Fact File Gastro Intestinal Hormones
3
GASTRO INTESTINAL HORMONES - GI HORMONES Biologically active polypeptides secreted by the cells of Gasrtointestinal tract and also nerve cells present in brain. Also called as Gut Polypeptides. Paracrine cells or histocrine cells Endocrine cells secrete GI homones APUD cells Amine Precursor Uptake and Decarboxylation - Paracrine cells. Hormone Full name Site of production Additional regions that possess cells Target part Action Gastrin Gastrin G- cells of intestinal wall and upper gastric wall TG cells stomach Pitiutary medulla, hypothalam us Gasrtic gland. Oesophage al Sphincter Stimulate gastric juice secretion,insul in secretion CCK -PZ Chole cystokinin- Pancreozymi n I cells of duodenum Ileum ,col on , brain Pancreas, Small intestine Stimulate pancreatic juice and enterokinase secretion.Contr action of gall bladder. Secretin Secretin S- cells of small intestine Brain Pancreas and bile duct Bicarbonate secretion, contraction of pyloric sphincter . Secreted when stomach becomes acidic. GIP Gastric inhibitory peptide K- cells of duodenum and jejunum Brain Pancreas Gastric gland Stimulate insulin secretion, Inhibit gastric secretion. Also called Glucose dependent- insulino tropic hormone- Stimulated by
-
Upload
sudip-devadas -
Category
Documents
-
view
8 -
download
0
description
Fact File Gastro Intestinal Hormones
Transcript of Fact File Gastro Intestinal Hormones
GASTRO INTESTINAL HORMONES
GASTRO INTESTINAL HORMONES- GI HORMONES
Biologically active polypeptides secreted by the cells of Gasrtointestinal tract and also nerve cells present in brain.
Also called as Gut Polypeptides.
Paracrine cells or histocrine cellsEndocrine cells secrete GI homones
APUD cellsAmine Precursor Uptake and Decarboxylation- Paracrine cells.
HormoneFull nameSite of productionAdditional regions that possess cellsTarget partAction
GastrinGastrinG- cells of intestinal wall and upper gastric wallTG cells stomach
Pitiutary medulla, hypothalamus
Gasrtic gland. Oesophageal
SphincterStimulate gastric juice secretion,insulin secretion
CCK -PZChole cystokinin-PancreozyminI cells of duodenumIleum ,colon , brainPancreas, Small intestineStimulate pancreatic juice and enterokinase secretion.Contraction of gall bladder.
SecretinSecretinS- cells of small intestineBrainPancreas and bile ductBicarbonate secretion, contraction of pyloric sphincter . Secreted when stomach becomes acidic.
GIPGastric inhibitory peptideK- cells of duodenum and jejunumBrainPancreas Gastric glandStimulate insulin secretion, Inhibit gastric secretion. Also called Glucose dependent-insulino tropic hormone-Stimulated by fat and glucose in the duodenum
VIPVaso active Intestinal PolypeptideGutBrainPancreas , Stomach Stimulate bicarbonate secretion by pancreas , Inhibits gastric secretion and motility
MotilinMotilinEC cells of duodenum-IntestineCauses intestinal motility. Prepares intestine for next meal
NeurotensinNeurotensinIleumMotor neurons of enteric nervous system.IntestineCauses increased blood flow in intestine . Inhibits intestinal motility
Substance PSubstance PIntestine-IntestineNot found in blood. Increases motility.
GRPGastrin Releasing PeptideVagal nerve endings.-StomachStimulate gastrin secretion
SomatostatinSomatostatinD cells of pancreasBody cellsGH inhibiting hormone. Stimulated by acid in the stomach
GlucagonEnteroglucagonA cells of stomach and duodenumA cells of pancreatic islets-Hyperglycaemia in diabetes mellitus
GLIGLI-glicentin---Similar to glucagon
GuanylinGuanylinPaneth cells of small intestinal epithelium crypts of lieberkuhn.--Recently identified hormone
DynorphinOpioid peptideDuodenumPost.pituitary--
SerotoninSerotoninEnterochromaffin cells and nerve endings.GI tractGI tractBoth GI hormone and neurotransmitter
BombesinBombesinTetra deca peptide from mammalian stomach .Frogs skin-Stimulate pancreatic secretion
