Workshop on Quantitative EPR - Center for EPR Imaging in Vivo
EPR e l’imaging retinico
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Transcript of EPR e l’imaging retinico
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Le Patologie MaculariXI Congresso SOC Cetraro 15-16 luglio 2011
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Not Commercial Interests
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2-4,5 milioni; 4200 cells/mm² in fovea
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Il tessuto coroideale presenta la più estesa vascolarizzazione per mm² / tessuto del corpo umano
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Barriera Ematoretinica Esterna
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VEGF=Vascular endothelial growth factor PEDF=Pigment epithelium-derived factorSurvivor factor antiapoptotico - angiogenico PEDFPEDFVEGFVEGF
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λλ= lunghezza d’onda= lunghezza d’onda (nm =10ˉ⁹ metri)(nm =10ˉ⁹ metri)
f f == frequenza frequenza 1/1/ λ λ
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Risoluzione Assiale 3/5 µm Risoluzione Assiale 3/5 µm
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TD/SD-OCTDiodo superluminescente
λ = 820/870 nm
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Risoluzione Trasversale 12/20 µmRisoluzione Trasversale 12/20 µm
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NFL: Nerve fiber layer OPL: Outer plexiform layer IS/OS: Interface between PR inner & outer segmentILM: Inner limiting membrane ONL: Outer nuclear layer
GCL: Ganglien cell layer OLM: Outer limiting membrane
OS: Photo receptor outer segment IPL: Inner plexiform layer IS: Photo receptor inner segment RPE: Retinal pigment epitheliumINL: Inner nuklear layer XXX: Verhoeff‘s membrane
ILMNFL IPL INL
Fovea
OPL GCLONL
Stratus OCT 1.2 sec Cirrus HD-OCT 15 ms
OS ChoroidIS/OSOLMIS XXXRPE
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Stratus v/s Cirrus: interpretazione clinica
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Spectral
Stratus
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+ Imaging oDefinizione
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Definizione Dimens. informatican. Pixel p.es. 640x480
#RisoluzionePuntixpolice ppp o DPIDots Per Inch. Pollice=2.54 cmEye= 250/290 DPI10 linee x mm
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Retinal Nerve Fiber Layer
Ganglion Cell Layer
Inner Nuclear Layer
Photoreceptor Layer
Retinal Pigment Epithelium
Outer Plexiform Layer
Inner Plexiform Layer
SD-OCT v/s istologia
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USA : 10 fornitori di OCT Business OCT: 2010: $ 250 milioni Business OCT: 2017: $ 650 milioniIndustrie: per OCT 30-60 m $ investiti/anno
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Luce Aneritra - RedFree - Green (532-540nm) (an=negazione eritro=rosso), particolarmente utile per evidenziare i
vasi, drusen, essudati duri, membrane epiretiniche. Luce Blu -Verde - Cobalto (490 nm) utile per lo strato ganglionare e la superficie epiretinica. Luce Rossa (660-680 nm) utile per l’EPR e la coroide. Autofluorescenza - AF- FAF (luce blue 490nm, infrarosso
790 nm) si avvale di filtri simili a quelli per la fluoro, senza mezzo di contrasto, sfruttando la naturale fluorescenza retinica.
Infrared - IR (da 790 a 820 nm) invisibile al paziente, utile in presenza di cataratta. Retro Mode - RM (790 nm) immagini retiniche ottenute con luce laser infrarosso per
retrodiffusione. (F 10 brevetto Nidek Co.)
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Il presente: Retro Mode
F10 Nidek
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SD-OCT
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287 µ ± 75µSpessore Coroide
Diminuiscedi 16 µ/10aa
OCT Spectralis Blue-Peack
Richard F. Spaide
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Il presente: foto color vs autofluorescenza
P. J. Rosenfeld
Only the Topcon filters can reproducibly and reliably identify foveal center involvement in cases of GA in which the fovea is not involved.
Bascom Palmer EYE Institute
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50000 vs 40000 A-Scan/sec Fundus Camera vs Slo
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Osservatorio GeminiGemini North 4200 s.l.m. Emisfero Nord Gemini South 2700 s.l.m. Emisfero Sud Con ottica adattiva 8 mt. specchio primario Gestiti dall’AURA ( Ass.Univ. Resear.Astron.)
Costo: 184 m.$Gestione: 40.000 $/die
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Ottica Adattiva = Ottica Adattativa # Ottica Attiva
E-ELT= European Extremely Large TelescopeDiametro specchio primario 42 metri
800 milioni di ε 2017Il Telescopio più grande dl mondo!
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Natural Seeing With AO
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Mosaico dei coni con OA-OCT OA-OCT Ricostruzione computerizzata dei coni Long (rossi ) Medium (verdi) Short (blue)
Ultimate goal: OA-OCT OA-OCT Conta EPR e fotorecettori per campo d’indagine + algoritmo+data-base
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Adaptive Optics Retinal Camera
rtx1 Imagine Eyes - Orsay France
RUO: Research Use Only
Concentrazione dei coni 0°-2°-4° dalla fovea
Vari ingrandimenti del mosaico dei conirtx 1
1.2mmx1.2mm
4°x4° imaging field
250 Ippmm
En face reflectance imaging Flashed non coherent flood illumination+infrared 850nm
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Grazie per Grazie per l’attenzionel’attenzione
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EPR e l’imaging retinico
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