HEART TRANSPLANTATION

Overall

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsNumber of Transplants by Year

1982

1984

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

2008

2010

2012

0

500

1000

1500

2000

2500

3000

3500

4000

4500

50001

87 32

26

71 1,2

61 2

,35

82

,99

73

,52

63

,82

34

,52

44

,74

74

,72

54

,92

14

,82

14

,80

14

,68

24

,60

44

,51

94

,20

24

,10

24

,03

33

,90

73

,83

03

,79

83

,91

33

,96

63

,99

43

,99

04

,02

44

,13

74

,18

84

,19

6

Nu

mb

er

of

tra

ns

pla

nts

NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of heart transplants performed worldwide.2014

JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsNumber of Transplants by Year and Location

1982

1984

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

2008

2010

2012

0

500

1000

1500

2000

2500

3000

3500

4000

4500

5000Other

Europe

North America

Nu

mb

er

of

tra

ns

pla

nts

NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of heart transplants performed worldwide.2014

JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsAverage Center Volume (Transplants: January 2006 – June 2013)

1-4 5-9 10-19 20-29 30-39 40-49 50-74 75+0

20

40

60

80

100

120

0

10

20

30

40

50

60

50

71

114

38

11 4 8 1

Number of centers Percentage of transplants

Average number of heart transplants per year

Nu

mb

er

of

ce

nte

rs

% o

f tr

an

sp

lan

ts

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsRecipient Age by Year of Transplant

1982

1984

1986

1988

1990

1992

1994

1996

1998

2000

2002

2004

2006

2008

2010

2012

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

0

10

20

30

40

50

60

0-9 10-17 18-39 40-59 60-69 70+ Median Age

% o

f tr

an

sp

lan

ts

Me

dia

n r

ec

ipie

nt

ag

e (

ye

ars

)

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsMedian Recipient Age by Location

1988

1989

1990

1991

1992

1993

1994

1995

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

0

10

20

30

40

50

60

Europe North America Other

Me

dia

n r

ec

ipie

nt

ag

e (

ye

ars

)

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsDonor Age by Year of Transplant

19821984

19861988

19901992

19941996

19982000

20022004

20062008

20102012

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

0

5

10

15

20

25

30

35

0-9 10-17 18-39 40-59 60-69 70+ Median Age

% o

f tr

an

sp

lan

ts

Me

dia

n d

on

or

ag

e (

ye

ars

)

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsMedian Donor Age by Location

1988

1989

1990

1991

1992

1993

1994

1995

1996

1997

1998

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

2009

2010

2011

2012

0

5

10

15

20

25

30

35

40

45

50

Europe North America Other

Me

dia

n d

on

or

ag

e (

ye

ars

)

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsRecipient Age Distribution By Era

0-9 10-17 18-39 40-59 60-69 70+0

5

10

15

20

25

30

35

40

45

50

55

60

65

1982-1995 (N = 43,335)

1996-2005 (N = 41,566)

2006-6/2013 (N = 28,494)

Recipient age

% o

f tr

an

sp

lan

ts

p < 0.0001

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsDonor and Recipient Age (Transplants: January 2006 – June 2013)

0-9 10-17 18-39 40-59 60-69 70+0%

20%

40%

60%

80%

100%

0-9 10-17 18-39 40-59 60-69 70+

Recipient age

% o

f tr

an

sp

lan

ts

Donor Age:

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsDonor and Recipient Age (Transplants: January 2006 – June 2013)

0-9 10-17 18-39 40-59 60-69 70+0%

20%

40%

60%

80%

100%

0-9 10-17 18-39 40-59 60-69 70+

Donor age

% o

f tr

an

sp

lan

ts

Recipient Age:

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsRecipient Age Distribution by Location

(Transplants: January 2006 – June 2013)

Europe North America Other0%

20%

40%

60%

80%

100%

0-9 10-17 18-39 40-59 60-69 70+

% o

f re

cip

ien

ts

Recipient age (years): mean/median Europe = 47/51 North America = 45/52 Other = 43/47

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsDonor Age Distribution by Location

(Transplants: January 2006 – June 2013)

Europe North America Other0%

20%

40%

60%

80%

100%

0-9 10-17 18-39 40-59 60-69 70+

% o

f d

on

ors

Donor age (years): mean/median: Europe = 39/42 North America = 28/26 Other = 31/29

2014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsDonor and Recipient Age (Transplants: January 2006 – June 2013)

0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 800

10

20

30

40

50

60

70

80

Recipient age

Do

no

r a

ge

R2 = 0.24, p < 0.00012014JHLT. 2014 Oct; 33(10): 996-1008

Adult and Pediatric Heart TransplantsKaplan-Meier Survival

(Transplants: January 1982 – June 2012)

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 270

25

50

75

100

Years

Su

rviv

al (

%)

Median survival = 11 yearsMedian survival conditional on surviving 1st year= 14 years

N = 108,343

N at risk at 27 years = 108

2014JHLT. 2014 Oct; 33(10): 996-1008