Optho Times | Vol. IV May. 2016 to July. 2016

Eyes are undoubtedly the windows to the worldwww.opthoremedies.com

Serving Humanity Since 1973

OPTHO

R

From The Desk of Director - Sales

It gives me a sense of pride, as I release this annual issue of Optho times. As it is establishing our brand

image.

Director's speech on Annual Sales Meeting (2015-2016)

It gives me a great pleasure to welcome you all to this year's Annual Meeting, celebrating not only our last

year's accomplishments, but also 43 years' worth of Optho Remedies Pvt. Ltd achievements.

Such occasions & meetings builds more strong connections among us, after all-that's what it's all about for

us:. successful community inclusion. I want to start by thanking you for joining us today; your support and

presence here, is indicative of the steps we've made in the right direction.

This event is a key step towards a collective vision of integration and target achievement strategies. As it is a

deep belief that cooperation and integration will greatly strengthen our roots and bring benefits to all .

Thus, this meeting today embodies this belief.

The annual meeting was entitled as- “LAKSHYA". The Goal is self explanatory, In these two days we all have to make a giant pool of ideas,

innovations, strategies and goals, so that we can utilize these resources for achieving our LAKSHYA.

My dear team managers the achievement of your goal is assured the moment you commit yourself to it. It is imperative to have moral courage by

sticking to your beliefs: "A leader needs to pursue a course of action even in the face of overwhelming criticism and great adversity". This kind of

courage is always in short supply. Authenticity, is a key trait required in a leader. Other qualities can be picked up based on experience and

situations. As a leader it is unlikely that you will be able to inspire, arouse, excite or motivate people unless you can show what you stand for and

reveal that you are willing to learn. Be fair to colleagues and friends. The ability to judge well is often linked to an ability to mix with, and learn from,

other people.

In an organization, the value system has to percolate down to all the employees. This can only come about by demonstration, which starts at the

top. Therefore, the senior management must make it a point to interact with all employees, thereby constantly reinforcing the organizational

culture. How leaders behave will always reflect in how the rest of the employees behave.

Managers discipline is very important in sales, as we can't achieve targets without it. As, discipline on the positive side creates winners with goals

and on negative side, losers with excuses.

My team members, make your personal area wise strategies, and teach your inline people about the same. If the plan “A” doesn't work change it to

plan “B” but never change your goal.

Here, again I say that “INNOVATION” is the key to success, it is not just about doing new things, it is about doing things differently and a creative

manager is motivated by the desire to achieve, not by the desire to beat others.

Gentlemen, these are the times of historic changes. Many of you face challenges, I know too well from my own experiences, but these challenges

urge you to stay focused on your goals for more inclusion and resilience. till the goal is reached. ARISE, AWAKE and STOP NOT Rajesh Agarwal

O-Outstanding P-People serving T-Towards H-Humanity with O-Optimism

Rakesh Agarwal

From The Desk of Director - Operations

Last year, has been challenging & coming days to be more challenging . The updation & amendment in

the Drug Laws, revised pricing and FDC screening will make the ground more competitive, but our hard

work, dedication and patience has made us successful. All this has been possible because we worked as a

team and were true to the core values of the organization. Its good to see that sales team is well versed to

adapt the changes quickly and act on it swiftly. So demand for our products is not the question, the

balance between DEMAND & SUPPLY governs the success of an organization. To concrete our supply

chain management, we held Distributor's meet on 17th Feb. 2016. Distributors across the country have

participated in the meeting that arrived to fruitful conclusion and the same are under implementation.

To welcome the ocular allergy season and say good bye to ocular itch, now you have in your basket one

drop once daily ODIN 0.2% ahead this summer to treat better dry, eye patients your basket will add CCS LC

& HY-5. Product diversification and new introduction is on top priorities to support the sales team in all

possible ways. To honour and give gratitude to the body fuel which you invest to materialize company's goal can't be denied, so to keep the flame

to excel, glowing year 2016-17 has updated travel allowances along with the fabulous and lucrative incentive scheme for you all. The year has a lot in terms of growth and opportunities, rewards and recognition in the basket, thus, look at what you have got and make the best of it.

“The struggle you're in today is developing the strength you need for tomorrow, therefore overcome your barriers, intend the best, be patient &

don't give up.”

Dear,

Optho's family Members

Summers are in full swing, with scorching heat and high

rising temperatures. Our pursuit of excellence through

consolidation and growth continues unabated, reflecting

in steadily improving readers feedback and customer

satisfaction. Your support inspires us to excel.

Honesty, Integrity and truthfulness are absolutely

essential keys for success in all areas of life. Truthfulness,

the ability to take and give, honest and well intended

feedback, strength of character and conviction in one's

principles. Integrity is feeling myself the truth. And

honesty is telling the truth to other people.

A company cannot simply list it's values in the annual

report or post them in the staff lounge and expect

employees to follow suit. Values must be lived by everyone

in the company. Otherwise they're just good intentions.

Leaders, above all, must walk the talk.

This year's AIOS conference took place in Kolkatta, "The

city of joy". Here, we are presenting you a brief insight to thOptho's participation in 74 Annual conference of AIOS.

Plus, March is the month dedicated to women across the

globe, read about Optho's women's day celebration across

the nation.

While we are striving hard to give you the best, always

shortcomings do surface at times. I, on my part will always

welcome your feedback at (anushri@opthoremedies.com)

on any issue that you may come across. Wishing you, your

family happy holidays.

Regards

Anushri R. Agarwal

(Editor In Chief)

2

We Value Your FeedbackIt's a pleasure to read an article titled 'What Makes a G re a t M a n a g e r ' . I t i s welcome addition which inspires the aspir ing younger, lot of employees bubbling with confidence and enthusiasm and guide them to build their career in better and organized way.

You are suggested to make management re la ted article a permanent feature of Optho times touching upon various aspects the effort will make Optho times more purposeful.

March is the month dedicated in ophthalmic fraternity

for creating awareness and adding fuel to the fight

against Glaucoma. Optho remedies tries to contribute

the maximum to 'World Glaucoma Patient Association'

(WGPA). Optho remedies has been conducting regular

glaucoma awareness activities throughout the year on

6th of every month to symbolize the beginning of 'World

Glaucoma Week'. Glaucoma Awareness Walk &

Glaucoma OPD campaign have been done through out

the week, thousands of Glaucoma Patients were screened

in different parts of the country. We will be organizing

awareness camps round the year on 8th & 20th of every

month at leading hospitals & institutes, to mark the

beginning of “World Glaucoma Week 2017” and Optho

remedies foundation's day. Company aims to extend

campaigns for cataract and other ocular morbidities in

coming months.

Walk for Glaucoma Awareness

R. S. TripathiManager

(Field Administration)

Allahabad team organized a walk to raise awareness on Glaucoma

Dr. Rohit Saxena Dr. Ashok Km NandaDr. Raj Km Srivastav &

Dr. Ulka SrivastavDr Vinay Gupta & Dr. Mandal Pranad

Dr. Shrikant Tiwari & Dr. Ramesh Kumar Singh

Dr. Shrikant Tiwari & Dr. Ramesh Kumar Singh

th74 All India Ophthalmology Conference . Kolkatta

Dr. V. Panner Selvam Dr. HP Jain Dr Ramesh Ch. Gupta & Dr. Lalit Verma

Manoj Kumar & Dr. Ramesh Ch. Gupta

Dr. Ahuja Arjun Sadhuram & Dr. Rohit

Dr. Rishi MohanDr Ramesh Mahar &

Dr. Ashok Bajaj Dr. B.P Jain Optho Remedies Team

thThe 74 . AIOC, 2016 was held at Kolkota from 25th-28th.Feb., 2016.The conference was organised by

All India Ophthalmic Society.The conference took place at Science City & Milan Mela ground . More

than 150 companies participated including surgical companies and publication houses. The event

witnessed the presence of more than six thousand delegates, including trade people.

Honourable Mr. Somnath Chatterjee, former speaker of parliament was the chief guest of the

conference. Prof. Priya Abraham of Christian Medical college and Hospital, Vellore, India and Prof.

Arunaloke Chakrabarti PGIMER, Chandigarh were the key speakers of the conference. The conference touched and focused on all

spheres like Eye Surgeries, Ophthalmology and Eye Health.

Highlight of the event: Medical session are common phenomenon to every conference, as management lesion has touched all

discipline of study so as medical science too.

Mr. Tourbo of Germany conducted a session on skill management for the doctors at AIOS, Kolkota has tied up with IIM, Kolkota to

conduct a session on skill management.

Optho was present at Trade Hall No.-2 ,Semi Pavilion Stall No. A, elegant stall right at the entrance to greet & welcome all

the delegates. All eminent doctor's left their footprint at our stall. Budding ophthalmologists enjoyed the casino game at

our counter. We unveiled our entire ophthalmic products range by means of product collage, displayed at the stall and we

have also distributed the AIOS interesting facts card among the delegates. Optho remedies is turning out to be curiosity

corner by the showcase. As a tradition we offered the best of best hospitality services to the doctor's fraternity.

3

Welcome on Board

*Previously associated with.

Shashi Kant Mishra Sale Admin Exe.-HO

Sudhir RajbharRM Mumbai

(*Cipla Akumentis)

North Delhi

Ranchi

Amritsar

Guntur

Sambalpur

Bareilly

Gorakhpur

Ghaziabad

Nagpur

Rohtak

Gorakhpur

Bikaner

Chennai

Chennai

North Delhi

Tirupati

Bolpur

Madurai

Ahmednagar

Hyderabad

Burdwan

Name of Staff Designation Headquarter

MR

MR

MR

MR

MR

MR

MR

MR

MR

SO

MR

MR

MR

MR

MR

MR

MR

MR

MR

MR

MR

Bhoop Singh

Anusha Thapa

Pankaj Sharma

Srinivas. Ballam

Utkala Keshari Mahapatra

Rahul Mishra

Ritesh Kumar

Manoj Kumar Sharma

Yogesh Dhok

Pawan Sharma

Abhay Shankar Tripathi

Tejaram Kumawat

Mr. R. Manikandan

B. Dasthageer

Aman

K Ramakrishana

Pemranjan Ghosh

Paramasivan Allais Saravanan

Tukaram Devrao Garje

Ramesh Chukka

Asish Rudra

Top Product Performer

SOC (Stabilized Oxychloro Complex)

SOC is biodegradable polymer and it is an oxidative-

type preservative.

SOC dissipates by converting into components normally

found in tears, such as sodium ions, chloride ions, oxy-

gen, and water. This unique quality makes SOC an

unusually gentle preservative that is ideal for chronic

use. For this reason, products containing SOC may have

an improved tolerability profile, reduced toxicity,

and, ultimately, better patient compliance.

SOC consists of an equilibrium mixture of oxychloro

species: 99.5% chlorite (ClO 0.5% chlorate (ClO), and

trace amounts of chlorine dioxide (ClO which have

bactericidal, fungicidal, and virucidal activity.

Thus SOC has preservative action in bottle and product

becomes virtually preservative free on ocular tissues,

which provides better tolerability.

Preservative-free approach in ocular lubricants

*Based on sales data till March. 2016

Products BrandsProducts Brands HeadquarterHeadquarter Hq. RepresentativeHq. Representative

Lubrinac Jamshedpur

Muzaffarpur

Nikesh Km Singh

Amit km Ranjan

IMEG-3 Gorakhpur

Hyderabad

Patna

Yugal Dubey

OP Mishra

Amar Singh & Om Mishra

Sachin Chandel

Raman Kumar

Shekhar Kothari

Muzaffarnagar

Darbhanga

Dehradun

Moxifax

Products Brands Headquarter Hq. Representative

Kanpur Sanjeev Mishra

Products Brands Headquarter Hq. Representative

4

5

Products of the Spring/Summer SeasonFalling leaves, flowers, blossoming all around and bright sunlight is the announcement of the arrival of the most beautiful spring season. It is the most pleasant and enjoyable season , the whole of the environment is filled with pollen grains lingering everywhere making the life of inhabitants miserable . Pollen grains are the main cause of ocular allergy. Thus, the beginning of the spring season in beginning of the ocular allergy. Optho is marketing various formulations to cover the allergic sign & symptoms. Odin eye drop is one of the formulation which cures the ocular allergy miraculously.Odin Eye drops :This is not a new product for all of you have been promoting it successfully since long . But now odin has arrived in the new look. As the concentration of the main effective ingredient olopatadine concentration has been raised to 0.2% as compared to 0.1% . The enhancement of our odin makes more efficacious and more convenient to use.Odin eye drop is clear ophthalmic solution to control the seasonal and perennial allergic conjunctivitis, and intense itching caused due to change of season (like spring ) and various allergens.Odin contains olopatadine in higher concentration of 0.2%.. Olopatadine is a white coloured powder, which is freely soluble in water to provide a clear and shining solution. Odin eye drop is especially designed to cure allergic conjunctivitis, associated with intense ocular itch and tearing from the eye. Which may caused due to change season or allergen such as pollen mould or animal danger . These are foreign body which is also known as allergens.The ocular allergic conjunctivitis is caused when allergen or antigen such as pollen grain mold binds with antibody on the surface of mast cells to induce degranulation which releases a content of granules or mixture of components (hiscamine, cycokine etc.) Thus, histamines releases in eyes and further causes the vascular response which is manifested in the form of redness, itching ,watery discharge & mucus discharge.Dual Activity of Odin :- The drug which counteracts in more than one component ,always play a better role ,Like wise Olopatadine , on the one hand blocks H1 activity and on the other hand it inhibits the release of histamines, tryptase PGE2 from human conjunctiva mast cells. The dual action of ODIN 0.2% makes it a unique anti allergic conjunctivitis drug.

Duration of Action : Most of the anti allergic preparation require frequent dosing and thus are inconvenient to use. ODIN 0.2% drop is unique wipes out itch immediately after the instillation of first drop and effective for 24 hrs, thus it once daily. Thus its most convenient for the use by patient.Dosage & Administration: 2 drop in affected eye one daily.ODIN is comfortable :- Odin provides minimum ocular discomfort after application.

ODIN VS KETOROLACBoth the drugs are for similar kind of use i.e . allergic conjunctivitis and ocular itch. Odin has faster onset of action as compared to Ketorolac (KT) KT requires frequent dosing every 2 hourly.KT (ketorolac) irritant nature, where ODIN has no ocular discomfort, thus great patient acceptance.

It starts its action within half an hour

and patients are relived from ocular

itch after 1-2 hours of instillation.

Its action starts instantaneously &

ocular itch is relived from 1st drop.

Half life not less than 7

Frequent Instillation is required

Irritant

Longer half life

OD dosing

Non Irritant

Our range of products possess a versatile preparation which is equally efficacious in treating ocular infections and inflammation in pre & post operative state and for ocular allergy associated with secondary infection .This is our Tocin - F eye drops . Tocin - F is anti bacterial & anti inflammatory preparation as it contains Tobramycin 0.3% w/v & Fluoromethalone 0.1% w/v in the form of microfine aqueous suspension.

TOCIN-F Eye dropsTobramycin sulphate:1. It is a white coloured powder which is freely soluble in water and gives a clear solution.2. It is broad spectrum antibiotic active against gram positive & gram negative microorganism. But unlike other antimicrobial its spectrum for gram-negative organism is very broad as compared to any other anti microbial. Due to its unique spectrum it is the most preferred antibiotic .3. S i n c e To b r a m y c i n i s n e v e r recommended as Oral or systemically hence resistance has never been reported.4. Tobramycin has minimal protein binding , a such it penetrates deeper in the corneal layer ensuring deeper penetration.5. Tobramycin is safest and well tolerated antibiotic for children and elderly patients.6. It belongs to aminoglycoside group of antimicrobial.7. Tobramycin is choice for treating the infection in pre & post operat ive state , corneal u lcer & ophthalmia neonatrum. The infection which occurs in eye of new born kids.Fluoromethalone:1. This is a white coloured powder and is insoluble in water to provide a suspension .2. It belongs to corticosteroid family .But it is considered to very safe drug as it does not raise the IOP . Reason for Safety: Fluoromethalone is very poorly absorbed by the cornea. Whatever quantity is absorbed by the cornea is very rapidly eliminated . Therefore this can be used for longer period of time without any steroidal side effect.3. Being a corticosteroid fluoromethalone is anti-inflammatory and anti allergic. Especially in chronic conjunctivitis which persist for longer period , fluoromethalone can be used to eradicate the same very safely.4. Offcoure fluoromethalone being a corticosteroid is strictly contraindicated in Glaucoma & corneal ulcer .

Both the molecules in TOCIN–F eye drop are safe for the use of prolonged therapy . The formulation safe & well tolerated in (babies/kids)* .Therefore whenever the patients coming with allergic conjunctivitis and secondary infection, or in chronic allergic conjunctivitis persisting for long time .TOCIN – F is a drug of choice .It can also be prescribed, when the patient are not responding to other antimicrobial drugs and have developed resistance.

* It is suggested to promote Tocin-F among paediatric doctor's too.

6

Doctor’s Speak

Causes of Red Eye :

Conjunctivitis is the most common cause of red eye and is one

of the leading indications for antibiotics. Causes of

conjunctivitis may be infectious (e.g., viral, bacterial,

chlamydial) or noninfectious (e.g., allergies, irritants). Most

cases of viral and bacterial conjunctivitis are self-limiting.

Other common causes of red eye include:

1. Blepharitis

2. Corneal abrasion.

3. Foreign body.

4. Subconjunctival hemorrhage.

5. Keratitis.

6. Iritis.

7. Glaucoma.

8. Chemical burn.

9. Scleritis.

A thorough patient history and eye examination may provide

clues to the etiology of red eye. The history should include

questions about unilateral or bilateral eye involvement,

duration of symptoms, type and amount of discharge, visual

changes, severity of pain, photophobia, previous treatments,

presence of allergies or systemic disease, and the use of

contact lenses. The eye examination should include the

eyelids, lacrimal sac, pupil size and reaction to light, corneal

involvement, and the pattern and location of hyperemia.

Preauricular lymph node involvement and visual acuity must

also be assessed. Common causes of red eye and their clinical

presentations are summarized under:

Red EyeRed EyeRed EyeRed eye is one of the most

common ophtha lmo log i c

conditions in the primary care

setting. Inflammation of almost

any part of the eye, including the

lacrimal glands and eyelids, or

faulty tear film can lead to red

eye. Primary care physicians

often effectively manage red

eye, although knowing when to refer patients to an

ophthalmologist is crucial.

Dr. Rohit AgarwalDiagnosis and Management of Red Eye in Primary Care

Diagnosis of the Underlying Cause of Red Eye

Patient presents with red eye

Pain*

Mild or no pain, with mildblurring or normal vision

Moderate to severe pain

HyperemiaVision loss, distorted pupil,corneal invelvement

Focal Diffuse

Episcleritis Discharge?

No Yes

Emergency ophthalmology referral

Subconjunctivalhemorrhage

Intermittent Continuous

Dry eye

Wateryor serous

Mucopurulentto purulent

Itching

Chlamydialconjunctivitis

Acutebacterialconjunctivitis

Mild tonone

Moderateto severe

Viralconjunctivitis

Allergicconjunctivitis

Note : Blepharitis, hordeolum, and chalzaion are associated with a localized red, swol-len, tender eyelid; other symptoms are rare.

*—Patients with corneal abrasion may present with severe pain, but can be treatedby a primary care physician.+—Paradoxical tearing of the eye

Vesicular rash (herpetic keratitis),

severe mucopurulent discharge

(hyperacute bacterial conjunctivitis),

keratitis, corneal ulcer, acte angle

glaucoma, iritis, traumatic eye

injury, chemical burn, scleritis

Causes of Red Eye

DRUGS USED IN ALLERGIC DISEASES OF THE EYE

Sr.No.

Name

2

3

Vasoconstrictor

Mast Cell Stabiliser

4 Multiple Action Drugs

Effect Examples Indication Dosage Adverse Effect

Decongestion

Used for prophylaxis

Oxymetazoline, Nephazoline, Tetrahydrozoline, Phenylephrine

Sodium cromoglycate, Lodoxamine

Burning, Stinging, Mydriasis, rebound hyperaemia conjunctivitsmedicamentosa with chronic use

Requires loading period before exposure to antigen hence requires very good compliance

PAC,SAC

PAC,SAC

1 AntihistaminesRelieves Itching & Redness

Antazoline, Pheniramine, Levocabastine (0.5%)

Irritation especially on prolonged use

PAC,SAC

Tds toqid

Tds

Tds

5

NSAID (Non Steroidal Anti-inflammatory Drugs)

Reduces the Conjunctival hyperaemia & the pruritus caused by

Ketorolac (0.5%), Pranoprofen, Fluribiprofen, Diclofenac

Burning, StingingSAC, VKC Tds

Relieves itching, redness, edema with immediate effect

Olopatadine (0.1%) Ketotifen (0.025%), Nedocromil, Azelastine, Epinastine (0.05%)

Blurred vision, buming& stinging

PAC, SAC, VKC, AKC

BD

1

2

3

4

5

6

7

8

9

11

12

13

14

History of atopy

Age

Gender

Seasonal Springs SpringsPerennial Perennial

Common Common Possible Possible PossibleConstnt

Children / Adults Children / AdultsChildren / Adults Children / Adults AdultsAdolescent /

Adults

No predilection No predilection No predilection No predilectionMales Males

Perennial /Summer

No

NoNoYesYesNoNoCornea

Vision Minimal Minimal MinimalMild Severe Minimal

Papillaryhypertrophy No No No<1 >1

Edema Edema Edema Edema

7-8 mm LimbusAffected

NoNo No No No YesExposure to

drugs

Periocular skininvolvement

Dermatiris Dermatiris

Serum IgE Elevated Elevated Variable Variable VariableGreatly Elevated

Variable

Variable

Variable

Variable

No Frequent No FrequentFrequent Very Frequent Characteristic CharacteristicEosinophils inconjunctival

swab

Globeled Cells Increased Increased Increased Decreased

Skin Test Positive Positive PositiveNon Specific

16 NoYes Yes Low Low VariableResponse to Anti

Allergic Drugs

18Immuno-

supressivesBurning Ocular

PainTDSAKC VKC

Cyclosprine (1%,2%) Tacrolimus

(0.003%)

Decreases sterioddosage

& tracolimus isuseful in steroidresistant cases

Cyclosprine inhibitseosinophil infiltration by affecting type IV

hypersensitivity reaction.Tarcolimus acts

by inhibiting the action of T-Cells

Sr.No.

Features SAC PAC VKC AKC GPC CDC

19Oral

Antihistamines

Dry eye especially with second generation

antihistamines

Od ; bdSevere Allergic

Conditions Od ; bd

Cetirizine, Loratadine, Ebastine,

Levocetirizine, Fexofenadine

These block H 1 receptors some have anti inflammatory properties

by inhibiting ICAM 1 & PGF

Reduces itching, edema

vasodilatation in severe allergic

conjunctivitis

7

8

Discipline is important in every sphere of life. So as in office

where we spend 1/3rd of our day. Adherence to discipline &

etiquette are mandatory at work place .With this

questionnaire self analyze whether, you are a good employee

or not ......???

How is your conduct at office?

Work excellence supports to get jobs , whereas right code of

conduct helps you to survive and sustain in an organization.

This can affect employee's ratings and credibility in an

organization. Answer the below given questions and analyze

your personality.

1. Do you obey the rules and regulation?

A Fully

B Sometime its practically not possible

C Whatever is possible, stick to same

D Don't believe in following rules

2. How is your office outfit?

As per given dress codeA

Love to wear casualB

Wear whatever is there in wardrobeC

Follow the fashion trend.D

3. How is your behavior towards office colleague.

Do you support /help them?

Always ready to supportA

Helps those who help meB

Says straightly noC

Minds my own business.D

4. What is your reaction towards a subordinate's

mistake?

Call him/her and discuss the mistake.A

Hide the mistakeB

Complain to the bossC

Tell it to other staffD

5. What do you do if urgent important work creeps

in on an off day/post office hours?

A Give importance to the work

B Place your problems before boss with

reason of inability to attend.

C Make excuse and walk away.

Give excuse that work hour are over.D

6. You take steps to make sure that there no noise at

work station?

A Keep the cellphone in silent mode .

B Talk politely over phone

C Walkaway from desk and talk so that others

are not disturbed.

D Bit of noise should be there in office

7. How much you are conscious of self &

colleague's privacy?

A Don't use any one system phone or pc

without permission

B Talk about there personal lives

C No question of privacy among office

colleagues

D Knock before entering anyones cabin.

8. How organized is your work & work station?

A Keep the desk c l ean and remove

unnecessary paper time to time.

B Organize your file before leaving the office.

C Peon will do his duty

D Some degree of unorganization is part of

office.

9. How much conscious you are about office

cleanliness & organization etc?

A Check cleanliness as you arrive to office

B Throw waste paper and other things in

dustbin.

C Hygiene dept. is there to maintain.

D Stop people from doing wrong things.

10. Deadlines means to you?

A Always complete the work on time.

B Always reach office on time.

C Love to postpone work.

D Work as per your convenience.

KNOW YOUR SCORE

Answer all question and sum-up your score.

Option A – 4

Option B - 3

Option C - 2

Option D - 1

If your score is between 30-35 you are an excellent employee.

If your score is between 25-30 you are disciplined, but you

can improve your skills.

If your score is below 20 you need to work on your behavior,

a lot of improvement is needed.

1. ---------------- Also known as conjunctivitis.

2. Combination reduces aqueous humor production by

35%.

3. Choice of drug for corneal edema.

Recommended for opthalmia neonatrum.

4. Gold standard therapy for IOP & Open Angle Glaucoma.

5. Prolonged exposure to visual screen causes.

6. Anti Allergic preparation that require adminstration after

every 2 hours.

7. Cold Compression is recommended primary treatment for

………………………..

8. Choice of drug for Chronic Alleric conjunctivitis.

9. Lubricant recommended for Post LASIK surgery.

Note: Mail the correct answers at opthotimes@opthoremedies.com Winners will be rewarded in the next issue.

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H

3

X

V

Z

V

6

G

A

B

D

C

D

R

Y

E

Y

E

R

J

D

5

J

V

X

L

Volume 4 Quiz:

Amazing Picturesque Facts in Ophthalmology

*Search for the suitable answers from the given grid of cross word puzzle, , Horizontally & Vertically.

9

Ankur Sharma

MR (Amritsar)

Sandeep Yogi

AM (Jalandhar)

Optho Times Vol. 3 Quiz Answers:Ocular disease:

1. Dry eye

2. Ocular allergy

3. Glaucoma

4. Pink eye

5. Conjunctivitis

Competitor brands:

1. Refresh

2. Olopat

3. Olap

4. Iotim

Our brands:

1. Brimotim

2. Moxifax

3. Gatifax

4. Lotemox

5. Glutim

6. Odin

7. CCS

8. Tocin

Volume 3 Quiz Winners

10

Gandhiji said, “ Intellectually, mentally and spiritually, woman is equivalent to a man.” Also Article No 14 of the constitution accords equality for both gender. Only in India, women is worshipped as "Shakti" (Strength), "Saraswati" (Knowledge) and "Lakshmi" (Prosperity). Pages of

history have numerous stories of women, from Sita in Ramayana to Kannagi in Silapathikaram to Rani of Jhansi are not only celebrated women but also their contribution to social change & awareness had been held immense. Women in India have always been honored &

respected . Women are the most beautiful creation of God. They have left their footprints in all fields, surpassed the mount everest & stepped in space. Women have great adaptability, they fit in all roles, plus surpassed different phases of life. Women have proved to be great

leader like men too, women are leaders everywhere you look -- from the CEO who runs a million dollar company to the housewife who raises her children and heads her household. “Women are the largest untapped reservoir of talent in the world”.

International Women's Day Celebration started long back in 1911 but efforts took proved to be small enough to provide equal platform. International women's day 2016 appeals & takes the Pledge for Parity. Optho Remedies acknowledged & honoured all the women working

for optho Remedies at HO/BO and sales staff on the behalf of women's day. To align with the International Women's Day, optho has also saluted and greeted all leading women ophthalmologist/optometrist and other staffs of all leading Institutions/Hospital & Clinics.

Women's Day Special

Women's Day Celebration

I am a Woman.I bend.

I don't break

11

12

Mr. Baldev

(Baldev Medical Agencies - 'KARNAL' (HARYANA)

Mr. Mukesh Agarwal

(Medichem Distributor's - 'JABALPUR' (M.P.)

Our Valuable

Distributors

Q. 1: How did your journey as a distributor start?

I started my journey as salesman in 1970-1975 from Prakash

medicine agencies, under the supervision of Om Prakash Shareen.

After 1975, we had overtaken the business of shareen distributors

and named as baldev distributors in Karnal (Haryana).

Q. 2: Share with us some experience from your growing

years?

An association with Optho remedies since last 40 years, I

remember the many important events which really happened.

Such close interactions with the founder of Optho remedies

during the events praise me a lot because his dedication towards

the work always inspire me and often suffused me with emotions

& grief.

Q. 3: How is your relationship with company's director/NSM?

The director/NSM of Optho remedies both has a potential to

intentionally cultivate and maintain connections with vendors &

distributors and this quality builds a healthy & friendly relations

with them and also with the company, such a strong business

relations can promote customer loyalty, customer retention and

collaboration between businesses in the supply chain.

Q. 4: Name our manager who introduced you to Optho?

The capabilities of the affected individuals are not limited to

recalling specific events from their personal experience, thus, I

remember the words of Late Mr R.K. Agarwal “Never get tired until

you achieve the success & dignity for what you are paying since

last years.”

This statement of him really boost me a lot and maybe this is the

only reason of my success and long term relations with Optho

family.

Q. 5: What does Optho do for its dealers that no other brand

does?

Optho's deal & requisition are much more unique & different than

others. This company is a great idea driven along with strong

focus and working with such a friendly & cooperative

environment enforce us to be the part of this firm as longer as we

can.

Q. 6: Is your family also involved in the business with you? If

yes, how does the young generation take the association with

Optho?

Yes!! Me & my children are involved in the business of pharma

distributors; therefore, I can assure you that the young generation

of Baldev distributors will also carry their candidature with Optho

family because they are also very fond of the friendly environment

of the company.

At last, Baldev said that “In such a long tenure with Optho our

relationship builds stronger & healthier, we find that the company

is growing in an ophthalmic market”.

Q. 1: How did your journey as a distributor start?

My journey as Pharma Distributor started since long back from

1972. In those days supply chain/distributions business was on

rise, therefore we have started our business in a pharma

distribution.

Q. 2: Share with us some experience from your growing

years?

In growing years with Optho Remedies, we have experience a lot

of changes, but let me share one thing over here that commitment

is the biggest word in the business and Optho always stand by its

statement and this is the major part of their success in the market.

Q. 3: How is your relationship with company's director/NSM?

Successful businesses don't just communicate with prospects and

customers for special sales. They need to build a healthy

relationship with their distributors, vendors or any kind of supply

chain. We have found that Director/NSM of the Optho Remedies

has a quality to develop such strategies to build a strong

relationship with us, this quality of Optho Remedies transform

into a valuable resource.

Q. 4: Name our manager who introduced you to Optho?

Memories are not always good; we remember the day when Late

R.K. Agarwal (Founder of Optho) has passed away, but the way his

two sons carry away his business this is really quiet appreciable

and prideful.

Q. 5: What does Optho do for its dealers that no other brand

does?

Chuckles.... “Deals & benefits are the major part of us, we are the

dealers and we need the best deal in every aspect.”

So, Yes! Optho is the company which provide us the valuable deal

in acceptable price and we get the evident benefit from the Optho

goods.

Q. 6: Is your family also involved in the business with you? If

yes, how does the young generation take the association with

Optho?

Yes! My entire family is involved in the same business along with

my son. Optho has supported us, not only in the term of business

but also solely, thus, our next generation will also like to carry the

same bond as we are in with.

413

Distribution & market channel are important part of any organization to deliver their products & services to consumer properly.

Distribution channel & distributors play a pivotal role in the success of healthcare industry. We at Optho have strong distribution

system to cater our quality products to the consumers through the distribution channel. Our dignified distributors have been doing

a commendable job and have delivered services at par excellence. We at Optho strongly believe in WIN-WIN principle, thus we

ensure that everyone in the business cycle wins whether its Distributor-Whole seller-Retailer. Our distributors have been the

connecting link between stockist & company. Our quality products pass through our distributors to stockists and so on. To

recognize and acknowledge the efforts of our distributors we held a meeting on 17th Feb. 2016. The meet was confluence of

distributors all across the nation. In a cordial environment a round table conference took place that witnessed exchange of ideas

towards further strengthening the distribution system & make it error free. Company's vision and forthcoming plans for the new

fiscal year were share. The journey to Allahabad is incomplete without the holy dip at Sangam, thus the same was arranged for our

distributors. At last, such more meetings we will be organized in the future to build a strong bonding within us.

Annual Distributor's Meet at H.O.

National Conferences

Disclaimer : Information provided in conference calendar is meant for general information. Publication does not hold any

responsibility in-case of change or discrepancy. Kindly confirm respective official body.

Inter-National Conferences

Title of Conference City Date Venuest1 May-2016

th th17 - 19 June 2016

nd rd2 - 3 July 2016th th19 - 20 Aug. 2016

th th03 - 04 Sep. 2016th th14 - 16 Oct. 2016th th15 - 17 Oct. 2016

th th4 - 6 Nov. 2016

th th30 - 4 Dec. 2016

nd th2 - 4 Dec. 2016

Hotel Hyson Heritage, Calicut

Renaissance Mumbai Convection

Center Hotel

Hotel IITC Grand Chola

ITC Maratha, Hyatt Regency &

Hilton, Mumbai

Hotel ITC Grand Chola Chennai

CIDCO Exhibition Centre, Vashi

Chennai Trade Centre, Chennai

Palampur, Kangra, H.P.

Hotel Hyatt Regency

Jaipur Marriott Hotel

Calicut

Mumbai

Chennai

Mumbai

Chennai

Navi-Mumbai

Chennai

Palampur

Chandigarh

Jaipur

Opthalmology Update

2016 (KSOS)

Eye Advance 2016

IIRSI 2016

Boa-focus 2016

WCOA 2016

Moscon-2016

India International Optical

& Ophthalmology Expo 2016

Galucoma Society Of

India 26th Annual

Meeting -2016

Vitreoretinal Society Of India

Annual Conference 2016

(VRSI 2016)

AAPOS | SPOSI Joint

Meeting- 2016

Title of Conference City Date Venueth th27 - -30 July

th th25 - 29 Sep. 2016

th st29 Sep. – 1 Oct. 2016

Bali Nusa Dua Convention

Center

Keio Plaza Hotel

Shangrila Hotel, JAKARTA

Bali, Indonesia

Shinjuku-KU,

Tokyo, JAPAN

Jakarta, Indonesia

th26 APCRAS

nd22 Biennial Meeting Of

The International Society For

Eye Research 2016th14 National Congress And

The 41st Annual Scientific

Meeting Of The Indonesian

Ophthalmologists Association

2016

Media Gallery

CME on Occuplasty & Ocular Oncology at IGIMS PatnaDr. Santosh G Honavar

AIOS Conference 2016 DOS Conference 2016

Medical Humors

Annual Sales Meeting-2016

Doctor to Medical student- Where is

the eye located???

Medical student replied- Between

the 'H' & the 'J'.

Doctor to Medical student- What

music do ophthalmologists listen to?

Medical student replied- I tunes.

A w o r r i e d p a t i e n t t e l l s a n

opthalmologist (eye doctor): "Doc, I am

very scared about the outcome of the

operation on my left eye. What are my

chances?" Grinning doctor to the

patient: "Hey don't worry, you won't be

able to see the difference."

14

20th April 2016 will be marked in the history of Optho Remedies as a 'Remarkable Day'

An annual sales meeting is integral to the success of the year's sales performance. It's a one-time opportunity to recognize

past performances and inspire achievement for the next twelve months. It brings all the companys sales people together to look

at new products and learn from each other what is working or not working in each other's territories.

The day witnessed a meet with new vision, self analysis & zeal towards reformation. Highlights of the day were the annual

sales achievement, discussion on quarterly revenue, awarding ceremony of our annual sales achievers and at last the

motivational speech reflects the strength of bonding between the company & its employees. The unending devotions &

indispensable contributions of our managers towards the organization will unequivocally helps us to accomplishing company's

set goals.

So, as we step into a new phase of vitality, we continue to rely on this support and confidence that- “Setting goals is the first step

in turning the invisible into the visible."

Managers team with Directors Head office team with Directors

16

(Sodium Hyaluronate 0.1%)

4-Muco-adhesive and Muco-mimetic properties -Long staying

5-Anti-oxidant and Anti-inflammatory properties-Epithelium cyto-protection

HY-5 is a balanced hypotonic solution (149 mOsmol/l) along with an excellent topical tolerance, due to physiological pH 7.4.

How the corneal epithelial wounds develop and which mechanisms are involved in the resurfacing of the cells??

Damage to the corneal epithelium caused by chemical, physical or microbial insults results in swelling of the stroma, activation of stromal fibroblasts and infiltration of various inflammatory cells, leading to the loss of corneal transparency and integrity. Therefore, it is important to repair corneal epithelial damage as rapidly as possible. Most corneal epithelial wounds are indeed repaired promptly. However, under certain clinical conditions, resurfacing of the corneal epithelium is delayed. Knowledge of the mechanisms that underlie the healing of corneal epithelial wounds is crucial for the development of new treatments. Resurfacing of corneal epithelial defects occurs in three phases: 1) Immediately after the wound or injury of epithelial cells, the neighbouring intact epithelial cells begin to migrate over the affected area until they cover it with a cell monolayer.

2) This is followed by the proliferation of the migrated epithelial cells, resulting in the restoration of the normal epithelial thickness.

3) A few weeks after the wounding occurred, the epithelial cells begin to differentiate, the surface of the healed region becomes smooth and a well-layered structure is restored.

The three phases of corneal epithelial wound healing are thus characterized by migration, cell proliferation, and cell differentiation, respectively. Two different types of epithelial movement during the covering process of the exposed area of the cornea have been observed as shown in figure 1: epithelial abrasion (upper panel) is followed by an initial sheet-like movement of individual epithelial cells (middle panel) and a subsequent landslide-like movement of the remaining epithelium enmasse (lower panel).

For patients seeking relief from a variety of eye conditions ranging from dry eye to recovery from LASIK eye surgery, HY-5 which can be used as part of a continuum of care with their existing Lubricant eye drops to personalise the treatment regime around patient need.HY-5 eye drops conta in Sodium hyaluronate 0.1%, an effective lubricant that can replenish the tear film and provide enduring rel ief from dr y

1e y e . S o d i u m h y l a u r o n a t e i s a biocompatible, non-immunogenic, high range molecular weight polymer with a unique physical characteristics; Hy-5 has been designed to give a high level of ocular protection, viscosity, and hydration over an extended period of time which prolonged the contact

2time to the ocular surface. It is also indicated for the medication of wounds and abrasions of the ocular surface caused by traumatic events and following surgery associated with lachrymal film alterations.

HY-5 (sodium hyaluronate 0.1%) has five unique properties:

1-Re-epithelialisation properties - Promotes healing and protection

2-Viscoelastic and Pseudoplastic properties - good ocular retention time

3-Water retaining and wetting properties - Long lasting lubrication.

17

Fig. 2 : MMPs in Corneal Wound Healing

Sodium hyaluronate and provides superficial healing of keratitis

Fig. 1 : Etithelial Movement

The matrix metalloproteinases (MMPs) are a family of

proteolytic enzymes whose function is to maintain and

remodel the tissue architecture. They have been implicated in a

wide range of processes and diseases and their substrates

comprise a variety of extracellular matrix components,

secreted cytokines and cell surface molecules. MMPs including

MMP-9 (gelatinase B), -2 (gelatinase A), and -1 (collagenase)

have been reported to be involved in the pathogenesis of 2ulceration and pterygia of the cornea.

Role of CD44 in regeneration of corneal cells with the help

of sodium hyaluronate:

CD44: The CD44 antigen, a type 1 transmembrane

glycoprotein, is the main receptor for hyaluronan. It is present

on cell membranes of almost all human cells. A specific

function of CD44 is the capability to bind and internalize HA;

however, it can interact with other ligands, such as fibronectin,

collagens, osteopontin, and matrix metalloproteinases

(MMPs). It has proven to work as a docking agent for MMP9 and 5as a growth factor reservoir. In a wound environment, CD44 is

responsible for cellular internalization of HA degradation

products. The other role of CD44 signalling in the wound

environment is to induce fibroblast migration from

surrounding tissue into the wounded area. It is noteworthy

that neither CD44 nor HA alone can induce cell migration and

promote wound healing; an interaction between HA and CD44 5,6is essential to activate this process. . the ability of hyaluronan

particles to bind with the CD44 receptor depends on its

molecular size.

CD44 (receptor) are involved in cell- cell interaction and that

they provide tensile strength for healing epithelial cells,

whereas the others may serve as an adhesion molecule that is

required in cell-matrix interactions for effective cell migration,

including the lateral movement observed during wound

closure and the upward movement seen during epithelial cell

hyper proliferation.

1 . R E - E P I T H E L I S AT I O N P R O P E R T Y O F H Y - 5 :

(PROLIFERATION & MIGRATION OF CELLS)

How Cell Regenrates With Sodium Hyaluronate (hy-5 Eye Drops) And Provides Wound Healing??

Hyaluronan is a natural polymer and its concentration increases in response to ocular damage and during corneal wound healing.

Hyaluronate promotes cell migration and can stabilise ocular surface epithelial barrier, suggesting that it may be directly involved in the process of epithelial repair by activation of the CD44 (the hyaluronate receptor). Moreover, binding of

6,7,hyaluronate to CD44 may stimulate cell proliferation

N OT E : S o d i u m hyaluronate has been shown to f o s t e r t h e c e l l m i g r a t i o n o f corneal epithelial cells, ability for s t i m u l a t i n g e p i t h e l i a l c e l l proliferation and which promotes c o rn e a l wo u n d healing. This may be facilitated by t h e a d h e s i o n between CD44 on t h e c e l l s a n d hyaluronic acid, which coats the surface of the denuded cornea. It was concluded that Sodium Hyaluronate may effectively improve ocular surface damage

6,7,8.associated with dry eye syndrome

CLINICAL STUDIES

Sodium hyaluronate (hyaluronic acid) promotes migration of human corneal epithelial cells in vitro.J A P Gomes1, R Amankwah2, A Powell-Richards2, H S Dua2

Abstract

Purpose: Sodium hyaluronate (hyaluronic acid) is known to promote corneal epithelial wound healing in vivo and in vitro, in animal experiments. Sodium hyaluronate is the ligand for CD44, a cell surface adhesion molecule which has been found on normal human corneal epithelial cells. The purpose of this study was to investigate the effect of sodium hyaluronate on human corneal epithelial cell migration, proliferation, and CD44 receptor expression.

18

Between blinking: HA forms long

lasting protective coating

A

During blinking: HA molecules

align & spreads easily over the cornea.

B

A) Between blinks SH forms a long- lasting protective coating.

B) While blinking, SH molecules align and spread easily over the cornea.

Representation of Sodium Hyaluronate Pseudoplastic behaviour during blinking

The low angle of contact and high surface tension is highly 4,5effective in coating the cornea .

Clinical StudiesOcular surface residence times of artificial tear solutions.Snibson GR1, Greaves JL, Soper ND, Tiffany JM, Wilson CG, Bron AJ. Cornea, 1992 Jul; 11(4):288-93.

Case StudyRe-epithelialisation proppertiesIn a clinical study comppleted by P. Aragona et al, the effects of longer term treatment with 0.15%Sodium Hyaluronate (preservative-free) compared with 0.9% Sodium Chloride (Saline), on the ocular surface of patients with dry eye syndrome was investigated. After 3 month treatment in patent with medium to severer dry eye, sodium hyaluronate improved the impression cytology score with a statistically significant difference compared to the baseline significant difference compared to the baseline value (p=0.024 v baseline). At the same time the difference compared to 3 months treatment with 0.9% Sodium Chloride was also statistically significant (p=0036 v Sodium Chloride 0.9%). After 3 months treatment with 0.15% Sodium Hyaluronate the main cytological further of impressions made against the temporal interppalpebral bulbar conjunctiva were the presences of smaller cells with both polygonal and round shape and the presence of goblet cells. This was compared to the 0.9% Sodium Chloride treated group where cytological features were presence of polygonal cells with keratinised, basophilic cytophlasm, markedly reduced nucleus/cytoplasm ratio and an absence of globlet cells. It was concluded that 0.15% Sodium Hyaluronate may effectively improve ocular surface damage associated with dry eye

6syndrome .

Methods: Human corneal epithelial cell cultures were established from 32 donor corneoscleral rims and maintained separately in three different culture conditions: (1) culture medium only, (2) sodium hyaluronate enriched (0.6 mg/ml) medium, and (3) hydroxypropylmethylcellulose enriched (2.5 mg/ml) medium. The total area of migrating epithelial cell sheets in each case was measured by planimetry on days 4, 8, 12, and 16. Cytospin preparations of cells cultured in the different culture conditions were examined immune-histochemically for proliferation and CD44 receptor expression using antibodies directed against Ki67 and CD44 respectively.

Results: Cells cultured in the presence of sodium hyaluronateshowed significantly increased migration at days 12 and 16 (Friedmen test: p� =� 0.0012, day 16; p� =� <0.001, day 12) compared with cells cultured in the other media. There was no difference in cell proliferation (Ki67) or CD44 expression on cells cultured in the different culture conditions.

Conclusions: Sodium hyaluronate promotes migration but not proliferation or CD44 expression on human corneal epithelial cells in vitro. The beneficial effect of sodium hyaluronate in corneal wound healing is likely to be related to rapid migration of cells leading to rapid wound closure. This may be facilitated by the adhesion between CD44 on the cells and hyaluronic acid, which coats the surface of the denuded cornea.

EVIDENCE OF CORNEAL RE-EPITHELISATION & CORNEAL REPAIR

P. Aragona et al., Long term treatment with Sodium Hyaluronate- containing artificial tears reduces ocular surface damage in patients with dry eye. Br J Ophthalmology 2002; (86): 181-184.

2. VISCO ELASTIC PROPERTY OF HY-5:The most important property of HA solutions is their viscoelasticity, which combines the viscous properties of a liquid with the elastic properties of a solid, depending on the shear stress applied.When used as an ocular lubricant, the unique viscoelastic properties of HA increase the stability of the pre-corneal tear film and maximize

.4, 5tear film residence time .

During blinking, Sodium Hyaluronate fluidity increases so enabling it to coat the entire surface of the eye. At rest in the non- blinking eye, Sodium Hyaluronate recovers its initial viscosity, granting it one of the longest retention times on the

3ocular surface compared to other artificial tears.

This characteristic of Sodium Hyaluronate is described as pseudoplastic behaviour. The pseudo plastic properties of Sodium Hyaluronate enable it to be a sufficiently viscous and static substance when at rest and to transform to a more fluid and mobile substance when a stress force is applied. This behaviour ensures a high lachrymal viscosity when the eye lids are open which contributes to enhanced tear film stability and a reduction in tear film evaporation. This should also equate to a reduced requirement on the frequency of instillation of Sodium Hyaluronate for the treatment of dry eye. In addition during increased blinking and subsequent increased shear stress on the tear film, the progressive reduction in viscosity of sodium hyaluronate helps to reduce any friction of movement between the eye lids and the ocular surface.

19

Fluorophotometric measurement of the precorneal resisdence time of topically applied hyaluronic acid.

1 1 2H Mochizuki, M Yamada, S Hato1, T Nishida

AbstractPurpose: This study was performed to separately assess the aqueous flow applied with hyaluronic acid, and the behavior of hyaluronic acid itself on the ocular surface.

Methods : Two different fluorescent dyes, fluorescein sodium dissolved in 0.1% fluorescein conjugated with hyaluronic acid (F-HA) dissolved in saline, were used. A volum of 20 ul of tested solution was applied to teh eye of 10 healthy volunteers. Fluorescein sodium dissolved in saline served as a control. The fluorescent intensity of the precorneal tear film was measured at eh central cornea every minute for 10 min. The turnover rate was calculated using the equation that plots fluorescent intensity against time the equation that plots and expressed as % min.

Case Study Viscoelastic propertiesEsto,ates of the ocular surface residence times of 0.3% Hydroxpropylmethylcellulose (Hypromellose), 1.4% Plolyvinyl Alcohol and 0.2% Sodium Hyalyronate were made using quantitative gamma scinitigraphy in six patients with keratoconjunctivitis sicca. Sodium Hyaluronate hacl a mean half life on the ocular surface of 321 seconds, which was significantly longer than Hydroxproplymenthylcellulose 44 sconds; p=0.012 and Polyvinyl Alcohol 39 seconds; p=0.013. Given its prolonged residence time, favourable rheology, and emerging clinical support, Sodium Hyaluronate may

3come to pay a greater part in the treatment of dry eyes .

Conclusion : Our results indicate that the bulk aqueous flow applied with HA and the turnover of HA itself are different. HA molecules may adhere to the ocular surface by surface-chemical and/or the ocular surface may explain the mechanism in which hyaluronic acid has been show to enhance tear film stability for a few hours.

References: 1. 2007 Report of the International Dry Eye Workshop (DEWS),The Ocular Surface, April 2007, Volume 5, No.2.

2. Snibson G. R. et al., Ocular surface residence times of artificial tear solutions. Cornea 1992; 11(4): 288-293.

3. Saettone MF et al. Int J Pharm 1989; 51: 203–12

4. P. Aragona et al., Long term treatment with Sodium Hyaluronate- containing artificial tears reduces ocular surface damage in patients with dry eye. Br J Ophthalmology 2002; (86): 181-184.

5. Condon PI, McEwen CG, Wright M, et al. Double blind, randomized, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome.Br J Ophthalmol 1999;83:1121–4.

6. Gomes JAP, Amankwah R, Powell-Richards A, et al. Sodium hyaluronate promotes migration of human corneal epithelial cells in vitro. Br J Ophthalmol; 2004;88:821–5

7. Nokazaki Y et al. Jpn Pharmacol Ther: 1993; 21: 87–102.

Results: Turnover rates of topically applied 0.1% F-HA, 0.1% HA and saline were 8.1 (SD 3.6)% min, 21.6 (2.8)%, min 31.0 (3.7)%min, respectively. The turnover rate of F-HA was significantly lower than those of HA and saline (p=0.00012 adn p =0.00000022, respectively; Mann-Whitney test). The turnover rate of HA was significantly lower than that of saline (p=0.00001; Mann-Whitney test).

AbstractSolutions of hydroxypropylmethylcellulose (HPMC) and polyvinyl alcohol (PVA) are widely used as artificial tears. However, their usefulness is limited by the short duration of their effect. Dilute sodium hyaluronate (SH) solutions exhibit non-Newtonian rheology with high viscosities at low shear rates, which would be expected to enhance their ocular surface residence time. Using quantitative gamma scintigraphy, estimates of the ocular surface residence times of 0.3% HPMC, 1.4% PVA, and 0.2% SH were made in six patients with keratoconjunctivitis sicca. The sodium hyaluronate solution had a mean half-life on the ocular surface of 321 s, significantly longer than hydroxypropylmethylcellulose (44 s; p = 0.012) and polyvinyl alcohol (39 s; p = 0.013).

PatronMr. Rajesh Agarwal & Mr. Rakesh Agarwal

Editor in ChiefMrs. Anushri R. Agarwal

TeamMr. D. K. Srivastava, Mr. Satyendra Verma & Ms. Manjari Mishra

Special Thanks to Dr. Rohit Agarwal & Mr. Ridim Agarwal

Our Team Spectrum

OPTHO REMEDIES P. LTD.Head Office : 28, MNNIT, Industrial Estate, Teliarganj, Allahabad - 211004 Tel : +91-532-2545669

ndBranch Office : 8A/37, 2 Floor, Channa Market, Karol Bagh, New Delhi - 110005 http://www.facebook.com/opthorem | Log on : www.opthoremedies.com

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