Epidermolytic hyperkeratosis
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Transcript of Epidermolytic hyperkeratosis
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4 Dermatopathology
Epidermolytic hyperkeratosis • Coarse, irregular hypergranulosis associated
with disruption of cell membranes • Associated with keratin 1 and 10 mutations
Epidermotropism • Lymphocytes in epidermis with relative
absence of spongiosis: term usually reserved for mycosis fungoides
Erosion • Loss of the epidermis
Exocytosis • Lymphocytes in the epidermis with
associated spongiosis: term usually used when discussing spongiotic dermatitis
Festooning • Papillary dermis retains an undulating pattern
(often used to describe porphyria cutanea tarda)
Flame figure • Collagen encrusted with major basic protein
from eosinophils
Figure 1-12 Epidermolytic hyperkeratosis
Figure 1-13 Epidermotropism, mycosis fungoides
Figure 1-14 Lymphocyte exocytosis, subacute spongiotic dermatitis
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Figure 1-15 Flame figure, Well’s syndrome