FunMat annual seminar 14.8.2013

Functional materials and systems

Mesoporous silica nanoparticles for targeted drug delivery (JM Rosenholm et al.)

Solar cells with gold core-shell type nanoparticles (JH Smått et al.)

Personalized dosing of drugs

Paracetamol Chitosan-based drug delivery vehicle

Examples

An example on combining materials and expertise

Electrical

detection

A capacitive immunosensor for CRP

Whole blood

sample

Separation of analyte (Härmä et al.)

printed electrodes

Supramolecular

biorecognition layer

Impedimetric

detection

Ink formulation

Synthesis and processing of conducting materials

Subsequent adsorption of protein layers

Immobilization kinetics of

bio-CRP antigen on

streptavidin/SAM covered

Au electrode

Capacitive response

P. Ihalainen, H. Majumdar, T. Viitala, B. Törngren, T. Näreoja et al., Biosensors 3 (2013) 1-17.

A printed electrochemical cell

PEDOT-GOx

Glucose detection

PANI

pH detection

Määttänen, Ihalainen, Pulkkinen et al., Appl. Mater. Interfaces 4 (2012) 955.

ÅAU-LPhC HU-LPC

ÅAU-Analytical Chem

Määttänen, Vanamo, Pulkkinen et al. Sensors and Actuators B 177 (2012) 153.

Electrochemical sensors

Mixed DNA/alkanethiol SAM architecture • Highest signal with capacitive component (Creal)

at the lower frequency domain (< 1kHz) • No change in Creal with noncomplementary DNA

Biotin-SA-biotin supramolecular architecture • Highest signal with impedance modulus (|Z|) at

higher frequency domain (> 10 kHz) • No change in |Z| with noncomplementary DNA

Signal with

complementary DNA

Signal with

non-complementary DNA

Impedimetric detection of DNA hybridization

Ihalainen, P.; Petterson, F.; Pesonen, M.; Viitala, T.; Määttänen, A.; Österbacka, R.; Peltonen, J., Nanotechnology (2013), submitted.

Electrochemical impedance spectroscopy

Screening assays cells, biofilms, pharmaceutical ingridients

Colorimetric indicators biomaterials, hazardous gases, EC pixels

Electronic components electrodes, transistors, circuits

Electrochemical sensors glucose, pH

Chemoresistors hazardous gases. humidity

Capacitive sensors proteins

Fluidics Liquid transport and filtration

A paper-based assay platform

Staphylococcus aureus biofilm

Retinal pigment epitheal cells

An electrical sensor platform

Circuit diagram Transistors Sensors

H2S off H2S on

Sarfraz, Määttänen, Ihalainen, Keppeler, Linden, Peltonen, Sensors Actuators B 173 (2012) 868. H. Sandberg et al. Advanced Materials 16, (2004) 1112; R. Bollström et al, Organic Electronics 10 (2009) 1020 Hassinen, Kauppila et al., Analytical and Bioanalytical Chemistry (2013) Jalkanen, Mäkilä, Määttänen, Tuura, Kaasalainen, Lehto, Ihalainen, Peltonen, Salonen, Applied Physics Letters 101 (2012).

NO2 sensor

Humidity

sensor - Porous silicon

H2S sensor - Cu-acetate

Flex-Sens

A sensor platform for wireless sensing

0 5 10 15 20 2510

1

102

103

104

105

106

107

108

R in

Oh

ms

time in min

exposed to H2S

J. Koskela, J. Sarfraz, P. Ihalainen, A. Määttänen, A. Kilpelä, J. Peltonen, to be submitted

• An industrially processed, custom-made

sensor platform with a capacitor, antenna and

sensor (CuAc active layer) on a PET-

substrate).

• The Q-value can be ”read” using a 13.56 MHz

(NFC / RFID) or 8.2MHz (EAS) transmitter

circuit -> the output power varies according to

the Q-value of the RLC-circuit.

Fabricated in Elcoflex, Oulu

sensor

antenna

capacitor

Food-Sens

OU-Electronics HU-Food Chem

ÅAU-LPhC

Tekes – TUTL (Tutkimuksesta uutta tietoa ja liiketoimintaa)

The sensor

response can be

selected by

changing the

sensing material

printed on the

electrode

Food-Sens

A sensor platform for wireless sensing

New functionalities can be created by combining advanced chemistry and complex

materials with printing technologies

Summary

Thank you !

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