INVESTIGATION ABOUT INVESTIGATION ABOUT PROTEINS: BROCHUREPROTEINS: BROCHURE

JUAN CAMILO LOPERA RESTREPO000175272

UNIVERSIDAD PONTIFICIA BOLIVARIANAFACULTAD DE MEDICINA

TERCER SEMESTRECOLOMBIA

MEDELLIN2011

INTRODUCTIONINTRODUCTION

The general idea of this brochure is to show a couple of news related to proteins that have some relationship with the medical enviroment and can serve as motivation for future research.

EXPLANATION FIRST NEWS (A)EXPLANATION FIRST NEWS (A)

Scientists of the University of Leeds

They unravel the way in which it begins the process of production of amyloid proteins

Alzheimer's, Parkinson's and Diabetes Mellitus: Unfolding Amyloid Secrets

EXPLANATION FIRST NEWS (B)EXPLANATION FIRST NEWS (B)

Amyloid proteins are the raw material for many diseases because it combine to generate long structures as strings

"We wanted to discover what

happened to make a perfectly normal protein into one which was prone to aggregation because if we can stop the very first event, which causes a snowball effect, it provides us with new targets for future therapies.”

The team first had to make a protein called beta-2 micro globulin, which is known to have a major role to play in the formation of amyloid fibres.

Using nuclear magnetic resonance spectroscopy (NMR), they found that only a small change or misfold in the protein made it unstable, causing it to become highly excitable and dynamic. This made it more likely to stick to other proteins, influencing their structure and starting off the snowball effect of aggregation.

EXPLANATION FIRST NEWS (C)EXPLANATION FIRST NEWS (C)

"This is a huge step forward, not just for renal patients, but in our fundamental understanding of how amyloid fibres may form in other diseases as well. Many amyloid diseases are due to changes in protein structure and our next steps will be to see if similar changes are taking place with other protein types."

EXPLANATION FIRST NEWS (D)EXPLANATION FIRST NEWS (D)

PERSONAL COMMENT FIRST NEWSPERSONAL COMMENT FIRST NEWS

Any progress that can be done to try to find solutions or at least approach them aboutimportant and degenerative diseases such as those of the news is certainly a step forward and for this reason that the article invites us to investigate every more day to try to reach a solution soon, it is clear the important role played by proteins in the regulation of our whole body in general and how important it is to understand thoroughly.

EXPLANATION SECOND NEWS (A)EXPLANATION SECOND NEWS (A)

Study presented by scientists led by Professor Thomas Kiefhaber in collaboration with Professor Gunter Fischer's.

They found a mechanism to discover how it is carried out the process of recognition between proteins upstream of union

Mystery About Recognition of Unfolded Proteins Solved: The Lock Shapes the

Key

Thomas Kiefhaber

EXPLANATION FIRST NEWS (B)EXPLANATION FIRST NEWS (B)

The big question revolved around whether it was sufficient to analyze the local properties of two proteins to join or whether it was necessary to conduct a complete analysis of the structural properties of proteins and their components.

The model system was the enzyme ribonuclease S, which in its active form comprises the S-protein and an α-helical S-peptide. While the S-protein has a defined three-dimensional shape, the S-peptide on its own is initially unfolded. The scientists attempted to determine whether the S-protein recognizes the unstructured S-peptide or a small fraction of peptide molecules in their helical conformation. To this end, the oxygen atoms in the peptide bonds were replaced by sulfur atoms via chemical protein synthesis, causing individual hydrogen bonds to become destabilized.

EXPLANATION FIRST NEWS (C)EXPLANATION FIRST NEWS (C)

Protein-protein recognition in this case takes place via hydrophobic interaction of the S-protein with two spatially clearly defined areas of the unstructured S-peptide.

The increased importance of this study is that the method used can be applied to other research in helping to clarify the future multiple questions that may arise in regard to unions between proteins.

EXPLANATION FIRST NEWS (D)EXPLANATION FIRST NEWS (D)

It is important to understand the physiological processes from the ground, smaller components in order to start from there to develop more advanced projects, which is why the work of these men is of great value, must also be a motivating factor for the development of new research

PERSONAL COMMENT SECOND PERSONAL COMMENT SECOND NEWSNEWS

MEDICAL UTILITY EXPLANATION MEDICAL UTILITY EXPLANATION (A)(A)

Is necessary when talking about the medical usefulness of research related to protein, start by saying that these are the basis for numerous physiological and pathological processes in the body. For example we have: enzimes, plasma protein etc.

Given the above it is easy to recognize that any advance in understanding the processes that affect the protein is a step forward in curing serious diseases such as diabetes mellitus, Alzheimer’s or Parkinson’s

MEDICAL UTILITY EXPLANATION MEDICAL UTILITY EXPLANATION (B)(B)

MEDICAL UTILITY EXPLANATION MEDICAL UTILITY EXPLANATION (C)(C)

The development of methods of study or research in order to analyze a wide range of proteins, in this case the interaction between their structures is emerging as a breakthrough because it allows the progress of other research with similar needs, facilitating the speed with which the research its done

These studies not only represent an important step in proteomics. Besides it must be said that researchers are presented as role models for younger generation of researchers to begin to discover the world of innovation. This generally promotes the continuity of  medical advances

MEDICAL UTILITY EXPLANATION MEDICAL UTILITY EXPLANATION (D)(D)

BIBLIOGRAFIABIBLIOGRAFIA

Science Daily: News & Articles in Science, Health, Environment & Technology [Web en línea]. <> HTTP://www.sciencedayly.com <> [Consulta: 23-02-2011]

MARTINEZ Lina, Biología molecular libro de clase, 6 Edición 2011 UPB. Pág. 105 -109

National Institute of Neurological Disorders and Stroke (NINDS) [Web en línea. <> http://www.ninds.nih.gov/disorders/alzheimersdisease/alzheimersdisease.htm <> [Consulta: 03-03-2011]

 

““The future has many names: The future has many names: for the weak it is unattainable, for the weak it is unattainable, for the fearful, the unknown. for the fearful, the unknown. For the brave, the For the brave, the opportunity.”opportunity.”

THANKS