wSccurrtrl


1) Professionalty acceptaMe standards governing the care, treatmeot, and use of animals, including appropriate we of anestetic, analgesic, and trarquiliing drugs, prior to, during, and folkwing actual research, teaching, testing, surgery, or experimentation were followed by this nuearctr facility.


3) This facility is adhering to the standards and regulatioru under the Ad, and it has required that exceptions to the standards and regulations be specified and evlained by the principal investigator and approved by the Institutional Animal Care and Use Committee (WCUC). A summary of all such exceptlons k attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a brief exqlanation d the exceptions, as well as the species and number of animals affeded.

4) The attending veterinarian for this research faalii has appropriate authority to ensum the provision of adequate veterinary cam and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFlClAL ( Chief Executive Ofticer or Legalfy Responsible Institutional Ofiicial )

DATE SIGNED

APHIS FORM 7023 (Replaces VS FORM 18-23 (OCT 88). which is obsolete.

( AUG 91 ) L

b.-.. . - - ,&ee attached form for

7- Thts reoort 1s reaulred by law (7 USC 21431. Fatlure to report accordmg to the regulat~ons Interagency Report Control No.: . . -xn additional information



I 1. CERTIFICATE NUMBER: 34-R-0 144


Parkedale Pharmaceuticals 870 Parkdaie Road Rochester, MI 48307

, REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation. or held for these purposes. Anach additional sheets if necessary )

FAClLrrY LOCATIONS ( S i i ) - See Atached Listing

Psrkgdale P-s R-P 77 . - ( s e e above ad


REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A 1


5. Cats

A.


welfare Regulations

/ .

4. Dogs

6. Guinea Pigs

C. Numberof animals upon which teaching. research. experiments, or tests were conducted involving no pain, distress. or use of pain- relieving drugs.

6. Number of animals being bred. -

conditioned, or held for use in teaching. testing. experiments. research. or surgery but not yc

7. Hamsters I I I I I 8. Rabbits I I I

D. Number of animals upon which experiments. teaching. research. surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

9. Nonhuman Primate I I I I I

E. Number of animals upon which teaching. experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic. or tranquilizing drugs would have advmely affected the procedures, results. or interpretation of the teaching, research, experiments. surgery, w tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached lo

10. Shwp

1 1. Pigs - - --

12. Other F m Animals

13. Other Animals

1) Professionally acceptable standards governing the care, treatment, and use of animals. including appropriate w e of anestetic, analgesic. and tranquilizing drugs, prior to. during, and following actual research, teaching, testing, surgery, or experimentation wen, followed by this mearch facility.

2) Eech principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Ad, and it has required that exceptions to the standards and regulations be speafied and explained by the principal investigator and approved by the Institutional Animal Can, and Use Committee (IACUC). A summary of all such exceptions Is at!ached to this annual report In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the spedes and m#nber of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary cars and to oversee the adequacy of other aspects of animal care and

CERllFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Ofticer or Legally Responsible Institutional Official )

-

/

DATE GN

/&,&

This report IS requlred by law (7 USC 2143). Fa~lure to report according to the regulations can



,. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, tes

See attached form for additional information


1. CERTIFICATE NUMBER: 34-R-0 145


n

Esperion Therapeutics, Inc. 3621 S. State Street 695 Kms Place Ann Arbor, MI 481 08

Telephone: (734) -677-1 559

1, or experimentation, w held for these purposes. Attach additional sheets if necessary )

FAClLrrY LOCATIONS ( s i i ) - See Atached Listing

k B. Number of animals being bred, --

Animals Covered conditioned. or By The knimai held for use in

Welfare Regulations teaching.

testing, expenments. research. or surgery but not y t

4. Dogs

C. Number of animals upon which teaching. research. experiments. or tests were conducted involving no pain, distress, or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

5. Cats I 6. Guinea Pigs I 7. Hamsters I 8. Rabbits I

-

9. Non-human Primate I 10. Sheep

11. Pigs


13. Other Animals I

I ASSURANCE STATEMENTS

E. Number of animals upon which teaching. experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic. anaigesic. or tranquiliong drugs w i d have adversely affected the procedures, results. or interpretation of the teaching. research, experiments. surgery, or tests. ( An explanation of the procedures producing pan or distress in these animals and the reasons such drugs were not used must be attached to

F.



1) Pmfessionally acceptable standards governing the care, habmmt and use of animals, including appmpriats use af anestetic, analgesic, and h-anquiiiing drugs, prior to, during, and following actual research, teaching, testing. surgery, or experimentstion were followed by this research facility.

2) Each principal investigator has comidered alternatives to painful pmcedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veferimian for this research facility has appropriate authority to enwre the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICLAL ( Chief Executive Officer or Legally Responsible Institutional Official )

DATE SIGNED

This report is required by law (7 USC 2143). Failure to report according to the regulattons can See reverse side for result In an order to cease and desist and to be subject to penalties as provided for in Section 21 50. addittonal information.

interagency Report Control No 01 80-OOA-AN

3201 BURTON ST.. SE GRAND RAPIDS. MI 49506

1 3. REPORTING FACILITY (List all locations wbere animals were housed or used in actual research, testing, teaching, w expenmentation, or held for these purposes. Attach additional



ANNUAL REPORT OF RESEARCH FACILITY (TYPE OR PRINT)

J sheets if necessary.)

FACILITY LOCAT1ONS(stes)

WEST MICHIGAN REGIONAL LABS GRAND RAPIDS, MI 49506

1. REGISTRATION NO. CUSTOMER NO. 34-R-0147 101 06

2 HEADQUARTERS RESEARCH FAClUTY (Name and Address, as registered wth USDA, indube z p Code)

WEST MICHIGAN REGIONAL LABS CALVIN COLLEGE

F.


(Cds. C + D + E)

C. Number of animals upon which teaching, research. experiments, or tests were conducted involving no pain. distress, w use of pain- relieving drugs.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and q la ined by the principal investigator and approved by the Institutional Animal Care and Use CMlmiee (IACUC). A summary of all the exceptions is attached to Wit annual report. In addition to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions. as well as the speaets and number of animals affected.

OF RESEARCH FAClUlY (Attach addYbbnd sheets lnecessary or use A M FORM 7023A ) 1 REPORT OF ANIMALS USED BY

A.


Welfare Regulations

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Non-Human Primates

10. Sheep

11. Pigs


13. Other Animals


0. Number of animals upon which experiments. teaching, research. surgery. w tests were conducted involving accompanying pain or distress to the animals and for w h i appropriate anesthetic, analgesic, or tranquilizing drugs were used.

4) The attending veterinarian for this research facility has appropriate authority to enswe the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

1) Professionally acceptable standards governing the care, treatment, and use of animals. induding appropriete use of anesthetic, anal- and tranquilizing drugs, prior to, during. and following adw l research, teaching. testing. surgery, or experhentation were followed by this research facility.

OR UNDER CONTROL

B. Number of animals being brad, conditioned, or held for use in teaching, testing. experjments. research. or surgery but not yet used for such purposes.

14

10

E. Number of animals upon whtch teaching. experimentr, research. s w ~ e r y or tests were conducted invo lv i accompanying pain or distress to the animals and for which the use of appropriate anesthetic.anaigesic, or tranquilizing drugs would have adversely affected the procedures. results. or interpretation of the teaching, research. exp&rnents. surgery, or te& (An explanahon of me procedures producing pain or distress in these amma/s and the reasons such drugs were not used must be attached to this @port)


I certify that the above is true, correct. and complete (7 U.S.C. Section 2143) SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL I NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Print) ( DATE SIGNED

1 1 ll19/2002 I C I rn I

APHIS FORM 7023 (Replaces VS FORM 18-23 (Oct 88). which is obsolete P A R T 1 - HEADQUARTERS (AUG 91)

This repon IS requ~red by law (7 USC 2143). Failure to report according to the regulations ran


Interagency Report Con ye ol No..


CUSTOMER NUMBER: 1 1432 I FORM APPROVED OMB NO. 0579-0036

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRINT ) I Tsd, lnc

Tsrl, lnc 540 Avis Dr., Suite A Ann Arbor, MI 48108

Telephone: (734) -663-4233

. 3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary ) I


I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I


Welfare Regubtlons

B. Number of animals being bred. conditioned, or held for use in teaching. testing. experiments. research, or surgery but not ye

4. Dogs

5. Cats

6. Guinea Pigs I 7. Hamsters I 8. R a b b i I

10. Sheep

13. Other Animals I

ASSURANCE STATEMENTS s

- - - - -- - - - - --

C. Numberof animals upon which teaching. research. experiments. or tests were conducted involving no pain, distress. or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic. a

E. Number of animals upon which teaching. experiments, research, surgery or tests were conducted involving Bccompanying pain or distress to the animals and for which the use of appropriate anesthetic. analgesic, or tianquilizing drugs would have adversely affected the procedures. results, or interpretation of the teaching, research. experiments, surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

TOTAL NUMBER OF ANMALS


1) Professionally acceptable standards governing lhe care, treatment, and use of animals, including appropriate use of anestetk, analgesic, and tranquilizing drugs, prior to, during, and following actual research, teeehing, testing, surgery, or experiment8t'in were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specilied and explained by the principal investigator and approved by the lnstiional Animal Care and Use Committee (IACUC). A summary of all such exceptions h attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the exwptions, as weH as the species and number of animals affected.

4) The attending veterinarian for this research fm.lity has appropriate authority to ensure the provision of adequate veterinary care end b oversee the adequacy of other aspects of animal care and

CATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL Executive Ofiicer or Legally Responsible Institutional Oftlaat )

DATE SIGNED

2 h is obsolete.



Registration Number 34-R-0148 Customer Number: 1 1 432 Facility: TSRL, INC

540 AVlS DR., SUITE A ANN ARBOR, MI 48108 (734) 663-4233

TSRL, INC 540 AVlS DR., SUITE A ANN ARBOR, MI 481 08

This report is req~ired by law (7 USC 2143). Failure to report according to the regulallons -- See attached form for additional information

lnteragcmy Report C4nW No.:

UNlTED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVlCE I 1. CEKIWICATE NUMBER: 34-R-0149

CUSTOMER NUMBER: 13477 I FORM APPROVED OM6 NO. 05794036

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRINT ) I Grand Valley State University

401 W Fulton Grand Rapids, MI 49504

I Telephone: (61 6) -336-7265 . .

3. REPORTING FACIUTY ( List all locations where animals were housed or wed in actual research, testing, or experimentation. or held for these purposes. Attach additional sheets if necessary )

- -

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if n-rv or use APHIS Form 7023A 1 I

Animals Covered By The .Animal

Welfare Regulations

8. Numberof - anlrmls being bnd. conditioned. or held for w e in teaching. testing. experiments. research, or suGery but not ye

C. Numberof a n i d s upon which leaching, research,

I experiments. or 1 tests ware conducted involving no pain. distress, or use of pain-

D. Number of animals upon which experiments. teaching. reseanh. surgery. or tests were conducted inwiving accompanying pain or distress to the anirnals and for which appropdate anesthetic. a

E. Number of animals upon which teaching, uperfrnenk, research, surgery or tests were conduded indving accmpanying pain or distress to the animals and for which the w e of appropdale anesthelic. analgesic, or tranquilizing drugs wculd haw adversely affected the procedures. results. or interpretation of the teaching, retcarch, uperiments, surgery, or tests. ( An explanation of be procedures producing pain or distress in these animls and the reasons such drugs were not used must be attached to

TOTAL NUMBER OF ANlMALS

1 (COLUMNS C + D + E )

I

5. Cats

4. Dogs

relieving drugs.

6. Guinea Pigs

7. Hamsters

8. Rabbits


10. Sheep

11. Pigs

12 Other Farm Animals

ASSURANCE STATEMENTS I 1) ProfeuiorraWy acceptable standards governing the care, treatment, and use of animals. Indudhg appmprlats use of anestetic, malgesic, and tnnqtafrrino drugs, prior b, duing, and fdlawhO

I

13. Other Animals

- actual resea& teach'i testing. surgery, or experimsntation were followed by h is mearch facility.

I

r

2) Each principal hst igatcx has considered alternatives to painful procedur8s.

3) This facility Is adhering to the standards and regulations under the Ad, and it has required that exceptioru to the standards and rsgulatim be specihed and axpfained by the prlnSipd Investigator end approved by the institutional Animal Care and Use Committee (RCUC). A sumnury of aU such exceptlorn b athchrd to this annual repoR In addition b identifyiq the lACUGapprwved exc8ptiW, this summary indudes a bdef eaplanation of the coaeeptions, at well m the spdes and n m b r of animals &ected.

CERTIFICATION BY HEADQUARTERS RESEARCH FACLfW OFFICIAL ( Chief or Legally Responslile lnstihrtronal )

(

This report is renuired by law (7 USC 2143). Failure to report according to the regulations 3n

UNlTED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVlCE

ANNUAL REPORT OF RESEARCH FACILITY (TYPE OR PRINT )

REPORTlNG FACILITY ( Ut all locations where animals were housed or used in actual research. tes

See attached form for additlbnal information

interagency Report Control No.:

I - -

1. CERTIFICATE NUMBER: 34-R-0449 FORM APPROVED OMB NO. 05794036


Grand Valley State University 401 W Fufton Grand Rapids, MI 49504

Telephone: (61 6) -336-7265

g, & ~ m e n t a t i o h or held f c ~ these purposes. Anacfr additional sheets if necessary ) I

FACILITY LOCATIONS ( Sites ) - See Atached Usting

I TOTAL NUMBER OF ANIMALS

REPORT OF ANtMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if neceuarv or use APHIS Farm 7023A 1


5. Cats s

D. Number of animals upon which experiments, teaching. research, surgery. or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic. a

C. Number of animls upon which teaching. researth. uper imts. or tests were conducted involving no pain. distress. or use of pain- relieving drugs.

A.

Anlmalt Covered By The .4ninul

Welfare Regulatlom

4. Dogs

E. Number of animals upon which teaching. experiments. surgery w tests w e e conducted involving accompanying p i n or distress to the anlmls and for which the use of appropriate anesthetic. analgesic, or hnquilidng drugs wauld have adversely affected the prccedures, resJb, or interpretation of the teaching. research, expenmenls. surgecy. or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

6. Number of - anirmls being bred. conditioned. or held for use in teaching. testing. experiments. research. or surgery but not y t

6. Guinea Pigs

7. Hamsten

8. Rabbits

9. Nonhuman Primate

10. Sheep .

11. Pigs

1 2 Other Farm Animals

3) This facility h adhering to the standards and reguIatJons under the Act, and it has required that exceptim to the standard3 and m g d a t l ~ ~ ~ be sp6df1ed and exgf&sd by th8 phipal investigator and approved by the Institutional Animal Care and U t s Commitlee (LACUC). A summary of all such exceptions b attached to thb annual report In addition to identifying the WUC-approved axceptiorw, this nnvnary -&dude3 a brief explanation of the exceptions, as well as the specieu and number d animab affected.

I

13. Other Animals

4) The atlendii vekdmrian far fhb research faali has appropriate 8uthority to msum the pmw'sion ed adequate veterinary care and to orertes the adeqvacy of OW aspects of animd cIve end 4

CERTIFICATION BY HEADQUARTERS RESEARCH FACltlPl OFFICIAL

I I

I I

This report is re ired by law (7 USC 2143). Failure to report according to lhe regulations can



1. CERTIFICATE NUMBER: 34-R-0 149

CUSTOMER NUMBER: 13477 I FORM APPROVED OMB NO. 0579-0036 .I UNITED STATES DEPARTMENT OF AGRICULTURE

ANIMAL AND PLANT HEALTH INSPECTION SERVlCE

Grand Valley State University 401 W Fulton Grand Rapids, MI 49504

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE-OR PRINT )

Telephone: (61 6) -336-7265

IC 3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research. tes 1. or experimentation. or held for these purposes. Anach additional sheets if necessary ) I

--

FACILllY LOCATIONS ( Sites ) - See Atached Listing

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I - -- - - - - - -

D. Number of animals upon which experiments, teaching. research. surgery. or tests were conducted invdving accompanying pain or distress to the animals and for which appropriate anesthetic, a

1 E. Number of animals upon whtch teaching. 1 experiments, research. surgery or tests were

conducted involving accompanymg pain or distress to the animals and for lNhtch the use of appropriale anesthetic. analgestc. or tranquilizing drugs would have adversely affected the pmedures, results. w interpretation of the teaching, research, experiments. surgery. or tests. ( A n explanation of the procedures producing pain or distress in these antnrals and the reasons such drugs were not used m~st be anached to

B. Numberof - animals being bred. conditioned. 8r held for use in teaching. testing. experiments. research. or surgery but not ye

Number of anirnats upon which teaching. research. experiments, or tests were conducted involving no pain. distress, or use of pain- relieving drugs.


Anlmals Covered By The Anlmal

Welfare Regulations ( COLUMNS C + D + E )

4. Dogs

5. Cats I 6. Guinea Pigs I 7. Hamsters I 8. Rabbits I 9. Non-human Primate

10. Sheep

11. Pigs I 12. Other Farm Animals I

-- - - --

13. Other Animals

i

- -

1 ASSURANCE STATEMENTS I 1) Professionally ecceptable standards ooverning the uw, treatment. and use of animals, including appropriate use of amstetic, analgesic, md tranquiliing drugs, prior to, during. and fdlom'ng

echral rcueereh, t d n g , testing. surgery, or exp immbbn were followed by this research facility.

2) Each pn'ndpal imrestigator has considered alternatives to painful procedures.

3) This facility is adhen'ng to the standards and regul&.ons under the Act, and it has required that exceptions b the^ t t a n d d and regulations be specified and eqlained by the prindpal investigator and approved by the Institutional A n i i l Care and Use Committee (IACUC). A summary of all such exceptions Is attached to thlt annual repoR In addiian lo id- IACUC-approved mceptiw, this summary indudes a brid explanation of the exceptions, as well as the species end nmnbec of animals affected.

4) The attendim veterinarian for this resea& facility has a ~ p ~ a t e authority to enzure fb provision of adequate veteriwy care end to oversee the adequacy of other as- of animal c a f ~ end

CERTIFICATION BY HEADQUARTERS RESEARCH FACIUM OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Ofiicial )


Thts report is required by law (7 USC 2143). Fa~lure lo report accordtng to the regulations

1. CERTIFICATE NUMBER: 34-R-0150 I FORM APPROVED OMB NO. 0579-0036


can

Baker College . ; !Sf : . . . . : .. .. 1050 West Bristol Road ' - : ' 2 ...

".' ,! . .->

Flint, MI 48507 - c.'"? -C

Telephone: (81 0) -766-4288

UNITED STATES DEPARTMENT OF AGRICULTURE A N W L AND PLANT HEALTH INSPECTION SERVICE


9

FAClLrIY LOCATIONS ( Sites ) - See Atached Listing

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research. testing, or experimentation. or held for these purposes. Attach additional sheets if necessary )

1 REPORT OF ANIMALS USED BY OR UNDER ONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I 6. Numberof

animals being -- bred. conditioned, or held for use in teaching, testing. expenments, research. or surgery but not ye

C. Number of animals upon which teaching. research. experiments. or tests were conducted involving no pain, distress, or w e of pain- relieving drugs.

0

D. Number of animals upon which experiments, teaching. research. surgery. or tests were conducted involvtng accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. I F. experiments. research. surgery or tests were

I conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic. w tranquilizing drugs would have adversely affected the procedures. results, or interpretation of the teaching. research. expenments. surgery, or tests. ( An explanation of the procedures

TCTAL M!JMBER OF ANIMALS


Welfare Regulations ( COLUMNS C + D + E )

producing pain or distress in these animals and the reasons such drugs were not used must be attached to

5. Cats

8. Rabbits I C3 0

6. Guinea Pigs

7. Hamsters

0

0


10. Sheep

11. Pigs

D (3

0 I 0


--

1 ASSURANCE STATEMENTS I

0

0

13. Other Animals

-- -

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following

0

U

0

0

aciual research, teaching, testing, surgery. or experimentation were followed by this research faa l i .


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be sped~ed and explained by the principal investigator and approved by the Institutional Animal Cam and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to enswe the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

O 0

i9 0

(3

0

---- - -

BY HEADQUARTERS RESEARCH FACILIT~OFFICIAL

8

(3

0

0

( AUG 91 )

0 - 0 (3

0

I

0

0

DATE SIGNED

a

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IS bx - USDA-APHIS€¦ · ANIMAL AND PLANT HEALTH INSPECTION SERVICE ANNUAL REPORT OF RESEARCH...

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