Linkage Analysis in Merlin Meike Bartels Kate Morley Danielle Posthuma.
Health 2.0 Amsterdam: Prof. Meike Bartels from VU University
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Transcript of Health 2.0 Amsterdam: Prof. Meike Bartels from VU University
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Individual(Differences(in(Wellbeing((and(the(overlap(with(health(and(behavior((
(Prof.(Dr.(Meike(Bartels(Department(of(Biological(Psychology(
VU(University(Amsterdam(
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Major(Depressive(Disorder(–(Global(Burden(of(Disease(2010(((((((
Ferrari(et(al,(2013,(Plos(Medicine ( ( ( ( (YLD=(years(lived(with(disabiliNes((
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University(of(Leiceter,(2006(
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UNICEF(2007(
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Science(January(2010(
How(to(measure(WellXbeing?(
Science(29(January(2010:(Vol.(327(no.(5965(pp.(534X535((
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Large groups of people live healthy and happy lives
Individual Differences
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ENVIRONMENT(
GENES(
UNIQUE(ENVIRONMENT(SHARED(ENVIRONMENT(
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Twins(
IdenNcal(=(MonozygoNc((MZ)(( Fraternal(=(DizygoNc((DZ)(
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The(Classical(Twin(Design(
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Causes(of(Individual(Differences(in(Wellbeing(
0%( 10%( 20%( 30%( 40%( 50%( 60%( 70%( 80%( 90%( 100%(
Tellegen(et(al.,(1988((
Lykken(&(Tellegen,(1996((
Røysamb(et(al.,(2002((
Stubbe(et(al.,(2005(
Bartels(et(al.,(2009(
Bartels(et(al,(2010(
Nes(et(al.,(2010(
Kendler(et(al.,(2011(
Bartels(et(al,(2013(
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GENES- 40%
ENVIRONMENT- 60%
Current State of Art
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X0.70(
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Overlap(WellXbeing(and(Psychopathology(
Bartels(et(al,(Behavior(GeneNcs(2013(
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Bartels(et(al,(Behavior(GeneNcs(2013(
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Is(WellXbeing(Stable(within(a(person?(
SetXpoint(Theory(–(Hedonic(TreadmillX(Dynamic(Equilibrium(even(though(external(forces(are(constantly(changing(our(lives(and(our(life(
goals,(happiness(is(a(relaNvely(constant(state(
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Science,(Aug(2009(
Dodds(and(Danforth,(Journal(of(Happiness(studies(2010,(Science(Vol(325(2009(
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PNAS,(jan(2014(
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To(be(conNnued:(
X The(search(for(genes(X The(search(for(geneXenvironment(interplay((epigeneNcs)(