Endometriosis and fertility improvement
2
13.02.2015 1 Endometriosisandfertility improvement Dr Tevfik Yoldemir Marmara Üniversitesi Kadın Hastalıkları ve Doğum A.D. WES MontpellierConsortium • There is insufficient evidence of benefit of laparoscopic surgery prior to IUI/COS (weak). 50–80% • GnRHanalogue administered for 3–6 months prior to IVF/ICSI in women with endometriosis increases the clinical pregnancy rate (strong). 50–80% • There is insufficient evidence to support the use of the combined OCP prior to IVF/ICSI (weak). 50–80% • There are no data to compare the approach of pretreatment with the combined OCP versus gonadotrophin-releasing hormone agonists(GnRH-a) (weak). 50–80% • There is no evidence that surgical removal of endometriosis or surgical treatment of endometriomas(by aspiration or cystectomy) improves success rates through IVF (weak). 50–80% • Ovarian response might be reduced in some women who have undergone surgery for endometriomas(weak). >80% Human Reproduction, Vol.28, No.6 pp. 1552–1568, 2013 WES MontpellierConsortium • Laparoscopic surgical removal of endometriosis improves fertility in stage I and II endometriosis (strong). 50–80% • Although RCTs have failed to demonstrate benefit of excision over ablation, it is recommended to excise lesions where possible,especially where pain is present (weak). 50–80% • Laparoscopic excision (cystectomy) where possible for endometriomasis preferred to laparoscopic ablation (drainage andcoagulation) to enhance fertility (strong). >80% • The best surgical approach to deep endometriosis in women with infertility is unclear (weak). 50–80% • Medical adjunct therapy in conjunction with laparoscopic surgery has not been shown to have fertility benefit (strong). >80% • Since endometriomasmay damage the ovary, and since complications can arise in women with endometriomasundergoing ART,laparoscopic ovarian cystectomymay sometimes be recommended for women with endometriomaslarger than 3 cm diameter (weak). >80% Human Reproduction, Vol.28, No.6 pp. 1552–1568, 2013 ESHRE guideline • In infertile women with AFS/ASRM Stage I/II endometriosis, cliniciansshould perform operative laparoscopy (excision or ablation of theendometriosis lesions) including adhesiolysis, rather than performingdiagnostic laparoscopy only, to increase ongoing pregnancy rates(Nowrooziet al., 1987; Jacobsonet al., 2010). A • In infertile women with ovarian endometriomaundergoing surgery, clinicians should perform excision of the endometriomacapsule, insteadof drainage and electrocoagulationof the endometrioma wall, toincrease spontaneous pregnancy rates (Hart et al., 2008). A • The GDG recommends that clinicians counsel women with endometriomaregarding the risks of reduced ovarian function after surgery and the possible loss of the ovary. The decision to proceed withsurgery should be considered carefully if the woman has had previousovariansurgery. GPP Human Reproduction, Vol.29, No.3 pp. 400–412, 2014 ESHRE guideline • In infertile women with AFS/ASRM Stage III/IV endometriosis, clinicianscan consider operative laparoscopy, instead of expectant management, to increasespontaneous pregnancy rates (Nezhat et al., 1989; Vercelliniet al., 2006). B • In infertile women with AFS/ASRM Stage I/II endometriosis, cliniciansmay perform IUI with controlled ovarian stimulation, C – instead of expectant management, as it increases live birth rates (Tummonet al., 1997). – instead of IUI alone, as it increases pregnancy rates (Nulsenet al., 1993). • In infertilewomenwithAFS/ASRM Stage I/II endometriosis, clinicians mayconsider performing IUI with controlled ovarian stimulation within 6months after surgical treatment, since pregnancy rates are similar to thoseachieved in unexplained infertility (Werbroucket al., 2006). C Human Reproduction, Vol.29, No.3 pp. 400–412, 2014 ESHRE guideline • In infertile women with endometriosis, clinicians may offer treatmentwith ART after surgery, since cumulative endometriosis recurrencerates are not increased after controlled ovarian stimulation for IVF/ICSI(D’Hooghe et al., 2006; Benaglia et al., 2011) C • Clinicians can prescribe GnRHagonistsfor a period of 3–6 months prior totreatment with ART to improve clinical pregnancy rates in infertile women withendometriosis (Sallam et al., 2006). 10;Coccia et al., 2010; Benaglia et al., 2011). B • In infertile women with AFS/ASRM Stage I/II endometriosis undergoinglaparoscopy prior to treatment with ART, clinicians may consider thecomplete surgical removal of endometriosis to improve live birth rate,although the benefit is not well established (Opoienet al., 2011). C Human Reproduction, Vol.29, No.3 pp. 400–412, 2014
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Transcript of Endometriosis and fertility improvement
13.02.2015
1
Endometriosis and fertilityimprovement
Dr Tevfik Yoldemir
Marmara Üniversitesi
Kadın Hastalıkları ve Doğum A.D.
WES Montpellier Consortium
• There is insufficient evidence of benefit of laparoscopic surgery prior to IUI/COS (weak). 50–80%
• GnRH analogue administered for 3–6 months prior to IVF/ICSI in women with endometriosis increases the clinical pregnancy rate(strong). 50–80%
• There is insufficient evidence to support the use of the combined OCP prior to IVF/ICSI (weak). 50–80%
• There are no data to compare the approach of pretreatment with the combined OCP versus gonadotrophin-releasing hormoneagonists (GnRH-a) (weak). 50–80%
• There is no evidence that surgical removal of endometriosis or surgical treatment of endometriomas (by aspiration or cystectomy)improves success rates through IVF (weak). 50–80%
• Ovarian response might be reduced in some women who have undergone surgery for endometriomas (weak). >80%
Human Reproduction, Vol.28, No.6 pp. 1552–1568, 2013
WES Montpellier Consortium
• Laparoscopic surgical removal of endometriosis improves fertility in stage I and II endometriosis (strong). 50–80%
• Although RCTs have failed to demonstrate benefit of excision over ablation, it is recommended to excise lesions where possible, especially where pain is present (weak). 50–80%
• Laparoscopic excision (cystectomy) where possible for endometriomas is preferred to laparoscopic ablation (drainage and coagulation) to enhance fertility (strong). >80%
• The best surgical approach to deep endometriosis in women with infertility is unclear (weak). 50–80%
• Medical adjunct therapy in conjunction with laparoscopic surgery has not been shown to have fertility benefit (strong). >80%
• Since endometriomas may damage the ovary, and since complications can arise in women with endometriomas undergoing ART, laparoscopic ovarian cystectomy may sometimes be recommended for women with endometriomas larger than 3 cm diameter (weak). >80%
Human Reproduction, Vol.28, No.6 pp. 1552–1568, 2013
ESHRE guideline
• In infertile women with AFS/ASRM Stage I/II endometriosis, clinicians should perform operative laparoscopy (excision or ablation of the endometriosis lesions) including adhesiolysis, rather than performing diagnostic laparoscopy only, to increase ongoing pregnancy rates (Nowroozi et al., 1987; Jacobson et al., 2010). A
• In infertile women with ovarian endometrioma undergoing surgery,clinicians should perform excision of the endometrioma capsule, instead of drainage and electrocoagulation of the endometriomawall, to increase spontaneous pregnancy rates (Hart et al., 2008). A
• The GDG recommends that clinicians counsel women withendometrioma regarding the risks of reduced ovarian function aftersurgery and the possible loss of the ovary. The decision to proceed with surgery should be considered carefully if the woman has had previous ovarian surgery. GPP
Human Reproduction, Vol.29, No.3 pp. 400–412, 2014
ESHRE guideline
• In infertile women with AFS/ASRM Stage III/IV endometriosis, clinicians can consider operative laparoscopy, instead of expectant management, to increase spontaneous pregnancy rates (Nezhat et al., 1989; Vercellini et al., 2006). B
• In infertile women with AFS/ASRM Stage I/II endometriosis, clinicians may perform IUI with controlled ovarian stimulation, C– instead of expectant management, as it increases live birth rates
(Tummon et al., 1997).– instead of IUI alone, as it increases pregnancy rates (Nulsen et al.,
1993).
• In infertile womenwith AFS/ASRM Stage I/II endometriosis, clinicians may consider performing IUI with controlled ovarian stimulation within 6 months after surgical treatment, since pregnancy rates are similar to those achieved in unexplained infertility (Werbrouck et al., 2006). C
Human Reproduction, Vol.29, No.3 pp. 400–412, 2014
ESHRE guideline
• In infertile women with endometriosis, clinicians may offer treatment with ART after surgery, since cumulative endometriosis recurrence rates are not increased after controlled ovarian stimulation for IVF/ICSI (D’Hooghe et al., 2006; Benaglia et al., 2011) C
• Clinicians can prescribe GnRHagonists for a period of 3–6 months prior to treatment with ART to improve clinical pregnancy rates in infertile women with endometriosis (Sallam et al., 2006). 10;Coccia et al., 2010; Benaglia et al., 2011). B
• In infertile women with AFS/ASRM Stage I/II endometriosis undergoing laparoscopy prior to treatment with ART, clinicians may consider the complete surgical removal of endometriosis to improve live birth rate, although the benefit is not well established (Opoien et al., 2011). C
Human Reproduction, Vol.29, No.3 pp. 400–412, 2014
13.02.2015
2
ESHRE guideline
• In infertile women with endometrioma larger than 3 cm there is no evidence that cystectomy prior to treatment with ART improves pregnancy rates (Donnez et al., 2001; Hart et al., 2008; Benschop et al., 2010). A
• In women with endometrioma larger than 3 cm, theGDGrecommends clinicians only to consider cystectomyprior to ART to improve endometriosis-associated pain or the accessibility of follicles. GPP
• The GDG recommends that clinicians counsel women withendometrioma regarding the risks of reduced ovarian function after surgery and the possible loss of the ovary. The decision to proceed with surgery should be considered carefully if the woman has had previous ovarian surgery. GPP
Human Reproduction, Vol.29, No.3 pp. 400–412, 2014
ESHRE guideline
• The effectiveness of surgical excision of deep nodular lesions before treatment with ART in women with endometriosis-associated infertility is not well established with regard to reproductive outcome (Bianchi et al., 2009; Papaleo et al., 2011). C
• The GDG recommends that clinicians should not routinely perform surgical excision and ablation for an incidental finding of asymptomatic endometriosis at the time of surgery, since the natural course of the disease is not clear. GPP
• The GDG recommends that clinicians fully inform and counsel women about any incidental finding of endometriosis. GPP
Human Reproduction, Vol.29, No.3 pp. 400–412, 2014
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