Institute of Organic Chemistry National Academy of Sciences of Ukraine Innovative Opportunities
description
Transcript of Institute of Organic Chemistry National Academy of Sciences of Ukraine Innovative Opportunities
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Institute of Organic ChemistryNational Academy of Sciences of Ukraine
Innovative Opportunitiesand Prospects
Murmanska str., 5, 02660, Кyiv-94 www.ioch.kiev.ua
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The Institute’s Employees
Total # 243
Scientific 120
Dr. of Sci 22
PhD 73
PhD student 16
New young employees 17
Students in training 50
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The Institute’s Scientific Department
1. Organophosphorus Compounds2. Heteroatom Chemistry3. Colour and Structure of Organic Compounds4. Mechanisms of Organic Reactions5. Chemistry of Phosphoranes6. Chemistry of Bio-active Compounds7. Physico-chemical Investigations8. Chemistry of Organo-fluorine Compounds9. Chemistry of Organo-sulfur Compounds10. Bio-medical Investigations
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The Institute’s Basic Research
•fine organic synthesis•organoelement chemistry (P, S, Si)•heterocyclic chemistry•fluoroorganic chemistry•polymethyne dyes, colour theory•mechanisms of organic reactions•chemistry of biologically active compounds •supramolecular chemistry•calixarene chemistry
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Patent activity in 2013
submitted 12
granted 16
maintained 57
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Fluorination reagents and processes
OHO
HO
F
HO OMe
O
HO
F
HO OMe
F
F
R
Alk2NSF3
OCOOMe
F
H HS
CHF2
H
RN
OCO2CH2Ph
H HS
H
FH2C
O
OO
CO2H
H
Fluoromethylpenicillins
Fluorosteroids 8-Fluorocarbapenems
Fluoroproctaglandins
Fluoroalkylated Sugars
R
OHHO
OF
COOH
N
H
O
H
COOH
S R
FH
N
N
N
N
O
NH2
OH OH
H2NSO2O
F
N
NH
O
O
H3C
O
HOHO
HO
F
Fluoronucleosids, Fluoronucleotids
DAST
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DEVELOPMENT OF THE ACID SENSING ION CHANNELS ANTAGONISTS WITH NEUROPROTECTIVE ANTIISCHEMIC PROPERTIES
Ukraine patent № 66987; Fiziol. Zh. 2011, 57, 6, 31
KMS-005IC50 = 27 nM
Known blocker AmilorideIC50 = 4000 nM
X-ray Structure of Acid Sensing Ion Channel 1a
IN COOPERATION WITH BOGOMOLETZ INSTITUTE OF PHYSIOLOGY NAS OF UKRAINE
N
N
Cl
O O
NH
NH2
N
NNH
O
NH2
NH
NH2NH2
Cl
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New nano-sized catalytic compositions for selective chlorination of alkylaromatic compounds
Innovative Aspect and AdvantagesNew catalytic compositions based on thiocrown-ethers and Lewis catalysts (SbCl5, SbCl3, FeCl3) provide better yields of para-chlorotoluene in comparison with the known industrial Lewis Acid catalytic compositions
Structure of the nano-catalyst SbCl5 – benzodithio-18-crown-6 – Cl2
Products of toluene chlorination with usage of the nano-catalyst
Patent of Ukraine № И201104813
Me Me
Cl
Me
Cl
+
62 % 38 %
nano-catalyst
Cl2
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(a). Oscillogram of trains which arise on a background of spikes of free generation.(b). The ultrashort pulse of the passively mode-locked laser on Yb-Er glass (λ = 1540 nm) with saturable absorber based on dye 4919u.
4919u
BF4Ph
S
Ph
Ph
S
Ph
Ph
Solvatochromism and passive mode locking of erbium laser
MeCN
o-C6H4Cl2
10Dependency of photoconductivity JPH on electric field strength E in Al/PEPK + 0.5 mass % dye / SnO2 sample (thickness = 1.2 μm, I = 8 W•m–2)
N
MeMe
MeNH
NH
O
O
O
PEPK(polyepoxypropylcarbazole)
N
CH2
On
(D A) + h (D+ A )*
Dye excitation
(D+ A )* + PEPK (D A) • • • • PEPK+•
Electron transfer (formation of electron-hole pair)
(D A) • • • • PEPK+• (D A) • + PEPK+•
Dissociation of electron-hole pair in external electric field
Detection of internal microcrack in a railroad rail. The hologram was recorded usinb the polymer film doped with merocyanine D–A
Photothermoplastic holographic composite
Merocyanine (D–A)
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O O O O
R RR R
R R R R
CАТIONS АNIONS МОLECULES
CALIXARENE RECEPTORS
Calixarenes selectively recognize, bind and separate similar in properties species
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Institute of Organic Chemistry NAS Ukraine
Calixarene R&DResearchDesign of selective (chiral) receptors of cations, anions, molecules
and bio-molecules
Development
Radionuclide Extractants
Chemosensors
Drug Design
J. Am. Chem. Soc. 2007. 129. 1123-1131.J. Org. Chem. 2007. 72. 3223-3231.Pure Appl. Chem. 2008. 80. 1449-1458J. Phys. Chem. C. 2009. 113. 1137-1142Curr. Med. Chem. 2009. 16. 1630-1655 Bioorg. Med. Chem. Lett. 2010, 20, 483–487J.of Catalysis. 2011. 284. 42-49FEBS Journal. 2011. 278. 1244-1251
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Actinides extraction
Distribution D between nitrobenzotrifluoride and HNO3 (0.3M)
0
2
4
6
8
10
12
14D
Am(III) Cm(III) Pu(IV) Np(V)
O OO O
P
P P
P
O O Pr
PrPr
PrO O
Pr
Pr
Pr
Pr
0.01 M
Smirnov I. V., Karavan M. D., Efremova T. I., Babain V. A., Miroshnichenko S. I., Cherenok S. A., Kalchenko V. I.Radiochemistry. 2007. 49. 423-431
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Calixarene Micellar Complex
O OO O
P
P P
P
O O Pr
PrPr
PrO O
Pr
Pr
Pr
Pr
Alk Alk Alk Alk
Hydrophilic Rim
Hydrophobic Rim
Amphiphilic Calixarenes
radionuclide
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Micelle-mediated purification of radioactive water
radioactive water
micellarcomplexes
purified water
Ultrafiltration,or cloud pointextraction
Patent of Ukraine. 28405. 2007Russian patent. 2343161. 2007
O OO O
P
P P
P
O O Pr
PrPr
PrO O
Pr
Pr
Pr
Pr
radioactivewater
16Rodik R., Rozhenko A., Boyko V., Pirozhenko V., Danylyuk O., Suwinska K., Lipkowski J., Kalchenko V. Tetrahedron. 2007. 63. 11451-11457.
Calixarene bis-Quinazolinone - Methanol Complex
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Calixarene phosphonous acidsas receptors for biomolecules
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Наукові та виробничі зв'язки з підприємствами України
ЗАТ "Фармак", Київ Виробництво препарату Мебіфон - засобу для лікування раку моло-чної залози
ЗАТ НВЦ "Борщагівський хімфармзавод", Київ
Організація випуску препаратів Боризол для лікування хвороби Паркінсона. Флокалін - для лікування серцево – судинних захворювань
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Діяльність Дослідного виробництва
№з/п
Продукція
2012 2013 2014
Випуск (кг) Випуск (кг)
1 Декаметоксин 99 37
2 Таурін 300 500
3 Етоній медицинський - -
4 Етоній ветеринарний - -
5 Вазин 1800 1000
6 Карбацид 114 - -
7 Термостабілізатори ПВХ СКСК-20, 22, 28
4998 -
8 Комплексні добрива 12000 -
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ДЯКУЮ ЗА УВАГУ !