GCT PREMIER MASS SPECTROMETER

Do You Need:

• Wide dynamic range for characterization of complex mixtures?

• Rapid spectral acquisition rates to profile narrow chromatographic peaks?

• Highly specific exact mass measurement for structural elucidation?

• Selectivity of high resolution to provide low determination limits?

• High sensitivity full scan spectra to maximize sample information?

• A comprehensive suite of post-processing software to maximize productivity and information output?

Take GC/MS to the Highest Level

The Waters® Micromass GCT Premier™ Mass Spectrometer combines the proven elevated resolution and exact mass performance of the classic GCT™ with extended dynamic range. These unmatched capabilities (in addition to the high full scan sensitivity and rapid spectral acquisition rates) are ideal for full characterization and profiling of components in a whole range of sample types.

Use the GCT Premier for Characterization and Profiling in the following Application Areas:

• Metabolomics

• Metabonomics

• Synthetics confirmation and QC

• Natural products research

• Pesticide residues monitoring

• Unknown environmental contaminants ID

• Food research and QC

• Flavors and fragrances research and QC

• Material emissions monitoring and research

• Homeland security chemical monitoring

• Polymer research

• Petrochemicals

• Materials research and monitoring

Sales Offices:Austria 43 1 877 18 07

Australia 61 2 9933 1777

Belgium and Luxembourg 32 2 726 1000

Brazil 55 11 5543 7788

Canada 800 252 4752 X2205

Czech Republic 420 2 617 11384

Denmark 45 46 59 8080Denmark 45 46 59 8080Denmark

Finland 358 9 506 4140

France 33 1 3048 7200

Germany 49 6196 400600Germany 49 6196 400600Germany

Hong Kong 852 29 64 1800

Hungary 36 1 350 5086Hungary 36 1 350 5086Hungary

India 91 80 2837 1900

Ireland 353 1 448 1500

Italy 39 02 27 4211Italy 39 02 27 4211Italy

Japan 81 3 3471 7191

Korea 82 2 820 2700

Mexico 52 55 5524 7636

The Netherlands 31 76 508 7200

Norway 47 6 384 6050Norway 47 6 384 6050Norway

People’s Republic of China 86 10 8451 8918

Poland 48 22 833 4400

Puerto Rico 787 747 8445

Russia/CIS 7 095 931 9193

Singapore 65 6278 7997

Spain 34 93 600 9300

Sweden 46 8 555 11 500

Switzerland 41 62 889 2030

Taiwan 886 2 2543 1898

UK 44 208 238 6100UK 44 208 238 6100UK

US 800 252 4752

WATERS CORPORATION34 Maple St.Milford, MA 01757 U.S.A.T: 508 478 2000F: 508 872 1990www.waters.com

Waters, GCT, GCT Premier, ChromaLynx, MarkerLynx, TargetLynx, OpenLynx and Connections are trademarks of Waters Corporation.All other trademarks are property of their respective owners.©2005 Waters Corporation Printed in the U.S.A. June 2005 720001166EN AG&LW-CV

Waters Micromass GCT Premier Mass Spectrometer

Waters: For Complete Confidence

Waters Corporation is the world's leading provider of instruments, chemistries, software, and support services for chromatography, mass spectrometry, thermal analysis and laboratory informatics.

For more than 45 years, Waters has been supplying scientists with the analytical tools that allow them to better understand the secrets of chemistry and of life itself. Around the globe, Waters systems and solutions are used by pharmaceutical, life science, proteomics, food and beverage, environmental, clinical, industrial, and biotechnology researchers to push the boundaries of analytical science.

To learn more visit www.waters.com

Additional Techniques Provide Enhanced Versatility

The variety of ionization and probe techniques available on the GCT Premier Mass Spectrometermaximizes the amount of information that can be obtained across a wide range of sample types.

Figure 6. EI and CI are complementary techniques, providingstructural and molecular weight information.

Figure 7. FI is the softest ionization technique for generating molecular weight information on most compound types.

Figure 8. DCI is a softer alternative to solids probe CI for thermally labile compounds. The molecular ion can be seen at m/z 380.

Enhance Your Lab’s GC/MS Capabilities with the GCT Premier Technology Platform

The GCT Premier is a powerful orthogonal acceleration time-of-flight (oa-TOF) GC/MS that offers fast acquisition of full spectrum data with high sensitivity, extended dynamic range and elevated resolution. The GCT Premier’s elevated resolution minimizes the likelihood of mass interference. Exact mass capability, which leads to elemental composition determination, offers another dimension over traditional GC/MS.

With the GCT Premier, your lab will benefit from:

Compact Size: Powerful oa-TOF with reflectron technology minimizing linear bench space without sacrificing performance

Elevated Resolution: 7000 FWHM

Exact Mass Measurement: Sub-5 ppm RMS with internal lock mass correction

Sensitivity: High duty cycle compared to scanning instruments providing low- and sub-picogram sensitivity with full spectra

Dynamic Range: Enhanced up to four orders for both exact measurement and quantitative analysis

High Spectral Sampling Rate: Ion beam sampled up to 25,000 times per second eliminating spectral skew associated with traditional scanning instruments

High Spectral Acquisition Rate: Up to 20 spectra per second can be acquired to disk, enabling narrow chromatographic peaks to be accommodated and enhancing the performance of spectral deconvolution routines

Versatile Range of Sources and Probes: A full range of source and probe options are available, including Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Direct Insertion Probe (DIP)

GC and AutoSampler Control: Integrated control of Agilent®

6890N GC and Agilent 7683, and CTC-GCPal™ and CTC-CombiPal™ autosamplers

ChromaLynx™ Application Manager: Facilitates the rapid detection, identification and semi-quantitative determination of components in complex mixtures while enabling the comparison of sample and control extracts

MarkerLynx™ db Application Manager: Dynamic statistical processing and visualization of complex data sets for metabolomic and metabonomic applications

TargetLynx™ Application Manager: Dedicated target compound quantitation software allowing easy method setup and a full range of regulatory QC checks

OpenLynx™ Application Manager: Automated exact mass processing for batch confirmation of synthetics

Figure 1. Proven oa-TOF technology in a compact bench top GC/MS system.

Figure 2. Exact mass MS measurement enables compounds to be more easily identified. Confirming a measured m/z to within 5 ppm significantly increases confidence in assigning elemental composition.

Maximize Detection Capabilities with Dynamic Range Enhancement (DRE)

The advantage of the full mass range spectra produced by the GCT Premier enables a wide range of components, both known and unknown, to be detected with high sensitivity. Full mass range spectra are beneficial when trying to characterize samples in terms of identity and quantity.

The extended dynamic range of the GCT Premier delivers up to four orders of magnitude for exact mass measurement and quantitative studies allowing you to maximize information produced from a single analysis. Figure 3. This example of hexachlorobenzene (500 fg

to 8 ng on column) demonstrates >4 orders of linear dynamic range with DRE enabled.

Compound 1 thujopsene

Compound 3 cyclamen aldehydeCompound 2 fruitate

Figure 4. Example of spectral deconvolution of overlapping peaks in a complex chromatogram. This processing was performed using ChromaLynx Application Manager.

Increase Productivity with Rapid Spectral Sampling and Acquisition Rate

The GCT Premier samples the source ion beam at 25,000 times per second. This eliminates the spectral skew associated with scanning instruments, which means that accurate spectra and quantitative data can be obtained with fewer scans over the chromatographic peak. In addition, the high spectral acquisition rate (up to 20 spectra per second) enables narrow chromatographic peaks to be processed. In combination with Waters deconvolution algorithm, pure spectra can be obtained from partially co-eluting components in complex chromatograms.

Figure 5. Illustration of the absence of spectral skew from the GCT Premier Mass Spectrometer as chromatographic intensity changes.

Enhance Your Lab’s GC/MS Capabilities with the GCT Premier Technology Platform

The GCT Premier is a powerful orthogonal acceleration time-of-flight (oa-TOF) GC/MS that offers fast acquisition of full spectrum data with high sensitivity, extended dynamic range and elevated resolution. The GCT Premier’s elevated resolution minimizes the likelihood of mass interference. Exact mass capability, which leads to elemental composition determination, offers another dimension over traditional GC/MS.

With the GCT Premier, your lab will benefit from:

Compact Size: Powerful oa-TOF with reflectron technology minimizing linear bench space without sacrificing performance

Elevated Resolution: 7000 FWHM

Exact Mass Measurement: Sub-5 ppm RMS with internal lock mass correction

Sensitivity: High duty cycle compared to scanning instruments providing low- and sub-picogram sensitivity with full spectra

Dynamic Range: Enhanced up to four orders for both exact measurement and quantitative analysis

High Spectral Sampling Rate: Ion beam sampled up to 25,000 times per second eliminating spectral skew associated with traditional scanning instruments

High Spectral Acquisition Rate: Up to 20 spectra per second can be acquired to disk, enabling narrow chromatographic peaks to be accommodated and enhancing the performance of spectral deconvolution routines

Versatile Range of Sources and Probes: A full range of source and probe options are available, including Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Direct Insertion Probe (DIP)

GC and AutoSampler Control: Integrated control of Agilent®

6890N GC and Agilent 7683, and CTC-GCPal™ and CTC-CombiPal™ autosamplers

ChromaLynx™ Application Manager: Facilitates the rapid detection, identification and semi-quantitative determination of components in complex mixtures while enabling the comparison of sample and control extracts

MarkerLynx™ db Application Manager: Dynamic statistical processing and visualization of complex data sets for metabolomic and metabonomic applications

TargetLynx™ Application Manager: Dedicated target compound quantitation software allowing easy method setup and a full range of regulatory QC checks

OpenLynx™ Application Manager: Automated exact mass processing for batch confirmation of synthetics

Figure 1. Proven oa-TOF technology in a compact bench top GC/MS system.

Figure 2. Exact mass MS measurement enables compounds to be more easily identified. Confirming a measured m/z to within 5 ppm significantly increases confidence in assigning elemental composition.

Maximize Detection Capabilities with Dynamic Range Enhancement (DRE)

The advantage of the full mass range spectra produced by the GCT Premier enables a wide range of components, both known and unknown, to be detected with high sensitivity. Full mass range spectra are beneficial when trying to characterize samples in terms of identity and quantity.

The extended dynamic range of the GCT Premier delivers up to four orders of magnitude for exact mass measurement and quantitative studies allowing you to maximize information produced from a single analysis. Figure 3. This example of hexachlorobenzene (500 fg

to 8 ng on column) demonstrates >4 orders of linear dynamic range with DRE enabled.

Compound 1 thujopsene

Compound 3 cyclamen aldehydeCompound 2 fruitate

Figure 4. Example of spectral deconvolution of overlapping peaks in a complex chromatogram. This processing was performed using ChromaLynx Application Manager.

Increase Productivity with Rapid Spectral Sampling and Acquisition Rate

The GCT Premier samples the source ion beam at 25,000 times per second. This eliminates the spectral skew associated with scanning instruments, which means that accurate spectra and quantitative data can be obtained with fewer scans over the chromatographic peak. In addition, the high spectral acquisition rate (up to 20 spectra per second) enables narrow chromatographic peaks to be processed. In combination with Waters deconvolution algorithm, pure spectra can be obtained from partially co-eluting components in complex chromatograms.

Figure 5. Illustration of the absence of spectral skew from the GCT Premier Mass Spectrometer as chromatographic intensity changes.

Enhance Your Lab’s GC/MS Capabilities with the GCT Premier Technology Platform

The GCT Premier is a powerful orthogonal acceleration time-of-flight (oa-TOF) GC/MS that offers fast acquisition of full spectrum data with high sensitivity, extended dynamic range and elevated resolution. The GCT Premier’s elevated resolution minimizes the likelihood of mass interference. Exact mass capability, which leads to elemental composition determination, offers another dimension over traditional GC/MS.

With the GCT Premier, your lab will benefit from:

Compact Size: Powerful oa-TOF with reflectron technology minimizing linear bench space without sacrificing performance

Elevated Resolution: 7000 FWHM

Exact Mass Measurement: Sub-5 ppm RMS with internal lock mass correction

Sensitivity: High duty cycle compared to scanning instruments providing low- and sub-picogram sensitivity with full spectra

Dynamic Range: Enhanced up to four orders for both exact measurement and quantitative analysis

High Spectral Sampling Rate: Ion beam sampled up to 25,000 times per second eliminating spectral skew associated with traditional scanning instruments

High Spectral Acquisition Rate: Up to 20 spectra per second can be acquired to disk, enabling narrow chromatographic peaks to be accommodated and enhancing the performance of spectral deconvolution routines

Versatile Range of Sources and Probes: A full range of source and probe options are available, including Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Direct Insertion Probe (DIP)

GC and AutoSampler Control: Integrated control of Agilent®

6890N GC and Agilent 7683, and CTC-GCPal™ and CTC-CombiPal™ autosamplers

ChromaLynx™ Application Manager: Facilitates the rapid detection, identification and semi-quantitative determination of components in complex mixtures while enabling the comparison of sample and control extracts

MarkerLynx™ db Application Manager: Dynamic statistical processing and visualization of complex data sets for metabolomic and metabonomic applications

TargetLynx™ Application Manager: Dedicated target compound quantitation software allowing easy method setup and a full range of regulatory QC checks

OpenLynx™ Application Manager: Automated exact mass processing for batch confirmation of synthetics

Figure 1. Proven oa-TOF technology in a compact bench top GC/MS system.

Figure 2. Exact mass MS measurement enables compounds to be more easily identified. Confirming a measured m/z to within 5 ppm significantly increases confidence in assigning elemental composition.

Maximize Detection Capabilities with Dynamic Range Enhancement (DRE)

The advantage of the full mass range spectra produced by the GCT Premier enables a wide range of components, both known and unknown, to be detected with high sensitivity. Full mass range spectra are beneficial when trying to characterize samples in terms of identity and quantity.

The extended dynamic range of the GCT Premier delivers up to four orders of magnitude for exact mass measurement and quantitative studies allowing you to maximize information produced from a single analysis. Figure 3. This example of hexachlorobenzene (500 fg

to 8 ng on column) demonstrates >4 orders of linear dynamic range with DRE enabled.

Compound 1 thujopsene

Compound 3 cyclamen aldehydeCompound 2 fruitate

Figure 4. Example of spectral deconvolution of overlapping peaks in a complex chromatogram. This processing was performed using ChromaLynx Application Manager.

Increase Productivity with Rapid Spectral Sampling and Acquisition Rate

The GCT Premier samples the source ion beam at 25,000 times per second. This eliminates the spectral skew associated with scanning instruments, which means that accurate spectra and quantitative data can be obtained with fewer scans over the chromatographic peak. In addition, the high spectral acquisition rate (up to 20 spectra per second) enables narrow chromatographic peaks to be processed. In combination with Waters deconvolution algorithm, pure spectra can be obtained from partially co-eluting components in complex chromatograms.

Figure 5. Illustration of the absence of spectral skew from the GCT Premier Mass Spectrometer as chromatographic intensity changes.

GCT PREMIER MASS SPECTROMETER

Do You Need:

• Wide dynamic range for characterization of complex mixtures?

• Rapid spectral acquisition rates to profile narrow chromatographic peaks?

• Highly specific exact mass measurement for structural elucidation?

• Selectivity of high resolution to provide low determination limits?

• High sensitivity full scan spectra to maximize sample information?

• A comprehensive suite of post-processing software to maximize productivity and information output?

Take GC/MS to the Highest Level

The Waters® Micromass GCT Premier™ Mass Spectrometer combines the proven elevated resolution and exact mass performance of the classic GCT™ with extended dynamic range. These unmatched capabilities (in addition to the high full scan sensitivity and rapid spectral acquisition rates) are ideal for full characterization and profiling of components in a whole range of sample types.

Use the GCT Premier for Characterization and Profiling in the following Application Areas:

• Metabolomics

• Metabonomics

• Synthetics confirmation and QC

• Natural products research

• Pesticide residues monitoring

• Unknown environmental contaminants ID

• Food research and QC

• Flavors and fragrances research and QC

• Material emissions monitoring and research

• Homeland security chemical monitoring

• Polymer research

• Petrochemicals

• Materials research and monitoring

Sales Offices:Austria 43 1 877 18 07

Australia 61 2 9933 1777

Belgium and Luxembourg 32 2 726 1000

Brazil 55 11 5543 7788

Canada 800 252 4752 X2205

Czech Republic 420 2 617 11384

Denmark 45 46 59 8080Denmark 45 46 59 8080Denmark

Finland 358 9 506 4140

France 33 1 3048 7200

Germany 49 6196 400600Germany 49 6196 400600Germany

Hong Kong 852 29 64 1800

Hungary 36 1 350 5086Hungary 36 1 350 5086Hungary

India 91 80 2837 1900

Ireland 353 1 448 1500

Italy 39 02 27 4211Italy 39 02 27 4211Italy

Japan 81 3 3471 7191

Korea 82 2 820 2700

Mexico 52 55 5524 7636

The Netherlands 31 76 508 7200

Norway 47 6 384 6050Norway 47 6 384 6050Norway

People’s Republic of China 86 10 8451 8918

Poland 48 22 833 4400

Puerto Rico 787 747 8445

Russia/CIS 7 095 931 9193

Singapore 65 6278 7997

Spain 34 93 600 9300

Sweden 46 8 555 11 500

Switzerland 41 62 889 2030

Taiwan 886 2 2543 1898

UK 44 208 238 6100UK 44 208 238 6100UK

US 800 252 4752

WATERS CORPORATION34 Maple St.Milford, MA 01757 U.S.A.T: 508 478 2000F: 508 872 1990www.waters.com

Waters, GCT, GCT Premier, ChromaLynx, MarkerLynx, TargetLynx, OpenLynx and Connections are trademarks of Waters Corporation.All other trademarks are property of their respective owners.©2005 Waters Corporation Printed in the U.S.A. June 2005 720001166EN AG&LW-CV

Waters Micromass GCT Premier Mass Spectrometer

Waters: For Complete Confidence

Waters Corporation is the world's leading provider of instruments, chemistries, software, and support services for chromatography, mass spectrometry, thermal analysis and laboratory informatics.

For more than 45 years, Waters has been supplying scientists with the analytical tools that allow them to better understand the secrets of chemistry and of life itself. Around the globe, Waters systems and solutions are used by pharmaceutical, life science, proteomics, food and beverage, environmental, clinical, industrial, and biotechnology researchers to push the boundaries of analytical science.

To learn more visit www.waters.com

Additional Techniques Provide Enhanced Versatility

The variety of ionization and probe techniques available on the GCT Premier Mass Spectrometermaximizes the amount of information that can be obtained across a wide range of sample types.

Figure 6. EI and CI are complementary techniques, providingstructural and molecular weight information.

Figure 7. FI is the softest ionization technique for generating molecular weight information on most compound types.

Figure 8. DCI is a softer alternative to solids probe CI for thermally labile compounds. The molecular ion can be seen at m/z 380.

GCT PREMIER MASS SPECTROMETER

Do You Need:

• Wide dynamic range for characterization of complex mixtures?

• Rapid spectral acquisition rates to profile narrow chromatographic peaks?

• Highly specific exact mass measurement for structural elucidation?

• Selectivity of high resolution to provide low determination limits?

• High sensitivity full scan spectra to maximize sample information?

• A comprehensive suite of post-processing software to maximize productivity and information output?

Take GC/MS to the Highest Level

The Waters® Micromass GCT Premier™ Mass Spectrometer combines the proven elevated resolution and exact mass performance of the classic GCT™ with extended dynamic range. These unmatched capabilities (in addition to the high full scan sensitivity and rapid spectral acquisition rates) are ideal for full characterization and profiling of components in a whole range of sample types.

Use the GCT Premier for Characterization and Profiling in the following Application Areas:

• Metabolomics

• Metabonomics

• Synthetics confirmation and QC

• Natural products research

• Pesticide residues monitoring

• Unknown environmental contaminants ID

• Food research and QC

• Flavors and fragrances research and QC

• Material emissions monitoring and research

• Homeland security chemical monitoring

• Polymer research

• Petrochemicals

• Materials research and monitoring

Sales Offices:Austria 43 1 877 18 07

Australia 61 2 9933 1777

Belgium and Luxembourg 32 2 726 1000

Brazil 55 11 5543 7788

Canada 800 252 4752 X2205

Czech Republic 420 2 617 11384

Denmark 45 46 59 8080Denmark 45 46 59 8080Denmark

Finland 358 9 506 4140

France 33 1 3048 7200

Germany 49 6196 400600Germany 49 6196 400600Germany

Hong Kong 852 29 64 1800

Hungary 36 1 350 5086Hungary 36 1 350 5086Hungary

India 91 80 2837 1900

Ireland 353 1 448 1500

Italy 39 02 27 4211Italy 39 02 27 4211Italy

Japan 81 3 3471 7191

Korea 82 2 820 2700

Mexico 52 55 5524 7636

The Netherlands 31 76 508 7200

Norway 47 6 384 6050Norway 47 6 384 6050Norway

People’s Republic of China 86 10 8451 8918

Poland 48 22 833 4400

Puerto Rico 787 747 8445

Russia/CIS 7 095 931 9193

Singapore 65 6278 7997

Spain 34 93 600 9300

Sweden 46 8 555 11 500

Switzerland 41 62 889 2030

Taiwan 886 2 2543 1898

UK 44 208 238 6100UK 44 208 238 6100UK

US 800 252 4752

WATERS CORPORATION34 Maple St.Milford, MA 01757 U.S.A.T: 508 478 2000F: 508 872 1990www.waters.com

Waters, GCT, GCT Premier, ChromaLynx, MarkerLynx, TargetLynx, OpenLynx and Connections are trademarks of Waters Corporation.All other trademarks are property of their respective owners.©2005 Waters Corporation Printed in the U.S.A. June 2005 720001166EN AG&LW-CV

Waters Micromass GCT Premier Mass Spectrometer

Waters: For Complete Confidence

Waters Corporation is the world's leading provider of instruments, chemistries, software, and support services for chromatography, mass spectrometry, thermal analysis and laboratory informatics.

For more than 45 years, Waters has been supplying scientists with the analytical tools that allow them to better understand the secrets of chemistry and of life itself. Around the globe, Waters systems and solutions are used by pharmaceutical, life science, proteomics, food and beverage, environmental, clinical, industrial, and biotechnology researchers to push the boundaries of analytical science.

To learn more visit www.waters.com

Additional Techniques Provide Enhanced Versatility

The variety of ionization and probe techniques available on the GCT Premier Mass Spectrometermaximizes the amount of information that can be obtained across a wide range of sample types.

Figure 6. EI and CI are complementary techniques, providingstructural and molecular weight information.

Figure 7. FI is the softest ionization technique for generating molecular weight information on most compound types.

Figure 8. DCI is a softer alternative to solids probe CI for thermally labile compounds. The molecular ion can be seen at m/z 380.