0

-2

-4

-6

Sinetrol

Placebo

-5.6

kg

-22.

36%

0

-2

-4

-6

-8

-10

-12

-14

-16

-18

-20

-22

-24

Body weight loss Body fat mass reduction

p<0.

05

p<0.

05

porte

fat burning solution*Proven

First clinical study5

Commercial name Sinetrol®Xpur Sinetrol®Xpur EZ

Description Proprietary blend of citrus extracts

GMO free

Active compounds

Flavanones (HPLC) >20% >13%

Recommended dose 0,9g/day 1,4g/day

Solubility Moderate Water soluble

Applications Food supplements Instant solutions & beverages

References1 - World Health Organization - Obesity and overweight. www.who.int/mediacentre/factsheets/fs311/fr/2 - Shen X. et al.; Int. J. Vitam. Nutr. Res.; 2009, 79 (4): 255-2633 - Kuppusamy U. R. et al.; Biochem. Pharm; 1992, 44 (7): 1307-13154 - Dallas C. et al.; Phytomedicine; 2008, 15: 783-792 5- Dallas C. et al.; Phytother. Res.; 2014, 28(2): 212-218

• Randomized, double-blind, placebo-controlled.

• 20 overweight & obese subjects (BMI=27-33).

• 12-week supplementation.

• Sinetrol® or a placebo.

• 2 groups : Sinetrol® (N=10) and placebo (N=10).

• Normo-caloric balanced diet and no changein physical activity.

Proven ef� cacy4*A signi� cant decrease of body weight (-5.6kg, p<0.05) and a signi� cant body fat reduction of -22.4% (p<0.05) have been observed in the Sinetrol® group**.

Citrus polyphenolextract

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

** Before participating in any diet or exercise program, please consult your physician.Fytexia - contact@fytexia.com - +33 4 67 21 90 98

www.fytexia.com - www.sinetrol.com

Cré

atio

n/R

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.com

bes-

hund

.com

- S

iret

405

338

955

0002

5 -

Pho

tos

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olia

p<

0.00

01

600

500

400

300

200

100

0

Lipolytic effect: FFA release

-9.7

3%

0

-2

-4

-6

-8

-10

-5.1

5cm

0

-1

-2

-3

-4

-5

-6

0

-1

-2

-3

-4

-5

-6

-5.1

7cm

Reduction of hip sizeReduction of abdominal fat Reduction of waist size

488

µmo

/L

p<

0.00

01

p<

0.00

01

p<

0.00

01 Phy

sio

log

ical

sta

ndar

d

1%

56%

7%

97%

Control Caffeine Guarana

Sine

trol

®

Inhibition of PDE-4 by Sinetrol

1%

56%

7%

97%

Control Caffeine GuaranaSi

netr

ol®

Inhibition of PDE-4 by Sinetrol

The Mediterranean wayto lose weight*

0 10 20 30 40 min

utes

Caf

fein

e

Scienti� c evidence

Excess of weight concerns 1.9 billion adults today, among which more than 600 million are obese1. This risk factor is indirectly linked to the development of oxidative stress2 and considerably increases a person’s risk of affecting life expectancy. It is nevertheless preventable1.

Fytexia developed Sinetrol®, a proprietary weight loss ingredient* formulated with a selection of natural citrus extracts offering the health bene� ts of bioactive polyphenols.

Sinetrol® promotes the metabolism in reducing excess body fat to help reach and maintain a healthy body composition. Its synergistic action reduces oxidative stress and lowers the risk of metabolic disturbances associated with overweight and obesity.

Second clinical study5

• Collaboration with the Association Nationale de Prévention des Maladies (ANPM), Paris, France.

• Randomized, double-blind, placebo-controlled.

• 95 overweight subjects (BMI=26-29.9).

• 12-week supplementation.

• Sinetrol® Xpur (0.9g/day) or placebo.

• 1 capsule of 450mg twice a day, at breakfast and at lunch.

• 2 groups: Sinetrol® Xpur (N=47) and placebo (N=48).

• Normo-caloric balanced diet and 30min/week of physical activity.

Example of Sinetrol® HPLC � ngerprint (wavelength: 280 nm)

Proven Fat Burning solution

The proprietary formula of Sinetrol®

provides a synergy of bioactivepolyphenols known for their lipolytic action. Lipolysis is a catabolic process leading to the breakdown of triglyce-rides stored in fat cells (adipocytes), releasing free fatty acids (FFA) andglycerol.

Sinetrol® helps stimulate lipolysis* through the inhibition of phosphodies-terase 4 (PDE-4)3,4, the enzyme that catalyzes the hydrolysis of cAMP.

In addition, polyphenols in Sinetrol®

have been reported to helpinduce the expression of fatty acidoxidation genes, which coaxes the metabolism toward the use of FFA to produce additional energy yielding.

Demonstrated ef� cacy5*Ef� cacy and safety of Sinetrol® Xpur for body weight management and improvement of metabolic disturbances with reduction of stress have been assessed in this clinical study.

In this study, Sinetrol® Xpur helps in supporting a healthy body composition:

- abdominal adiposity ratio reduction (-9.73%, p<0.0001),

- waist size reduction (-5.15 cm, p<0.0001) and hip size reduction (-5.17 cm, p<0.0001)

- enhanced lipolysis (10 times more free fatty acids release, p<0.0001)

- oxidative stress reduction and healthy in� ammatory response support.Sinetrol® is a patented synergistic blend of bioactive polyphenols, selected for their bene� ts on body weight management. It includes naringin and hesperidin as main active compounds extracted from citrus of the Mediterranean shores: sweet orange, blood orange & grapefruit.The activity of Sinetrol® is enhanced with natural caffeine from guarana.

Recommended dose 2 x 450 mg maintains a healthy body composition*

p<

0.00

01

600

500

400

300

200

100

0

Lipolytic effect: FFA release

-9.7

3%

0

-2

-4

-6

-8

-10

-5.1

5cm

0

-1

-2

-3

-4

-5

-6

0

-1

-2

-3

-4

-5

-6

-5.1

7cm

Reduction of hip sizeReduction of abdominal fat Reduction of waist size

488

µmo

/L

p<

0.00

01

p<

0.00

01

p<

0.00

01 Phy

sio

log

ical

sta

ndar

d

1%

56%

7%

97%

Control Caffeine Guarana

Sine

trol

®

Inhibition of PDE-4 by Sinetrol

1%

56%

7%

97%

Control Caffeine Guarana

Sine

trol

®

Inhibition of PDE-4 by Sinetrol

The Mediterranean wayto lose weight*

0 10 20 30 40 min

utes

Caf

fein

e

Scienti� c evidence

Excess of weight concerns 1.9 billion adults today, among which more than 600 million are obese1. This risk factor is indirectly linked to the development of oxidative stress2 and considerably increases a person’s risk of affecting life expectancy. It is nevertheless preventable1.

Fytexia developed Sinetrol®, a proprietary weight loss ingredient* formulated with a selection of natural citrus extracts offering the health bene� ts of bioactive polyphenols.

Sinetrol® promotes the metabolism in reducing excess body fat to help reach and maintain a healthy body composition. Its synergistic action reduces oxidative stress and lowers the risk of metabolic disturbances associated with overweight and obesity.

Second clinical study5

• Collaboration with the Association Nationale de Prévention des Maladies (ANPM), Paris, France.

• Randomized, double-blind, placebo-controlled.

• 95 overweight subjects (BMI=26-29.9).

• 12-week supplementation.

• Sinetrol® Xpur (0.9g/day) or placebo.

• 1 capsule of 450mg twice a day, at breakfast and at lunch.

• 2 groups: Sinetrol® Xpur (N=47) and placebo (N=48).

• Normo-caloric balanced diet and 30min/week of physical activity.

Example of Sinetrol® HPLC � ngerprint (wavelength: 280 nm)

Proven Fat Burning solution

The proprietary formula of Sinetrol®

provides a synergy of bioactivepolyphenols known for their lipolytic action. Lipolysis is a catabolic process leading to the breakdown of triglyce-rides stored in fat cells (adipocytes), releasing free fatty acids (FFA) andglycerol.

Sinetrol® helps stimulate lipolysis* through the inhibition of phosphodies-terase 4 (PDE-4)3,4, the enzyme that catalyzes the hydrolysis of cAMP.

In addition, polyphenols in Sinetrol®

have been reported to helpinduce the expression of fatty acidoxidation genes, which coaxes the metabolism toward the use of FFA to produce additional energy yielding.

Demonstrated ef� cacy5*Ef� cacy and safety of Sinetrol® Xpur for body weight management and improvement of metabolic disturbances with reduction of stress have been assessed in this clinical study.

In this study, Sinetrol® Xpur helps in supporting a healthy body composition:

- abdominal adiposity ratio reduction (-9.73%, p<0.0001),

- waist size reduction (-5.15 cm, p<0.0001) and hip size reduction (-5.17 cm, p<0.0001)

- enhanced lipolysis (10 times more free fatty acids release, p<0.0001)

- oxidative stress reduction and healthy in� ammatory response support.Sinetrol® is a patented synergistic blend of bioactive polyphenols, selected for their bene� ts on body weight management. It includes naringin and hesperidin as main active compounds extracted from citrus of the Mediterranean shores: sweet orange, blood orange & grapefruit.The activity of Sinetrol® is enhanced with natural caffeine from guarana.

Recommended dose 2 x 450 mg maintains a healthy body composition*

0

-2

-4

-6

Sinetrol

Placebo

-5.6

kg

-22.

36%

0

-2

-4

-6

-8

-10

-12

-14

-16

-18

-20

-22

-24

Body weight loss Body fat mass reduction

p<0.

05

p<0.

05

porte

fat burning solution*Proven

First clinical study5

Commercial name Sinetrol®Xpur Sinetrol®Xpur EZ

Description Proprietary blend of citrus extracts

GMO free

Active compounds

Flavanones (HPLC) >20% >13%

Recommended dose 0,9g/day 1,4g/day

Solubility Moderate Water soluble

Applications Food supplements Instant solutions & beverages

References1 - World Health Organization - Obesity and overweight. www.who.int/mediacentre/factsheets/fs311/fr/2 - Shen X. et al.; Int. J. Vitam. Nutr. Res.; 2009, 79 (4): 255-2633 - Kuppusamy U. R. et al.; Biochem. Pharm; 1992, 44 (7): 1307-13154 - Dallas C. et al.; Phytomedicine; 2008, 15: 783-792 5- Dallas C. et al.; Phytother. Res.; 2014, 28(2): 212-218

• Randomized, double-blind, placebo-controlled.

• 20 overweight & obese subjects (BMI=27-33).

• 12-week supplementation.

• Sinetrol® or a placebo.

• 2 groups : Sinetrol® (N=10) and placebo (N=10).

• Normo-caloric balanced diet and no changein physical activity.

Proven ef� cacy4*A signi� cant decrease of body weight (-5.6kg, p<0.05) and a signi� cant body fat reduction of -22.4% (p<0.05) have been observed in the Sinetrol® group**.

Citrus polyphenolextract

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

** Before participating in any diet or exercise program, please consult your physician.Fytexia - contact@fytexia.com - +33 4 67 21 90 98

www.fytexia.com - www.sinetrol.com

Cré

atio

n/R

éalis

atio

n : w

ww

.com

bes-

hund

.com

- S

iret

405

338

955

0002

5 -

Pho

tos

: Fot

olia