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1/5

Exposure to

Entry of

Sensitization of bronchial mucosa of tissue specific

antibodies (immunoglobulin E)

IgE mediators are affixed to mast cells of tracheobronchial tree

Activation of mucosal mast

Release of different inflammatory chemical

Release of

Release of

eosinophils to

Release of T-

lymphocytes

Regulates release of

numerous cytokines

prostaglandins

Opens mucosal

intracellular junction

Surface

epithelial cells

Inflammatory

rocess

Secretes

glycoproteins

Formation of

mucous plugs

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2/5

Airway

Increase vascular

Mucosal edema

Occludes

airway lumen

Airwall

becomes

edematous

Further release of leukocytes,

neutrophils, eosinophils, basophils

Decrease number of mucus

by goblet cells in mucosa

Hypertrophy ofsubmandibular glands

Excessive mucous

roduction

Intense inflammation of bronchial

Bronchoconstriction

Decrease ciliary functionInvasion of pathogens in the

respiratory tract

Triggers immune system to

send neutrophils

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phagocytosis

Bacteria releases

Release ofc tokines

Invasion of alveolar

epithelium

Irritates the walls of the

Inflammation of pulmonary

tissue

Edema of the alveolar

Gases cannot cross

edematous alveolar

Dilatation of blood

Reduced blood

Alveoli fill with exudates from

inflammation

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4/5

Impaired gas

Air cannot enter fluid filled

alveoli

Hypoxia occurs with retention

of CO2

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5/5