0001144204-16-094925.txt : 201604190001144204-16-094925.hdr.sgml : 2016041920160418214356ACCESSION NUMBER:0001144204-16-094925CONFORMED SUBMISSION TYPE:FWPPUBLIC DOCUMENT COUNT:28FILED AS OF DATE:20160419DATE AS OF CHANGE:20160418

SUBJECT COMPANY:

COMPANY DATA:COMPANY CONFORMED NAME:Cancer Prevention Pharmaceuticals, Inc.CENTRAL INDEX KEY:0001471002STANDARD INDUSTRIAL CLASSIFICATION:PHARMACEUTICAL PREPARATIONS [2834]IRS NUMBER:262772394STATE OF INCORPORATION:DEFISCAL YEAR END:1231

FILING VALUES:FORM TYPE:FWPSEC ACT:1934 ActSEC FILE NUMBER:333-208718FILM NUMBER:161577877

BUSINESS ADDRESS:STREET 1:1760 E RIVER ROAD #250CITY:TUCSONSTATE:AZZIP:85718BUSINESS PHONE:(520) 908-7774

MAIL ADDRESS:STREET 1:1760 E RIVER ROAD #250CITY:TUCSONSTATE:AZZIP:85718

FORMER COMPANY:FORMER CONFORMED NAME:Cancer Prevention Pharmaceuticals, LLCDATE OF NAME CHANGE:20090826

FILED BY:

COMPANY DATA:COMPANY CONFORMED NAME:Cancer Prevention Pharmaceuticals, Inc.CENTRAL INDEX KEY:0001471002STANDARD INDUSTRIAL CLASSIFICATION:PHARMACEUTICAL PREPARATIONS [2834]IRS NUMBER:262772394STATE OF INCORPORATION:DEFISCAL YEAR END:1231

FILING VALUES:FORM TYPE:FWP

BUSINESS ADDRESS:STREET 1:1760 E RIVER ROAD #250CITY:TUCSONSTATE:AZZIP:85718BUSINESS PHONE:(520) 908-7774

MAIL ADDRESS:STREET 1:1760 E RIVER ROAD #250CITY:TUCSONSTATE:AZZIP:85718

FORMER COMPANY:FORMER CONFORMED NAME:Cancer Prevention Pharmaceuticals, LLCDATE OF NAME CHANGE:20090826

FWP1v437110_fwp.htmFWP

1 Investor Presentation April 2016 Issuer Free Writing Prospectus Filed pursuant to Rule 433 Registration No. 333 - 208718 April 18, 2016

2 Forward - looking statements This presentation contains certain statements that may be deemed to be forward - looking statements within the meaning of applicable federal securities laws. In some cases, these forward - looking statements can be identified by the use of forward - looking terminology, including the terms believes, estimates, anticipates, expects, plans, intends, may, could , might, will, should, approximately or, in each case, their negative or other variations thereon or comparable termino log y, although not all forward - looking statements contain these words. All statements, other than statements of historical facts, that address activities, events, or developments that Cancer Prevention Pharmaceuticals, Inc. (the Company, CPP, us, we, or our) expects, projects, believes or anticipates will or may occur in the future, including, without limitation, the expecte d s afety and efficacy of our product candidates, our ongoing and planned development of drugs, the projected milestones, our ongoing and planned preclinical and clinical studies and trials, the timing of and our ability to make regulatory filings and obtain and maintain regulatory approvals, market size, the strength and breadth of our intellectual property, general industry condition s and opportunities and other such similar matters, are forward - looking statements. By their nature, forward - looking statements involve risks and uncertainties because they relate to events, competitive dynamics, and healthcare, regulatory and scientific developments and depend on the economic circumstances that may or may not occur in the future or may occur on longer or shorter timelines than anticipated. Although the Company believes that its expectations stated in this presentation are based on reasonable assumptions, actual results may differ materially from those projected in the forward - looking statements contained in this presentation as a result of, among other factors, the factors referenced in the Risk Factors section of our Registration Statement on Form S - 1 (Registration No. 333 - 208718) initially filed with the Securities and Exchange Commission (the SEC) on December 23, 2015 as subsequently amended to date (our Registration Statement). In addition, even if our results of operations, financial condition and liquidity, and the develop men t of the industry in which we operate are consistent with the forward - looking statements contained in this presentation, they may not be predictive of results or developments in future periods. Any forward - looking statements that we make in this presentation speak only as of the date of such statement, and we undertake no obligation to update such statements to reflect events or circumstances after the date of this presentation, except as required by law. You should read carefully our Special Note Regarding Forward - Looking Statements and the factors described in the Risk Factors sections of our Registration Statement to better understand the risks and uncertainties inherent in our business.

3 Free writing prospectus statement This presentation highlights basic information about us . Because it is a summary, it does not contain all of the information that you should consider . We have filed our Registration Statement (including a preliminary prospectus) with the SEC . The Registration Statement has not yet become effective . You should read the preliminary prospectus in the Registration Statement (including the risk factors described therein) and other documents we have filed with the SEC for more complete information about us . You may get these documents for free by visiting EDGAR on the SEC website at http : //www . sec . gov . The preliminary prospectus, dated April 18 , 2016 , is available on the SEC website at http : //www . sec . gov . Alternatively, we or Aegis Capital Corp . will arrange to send you the prospectus if you contact Aegis Capital Corp . , Prospectus Department, 810 Seventh Avenue, 18 th Floor, New York, NY 10019 , telephone : 212 - 813 - 1010 , e - mail : prospectus@aegiscap . com .

4 SHARES OFFERED 1,923,076 Shares (100% Primary) PRICE RANGE $12.00 - $14.00 per Share EXCHANGE / TICKER NYSE MKT / CPP OVER - ALLOTMENT 15% or 288,462 Shares (100% Primary) USE OF PROCEEDS To fund the completion of our Phase 3 clinical trial of CPP - 1X/sul for FAP and additional studies necessary for filing a NDA with the FDA, to support our efforts developing other indications for CPP - 1X/sul, to advance any additional product candidates that we select, and to expand our internal research and development capabilities to explore new product candidates. Other general corporate purposes . SOLE BOOK RUNNER Aegis Capital Corp . Offering Summary

5 >65 - 80% of common colon cancers driven by same genetic mutation as FAP Prevent colon cancer recurrence; colon adenoma therapy CAT An innovative approach to fight colon cancer by preventing it from (re)occurring A genetic disease caused by APC mutations where colon polyps develop early in life Nearly 100% of patients will develop colon cancer if the polyps are left untreated Colon cancer survivors 600 K in US 1 MM in EU FAP (orphan disease) 30 K in US 50 K in EU Phase 3 / FAP - 310 $300 - 800 MM Phase 3 PACES Trial Colon Cancer Risk Reduction Phase 2/3 Meyskens Trial Completed & Published $1B+ market potential FAP Colon Cancer Survivors Have common genetic mutation to FAP and high - risk of developing colon cancer Prevent polyps and colon cancer from forming High - risk polyp formers 3 MM in US 5 MM in EU High - risk Polyp Formers

6 FAP is a lifelong continuum of disease and intervention Before surgery duodenum colon rectum Colectomy: colon removal Surgically removed segment of colon Removal of: rectum, surgical pouch, high - risk polyps Duodenectomy: duodenum removal FAP requires increasingly severe surgical interventions including: FAP causes extreme polyposis in the colon, rectum, duodenum requiring surgery

7 Opportunity to target one pathway to prevent multiple cancers Mutations in Adenomatous Polyposis Coli (APC gene) drive polyposis and are implicated in FAP and in >65 - 80% of sporadic colon polyps and in other cancers, including neuroblastoma. ODC APC MYC Other Regulatory Genes Polyamines Increased ODC and polyamines drive uncontrolled cell growth and polyposis Clinical progression of colon cancer Normal Adenomas (High - Risk Polyps) Colon Cancer

8 CPP - 1X/sul reduces polyamines via dual mechanism of action ODC PPAR g Polyamine Elimination Polyamine Synthesis SAT * CPP - 1X has never been approved in oral form, is not on the market in any systemic dosage form, and is not available in any generic form. Sulindac CPP - 1X CPP - 1X* decreases polyamine synthesis by blocking Ornithine Decarboxylase (ODC1) Sulindac increases polyamine catabolism and export by up - regulating transport genes ( PPAR g and SAT ) CPP - 1X/sul Reduces Polyamines & Polyps

9 No statistically significant serious adverse events in Phase 2/3 Meyskens trial with 375 patients and three years of daily dosing of CPP - 1X/sul Sulindac (sul) approved for arthritis and used extensively for many years CPP - 1X/sul contains only the dose approved for other indications CPP - 1X (eflornithine) used in many previous NCI - funded trials Subclinical ototoxicity (hearing loss) only for specific genetic subgroup, which may be a useful genetic screening tool to predict those most likely to respond to the drug and to have minimal side effects CPP is using much lower doses than these previous trials Molecular diagnostic and clinical criteria strategies to manage low frequency toxicities in the future CPP - 1X/sul combination has extensive clinical experience and minimal toxicities

10 FAP preclinical data shows rationale for combination therapy Combo therapy of CPP - 1X and sulindac shows best results in FAP animal model High Grade Adenomas per Mouse CPP - 1X / sul 0 2 4 6 8 10 12 Ignatenko NA, et al. Nutr Cancer 2008, 60 Suppl 1:30 - 5. Comparison of treatments in APCMin/+ mouse model of FAP CPP - 1X 0.5% Celecoxib 500ppm CPP - 1X 2.0% Sulindac 167ppm CPP - 1X 2.0% + Celecoxib CPP - 1X 2.0% + Sulindac Control

11 Phase 2/3 Meyskens trial in high - risk polyp formers Primary: polyp occurrence Phase 2/3 Meyskens Trial Prospective, randomized, placebo - controlled trial (1:1 randomization) Three years of daily treatment Endpoints CPP - 1X (500 mg) Placebo + Sulindac (150 mg) Completed Trial 375 patients participated (patients at high risk of polyp formation and recurrence) UC Irvine, investigator - sponsored trial Dr. Meyskens is Associate Chair of SWOG Meyskens , et al. CAPR 2008, 1:32 - 28.

12 High - risk polyp formers are a key target market for CPP Marked Reduction of Polyps (Adenomas) with CPP - 1X/sul Daily Treatment Meyskens , et al. CAPR 2008, 1:32 - 28. Phase 2/3 Meyskens trial efficacy results Placebo CPP - 1X/sul Total Adenoma % of patients with metachronous (occurring at different times) adenomatous polyps 0 10 20 30 40 50 41.1% 12.3% 70% reduction p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