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Georg Klein Publications 1995-2008 1128) Hu, L. .F., Chen, F., Zhen, Q. .F., Zhang, Y. .W., Luo, Y., Zheng, X., Winberg, G., Ernberg, I. & Klein, G., Differences in the growth pattern and clinical course of EBV-LMP1 expressing and non-expressing nasopharyngeal carcinomas. European Journal of Cancer, 1995, 31A, 658-660. 1129) Wang, Y., Okan, I., Szekely, L., Klein, G. & Wiman, K. .G., Bcl-2 inhibits wild type p53-triggered apoptosis but not G1 cell cycle arrest and transactivation of WAF1 and bax. Cell Growth & Differentiation, 1995, 6, 1071-1075. 1130) Magnusson, K...P., Minarovits, J., Klein, G. & Wiman, K...G., A splice donor site mutation results in the insertion of five extra amino acids into p53 from SEWA mouse sarcoma cells. Gene, 1995, 162, 231-234. 1131) Okan, I., Wang, Y., Chen, F., Hu, L.-F., Imreh, S., Klein, G. & Wiman, K. .G., The EBV-encoded LMP1 protein inhibits p53-triggered apoptosis but not growth arrest. Oncogene, 1995, 11, 1027-1031. 1132) Lewin, N., Chen, F., Avila-Carino, J., Zou, J.-Z., Mellstedt, H., Ernberg, I. & Klein, G., Epstein Barr Virus (EBV)-carrying cells of a chronic lymphocytic leukemia (CLL) subpopulation express EBNA1 and LMPs but not EBNA2 in vivo. Int.J.Cancer, 1995, 63, 486-490. 1133) Asker, C.h. .E., Magnusson, K. .P., Piccoli, S. .P., Andersson, K., Klein, G., Cole, M. .D. & Wiman, K. .G., Mouse and rat B-myc share amino acid sequence homology with the c-myc transcriptional activator domain and contain a B-myc specific carboxy terminal region. Oncogene, 1995, 11, 1963-1969. 1134) Bakalkin, G., Selivanova, G., Yakovleva, T., Kiseleva, E., Kashuba, E., Magnusson, K. .P., Szekely, L., Klein, G., Terenius, L. & Wiman, K. .G., p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain. Nucleic Acids Research, 1995, 23, 362-369. 1135) Kono, k., Petersson, M., Ciupitu, A. .M. .T., Wen, T., Klein, G. & Kiessling, R., Methylcholanthrene-induced mouse sarcomas express individually distinct major histocompatibility complex cell lines.. Cancer Research, 1995, 55, 5648-5655. 1136) Berke, Z.s., Wen, T., Klein, G. & Dalianis, T., Polyoma Persists in CD4/8 Double-Knockout, but Not in CD4 or CD8 Single-Knockout Mice. Virology, 1995, 212, 268-271. 1137) Wang, Y., Okan, I., Szekely, L., Klein, G. & Wiman, K. .G., Bcl-2 inhibits wild type p53-triggered apoptosis but not G1

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cell cycle arrest and transactivation of WAF1 and Bax.. Cell Growth & Diff., 1995, 6, 1071-1075. 1138) Axelson, H., Henriksson, M., Wang, Y., Magnusson, K. .P. & Klein, G., The Amino-terminal Phosphorylation ites of C-MYC are Frequently Mutated in Burkitt's Lymphoma Lines but not in Mouse Plasmacytomas and Rat Immunocytomas. European Journal of Cancer, 1995, 31A, 2099-2104. 1139) Kashuba, V. .I., Szeles, A., Allikmets, R., Nilsson, A.S., Bergerheim, U. .S. .R., Modi, W., Grafodatsky, A., Dean, M., Stanbridge, E. .J., Winberg, G., Klein, G. & Zabarovsky, E. .R., A group of Not1 jumping and linking clones cover 2.5 Mb in the 3p21-p22 region suspected to contain a tumor suppressor gene. Cancer Genet Cytogenet, 1995, 81, 144-150. 1140) Szekely, L., Wang, Y., Klein, G. & Wiman, K. .G., RB-reconstituted human retinoblastoma cells form RB-positive intraocular and intracerebral but not subcutaneous tumors in SCID mice. Int J Cancer, 1995, 61, 683-691. 1141) Szekely, L., Jiang, W. .Q., Pokrovskaja, K., Wiman, K. .G., Klein, G. & Ringertz, N., Reversible nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 and hsp70 proteins after exposure to heat shock or cell density congestion. Journal of General Virology, 1995, 76, 2423-2432. 1142) Wennborg, A., Classon, M., Klein, G. & von Gabain, A., Downregulation of c-myc expression after heat shock in human B-cell lines is independent of 5' mRNA sequences. Biol. Hoppe-Seyler, 1995, 376, 671-680. 1143) Talmadge, C. .B., Zhen, G.-K., Wang, J.-Y., Berglund, P., Li, B.-F., Weston, M. .D., Kimberlling, W. .J., Zabarovsky, E. .R., Stanbridge, E. .J., Klein, G. & Sumegi, J., Construction and characterization of a NotI linking library from human chromosome region 1q25-qter. Genomics, 1995, 29, 105-114. 1144) Klein, G., Om värderelativismen. OBS! i Sveriges Radio P1 den 13 oktober 1995. 1145) Sugiyama, H., Silva, S., Wang, Y. & Klein, G., Strain-related celular mechanisms as a determinant for susceptibility and resistance to PC induction.. Curr.Top.Microbiol.Immunol., 1995, 194, 93-97. 1146) Chen, F., Hu, L. .F., Christensson, B., Zheng, X., Ernberg, I., Klein, G. & Winberg, G., Coupled transcription of Epstein-Barr virus latent membrane protein LMP1 and LMP2B genes in NPC. J Gen Virol, 1995, 76, 131-138. 1147) Klein, G., B-cell neoplasia in a developmental framework.

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Int J Dev Biol, 1995, 39, 713-718. 1148) Lennette, E. .T., Winberg, G., Yadav, M., Enblad, G. & Klein, G., Antibodies to LMP2A/2B in EBV-carrying malignancies.. European Journal of Cancer, 1995, 31A, 1875-1878. 1149) von Gabain, A., Eisenstadt, S...N... & Klein, G., Political influences on the content and pursuit of science in dictatorship and democracy. DAS GANZE UND SEINE TEILE, Europäisches Forum Alpbach 1995, 1996, , 88-106. 1150) Contreras-Brodin, B., Karlsson, A., Nilsson, T., Rymo, L. & Klein, G., B cell-specific activation of the Epstein-Barr virus-encoded C promoter compared with the wide-range activation of the W promoter. J General Virol, 1996, 77, 1159-1162. 1151) Szeles, A., Bajalica-Lagercrantz, S., Lindblom, A., Lushnikova, T., Kashuba, V. .I., Imreh, S., Nordenskjöld, M., Klein, G. & Zabarovsky, E. .R., Mapping of a new MAP kinase activated protein kinase gene (3PK) to human chromosome band 3p21.2 and ordering of 3PK and two cosmid markers in the 3p22-p21 tumour-suppressor Region by two-colour fluorescence in situ hybridization. Chromosome Research, 1996, 4, 310-313. 1152) Ehlin-Henriksson, B., Klein, G. & Patarroyo, M., Differential expression of integrins and other adhesion molecules on blood and tonsil B (CD19+) lymphocytes. In Leukocyte typing 5, 2 (Schlossman et al (eds)), pp. 1604-1605, Oxford University Press, 1995. 1153) Allikmets, R., Kashuba, V., Modi, W., Kisselev, L., Dean, M., Huebner, K., Klein, G. & Zabarovsky, E...R..., Mapping of 25 NOTI linking clones on human chromosome 3 by PCR and somatic cell hybrid panels. Chromosome Research, 1996, 4, 33-37. 1154) Bergerheim, U...S...R..., Söderhäll, M., Zabarovsky, E., Franzen, B., Manneborg-Sandlund, A., Chunde, L., Jacobson, S...H., Auer, G., Klein, G. & Collins, P., Genotypic and phenotypic characterization of two new established renal cell carcinoma (RCC) cell lines. Cancer Genet. Cytogenet, 1996, 86, 95-101. 1155) Gunven, P., Öst, Å. & Klein, G., Kan lymfom botas med antibiotika? Läkartidningen, 1996, 93, 767-768. 1156) Klein, G., EBV-B Cell interactions: Immortalization, rescue from apoptosis, tumorigenicity. Acta Microbiologica et Immunologica Hungarica, 1996, 43, 97-105. 1157) Avila-Carino, J., Lewin, N., Tomita, Y., Szeles, A., Sandlund, A., Mosolits, S., Mellstedt, H., Klein, G. & Klein, E., B-CLL cells with unusual properties. Int.J.Cancer, 1996, 67,

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1-8. 1158) Klein, G., Tumor Suppressor Genes: Specific Classes.. Encyclopedia of Cancer, 1996, III, 1940-1967. 1159) Wang, Q., Hu, L. .F., Chen, F., Wang, Y., Magnusson, K. .P., Kashuba, E., Klein, G. & Wiman, K. .G., Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma.. Oral Oncol, Eur J Cancer, 1995, 31B, 328-332. 1160) Pokrovskaja, K., Ehlin-Henriksson, B., Bartkova, J., Bartek, J., Scuderi, R., Szekely, L., Wiman, K...G. & Klein, G., Phenotype-related Differences in the Expression of D-Type Cyclins in Human B Cell-derived Lines. Cell Growth & Differentiation, 1996, 7, 1723-1732. 1161) Zabarovsky, E. .R., Kashuba, V., Gizatullin, R., Winberg, G., Zabarovska, V., Erlandsson, R., Domninsky, D. .A., Bannikov, V. .M., Pokrovskaya, E., Kholodnyuk, I., Petrov, N., Zakharyev, V. .M., Kisselev, L. & Klein, G., Not 1 Jumping and Linking Cloes as a Tool for Genome Mapping and Analysis of Chromosome Rearrangements in Different Tumors.. Cancer Detection and Prevention, 1996, 20(1), 1-10. 1162) Protopopov, A., Gizatullin, R. .Z., Vorobieva, N. .V., Protopopova, M. .V., Kiss, C., Kashuba, V. .I., Klein, G., Kisselev, L. .L., Graphodatsky, A. .S. & Zabarovsky, E. .R., Human chromosome 3: high-resolution fluorescence in situ hybridization mapping of 40 unique NOT1 linking clones homologous to genes and cDNAs.. Chromosome Research, 1996, 4, 443-448. 1163) Protopopova, M. .V., Vorobieva, N. .V., Protopopov, A. .I., Gizatullin, R. .Z., Kashuba, V. .I., Klein, G., Zabarovsky, E. .R. & Graphodatsky, A. .S., Assignment of the ERM gene (ETV5) coding for the ets-related protein to human chromosome band 3q28 by in situ hybridization.. Cytogenet Cell Genet, 1996, 74, 220-. 1164) Gizatullin, R. .Z., Protopopov, A. .I., Zabarovska, V., Zakharyev, V. .M., Kashuba, V. .I., Klein, G. & Zabarovsky, E. .R., Assignment of MOBP, encoding myelin_associated oligodendrocytic basic protein, to human chromosome bands 3p22>p21.3 using somatic cell hybrids.. Cytogenet Cell Genet, 1996, 74, 291-292. 1165) Wei, M. .H., Latif, F., Bader, S., Kashuba, V., Chen, Y. .Y., Duh, F. .M., Sekido, Y., Lee, C. .C., Geil, L., Kuzmin, I., Zabarovsky, E. .R., Klein, G., Zbar, B., Minna, J. .D. & Lerman, M., Construction of a 600-Kilobase Cosmid Clone Contig and Generation of a Transcriptional Map Surrounding the Lung Cancer

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Tumor Suppressor Gene (TSG) Locus on Human Chromosome 3p21.3: Progress toward the Isolation of a Lung Cancer TSG.. Cancer Research, 1996, 56, 1487-1492. 1166) Sithanandam, G., Latif, F., Duh, F.-M., Bernal, R., Smola, U., Li, H., Kuzmin, I., Wixler, V., Geil, L., Shrestha, S., Lloyd, P. .A., Bader, S., Sekido, Y., Tartof, K., Kashuba, V. .I., Zabarovsky, E. .R., Dean, M., Klein, G. & et al, ., 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the smal cel lung cancer tumor suppressor gene region.. Molecular and Cellular Biology, 1996, 16, 868-876. 1167) Hu, L. .F., Eiriksdottir, G., Lebedeva, T., Kholodniouk, I., Alimov, A., Chen, F., Luo, Y., Zabarovsky, E. .R., Ingvarson, S., Klein, G. & Ernberg, I., Loss of heterozygosity on chromosome arm 3p in nasopharyngeal carcinoma. Genes, Chromosomes & Cancer, 1996, 17, 118-126. 1168) Silva, S., Babonits, M. & Klein, G., Ig/myc translocations of the plasmacytoma-prone BALB/c strain occur independently of the genetic and parental origin of the affected chromosomes 6, 12, and 15. Genes, Chromosomes & Cancer, 1996, 17, 179-184. 1169) Klein, G., Book Review of "Racing to the Beginning of the Road: The Search for the Origin of Cancer" by Robert A. Weinberg.. Science, 1997, 275, 36-. 1170) Silva, S., Wang, Y., Babonots, M., Imreh, S., Wiener, F. & Klein G, ., Spontaneous Development of Plasmacytomas in a Select Subline of BALB/cJ Mice. European Journal of Cancer, 1997, 33, 479-485. 1171) Imreh, S., Szekely, L., Wiman, K. .G. & Klein, G., Oncogenes and tumor suppressor genes, a practical approach.. In In: Mechanisms of Oncogene perturbatin in Frontiers in Molecular Biology. (Gordon Peters & Karen Vousden (Eds.)), pp. 4-31, Oxford University Press, 1997. 1172) Kholodnyuk, I., Kost-Alimova, M., Kashuba, V., Gizatullin, R., Szeles, A., Stanbridge, E. .J., Zabarovsky, E. .R., Klein, G. & Imreh, S., A 3p21.1 Region is Preferentially Eliminated from Human Chromosome 3/mouse Microcell Hybrids During Tumour Growth in SCID Mice.. Genes, Chromosomes and Cancer, 1997, 18, 200-211. 1173) Wang, Q., Kashuba, E., Magnusson, K. .P., Pokrovskaja, K., Okan, I., Klein, G. & Wiman, K. .G., Role of p53 mutation in polyomavirus-induced tumorigenesis.. J Gen Virol, 1997, 78, 893-903. 1174) Laytragoon-Lewin, N., Chen, F., Avila-Carino, J., Klein, G. & Mellstedt, H., Epstein-Barr virus (EBV) gene expression in lymphoid B cells during acute infectious mononucleosis (IM) and clonality of the directly growing cell lines. Int J Cancer, 1997, 71, 345-349. 1175) Klein, G., Commentary.Rejection antigens in chemically

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induced tumors.. Proc Natl Acad Sci USA, 1997, 94, 5991-5992. 1176) Wiman, G. .K. & Klein, G., An old acquaintance resurfaces in human mesothelioma. Nature Medicine, 1997, 3, 16-17. 1177) Imreh, S., Szekely, L., Wiman, K. .G. & Klein, G., Mechanisms of oncogene perturbation. In Oncogenes and tumour suppressors (Peters G and Vousden K), pp. 3-32, IRL Press at Oxford University Press, Oxford New York Tokyo, 1997. 1178) Klein, G., Malign Evolution. Commentary.. Discover, 1997, 46. 1179) Yamasaki, T., Akiyama, Y., Fukuda, M., Kimura, Y., Moritake, K., Kikuchi, H., Ljuanggren, H.-G., Kärre, K. & Klein, G., Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression. Int J Cancer, 1996, 67, 365-371. 1180) Suemgi, J., Wang, J.-Y., Zhen, D.-K., Eudy, J. .D., Talmadge, C. .B., Li, B.-F., Berglund, P., Weston, M. .D., Yao, S.-F., Ma-Edmonds, M., Overbeck, L., Kelley, P. .M., Zabaraovsky, E., Uzvolgyi, E., Stanbridge, E. .J., Klein, G. & Kimberling, W. .J., The construction of a yeast artificial chromosome (YAC) contig in the vicinity of the Usher syndrome type IIa (USH2A) gene in 1q41.. Genomics, 1996, 35, 79-86. 1181) Lanyi, A., Li, B.F., Li, S.B., Talmadge, C. .B., Brichacek, B., Davis, J. .R., Kozel, B. .A., Trask, B., van den Engh, G., Uzvolgyi, E., Stanbridge, E. .J., Nelson, D. .L., Chinaualt, C., Heslopo, H., Gross, T. .G., Seemayer, T. .A., Klein, G., Purtilo, D. .T. & Sumegi, J., A yeast artificial chromosome (YAC) contig encompassing the critical region of the X-linked lymphoproliferative disease (XLP locus.. Genomics, 1997, 39, 55-65.

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1182) Nalesnik, M. .A., Rao, A. .S., Zeevi, A., Fung, J. .J., Pham, S., Furukawa, H., Gritsch, A., Klein, G. & Starzl, T. .E. Autologous lymphokine-activated killer cell therapy of lymphoproliferative disorders arising in organ transplant recipients.. Transplantation Proc., 1997, 29, 1905-1906. 1183) Nalesnik, M. .A., Rao, A. .R., Furukawa, H., Pham, S., Zeevi, A., Fung, J. .J., Klein, G., Gritsch, A., Elder, E., Whiteside, T. .L. & Starzl, T. .E., Autologous lymphokine-activated killer cell therapy of Epsten-Barr virus positive- and negative lymphoproliferative disorders arising in organ transplant recipients.. Transplantation, 1997, 63, 1200-1205. 1184) Trivedi, P., Winberg, G. & Klein, G., Differential immunogenicity of Epstein-Barr virus (EBV) encoded growth transformation-associated antigens in a murine model system.. European Journal of Cancer, 1997, 33, 912-917. 1185) Klein, G., Remembering George Snell.. Immunogenetics, 1997, 46, 2. 1186) Wen, T., Kono, K., Shahinian, A., Kiessling, R., Mak, T. .W. & Klein, G., CD28 is not required for rejection of unmanipulated syngeneic and autologous tumors. Eur J Immunol, 1997, 27, 1988-1993. 1187) Jiang, W-Q., Szekely, L., Klein, G., Ringertz, N. Intranuclear Redistribution of SV40T, p53, and PML in a Conditionally SV40T-Immortalized Cell Line. Experimental Cell Research, 1996, 229, 289-300. 1188) Szekely, L., Pokrovskaja, K., Klein, G. Differential expression of nucleoskeleton and cytoskeleton associated proteins in Burkitt lymphoma derived and Epstein-Barr Virus immortalized lymphoblastoid cell lines. Cell Growth & Differentiation, 1997, 8:599-609. 1189) Pokrovskaja, K., Trivedi, P., Klein, G. and Szekely, L. Epstein-Barr virus-encoded LMP1 protein upregulates the pNDCF group of nucleoskeleton-cytoskeleton-associated proteins. Journal of General Virology, 1997, 78, 2031-2040. 1190) Klein, G. Foulds´Dangerous Idea Revisited: The Multistep Development of Tumors 40 Years Later. Advances in Cancer Research, 1997, vol.72, 2- 23. 1191) Klein, G., Klein, E. Epstein-Barr Virus and Human Lymphomas. The Lymphomas, (Eds. Canellos GP, Lister TA and Sklar, JL) W B Saunders Company, 1997, 63-73.

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1192) Lushnikova, T., Szeles, A., Kiss, C., Gizatullin, R.Z., Kashuba, V., Kelve, M., Zakharyev, V.M., Winberg, G., Klein, G. & Zabarovsky, E.R. Regional localisation on human chromosome 3 of four Notl clones with expressed sequences, including the arh12 gene, using FISH and a panel of hybrid cell lines. Acta Medicia Lituanica, 1997, Suppl.1, 43-47. 1193) Fedorova, L., Kost-Alimova, M., Gizatullin, R.Z., Alimov, A., Zabarovska, V., Szeles, A., Protopopov, A., Vorobieva, N.V., Kashuba, V., Klein, G., Zelenin, A.V., Sheer, D. & Zabarovsky E.R. Assignment and ordering of twenty-three unique Notl-linking clones containing expressed genes including the guanosine 5´-monophospate synthetase gene to human chromosome 3. Eur. J. Human Genetics, 1997, 5:110-116. 1194) Imreh, S., Kost-Alimova, M., Kholodnyuk , I., Ying, Y., Szeles, A., Kiss, H., Liu, Y., Foster, K., Zabarovsky, E., Stanbridge, E. & Klein, G., Differential elimination of 3p and retention of 3q segments in human/mouse microcell hybrids during tumor growth. Genes Chromosomes & Cancer, 1997, 20: 224-233. 1195) Klein, G. Vetenskapens skuld? Moderna Tider, 1997, 85: 33-35. 1196) Klein, G. Tumörbiologi i sociohistorisk vinkling. Läkartidningen, 94: nr 44, 3986-3988. 1197) Szekely, L., Klein, G. Multiple myeloma and Kaposi´s sarcoma-associated herpesvirus - a paracrine model of tumorigenesis? Trends in Microbiology, 1997, 5:424-426. 1198) Enblad, G., Sandvej, K., Lennette, E., Sundström, C., Klein, G., Glimelius, B., Pallesen, G. Lack of correlation between EBV serology and presence of EBV in the Hodgkin and Reed-Sternberg cells of patients with Hodgkin´s disease. Int.J.Cancer, 1997, 72: 394-397. 1199) Klein, G. Review of the book Old Wine, New Flasks: Reflections on Science and Jewish Tradition, by Roal Hoffman and Shira Leibowitz Schmidt. Nature, 1997, 390: 354-355. 1200) George Klein and Edward Shorter: Discussion on the nature and origin of psychosomatic symptoms. Scand J Work Environ Health, 1997, 23 suppl.3:105-112. 1201) Klein G. Det naturliga urvalet och cancerns utveckling. Forskning och Framtid, 1998, nr 1, 21-25. 1202) Szeles, A., Yang, Y., Mannerborg-Sandlund, A., Kholodnyuk, I., Kiss, H., Kost-Alimova, M., Zabarovsky, E.R., Stanbridge, E., Klein, G., Imreh, S. Human/Mouse Microcell Hybrid Based Elimination Test Reduces the Putative Tumor Suppressor Region at 3p21.3 to 1.6 cM. Genes, Chromosomes & Cancer, 1997, 20:329-336. 1203) Klein, G., Klein, E. Torbjörn Caspersson – Georg och Eva Kleins läromästare. En vägvisare till cellernas och Sveriges inre värld. Läkartidningen, 1998, 95: 11 februari, 654-658.

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1204) Fisch, P., Meuer, E., Pende, D., Rothenfusser, S., Viale, O., Kock, S., Ferrone, S., Fradelizi, D., Klein, G., Motetta, L., Rammensee, G., Boon, T., Coulie, P., van der Bruggen, P. Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vγ9/Vδ2 T cells in tumor immunity. Eur. J. Immunol. 1997, 27:3368-3379. 1205) Mukherjee, S., Trivedi, P., Dorfman, D., Klein, G., Townsend, A. Murine Cytotoxic T Lymphocytes Recognize an Epitope in an EBNA-1 Fragment, but Fail to Lyse EBNA-1-expressing Mouse Cells.. J. Exp. Med. 1998, 187:445-456. 1206) Ehlin-Henriksson, B., Björck, P., Paulie, S., Klein, G., Patarroyo, M. Differential expression of adhesion molecules on resting and activated tonsil cells. Restoration of L-selectin expression by activation with anti-CD40 plus IL-4. Leukocyte typing VI, ed Kishimoto T et al, Garland Publishing, New York 1997. 1207) Szekely, L., Chen, F., Teramoto, N., Ehlin-Henriksson, B., Pokrovskaja, K., Szeles, A., Manneborg-Sandlund, A., Löwbeer, M., Lennette, E.T., Klein, G. Restricted expression of Epstein-Barr virus (EBV)-encoded, growth transformation-associated antigens in an EBV- and human herpesvirus type 8-carrying body cavity lymphoma line. Journal of General Virology, 1998, 79, 1445-1452. 1208) Georg Klein, Varför tiger läkarna i humangen-etiska Frågor? Nordisk Medicin, nr 5, sid 170, 1998. 1209) Kiss, C., Li, J., Szeles, A., Gizatullin, R.Z., Kashuba, V., Lushnikova, T., Protopopov, A., Kelve, M., Kiss, H., Kholodnyuk, I., Imreh, S., Klein, G., Zabarovsky, E.R. Assignment of the ARHA and GPX1 genes to human chromosome bands 3p21.3 by in situ hybridization and with somatic cell hybrids. Cytogenetics and Cell Genetics, 1997, 79:228-230. 1210) Berke, Z., Mellin, S., Heidari, S., Wen, T., Berglöf, A., Klein, G., Dalianis, T. Adult X-linked immunodeffciency (XID) Mice, IGM -/- single knockout and IGM-/- CD8-/- double knockout mice do not clear polyomavirus infection. in vivo, 1998, 12: 143-148. 1211) Klein G. Fjärilars bedrägliga prakt och männiksans SÖTA LÖGNER. Moderna Tider, juni 1998, 32-36. 1212) Laytragoon-Lewin, N., Kashuba, V., Mellstedt, H., Klein, G. bcl-2 rearrangement detected by pulsed-field gel electrophoresis (PFGE) in B-chronic lymphocytic leukemia (CLL) cells. Int.J. Cancer, 1998, 76, 909-912. 1213) Klein, G. Dysregulation of B lymphocytes by chromosomal translocations and auxiliary changes associated with malignant transformation. The International Symposium on Immunoglobulin Genes and B Lymphocytes. Edited by Tasuku Honjo. 1998. 183-189. 1214) Teramoto, N., Szekely, L., Pokrovskaja, K., Hu, L-F., Toshino, T., Akagi, T., Klein, G.

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Simultaneous detection of two independent antigens by double staining with two mouse monoclonal antibodies. Journal of Virological Methods, 1998, 73:89-97. 1215) Wen, T., Trümper, L., Fung-Leung, W., Rahemtulla, A., Klein, E., Klein, G. Requirement of the CD8+ or CD4+ T lymphocyte subsets for the rejection of lymphoma and fibrosarcoma grafts studied in gene knockouts hosts. Immunology Letters, 1998, 61: 187-190. 1216) Klein, G., Friberg, S. Tumörbiologi I: Cancergener, suppressorgener och den maligna flerstegsevolutionen.Onkologi, Liber AB, Stockholm 1998, 35-50. 1217) Klein, G and Klein E. Sinking surveillance´s flagship. Nature, 1998, 395:441-442. 1218) Klein, G. Immunoglobulin gene associated chromosomal translocations in B-cell derived tumors. Workshop on the mechanisms of B cell neoplasia. In Current Topics of Microbiology and Immunology. 1999, Vol 246. 1219) Nagy, N., Vánky, F., Klein, E. Tumor surveillance: expression of the transporter associated with antigen processing (TAP-1) in ex-vivo human tumor samples and its elevation by in vitro treatment with IFN-γ and TNF-α Immunology Letters, 1998, 64:153-160.. 1220) Teramoto, N., Szekely, L. & Klein, G., Differential expression and localization of EBER-1 and EBER-2 in Epstein-Barr virus- carrying cells. J. Human Virol, 1998, 1:307-313. 1221) Klein, G. EBV and B Cell Lymphomas, Herpesviruses and Immunity, 1998, edited by Medveczky et al. Plenum Press, New York, 165-189. 1222) Klein, G. Introduction. Post-transplantation lymphoproliferative disease. In: Springer Semin. In Immunopathol, 1998 20:319-323. 1223) Magnusson, K., Satalino, R., Wang, Q., Klein, G. & Wiman, K.G., Is conversion of solid into more anoxic ascites tumors associated with p53 inactivation? Oncogene, 1998, 17, 2333-2337. 1224) Klein György. Rosszindulatú daganatok több lépésben végbemenö kialakulása. fizikai szemle 1999/2, 40-43. 1225) Alimova-Kost, M., Imreh, S., Buchman, V., Ninkina, N. Assigment of phosphotriesterase-related gene (PTER) to human chromosome band 10p 12by in situ hybridization. Cyt. Cell Gen. 1998, 83:16-17. 1226) Nagy, N., Vanky, F. Transforming growth factor β, (TGFβ) secreted by immunogenic ex vivo human carcinoma cell, counteracts the activation and inhibits the function of autologous cytotoxic lymphocytes. Pretreatment with interferon γ and tumor necrosis factor α reduces the production of active TGFβ. Cancer Immunol. Immunother, 1998, 45: 306-312. 1227) Klein, G. Die sieben ”Gen-Welten” des Zell-Zyklus. Robert Koch Stiftung e.V. Beiträge und Mitteilungen. 1999, 23:39-43.

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1228) Pokrovskaja, K., Okan, I., Kashuba, E., Lowbeer, M., Klein, G., Szekely, L. Epstein-Barr virus infection and mitogen stimulation of normal B cells induces wild-type p53 without subsequent growth arrest or apoptosis. J. Gen. Vir. 1999, 80:987-995. 1229) Alimov, A., Rodova, M., Gizatullin, R., Kost-Alimova, M., Fedorova, L., Barsky, E., Kashuba, V., Klein, G., Zabarovsky, E., Zelenin, A. A micro-dissection approach for isolation of NotI linking clones from regions frequently deleted in RCC and SCLC. Genetic Analysis, 1997, 14:21-23. 1230) Kashuba, V., Gizatullin, R., Protopopova, A., Allikmets, R., Korolev, S., Li, J., Boldog, F., Tory, K., Zabarovska, V., Marcsek, Z., Sumegi, J., Klein, G., Zabarovsky, E., Kisselev, L. NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors. FEBS Letters, 1997, 181-185. 1231) Teramoto, N., Pokrovskaja, K., Szekely, L., Polack, A., Yoshino, T., Akagi, T., Klein, G. Expression of cyclin D2 and D3 in lymphoid lesions. Int.J.Cancer, 1999, 81: 543-550. 1232) Klein, G. Véletlenek sorozata: A koreai repülögép és a rák. fixikai szemle, 1998, 12, 411-413. 1233) Szeles, A., Falk, K., Imreh, S., Klein, G. Visualization of alternative Epstein-Barr virus expression programs by fluorescent in situ hybridization at the cell level. J. Virol. 1999, 73:5064-5069. 1234) Kashuba, E., Pokrovskaja, K., Klein, G., Szekely, L. Epstein-Barr virus-encoded nuclear protein EBNA-3 interacts with the ε-submit of the T-complex protein 1 chaperonin complex. J.Human Virol. 1999, 2:33-37. 1235) Holmgren, L., Szeles, A., Rajnavölgyi, E., Folkman, J., Klein, G., Ernberg, I., Falk, K. Horizontal Transfer of DNA by the uptake of apoptotic bodies. Blood, 1999, 93:3956-3963. 1236) Li, J., Protopopov, A., Gizatullin, R., Kiss, C., Kashuba, V., Winberg, G., Klein, G., Zabarovsky, E. Identification of new tumor suppressor genes based on in vivo functional inactivation of a candidate gene. FEBS Letters, 1999, 289-294. 1237) Klein, G. The tale of the great cuckoo egg. Nature, 1999, 400:515. 1238) Klein G. Var nazisterna föregångare i kampen mot cancer? Svenska Dagbladet, 1999. 1239) Ehlin-Henriksson, B., Zou, J-Z., Klein, G., Ernberg, I. Epstein-Barr virus genomes are found predominantly in IgA-positive B cells in the blood of healthy carriers. Int. J. Cancer, 1999, 83:50-54.

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1240) Silva, S., Klein, G. Plasmacytoma induction in specific pathogen-free (SPF) bcl-2 transgenic BALB/c mice. Current Topics in Microbiology and Immunology, 1999, 246: 379-385. 1241) Kiss H., Kedra, D., Yang Y., Kost-Alimova, M., Kiss, C., O´Brien, K.P., Fransson, I., Klein,G., Imreh, S., Dumanski, J.P. A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. Human Genetics, 1999, 105:552-559. 1242) Szekely, L., Kiss, C., Mattsson, K., Pokrovskaja, K., Juhasz, A., Holmvall, P-. Klein, G. Human Herpesvirus-8-encoded LNA-1 accumulates in heterochromatin-associated nuclear bodies. J Gen Virol, 1999, 80:2889-2900. 1243) Liu J, Zabarovska VI, Braga E, Alimov A, Klein G, Zabarovsky ER. Loss of heterozygosity in tumor cells requires re-evaluation: the data are biased by the size-dependent differential sensitivity of allele detection. FEBS Lett 1999; 462:121-128.

1244) Kashuba V.I., Gizatullin R.G., Protopopov A.I., Li J., Vorobieva N.V., Fedorova L., Zabarovska V.I., Muravenko O.V., Kost-Alimova M., Zakharyev V.M., Domninsky D.A., Kiss C., Allikmets R.L., Zakharyev V.M., Braga E.A., Sumegi J., Lerman M., Zelenin A.V., Sheer D., Winberg G., Grafodatsky A., Kisselev L.L., Klein G. Zabarovsky E.R.,: Analysis of NotI linking clones isolated from human chromosome 3 specific libraries. Gene. 1999, 239: 259-271. 1245) Peterson, M., Charo, J., Salazar-Onfray, F., Noffz, G., Mohaupt, M., Qin, Z., Klein, G., Blankenstein, T., Kiessling, R. Constitutive IL-10 production accounts for the high NK sensitivity, low MHC class I expression, and poor transporter associated with antigen processing (TAP) –1/2 function in the prototype NK target YAC-1.Journal of Immunology, 1998, 161:2099-2105. 1246) Yang, Y., Kiss, H., Kost-Alimova, M., Kedra, D., Fransson, I., Seroussi, E., Li, J., Szeles, A., Kholodnyuk, I., Imreh, P., Fodor, K., Hadlaczky, G., Klein, G., Dumanski, J., Imreh, S. A one megabase PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors. Genomics 1999, 62, 147-155. 1247) Charo, J., Ciuptu, A-M., Le Chevalier de Préville, A., Trivedi, P., Klein, G., Hinkula, J., Kiessling, R. A long-term memory obtained by genetic immunization results in full protection from a mammary adeno-carcinoma expressing an Epstein-Barr virus (EBV) gene. J, Immunol, 1999, 163:5913- 5919. 1248) Alimov, A., Chunde, L., Gizatullin, R., Fredriksson, V., Sundelin B., Klein, G., Zabarovsky, E., Bergerheim, U. Somatic mutation and homozygous deletion of PTEN/MMCA1 gene at 10q23 in renal cell carcinoma. Anticancer Research, 1999, 19:3841-3846.

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1249) Kashuba, E., Kashuba V., Pokrovskaja, K., Klein, G., Szekely, L. Epstein-Barr virus encoded nuclear protein EBNA-3 binds XAP-2, a protein associated with Hepatitis B virus X antigen. Oncogene, 2000, 19:1801-1806. 1250) Klein, G. Dysregulation of lymphocyte proliferation by chromosomal translocations and sequential genetic changes. BioEssays, 2000, 22: 414-422. 1251) Klein G. Virusok Jeruzsálemben. KORUNK, 2000, 34-42. 1252) ) Trivedi, P., Cuomo, L., Christensson B., Hu, L-F., Morrone, S., Frati, L., Faggioni, A., Winberg, G., Klein, G. Augmentation of leukocyte infiltration in murine tumors expressing B-cell derived but not nasopharyngeal carcinoma derived EBV membrane protein LMP1. J. Med. Virol. 2000, 60:417-424. 1253) Teramoto N., Maeda, A., Kobayashi, K., Hayashi, K., Oka, T., Takahashi, K., Takada, K., Klein, G., Akagi, T. Epstein-Barr virus infection to Epstein-Barr virus-negative nasopharyngeal carcinoma cell line TW03 enhances its tumorigenicity. Laboratory Investigation, 2000, 80 (3):303-312. 1254) Klein, G. Ökad förståelse för cancercellers biologi. Läkartidningen, 2000, 97:3260-3264. 1255) ) Zabarovska, V., Li, J., Fedorova, L., Muravenko, O., Braga, E., Ernberg, I., Wahlstedt, C., Klein, G., Zabarovsky, E. CIS - cloning of identical sequences between two complex genomes. Chromosome Research, 2000, 8: 77-84. 1256) Alimov, A., Kost-Alimova, M., Liu, J., Li, C., Bergerheim, U., Imreh, S., Klein, G., Zabarovsky, E.R. Combined LOH/CGH analysis proves the existence of interstitial 3p deletions in renal cell carcinoma. Oncogene, 2000, 19:1392-1399. 1257) Hu, L., Troyanosky, B., Zhang, X., Trivedi, P., Ernberg, I., Klein, G. Differences in the immunogenicity of latent membrane protein 1 (LMP1) proteins encoded by Epstein-Barr virus genomes derived from LMP1-positive and –negative nasopharyngeal carcinoma. Cancer Research, 2000, in press. 1258) Kashuba, V., Protopopov, A. ,Podowski, R., Gizatullin, Li, J., Klein, G., Wahlestedt, C., Zabarovsky, E.R. Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A). European Journal of Human Genetics, 2000, 8:407-413. 1259) Klein, G. Simian virus 40 and the human mesothelium. PNAS, 2000, 97:9830-9831. 1260) Teramoto, N., Gogolak, P., Nagy, N., Maeda, A., Kvarnung, K., Björkholm, M., Klein, E. Epstein-Barr virus- infected B-chronic lymphocyte leukemia cells express the virally encoded nuclear proteins but they do not enter the cell cycle. J Hum. Virology, 2000, 3:1-12. 1261) Klein, G. How it was discovered. MTC News, 2000, 27: 1, 2, 20, 21.

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1262) Hu, L-F., Troyanovsky, B., Zhang, X., Trivedi, P., Ernberg, I., Klein, G. Differences in the immunogenicity of latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus genomes derived from LMP1-positive and –negative nasopharyngeal carcinoma. Cancer Reseach, 2000, 60:5589-5593. 1263) Bejarano M.T., Albihn, A., Cornvik, T., Osterdahl Brijker, S., Asker, C., Osorio, L.M., Henriksson, M. Inhibition of cell growth and apoptosis by inducible expression of the transcriptional repressor Mad1. Experimental Cell Research, 2000, 260:61-72. 1264) Nagy, N., Cerboni, C., Mattson, K., Maeda, Akihiko., Gogolak, P., Sümegi, J., Lányi, Árpád., Szekely, L., Carbone, E., Klein, G., Klein, E. SH2D1A and SLAM protein expression in human lymphocytes and derived cell lines. Int. J. Cancer, 2000, 88:439-447. 1265) Pokrovskaja, K., Mattsson, K., Kashuba, E., Klein, G., Szekely, L. Proteasome inhibitor induces nucleolar translocation of EBV encoded EBNA-5. J. Gen. Virol. Online 31 October, 2000. 1266) Sumegi, J., Huang, D., Lanyi, A., Davis JD., Seemayer TA., Maeda, A., Klein, G., Seri, M., Wakiguchi H., Purtilo, DT., Gross TG. Correlation of mutations of the SH2D1A gene and Epstein-Barr virus infection with clinical phenotype and outcome in X-linked lymphoproliferative disease. Blood, 2000, 96: 3118-3125. 1267) Kashuba, V., Protopopov. A., Li, J., Klein, G., Zabarovsky, E. The 630 kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 tumor suppressor gene Consortium (Lermann M.I: and Minna J.D.) Cancer Res. 2000, 60:6116-6133. 1268) Lerman, M., Minna, J.D for The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium, including Kashuba, V., Protopopov, A., Li, J., Klein, G., Zabarovsky, E.., The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. Cancer Research, 2000, 60:6116-6133. 1269) Klein, G. Lysande, baktalad drottning. Liberal debatt, 2000, nr 5, 20-25, 1270) Kholodnyuk, I., Szeles, A., Yang, Y., Klein, G., Imreh, S. Inactivation of the Human FHIT gene at 3p14.2 in monochromosomal human/mouse microcell hybrid derived SCID mouse tumors. Cancer Research, 2000, 60: 7119-7125. 1271) George and Eva Klein, The scientist as a poet, Science Reviews, 2000, 25.256-260. 1272) Yang, Y., Kost-Alimova, M., Ingvarsson, S., Qianhui, Q., Kiss, H., Szeles, A., Kholodnyuk, I., Cuthbert, A., Klein, G., Imreh, I. Similar regions of human chromosome 3 are eliminated from, or retained in human/human and human/mouse microcell hybrids during tumor growth in severe combined immunodeficient (SCID) mice. PNAS, 2001, 98:1136-1141. 1273) Klein, G. Role of tumor viruses in human cancers. In Molecular Genetic Basis of Cancer. Edited by Maria Li Lung et al, 2001, 3-9. Hongkong.

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1274) Klein, G. Slumpens verk. Forskning & Framsteg, 2001, Nr.3, April, 24-27. 1275) Klein, G. The strange road to the tumor specific transplantation antigens (TSTAs). Cancer Immunity, 2001,1: 6-9. 1276) Klein, G. Are there uncharted regions of tumor suppressor genes? IUBMB Life, 2001, 51: 1-3. 1277) Dreijerink, K., Braga, E., Kuzmin, I., Geil, L., Duh, F-M., Angeloni, D., Zbar, B., Lerman, M., Stanbridge, E.J., Minna, J.D., Protopopov, A., Kashuba, V., Li, J., Klein, G., Zabarovsky, E. The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis. PNAS, 2001, 98:7504-7509. 1278) Klein, G., Klein, E. Whither Tumor Immunology? In: Background and Future of Cancer Immunotherapy, Sankyo Company, pp. 41-44, 2001. 1279) Klein,G. and Klein E. Bridge or ravine? Nature, 2001, 413:27 September, 365. 1280) Maeda, A., Kiss, C., Chen, F., Ehlin-Henriksson, B., Nagy, N., Szekely, L., Takada, K., Klein, E., Klein, G. EBNA promoter usage in EBV negative Burkitt lymphoma cell lines converted with a neomycin-resistant EBV strain. Int. J. Cancer, 2001, 93(5):714-719. 1281) Bandobashi, K., Maeda, A., Teramoto, N., Nagy, N., Szekely, L., Taguchi, H., Miyoshi, I., Klein, G., Klein, E. Intranuclear localization of the transcription coadaptor CBP/p300 and the transcription factor RBP-Jk in relation to EBNA-2 and –5 in B lymphocytes. J. Virology, 2001, 288:275-282. 1282) Klein,G. Multistep development. Encyclopedic Reference of Cancer, Manfred Schwab (Ed), Springer Verlag, 2001, 601-604. 1283) Klein G. PREFACE, Wiley Encyclopedia of Molecular Medicine, (John Wiley & Sons, Inc., New York) 1: v –vi, 2002. 1284)) Mattson, K., Kiss, C., Platt, G., Simpson, G., Kashuba, E., Klein, G., Schultz, T.F. Szekely, L. Latent nuclear antigen of Kaposi´s sarcoma herpesvirus/human herpesvirus -8 induces and relocates RING3 to nuclear heterochromatin regions. J. General Virology, 2002, 83:179-188, 2002. 1285) Klein, G. EBNA, Encyclopedia of Genetics. Editors S. Brenner and J.H. Miller, 2001, 559. 1286) Klein, G. Nasopharyngeal Carcinoma (NPC). Encyclopedia of Genetics. Editors S. Brenner and J.H. Miller, 2001, 1199. 1287) Klein, G. Epstein-Barr Virus (EBV). Encyclopedia of Genetics. Editors S. Brenner and J.H. Miller, 2001, 641-644. 1288) Maeda A., Bandobashi, K., Nagy, N., Teramoto, N., Gogolak, P., Pokrovskaja, K., Szekely, L., Björkholm, M., Klein, G., Klein, E. Epstein-Barr virus can infect B-chronic lymphocytic leukemia cells but it does not orchestrate the cell cycle regulatory proteins. Journal of Human Virology, 2001, 4:227-238.

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1289) Klein, G., Powers, A., Croce, C. Association of SV40 with human tumors. Oncogene, 2002, 21:1141-1149. 1290) Mattsson K., Pokrovskaja, K., Klein, G., Szekely, L. Proteins associated with the PML-containing nuclear body move to the nucleolus upon inhibition of proteasome-dependent protein degradation. PNAS, 2001, 98:1012-1017. 1291) Klein, G. The discovery of EBNA. MTC News, 2002, 38:1-15. 1292) Liu A., Klein, G., Bandobashi, K., Klein, E., Nagy, N. SH2D1A expression reflects activation of T and NK cells in cord blood lymphocytes infected with EBV and treated with the immunomodulator PSK. Immunology Letters, 2002, 80:181-188. 1293) Kiss, H., Kedra, D., Kiss, C., Kost-Alimova, M, Klein, G., Imreh, I., Dumanski, P. The LZTFL1 gene is a part of transcriptional map covering 250kb within the common eliminated region 1 (C3CER1) in 3p21.3. Genomics, 2001, 73:10-19 1294)Kassis, J., Maeda, A., Teramoto N., Takada, K., Wu, C., Klein, G., Wells, A. EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness. Int. J Cancer, 2002, 10 April, online. 1295) Kiss H., Yang, Y., Kiss, C., Andersson, K., Klein, G., Imreh, S., Dumanski, J.P. The transcriptional map of the common eliminated region 1 (C3CER1) in 3p21.3. Eur. J Human Genetic, 2002, 10:52-61. 1296) Kiss, C., Kost-Alimova, M., Klein, G., Szekely, L. Optimization of the degenerate oligonucleotide primed PCR (DOP-PCR) for capillary thermocycler. The analysis of DOP-PCR priming. Biomolecular Engineering, 2002, 19(1): 31-34. 1297) Li, J., Protopopov, A., Wang, F., Sentchenko, V., Petushkov, V., Vorontsova, O., Petrenko, L., Zabarovska, V., Muravenko, O., Braga, E., Kisselev, L., Lerman, M., Kashuba, V., Klein, G., Ernberg, I., Wahlestedt, C., Zabarovsky, E. NotI subtraction and Not I-specific microarrays to detect copy number and methylation changes in whole genomes. PNAS, 2002, 99:10724-10729. 1298) Protopopov, A., Li, J., Winberg, G., Gizatullin, R., Kashuba, V., Klein, G., Zabarovsky, E. Human cell lines engineered for tetracycline-regulated expression of tumor suppressor candidate genes from a frequently affected chromosomal region 3p21. The Journal of Gene Med, 2002, 4:397-406. 1299) Klein G. Tumor suppressor genes: specific classes. Encyclopedia, of Cancer, 2002,4:491– 499. 1300) Klein, G. Introduction, “Genetic and Epigenetic Contributions to Tumor Evolution” Seminars in Cancer Biology, 2002, 12:327-330. 1301) Nagy, N., Maeda, A., Bandobashi, K., Kis, L., Nishikawa, J., Trivedi, P., Faggioni, A., Klein, G., Klein, E. SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive

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group I lines and is downregulated in parallel with immunoblastic transformation. Int. J Cancer, 2002, 100:433-440. 1302) Braga, E., Bazov, I., Senchenko, V., Loginov, V., Liu, J., Ermilova, V., Kazubskaya, T., Garkavtseva, R., Mazurenko, N., Kisseljov, F., Lerman, M., Klein, G., Kisselev, L., Zabarovsky, E. Critical tumor-suppressor gene regions on chromosome 3p in major human epithelial malignancies: allelotyping and quantitative real-time PCR. Int J Cancer, 2002, 10:534-541. 1303) Zetterberg, H., Jansson, A., Rymo, L., Chen, F., Karlsson, A., Klein, G., Brodin, B. The Epstein-Barr virus ZEBRA protein activates transcription from the early lytic F promoter by binding to a promoter-proximal AP-1-like site. J Gen Vir., 2002, 83:2007-2014. 1304) Kholodnyuk I., Kost-Alimova M., Yang Y., Kiss H., Fedorova L., Klein G. and Imreh S. The Microcell Hybrid Based “Elimination Test” Identifies a 1-Mb Putative Tumor Suppressor Region at 3p22.2-p22.1 Centromeric to the Homozygous Deletion Region Detected in Lung Cancer. Genes, Chromosomes and Cancer, 2002, 34, 341-344. 1305) Kashuba, E., Kashuba, V., Sandalova, T., Klein, G., Szekely, L. Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. BMC Cell Biology, 2002, 3:23. 1306) Pokrovskaja, K., Ehlin.Henriksson, B., Kiss, C., Mattson, K., Klein, G., Szekely, L. CD40 ligation downregulates EBNA-2 and LMP-1 expression in EBV -transformed lymphoblastoid cell lines. Int. J. Cancer, 2002, 99, 705-712. 1307) Klein, G. Commentary: nasopharyngeal cancer, Seminars in Cancer Biology, 2002, 12:415-418. 1308) Kiss, H., Darai, E., Kiss, C., Kost-Alimova, M., Klein, G., Dumanski, J.P., Imreh, S. Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3. Human Genome, 2002, 13:646-55. 1309) Protopopov, A., Kashuba, V., Zabarovska, V., Muravenko, O., Lerman, M., Klein, G., Zabarovsky, E.R. An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3 (AP20) region implicated in major human epithelial malignancies. Cancer Research, 2003, 63:404 412. 1310) Ehlin-Henriksson, B., Gordon, J., Klein, G. B lymphocyte subpopulations are equally susceptible to Epstein-Barr virus-infection irrespective of immunoglobulin isotype expression. Immunology, 2003, 109, 1-4.

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1311) Kis, L., Nagy, N., Klein, G., Klein, E. Expression of SH2D1A in 5 classical Hodgkin´s disease-derived cell line. 2003, Int. J.Cancer, 104: 658-661. 1312) Yang, Y., Jingfeng, L., Szeles, A., Imreh, M.P., Kost-Alimova, M., Kiss, H., Kholodnyuk, I., Fedorova, L., Darai, E., Klein, G., Imreh, S. Consistent downregulation of human lactoferrin gene, in the common eliminated region 1 on 3p21.3, following tumor growth in severe combined immunodeficient (SCID) mice. Cancer Letters,2003, 191:155-164. 1313) Senchenko, V., Liu, L., Braga, E., Mazurenko, N., Loginov, W., Seryogin, Y., Bazov, I., Protopopov, A., Kisseljov, F.L., Kashuba, V., Lerman, M., Klein, G., Zabarovsky, E.R. Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas. Oncogene 2003, 22:2982-2992. 1314) Kost-Alimova, M., Kiss, H., Fedorova, L., Yang, Y., Dumanski, J.P., Klein, G., Imreh, S. Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3. PNAS, 2003, 100:6622-6627. 1315) Klein G & Klein E. Biographical memoirs, Torbjörn Caspersson. Proceedings of the American Philosophical Society, 2003, 147:72-75. 1316) Drotar, M., Silva, S., Barone, E., Campbell, D., Tsimbouri, P., Jurvansu, J., Bhatia, P., Klein, G., Wilson, J.B. Epstein-Barr virus nuclear antigen-1 and myc cooperate in lymphomagenesis. Int. J Cancer, 2003, 106:388-395 1317) Höglund, P., Kärre, K., Klein, G. The uterine cervix – a new member in the family of immunologically exceptional sites? Cancer Immunity, 2003, 3:6-8. 1318) Kiss, C., Nishikawa, J., Takada, K., Trivedi, P., Klein, G., Szekely, L. T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus- carrying Burkitt lymphoma lines. PNAS, 2003, 100:4813-4818.. 1319) Kiss, C., Nishikawa, J., Dieckmann, A., Takada, K., Klein, G., Szekely, L. Improved subtractive suppression hybridization combined with high density cDNA array screening identifies differentially expressed viral and cellular genes. J. Virol. Methods, 107: 195-203. 2003. 1320). Imreh, S., Klein, G., Zabarovsky, E.R. Search for unknown tumor antagonizing genes. Genes, Chromosomes and Cancer, 38:307-321, 2003.

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1321) Nishikawa, J., Kis, L., Liu A., Takahara M., Zhang, X., Kiss, C., Nagy, N., Okita, K., Szekely, L., Klein, G., Klein, E. Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line. Virus Genes, 28:1 117-124, 2004. 1322) Nishikawa, J., Kiss, C., Imai, S., Takada, K., Okita, K., Klein, G., and Szekely, L. Upregulation of the truncated basic hair keratin 1(hHb1-DeltaN) in carcinoma cells by Epstein-Barr virus (EBV). Int J Cancer 107(4), 597-602. 2003. 1323) Kashuba, E., Mattsson, K., Pokrovskaja, K., Protopopova, M., Kiss, C., Ehlin-Henriksson, B., Klein, G., Szekely, L. EBV-encoded EBNA-5 associates with 14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells. Int J. Cancer, 105:644-653, 2003. 1324) E. Kashuba, E., Mattsson, K., Klein, G., Szekely, L. p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes. Molecular Cancer, 2: 1-9, 2003.

1325) Klein, G. Cancer, Apoptosis and Non Immune Surveillance. Cell Death and Differentiation, 1: 13-17, 2004.

1326) Silva, S., Kovalchuk, A., Kim, J.s., Klein, G., Janz, S. BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with co-existing T (12;15) and T(6;15) translocations. Cancer Research, 63:8656-8663, 2003. 1327) Kashuba, V., Li, J., Wang, F., Senchenko, V., Protopopov, A., Malyukova, A., Kutsenko, A., Kadyrova, E., Zabarovsky, V., Muravenko, O., Zelenin, A., Kisselev, L., Kuzmin, I., Minna, J., Winberg, G., Ernberg, I., Braga, E., Lerman, M., Klein, G., Zabarovsky, E. RBSP3 (HYA22) is a tumor suppressor gene implicated in major epithelial malignancies. PNAS, 2004, 101:4906-4911. 1328) Klein G. Sanningar. Den undflyende sanningen, en vängåva till Åke Ortmark. 2004, 189-196. 1329) Senchenko, V., Liu, J., Loginov, W., Bazov, I., Angeloni, D., Seryogin, S., Ermilova, V., Kazubskaya, T., Garkavtseva, R., Zabarovska, V., Kashuba, V., Kisselev, L.L., Minna, J.D., Lerman, M.I., Klein, G., Braga, E., Zabarovsky, E.R. Discovery of frequent homozygous deletions in chromosome 3p21.3 LUCA and AP20 regions in renal, lung and breast carcinomas. Oncogene, 2004, 23:5719-5728. 1330) Li, J., Wang, F., Protopopov, A., Kashuba V., Minna, J., Lerman, M., Klein, G., Zabarovsky, E.R. Inactivation of RASSF1C, Oncogene 2004, 23:5941-5949. 1331) Klein, G. Lysande, baktalad drottning. Läkartidningen, 2004, 101:2184-2189. 1332) Klein G. "Possible Relatives / Eventuella anhöriga" (Journal 2004).

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1333) Carbone, M., Klein, G., Gruber, J., Wong, M. Modern criteria to establish human cancer etiology. Cancer Research, 2004, 64: 5518-5524. 1334) Kost-Alimova M, Fedorova L, Yang Y, Klein G and Imreh S. Microcell-mediated chromosome transfer provides evidence that polysomy promotes structural inst ability in tumor cell chromosomes through asynchronous replication and breakage within late replicating regions. Genes, Chromosomes & Cancer, 2004, 40:316-324.

1335) Li, J., Wang, F., Malyukova, A., Protopopov, A., Duh, F-M., Geil, L., Kuzmin, I., Minna, J., Stanbridge, E., Braga, E., Kashuba, V., Klein, G., Lerman, M., Zabarovsky, E.R. Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C. Cancer Research 2004, 64:6438-6443.

1336) Klein G. Foreword-1, Cancer Research Front of Japan, 2003, Edited by Takashi Tsuruo and Tomoyuki Kitagawa, Japan Scientific Societies Press, Tokyo. 1337). Kis LL, Nishikawa J, Takahara M, Nagy N, Matskova L, Takada K, Elmberger PG, Ohlsson A, Klein G, Klein E. In vitro EBV-infected subline of KMH2, derived from Hodgkin lymphoma, expresses only EBNA-1, while CD40 ligand and IL-4 induce LMP-1 but not EBNA-2. Int J Cancer. 2005, 113:937-945. 1338) Nagy N., Takahara M., Nishikawa J., Bourdon J.C., Kis L. L., Klein G. and Klein E. Wild type p53 activates SAP expression in lymphoid cells. Oncogene. (2004). 23:8563-8570. 1339). Nishikawa J, Kis LL, Liu A, Zhang X, Takahara M, Bandobashi K, Kiss C, Nagy N, Okita K, Klein G and Klein E. Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line. Virus Genes (2004). 28:117-124. 1340). Liu A, Arbiser JL, Holmgren A, Klein G, Klein E. PSK and Trx80 inhibit B cell growth in EBV infected cord blood mononuclear cells through T cells activated by the monocyte products IL15 and IL12. Blood, 2005, 105:1606-13. 1341) Sharp, T.V., Munoz, F., Bourboulia, D., Presneau, N., Wang, H-W., Cannon, M., Darai, E., Ye, H., Kiss, H., Goldstraw, P., Nicholson, A.G., Klein, G., Imreh, S., Boshoff, C. LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription. PNAS, 2004, 101: 16531-16536. 1342) Kashuba, E., Yurchenko, M., Szirak, K., Stahl, J., Klein, G., Szekely, L. Epstein-Barr virus-encoded EBNA-5 binds to Epstein-Barr virus-induced Fte1/S3a protein. Exp Cell Res. 2005, 303:47-55.

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1343) Bandobashi, K., Liu, A., Nagy, N., Kis L.L., Nishikawa, J., Björkholm, M., Klein, G., Klein, E. EBV infection induces expression of the transcription factors ATF-2/c-Jun in B lymphocytes but not in B-CLL cells. Virus Genes, 2005, 30:3221-328. 1344)Klein, G. Surveillance team against cancer. Nature 2005, 434:150.

1345) Klein George: p53 as seen by an outsider. In “25 Years of p53 Research”, Eds. Klas Wiman & Pierre Hainant (IARC), Springer Verlag. 431-438, 2005. 1346) Klein, George. Brilliant, Maligned Queen: Reflections about the new biology. In Consciousness, Genetics and Society, Perspectives from the Engelsberg seminar 2005. Edited A Linklater. 1347) Darai, E., Kost-Alimova, M., Kiss, H., Kansoul, H., Klein, G., Imreh, S. Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the “elimination test”. Genomics 86: 1-12, 2005. 1348) Klein G and Klein E. Surveillance against tumors – Is it mainly immunological? Immunology Letters, 100/1, 29-33, 2005. 1349) Silva S., Wiener, F., Klein, G., Janz, S. Location of Myc, Igh, and Igk on Robertsonian fusion chromosomes is inconsequential for myc translocations and plasmacytoma development in mice, but Rb(6.15)-carrying tumors prefer Igk-myc inversions over translocations. Genes, Chromosomes & Cancer, 42:416-426, 2005. 1350) Klein G. EBV and the tumor virus context. In Epstein-Barr Virus, Edited by Erle S. Robertson, 23-28, 2005. Caister Academic Press. 1351) Louis, S., Benedek, K., Mowat, M., Klein, G., Mai, S. Elongated mouse chromosomes suitable for enhanced molecular cytogenetics. Cytotechnology,44:143-149, 2004. 1352) Benedek, K., Choduba, I., Klein, G., Wiener, F., Mai, S. Rearrangements of the telomeric region of mouse chromosome 11 in Pre-B ABL/MYC cells revealed by mBANDing, spectral karyotyping, and fluorescence in-situ hybridisation with a subtelomeric probe. Chromosome Research, 12:777-785, 2004. 1353) Kashuba, E., Gradin, K., Isaguliants, M., Szekely, L., Poellinger, L., Klein, G., Kazlauskas, A. Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus encoded EBNA-3 protein. JBC, October 2005.

1354) Stolt, C-M., Klein, G., Jansson, A. An analysis of a wrong Nobel Prize -Johannes Fibiger 1926. A study in the Nobel archives. Advances in Cancer research, 92: 1-12, 2004.

1355) Georg Klein, En förnekelse med katastrofala konsekvenser. Läkartidningen, 48:3694-3697, 2005.

1356) Georg Klein. ”En dödskandidats funderingar före examen.” I ”Att få hjälp att dö”. Red: Westrin & Nilstun, Studentlitteratur i Lund 2005.

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1357) Klein G. Brief aan het nageslacht. Nexis, Nr. 3, 2005. Red. Bob Riemen.

1358) Haltrich I, Kost Alimova M, Kovács G, Kriván G, Tamáska J, Klein G, Fekete Gy & Imreh S, Jumping translocation of 17q11-qter and 3q25-q28 duplication in a variant Philadelphia chromosome t(9;14;22)(q34;q32;q11) carrying childhood CML, Cancer Genet Cytogenet, 164, 74-80 2006. 1359) Haltrich I, Kost.-Alimova.M., Kovacs G, Klein G, Fekete G & Imreh S. Multipoint interphase FISH analysis of chromosome 3 abnormalities in 28 childhood AML cases. Eur J Haematol, 76:124-133, 2006.

1360)Klein, G., Klein, E. Surveillance against tumors – Is it mainly immunological?

Sapporo Cancer Seminar Foundation 2005, The 25th Anniversary, 7-13, 2005.

1361)Barbro Ehlin-Henriksson, Frida Mowafi, Francesca Chiodi, George Klein, Anna Nilsson. EBV infection of tonsil B lymphocytes modulates CXCR4 expression and reduces (SDF-1 induced ) migration. Immunology, 117, 379-385 2006 .

1362) Klein, G. Benno Müller-Hill, BIOspektrum, 1:1. 2006.

1363) Kholodnyuk I., Kozireva, S., Kost-Alimova, M., Kashuba, V., Klein, G., Imreh, S. Down-regulation of 3p genes: LTF, SLC, SLC38A3, and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe immunedeficiency mice. Int. J Cancer, Jan. Epub. 2006. 1364) Lorand L. Kis, Miki Takahara, Noemi Nagy, George Klein, and Eva Klein "IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B-lymphocytes, in Burkitt lymphoma-, and in NK-lymphoma derived cell lines". Blood 107: 15, 2006.

1365) Kis, L.L., Takahara, M., Nagy, N., Klein, G., Klein, E, Cytokine mediated induction of the major Epstein-Barr virus (EBV) encoded transforming protein, LMP-1. Immunology Letters, 104, 83-88, 2006. 1366) Klein, G. A Cellular and Molecular Foundation for Understanding Cancer. Book Review. Science, 313:762-763, 2006. 1367) Klein, G. Europese geschriften en het tragische levensgevoel. Nexus, 42: 7-25, 2005.

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1368) Rökaeus N., Klein, G., Wiman, K.G., Szekely, L., Mattsson, K. PRIMA –1 MET induces nucleolar accumulation of mutant p53 and PML nuclear body-associated proteins.Oncogene, 26:982-92, 2007. 1369) Klein G. LA LITTÉRATURE EUROPÉENNE ET LA CONSCIENCE TRAGIQUE DE L´EXISTENCE. Les Temps Modernes, No 640; 37-59, 2006. 1370) Takahara M, Kis LL, Nagy N, Liu A, Klein G, and Klein E. Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 and INF-gamma in the EBV-positive NK lines SNK6 and KAI3. Int. J. Cancer, 119:2775-2783, 2006. 1371) EV Kashuba, K Gradin, M Isaguliants, L Szekely, L Poeelinger, G Klein, A kazlauskas/Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus encoded EBNA-3 protein//J Biol Chem, 281: 1215-1223, 2006. 1372) Klein, E., Kis, L.L., Klein G. Epstein-Barr virus infection in humans: from harmless to life endangering virus-lymphocyte interactions. Oncogene, 26: 1297-1305, 2007. 1373) Kost-Alimova, M., Darai, E., Lung Yau, W., Sandlund, A., Fedorova, L., Yang, Y., Kholodnyuk, I., Cheng, Y., Lung, M., Klein, G., Imreh, S. Mandatory chromosomal segment balance in aneuploid tumor cells. BMC Cancer, 7:21, 2007. 1374) Darai-Ramqvist, E., Diaz de Stål, T., Sandlund, A., Klein, G., Dumanski, J., Imreh, S., Kost-Alimova, M. Array CGH and multipoint FISH to decode complex chromosomal rearrangements. BMC Genomics, online December 2006. 1375) Klein, G., DiMaio, D. Principles of human tumor virology. In: The Papillomaviruses. Editors: Bob Garcea and Daniel DiMaio.Springer Verlag, pp 1-11, 2007 . 1376) Klein George. Musicus, mens en meteoor. Het compromisloze voorbeeld van Béla Bartók. Nexus 2007. 1377) Stuber, G., Mattsson, K., Flaberg, E., Kati, E., Markasz, L., Sheldon, A., Klein, G., Schultz, T.F., Szekely, L. HHV-8 encoded LANA-1 alters the higher organization of the cell nucleus. Molecular Cancer, 6:1-16, 2007. 1378) Klein, G., Imreh, S., Zabarovsky, E.R. Why do we not all die of cancer at an early age? Advances in Cancer Research, 2007. Vol 98. 1-20. 1379) Klein, G., Ernberg, I. Effects on apoptosis, cell cycle and transformation, and comparative aspects of EBV with other known DNA tumor viruses. Human Herpesviruses: Biology, Therapy and Immunoprophylaxis. Editor Patrick S. Moore et al, Cambridge Press, 2007.

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1380) A. Savchenko, E. Kashuba, V.Kashuba, B. Snopok/ Imaging technique for the screening of protein-protein interactions using scattered light under surface plasmon resonance conditions. Anal. Chem, 79:1349-55, 2007.. 1381) B. Snopok, M. Yurchenko, L. Szekely, G. Klein, E. Kashuba / SPR based immuno-capturing approach for interfacial sencing architecture: Mapping of MRS18-2 binding site on retinoblastoma protein // Analytical and Bioanalytical Chemistry, 7-8: 2063-73, 2006. 1382) Klein G. Multiple safeguards against tumour development. Journal of Internal Medicine, 262: 505-508, 2007. 1383) Zhou, X., Klein, G., Popescu, N.C., Imreh, S. The interferon- α responsive gene TMEM7 suppresses cell proliferation and is down-regulated in human hepatocellular carcinoma. Cancer Genetics and Cytogenetics, 177:6-15, 2007. 1384) Liu, A., Claesson, H-E., Mahshid, Y., Klein, G., Klein, E. Leukotriene B4 activates T cells which inhibit B cell proliferation in EBV infected cord blood derived mononuclear cell cultures. Blood 111:2693-703, 2008.

1385) Kashuba, E., Yurchenko, B., Yenamandra, SP., Snopok, B., Szekely, L., Klein, G. EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F complexes. PNAS, 105:5489-5494, 2008. 1386) Darai-Ramqvist, E., Sandlund, A., Müller, S., Klein, G., Imreh, S., Kost-Alimova, M. Segmental duplications an evolutionary plasticity at tumor chromosome break-prone regions. Genome Research, 18:370-379, 2008. Infört t.o.m 2785

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