Founded May 15, 2006

Institute for NanoBioTechnology

INBT

RESEARCH: at the interface of engineering, the sciences, medicine and public health

OUTREACH: create an entrepreneurial environment; tech transfer

EDUCATION: train the next generation of scientists & engineers skilled in many areas

To learn more visit: http://inbt.jhu.edu

Where is the Institute for NanoBioTechnology?

Offices located at 214 Maryland Hall on the Homewood Campus

Johns Hopkins School of Medicine

Whiting School of Engineering

Krieger School of Arts and Sciences

Applied Physics

Lab

Bloomberg School of Public

Health INBT

158 affiliated faculty from 5

divisions

INBT: Research FociCellular & Molecular Dynamics

“Basic Biological Science”

Therapeutics“Clinical Science”

Diagnostics“Clinical Science”

Health & Environment

“Public Health”

Nanoscience / Nanotechnology“Basic Engineering Science”

Seed Grants for Diagnostics Research- $20,000

• “Tumor imaging by silica nanoparticles: binding to prostate specific membrane antigen” Howard Katz (MatSc) & Ronnie Mease (Radiology)

• “Diagnosing colon cancer risk through direct experimentation on biopsied cells” Andre Levchenko (BioMed) & Andrew Feinberg (Medicine/Oncology)

• “Nanomechanical techniques for cancer diagnosis” Sean Sun (MechE), Greg Bowman (Biophysics) & Peter Searson (MatSc)

• “Innovative technologies to study mechanisms of inflammation-induced CNS axonal degeneration” Nitish Thakor (BioMed), Arun Venkatesan (Neurology) & Avindra Nath (Neurology)

• “An integrated microfluidic nanosensor platform for point mutation detection of cancers” Jeff Wang (MechE) & Le-Ming Shih (Pathology)

Seed Grants for Therapeutics Research-

$15,000-$25,000• “Corrolazine nanoparticles for photodynamic therapy and

magnetic resonance imaging” David Goldberg (Chemistry), Jeff Bulte (Radiology), & Anirban Maitra (Pathology/Oncology)

• “Bone-targeted biodegradable nano-spheres for localized treatment of skeletal disease” Scott Kominsky (Orthopaedic Surgery/Oncology), Justin Hanes (Chemical & Biomolecular Eng), & Kristy Weber (Orthopaedic Surgery/Oncology)

• “Selective prodrug activation in cancer cells using protein switches” Marc Ostermeier (Chemical & Biomolecular Engr), James Eshleman (Pathology/Oncology), & Craig Townsend (Chemistry)

• “Quantum dots as artificial antigen-presenting cells (aAPC) for tumor immunotherapy” Jonathan Schneck (Pathology), & Michael Edidin (Biology)

• “In vivo evaluation of sugar-SCFA nanoparticles” Kevin Yarema (Biomedical Engr) & Henry Brem (Neurosurgery)

Grants for Research in Cellular and Molecular

Dynamics- $75,000• “Nano- and micro-scale analysis of PKA regulation of cell

locomotion” Andre Levchenko (Biomedical Eng) & Jin Zhang (Pharmacology and Neuroscience)

• “Glyco-nanoparticles targeting dendritic cells for enhanced immune tolerance” Y. C. Lee (Biology), Hai-Quan Mao (Materials Science & Eng) & Shau-Ku Huang (Medicine)

• “Polymeric nanoparticle drug delivery systems for the development of an immunogenic ovarian tumor cell-based vaccine” Chien-Fu Hung (Pathology) & Justin Hanes (Chemical Eng)

INBT-Funded Pilot Projects for Health &

Environment• Influence of surface chemistry on the fate and environmental impact of

carbon nanotubes in aquatic environments, Bill Ball (WSE), Howard Fairbrother (KSAS)

• Exposure assessment: Probing size-dependent effects on the concentration and speciation of transition metals in particulate matter,

Alison Geyh (BSPH) & Howard Fairbrother (KSAS)• Generation of dissolved toxic species through reaction of manganese

oxide nanoparticles with biofluids, Joe Bressler (BSPH & KKI), Alan Stone (WSE) & David Veblem (KSAS)

• Nanomaterials as transporters of toxic agents into cell systems, Ellen Silbergeld (BSPH) & Howard Katz (WSE)

• Toxicological evaluation of nanoparticles in a mouse model of chronic lung disease, Shyam Biswal (BSPH) & Justin Hanes (WSE)

EDUCATION:Training the Next

Generation

To learn more visit: http://inbt.jhu.edu

• NanoBioMed Training Program sponsored by the Howard Hughes Medical Institute• Physical & Biomolecular Foundations for Designing Nanoprobes for Biology and

Medicine IGERT sponsored by the National Science Foundation• Highly selective summer REU funded by NSF

Highlights: Annual NanoBio Symposium

• May 1-2, 2008 at the Johns Hopkins School of Medicine

• 500 people over two days• “Nanotechnology for Cancer” workshop co-

hosted by Sidney Kimmel Comprehensive Cancer Center with 10 Hopkins faculty presenters

• Speakers from Harvard, Rice, NIH, Woodrow Wilson Center, University at Buffalo

• 100+ posters• 30+ businesses