Figure S1
4
Figure S1 A WM1361A NRAS mutant IKKε Actin WM1346 WM3670 WM1366 WM852 SKMel2 SBcl2 RAW246.7 SKMel173 SKMel30
description
Figure S1. A. NRAS mutant. SKMel30. WM1366. WM3670. SKMel2. SKMel173. WM1346. WM1361A. WM852. RAW246.7. SBcl2. IKK ε. Actin. Figure S2. A. WM1366 WM1346. - #2 - #2. siTBK1. TBK1. ERK. B. 100. siCTL. siTBK1 #2. 80. *. *. *. *. 60. - PowerPoint PPT Presentation
Transcript of Figure S1
Figure S1
A
WM
1361
A
NRAS mutant
IKKε
Actin
WM
1346
WM
3670
WM
1366
WM
852
SK
Mel
2
SB
cl2
RA
W24
6.7
SK
Mel
173
SK
Mel
30
Figure S2
A - #2 - #2
WM1366 WM1346
B
C
0
***
*
20
40
60
80
100
WM1346 WM1361A WM1366 SBcl2
Per
cen
t M
igra
tion
of C
on
tro
l siCTL
siTBK1 #2
**
*
*
0
20
40
60
80
100
WM1346 WM1361A WM1366 SBcl2
Per
cen
t In
vasi
on
of
Co
ntr
ol siCTL
siTBK1 #2
siCTL
siTBK1
siCTL
siTBK1
ERK
TBK1
siTBK1
Figure S3
0 0.01 0.1 1 5
Aurora A Thr288Aurora B Thr222Aurora C Thr198
Aurora B
WM1366 TR TBK1-myr
AZ909 (μM)
IKKε
PDK1
phospho-PDK1 Ser241
Aurora A
0 0.01 0.1 1 5
SKMel2
phospho-Aurora A/B/C
Figure S4
AZ909AZD6244
- - + +- + - +
WM1366
siTBK1AZD56244
- - + +- + - +
WM1366
Bim-EL
Mcl-1
Bim-EL
Mcl-1
Bmf Bmf
BA C
siCTL
siTBK1
siCTL
siTBK1
AZD6244 DMSO
