Generic Dostinex for Treatment of Hyperprolactinemic Disorders

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Generic Dostinex (Cabgolin Tablets) are used to reduce your body’s level of a hormone known as prolactin. Dostinex is also used to prevent the production of milk in women after birth, if breast-feeding is to be prevented for medical reasons.

Transcript of Generic Dostinex for Treatment of Hyperprolactinemic Disorders

  • 1. Generic Dostinex TabletsGeneric Dostinex (Cabgolin Tablets) are used forthe treatment of hyperprolactinemic disordersincluding amenorrhea, oligomenorrhea,anovulation and galactorrhea.Generic Dostinex is also used to treat patients withprolactin-secreting pituitary adenomas. The Swiss Pharmacy, Geneva Switzerland

2. Generic Dostinex TabletsActive IngredientThe active ingredient in GenericDostinex (Cabgolin Tablets) isCabergoline, which is a dopaminereceptor agonist.The 0.5 mg tablets of Cabgolincontain 0.5 mg of Cabergoline. The Swiss Pharmacy, Geneva Switzerland 3. Generic Dostinex TabletsChemical Structure The Swiss Pharmacy, Geneva Switzerland 4. Generic Dostinex TabletsIndicationsSuppression of LactationGeneric Dostinex (Cabgolin Tablets) canalso be prescribed to prevent theproduction of milk in women after birth, ifbreast-feeding is to be prevented formedical reasons. Generic Dostinexsuppresses physiological lactation byinhibiting prolactin secretion. The Swiss Pharmacy, Geneva Switzerland 5. Generic Dostinex TabletsIndicationsTreatment of Hyperprolactinaemic Disorders:Generic Dostinex is used for the treatment ofdysfunctions associated with hyperprolactinaemia,including amenorrhoea, oligomenorrhoea,anovulation and galactorrhoea. Cabgolin is alsoindicated in patients with prolactin-secretingpituitary adenomas (micro- andmacroprolactinomas), idiopathichyperprolactinaemia, or empty sella syndromewith associated hyperprolactinaemia. The Swiss Pharmacy, Geneva Switzerland 6. Generic Dostinex TabletsRecommended Adult DosageTreatment of HyperprolactinaemicDisorders:To treat high levels of prolactin(hyperprolactinaemia), the recommendedstarting dose is 0.25mg taken twice a week.The weekly dose of Generic Dostinex shouldbe increased gradually preferably by adding0.5mg per week at monthly intervals until theoptimal therapeutic response is achieved. The Swiss Pharmacy, Geneva Switzerland 7. Generic Dostinex TabletsRecommended Adult DosageInhibition of Lactation:To prevent the production of milk, therecommended dose is 1mg (two 0.5mgtablets) as a single dose taken once,on the first day after delivery. The Swiss Pharmacy, Geneva Switzerland 8. Generic Dostinex TabletsMissed DoseIf you miss a dose, take it as soon asyou remember.However, if you remember when it isalmost time for your next dose, takeonly your usual dose at that time. The Swiss Pharmacy, Geneva Switzerland 9. Generic Dostinex TabletsContraindicationsGeneric Dostinex Tablets arecontraindicated in the followingcases:Known hypersensitivity to Cabergoline orany inactive ingredients of this medication.Uncontrolled hypertension.Known hypersensitivity to ergotderivatives.History of cardiac valvular disordersHistory of pulmonary, pericardial, orretroperitoneal fibrotic disorders. The Swiss Pharmacy, Geneva Switzerland 10. Generic Dostinex TabletsSide Effects of Generic DostinexMost side effects were transient and mildto moderate in severity. The mostfrequently occurring side effects weredizziness/vertigo, headache, nauseaand abdominal pain. Rarely occuringside effects were palpitations, epigastricpain, somnolence, epistaxis andtransient hemianopsia, vomiting,syncope, asthenia, and hot flushes. The Swiss Pharmacy, Geneva Switzerland 11. Generic Dostinex TabletsWarnings And PrecautionsPregnancy: Dopamine agonists in general should notbe used in patients with pregnancy-inducedhypertension, for example, preeclampsia, eclampsia,and post partum hypertension, unless the potentialbenefit is judged to outweigh the possible risk.Cardiac Valvulopathy: All patients should undergo acardiovascular evaluation, including echocardiogramto assess the potential presence of valvular disease. Ifvalvular disease is detected, the patient should not betreated with Generic Dostinex.Extracardiac Fibrotic Reactions: Postmarketingcases of pleural, pericardial, and retroperitonealfibrosis have been reported following administrationof Generic Dostinex. The Swiss Pharmacy, Geneva Switzerland 12. Generic Dostinex TabletsWarnings And PrecautionsGeneral: Initial doses higher than 1.0 mg mayproduce orthostatic hypotension. Care should beexercised when administering Generic Dostinex withother medications known to lower blood pressure. The Swiss Pharmacy, Geneva Switzerland 13. Generic Dostinex TabletsOverdosage SymptomsOverdosage is likely to lead tosymptoms due to over-stimulation ofdopamine receptors.The adverse effects may includenausea, vomiting, gastric complaints,hypotension, nasal congestion,confusion hallucinations, psychosis orthought/perception disturbances. The Swiss Pharmacy, Geneva Switzerland 14. Generic Dostinex TabletsOverdose TreatmentAdministration of activated charcoal has tobe considered in the event of a potentiallytoxic ingestion. Activated charcoal is mosteffective when administered within 1 hourof ingestion.In patients who are not fully conscious orhave impaired gag reflex, considerationshould be given to administering activatedcharcoal via nasogastric tube once theairway is protected. The Swiss Pharmacy, Geneva Switzerland 15. Generic Dostinex TabletsOverdose TreatmentMeasures to support blood pressureshould be taken if necessary.In addition, in case of pronouncedcentral nervous system effects theadministration of dopamine antagonistdrugs may be advisable. The Swiss Pharmacy, Geneva Switzerland 16. Generic Dostinex TabletsCabgolin Tablets Manufactured bySun Pharmaceuticals Ltd., IndiaFor more information click here The Swiss Pharmacy, Geneva Switzerland