Homework #3 is due 11/19 Bonus #2 is posted .
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Transcript of Homework #3 is due 11/19 Bonus #2 is posted .
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Homework #3 is due 11/19Bonus #2 is posted
http://www.freshminds.com/animation/alan_watts_theater.html
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Do telomere dynamics link lifestyleand lifespan?
Pat Monaghan and Mark F. HaussmannTRENDS in Ecology and Evolution
Vol 21 pg 47
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Telomere length varies in different parts of adults:
telomeres - mitosisstomach &blood cells....short - often
muscle &brain……….long - rare
liver &kidney……..short - rare
gametes……long
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Telomeres are non-gene DNA at the ends of DNA strands.
Telomeres are more sensitive DNA damage, and may act as a sensor for overall DNA damage level in a cell.
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Does telomere length indicate longevity?
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Zebra finch
Telomere length in red blood cells of different birds
Fig. 1 TRENDS in Ecology and Evolution Vol 21 pg 47
Age (years)
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common tern
Telomere length in red blood cells of different birds
Fig. 1 TRENDS in Ecology and Evolution Vol 21 pg 47
Age (years)
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albatross
TRENDS in Ecology and Evolution Vol 21 pg 47
Telomere length in red blood cells of different birds
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Leach’s storm petrel
Telomere length in red blood cells of different birds
Fig. 1 TRENDS in Ecology and Evolution Vol 21 pg 47
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Zebra finch
Leach’s storm petrel
common tern
albatross
Telomere length in red blood cells of different birds, different species have different patterns of telomere length and age
Fig. 1 TRENDS in Ecology and Evolution Vol 21 pg 47
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Fig. 2 TRENDS in Ecology and Evolution Vol 21 pg 47
Telomere length in white blood cells of different aged people. Telomere length
generally declines, but there is wide variability
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THE LANCET • Vol 361 • pg 393
Telomere length and mortality in people over 60 years old
upper 50% of telomere length
lower 50% of telomere length
prop
orti
on s
urvi
ving
%
years after initial assessment
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Telomere length may indicate biological age.
Early stress may cause premature telomere degradation.
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For life to exist, the information (genes) must be passed on.
{Mitosis:producing more cells}
{Meiosis:producing gametes}
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The Cell Cycle
Fig 2.9
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Mitosis:A DNAPerspective
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Mitosis plays a role in:• Growth and Development
• Repair and Turnover of Cells
• Reproduction
–Asexual
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startofmitosis
Fig 2.10
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TheMitoticSpindle(micro-tubules)
SisterChromatids
A basic look at mitosis