George Twaddle Program Chair for Biotechnology Ivy Tech Community College of Indiana – South Bend
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Transcript of George Twaddle Program Chair for Biotechnology Ivy Tech Community College of Indiana – South Bend
George TwaddleProgram Chair for BiotechnologyIvy Tech Community College of Indiana – South Bend
The Ultimate Inquiry
Lessons from the Genetically
Engineered Machine Competition
How to get students interested in STEM careers?
Synthetic Biology• New area of biological
research• Combines science and engineering• Design and construction of artificial biological functions and systems
Genetic Code is UNIVERSAL-Discovery of “restrction enzymes” allows us to cut and build recombinant DNA and to express new genetic combinations..
The New Generation of “Micro” Computers?
Began in January of 2003Independent Activities Period (IAP) at MIT (The students designed biological systems to make cells blink).
A BIT O’ iGEM HISTORY
5 teams in 2004 13 teams in 200532 teams in 2006 54 teams in 2007 84 teams in 2008 112 teams in 2009 130 teams in 2010
2011.igem.orgThe
International Genetically Engineered Machine competition (iGEM) is the premiere undergraduate Synthetic Biology competition. Student teams are given a kit of biological parts at the beginning of the summer from the Registry of Standard Biological Parts. Working at their own schools over the summer, they use these parts and new parts of their own design to build biological systems and operate them in living cells. This project design and competition format is an exceptionally motivating and effective teaching method.
What’s an “iGEM?”
Kit of biological parts
at the beginning of the summer.
Build biological systems
out of the parts or new parts that they create and operate them in living cells
Come to a “Jamboree”
at the end to show-off and see who is most innovative.
An undergraduate synthetic biology annual competition
Tom Knight“BioBrick” inventorGinko BioWorks
Randy RettbergiGEM Competition“Open WetWare” Drew Endy
BioBricks Foundation
iGEM MIT Paternity
THE “BIOBRICK”A standard for interchangeable parts.
For building complex biological systems in cells
Standards achieved through unique “prefix” and “suffix” restriction sites.
A3 Assembly of BioBricks to Form a “Device”
Student created wiki part page
Elements of the Competition
Team wiki and Team Parts Pages
Poster presentation
Platform presentation
•Track Award Winners: Best Food or Energy Project: BCCS-Bristol•Best Environment Project: Peking•Best Health or Medicine Project: Washington & Freiburg Bioware (Tie)•Best Information Processing Project: ETHZ Basel & Tokyo Tech (Tie)•Best Manufacturing Project: MIT•Best New Application Area: Slovenia•Best Foundation Advance: Paris Liliane Bettencourt•Best Software Tool: USTC Software
•Special Prizes Winners: Best BioBrick Part, Natural: Minnesota (BBa_K311004)•Best New BioBrick Part or Device, Engineered: Slovenia (BBa_K323135)•Best Human Practices Advance: Imperial College London•Safety Commendation: SDU Denmark & VT-ENSIMAG Biosecurity (Tie) •Best Experimental Measurement: Duke•Best Model: Edinburgh•Best Wiki: Cambridge & Imperial College London (Tie)•Best Poster: KIT-Kyoto•Best Presentation: TUDelft•iGEMers Prize: Cambridge, Imperial, MIT, EPF Lausanne, & Slovenia
Medals and Awards
GoldSilverBronze
Inquiry-Based Learning“A student-centered / teacher-guided instructional approach that Engages students in investigating
Real World Questions that they choose within a broad thematic framework.
Students acquire and analyze information, develop and support propositions, provide solutions, and design technology that demonstrate their thinking and make their learning visible.” Northeastern Illinois University Dept. of Eduction
What’s your Problem?Food?Energy?
Environment?Health and Medicine?
Industrial & Biomanufacturing?
Software?
Process Advance?
Team Project DescriptionAberdeen AyeSwitch Genetic toggleBCCS-Bristol agrEcoli Soil Fertility SensorBrown Light Pattern Control of Cell CircuitsCaltech Bioplastic printer from soybeans and E. coliEFP-Lusanne Asaia GM bacteria antimalarialETHZ-Basel E. Lemming Remote contolled E. coliGronigen Hydrobiophilm Synthetic hydrophobic
surfaceHarvard iGarden Plant Engineering ToolkitHokkaidoU_Japan Dr. E.coli Protein microinjectorIvyTech-SouthBend To Swim or Not
to SwimP. Aeruginosa biosensor
Lethbridge Bioremediation of tailing pondsMexico Very Cool E.
coliProduce antifreeze ,15C
Missouri_Miners Electric E. coli E.Coli Fuel CellNewcastle BacillaFilla Bacteria concrete crack
fillerUT-Tokyo E. Coli Solves Sudoku
Team Groningen, Netherlands2009
Team British Columbia, Canada 2009
EPFL Luasanne, Switzerland 2010
University of Slovenia 2010
Ivy Tech Community College of IndianaBronze Medal Team
EducationCommunit
y Industry
Local Gov
State Gov.Feder
al Gov.
Foundations
Media
BioFuture: Partnerships in Biotechnology
Partnerships in the Future
SKILLS AND KNOWLEDGE STANDARDS FORASSOCIATE DEGREE IN BIOTECHNOLOGY PROGRAMS
IN INDIANA Created by:Alisa Wright, Baxter Pharmaceutical SolutionsGary Bormett, Dow AgroSciences LCCJose Hanquier, Robert MacKay, Roberta Talmage, Eli Lilly and CompanyWade Lange, Indiana Health Industry ForumAndy Cothrel, Roche Diagnostics Corp. June 30, 2003
Associate of Science orAssociate of Applied Science
In
BIOTECHNOLOGYBloomington Lafayette Lawrence South Bend Terra Haute
iGEM High School Division 2010
• Greenfield Central High School• Warren Central High School• “The DNA Architects of South Bend – Mishawaka (Marian, Penn and Riley High Schools
Illustration creditsLine of students: www.LowestPricedTrafficSchool.comGibson Assembly Song: www.cambrigeigem.orgSynthetic biology figures: “Biology” Campbell and Reece. Pearson, Benjamin-Cummings Publishers (2010) www.masteringbiology.comBacteria: Ministry of Public Works, Canada www.blog.poolcenter.comiGEM team photos, wiki screen shots, etc. 2011.igem.org