Future of Life Sciences

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At some point in the next few decades, the capability of technology could outpace that of life. However, life and technology are not disparate streams but are already starting to converge as high-impact research findings show in synthetic biology, DNA nanotechnology, nanomedicine, neuroimaging, whole brain simulation and longevity.

Transcript of Future of Life Sciences

  • Future of Life Sciences: The great convergence of life and technology Melanie Swan Research Associate MS Futures Group 415-505-4426 [email_address] www.melanieswan.com CONTACT 2009 April 3, 2009 Slides: http://slideshare.net/LaBlogga/slideshows
  • Agenda
    • Introduction: convergence of life and technology
    • Status of relevant high-impact research
    • Future implications
  • Source: http://www.kurzweilai.net/pps/Unither Full human brain neural simulation est: 2018 Average human: an estimated 20,000 trillion IPS and 1,000 TB memory 2 IBM Roadrunner: 1 petaflop/s (>1,000 trillion IPS) and 80 TB memory 1 1 http://www.top500.org/lists/2008/11, http://www.top500.org/system/8968 2 http://paula.univ.gda.pl/~dokgrk/bre01.html
  • Engineering life into technology 2029 Machine Human Human ? Capability Year Intelligence convergence: Life and Technology
  • Agenda
    • Introduction: convergence of life and technology
    • Status of relevant high-impact research
      • Evolving concept of life sciences
      • Genomic era
      • Synthetic biology
      • Nanomedicine
      • Intelligence research
      • Longevity
    • Future implications
  • Evolving concept of life sciences Model and simulate Enumerate and experiment Build BioSpice.org SimTK.org PartsRegistry.org
  • Evolving definition of health Source: http://www.mdpi.com/1660-4601/6/2/492 A new model of health and health care Cure Improvement Normalization Prevention Enhancement Self-expression Conditions Symptoms Genome Biomarkers Behavior Environment Health outcomes Measure Research Treat Intervene Experiment Track Measure Actions Self Professionals Peers
  • Evolving computing models Current model extensibility Linear, von Neumann Parallel Cloud, grid, distributed Biological models Novel models Traditional model Quantum Optical computing Cell broadband engine Liquid computer New materials 3D chip stacking Molecular electronics Solar transistors DNA nanotech DNA computing Biosensors Cellular colonies Bacterial intelligence Bioparadigm discovery
  • Genomic era Carlson curves: 12 mo speedups
    • Sequencing
      • (reading)
    • Synthesizing
      • (writing)
    Source: http://www.synthesis.cc/graphics/carlson_cost_per_base_nov_08.jpg
  • Direct-to-consumer genomics: 23andme Source: http://www.23andme.com; open source genomes http://www.snpedia.com/index.php/Genomes 580,000 SNPs scanned and mapped to 78 conditions
  • 23andme colorectal cancer marker Source: http://www.23andme.com
  • Next-gen sequencing: Pacific Biosciences Sources: http://www.pacificbiosciences.com/video_lg.html, http://www.sciencemag.org/cgi/content/abstract/323/5910/133, Science 2 January 2009: Vol. 323. no. 5910, pp. 133 138, DOI: 10.1126/science.1162986 Phospholinked nucleotides DNA polymerase wrapped around DNA chain Phospholinked nucleotide binds, fluoresces and detaches as nucleotide base is read 1 2 3a 3b
  • Next-gen biotech: synthetic biology
    • Engineering biological systems
      • Parts Registry
      • BioBricks Foundation
      • iGEM competition
    • Key work: Drew Endy, Jay Keasling, Craig Venter, Christina Smolke, Tom Knight
    Sources: http://openwetware.org, http://bbf.openwetware.org, http://www.igem.org, http://partsregistry.org
  • Registry of Standard Biological Parts
    • Modular building block components
    Source: http://partsregistry.org
  • Parts Registry: select measurement system Source: http://partsregistry.org
  • Parts Registry: obtain and print sequence DNA Synthesizer Source: http://partsregistry.org
  • Nanomedicine
    • Nanoparticles
    • DNA nanotechnology
      • DNA walker
    • Programmable matter
      • Quantum dots
    • Nanomachines
    Respirocytes Microbivore Artery cleaner Nanoparticles Sources: Nanoparticles: http://www.unithertechnologyconference.com DNA Nanotechnology: http://www.pnas.org/content/101/3/717.full.pdf Nanorobots: http://www.foresight.org/Nanomedicine/gallery/index.html#ExhibitCat Vasculocyte Clottocytes DNA walker Structural DNA: Holliday junction Quantum dot dyes
  • Radiosurgery and on-demand physicians Teleradiology da Vinci Robotic Surgery OR-Live.com On-demand consultation: American Well Accuray radiosurgery delivery path Accuray cyberknife radiosurgery
  • Simulation, modeling and virtual health Entelos virtual patient biosimulation Testis tour: OSU Medicine Sources: http://biospice.org, http://www.youtube.com/watch?v=O1YuRSyzBAE, secondlife://PalomarWest%20Hospital/36/125/34/, secondlife://NHS%20London/248/11/26 Second Health Operating Theatre BioSPICE open source simulation software Virtual hospital: Palomar West
  • Intelligence research by approach
    • Computer simulation
      • Cortical column simulation
      • Whole brain emulation
    • Neuroimaging & connectomics
      • KESM tissue volumes
    • Integration
      • Brain-computer interfaces (BCIs)
      • Body area networks (BANs)
        • IEEE standard 802.15.6
    • Robotics and AI
    Blue Brain rat cortical column Mouse brain block and cortex slice Sources: http://seedmagazine.com/content/article/out_of_the_blue, http://www.mcb.harvard.edu/lichtman/ATLUM/ATLUM_web.htm, http://research.cs.tamu.edu/bnl/kesm.html Vesicle
  • Longevity: extending lifespan and healthspan
    • Aging as a multidisciplinary pathology
    • Aubrey de Grey: Strategies for Engineered Negligible Senescence (SENS)
      • Nucleic and mitochondrial mutations
      • Intracellular and extracellular junk
      • Cell loss and senescence
      • Extracellular crosslinks
    • Solutions and escape velocity
      • Biomedical remediation
      • Mutation anti-suppressors
      • Cell strengthening
    • RealAge.com estimation tests
    U.S. Life Expectancy, 1850 2050e 83 77 69 50 39 Sources: http://www.mfoundation.org/index.php?pagename=mj_sens_sens, http://pimm.wordpress.com/2007/09/03/sens3-program-john-schloendorn-medical-bioremediation, http://www.mfoundation.org/files/sens/manu16.pdf, http://www.lmrf.org/LysoSENS.html LysoSENS: stained lysosomes Source: http://www.infoplease.com/ipa/A0005140.html Source: http://earthtrends.wri.org/text/population-health/variable-379.html
  • Agenda
    • Introduction: convergence of life and technology
    • Status of relevant high-impact research
    • Future implications
  • Engineering life into technology
    • Evolving concept of life sciences
    • Genomic era
    • Synthetic biology
    • Nanomedicine
    • Intelligence
    • Longevity
    2029 Machine Human Human ? Capability Year Convergence: Life and Technology Foundations of Convergence
  • What can be expected in the short-term?
    • Onboard computation and communication
    • Whole human genome scan
      • Era of personalized medicine
    • Next-gen biotech, the new cleantech
      • Focus on key cures: obesity, cancer
    • Peer-to-peer health
      • Health social networks
      • Long tail of medicine
    • Culture of biohacking
    Image: Natasha Vita-More, Primo Posthuman
  • Ultimate possibilities for life and technology
    • All matter (including life) designed to spec
      • Purpose-driven form factor, elective embodiment
    • Issues