INSULIN IMAGES

A model of the insulin molecule. The two chains are shown in different colours. Insulin molecules consist of two polypeptide chains (A and B) linked by disulphide bonds. Insulin decreases blood glucose concentrations and increases cell permeability to monosaccharides, amino acids and blood glucose

concentrations. It also increases cell fatty acids. Defects of insulin are the cause of hyperinsulinaemia and type 2 diabetes mellitus. Credit: T Blundell and N Campillo, Wellcome Images

Molecular model of insulin molecule

A model of the insulin molecule shown as a ribbon diagram. Each chain is shown in a different colour. The disulphide bonds are shown in yellow. Insulin molecules consist of two polypeptide chains (A and B) linked by disulphide bonds. Insulin decreases blood glucose concentrations and increases cell permeability to monosaccharides, amino acids and blood glucose concentrations. It also

increases cell fatty acids. Defects of insulin are the cause of hyperinsulinaemia and type 2 diabetes mellitus. Credit: T Blundell and N Campillo, Wellcome Images

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Molecular model of insulin molecule

A model of the insulin molecule shown as a ribbon diagram. Each chain is shown in a different colour. Insulin molecules consist of two polypeptide chains (A and B) linked by disulphide bonds. Insulin decreases blood glucose concentrations and increases cell permeability to monosaccharides, amino acids and blood glucose concentrations. It also increases cell fatty acids. Defects of insulin are the cause

of hyperinsulinaemia and type 2 diabetes mellitus. Credit: T Blundell and N Campillo, Wellcome Images

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Molecular model of insulin molecule

A model of the insulin molecule. The alpha-helices are represented as cylinders. Insulin molecules consist of two polypeptide chains (A and B) linked by disulphide bonds. Insulin decreases blood glucose concentrations and increases cell permeability to monosaccharides, amino acids and blood glucose concentrations. It also increases cell fatty acids. Defects of insulin are the cause of hyperinsulinaemia and

type 2 diabetes mellitus. Credit: T Blundell and N Campillo, Wellcome Images

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Molecular model of insulin molecule

Woman injecting herself with insulin to control diabetes. Credit: Wellcome Photo Library, Wellcome Images

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Insulin injection

This photomicrograph shows a section through the pancreas of a person with an insulinoma (tumour of the pancreas). It shows substantial amounts of amyloid (pink) in the islets. The brown cells are beta cells secreting insulin.

Credit: Anne Clark, University of Oxford, Wellcome Images

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Insulinoma, amyloid deposits in pancreas islets

A transmission electron micrograph showing collagen fibrils in the sclera. At the top of the picture, they are seen in longitudinal section; towards the bottom, they are seen in transverse section. The attached proteoglycans are seen as fine filaments on the fibrils running radially, axially and around the fibrils. The fibrils are approximately 130 nm in diameter.

Credit: Rob Young, Wellcome Images

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Beta cells secreting insulin in a human pancreas

A photomicrograph of a section through a normal human pancreas, labelled for insulin. It shows the islets of Langerhans, which control insulin secretion, situated in a sea of exocrine tissue. The insulin is secreted by special groups of cells called beta cells. Insulin is involved in the regulation of sugar metabolism, being responsible for removing

glucose from the blood by promoting glycogenesis and the uptake of glucose by respiring cells. Credit: Anne Clark, University of Oxford, Wellcome Images

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Insulin secretion in islets of Langerhans

Dr Frederick Banting was a Canadian doctor who was awarded a Nobel Prize for discovering insulin with Professor John Macleod. Credit: Wellcome Library, London

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Frederick Grant Banting

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