EEEESOPHAGEALSOPHAGEALSOPHAGEAL DDDDISORDERS...
Transcript of EEEESOPHAGEALSOPHAGEALSOPHAGEAL DDDDISORDERS...
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EE EE SOPHAGEALSOPHAGEALSOPHAGEALSOPHAGEAL DDDDISORDERSISORDERSISORDERSISORDERSEE EE SOPHAGEALSOPHAGEALSOPHAGEALSOPHAGEAL DDDDISORDERSISORDERSISORDERSISORDERS
ININININ
SS SS URGICALURGICALURGICALURGICAL PERSPECTIVEPERSPECTIVEPERSPECTIVEPERSPECTIVEDepartement of SurgeryDepartement of SurgeryDepartement of SurgeryDepartement of Surgery
Faculty of MedicineFaculty of MedicineFaculty of MedicineFaculty of Medicine
University Sumatera UtaraUniversity Sumatera UtaraUniversity Sumatera UtaraUniversity Sumatera Utara
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CONTENT
1. Esophageal Atresia
2. Achalasia
3. Esophageal Rupture3. Esophageal Rupture
4. Tumor
5. Stricture
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ESOPHAGEAL ATRESIA
� Incidence: 1 in 4000 live births
� Male > Female (25:3)
� 10-40% are preterm� 10-40% are preterm
� Antenatal history: polyhydramnios (60%)
� Etiology: failure in mesenchymal separation of upper foregut
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ETIOLOGY
Failure in mesenchymal separation of upper
foregut
((Incomplete partitioning of primitive foregut)((Incomplete partitioning of primitive foregut)
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TYPES(GROSS AND VOGT)
Esophageal atresia with distal TEF most common
7.7% 0.8% 86% 0.7% 4.2%
TEF : Tracheo-esophageal Fistulae
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CLINICAL PRESENTATION
choking on 1st feed
coughing
cyanosiscyanosis
excessive salivation
aspiration pneumonia
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Diagnosis
• inability to pass a suction catheter
into the stomach
• X-ray:
• coiled orogastric tube in the
cervical pouch
• air in the stomach and intestine
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Tracheoesophageal Fistula
Esophageal AtresiaEsophageal Atresia Tracheoesophageal Tracheoesophageal
FistulaFistula
Turnage RH, et al, Sabiston Textbook of Surgery,17Turnage RH, et al, Sabiston Textbook of Surgery,17thth Ed. 2004Ed. 2004
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VATER AND VACTERL
� 35-65% have associated anomalies
� V vertebral anomalies or VSD
� A anorectal malformation
� C cardiac anomalies (common)� C cardiac anomalies (common)
� T TEF
� E esophageal atresia
� R renal abnormalities
� L limb/radial malformation
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PREOPERATIVE PREPARATION
� Minimize pulmonary complication :
� NPO
� Head-up position
� Sump tube (repogle) on low continuous suction ±� Sump tube (repogle) on low continuous suction ±
gastrostomy under local anesthesia
� CXR, abdominal x-ray, renal ultrasound
� 12-L EKG and Echocardiogram : mandatory
� IV access ± arterial line
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INTRAOPERATIVE MANAGEMENT
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SURGICAL REPAIR
• ligation of fistula
�check air leak in suture line
• esophageal repair
�identify the pouch
�placement of feeding tube
• chest tube placement and closure of
thoracic cavity
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Tracheoesophageal Fistula
Main Cause of Mortality
associated anomalies
survival rates 85-90%
Long Term ComplicationsLong Term Complications
GE reflux
anastomotic stricture
tracheomalacia
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ACHALASIA
Achalasia ("does not relax") - loss of peristalsis in the distal esophagus and a failure of LES relaxation.
LES : Lower Esophageal Sphincter
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� Thomas Willis in 1674 first described it.
� Most common neuroanatomic change is a decrease or
loss of myenteric ganglion cells.
� Incidence of 0.4 to 0.6 per 100,000 & prevalence 0f 8
per 100,000.
� Described from infancy to 9th decade, but majority
present between 20 to 40 years
� Paediatric cases account for 2% - 5% of all cases
� Distal oesophageal diverticulum may develop
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DIAGNOSIS
� Endoscopic finding
� Dilated, patulous esophageal body with extensive
mucosal friability & ulcerations
� LES appears puckered and fails to open with air
insufflation, but is easily traversed with minimal
pressure
Manometry� Manometry
� Gold standard
� Absent peristaltis of distal smooth muscle
� LES relaxation pressures are elevated >35 mm Hg
� Radiographic findings
� Mediatinal widening, air-fluid level (midesophagus),
absence of gastric air bubble, abnormal pulmonary
marking due to repeated aspiration
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ENDOSCOPY
� Exclude
malignancies
� Dilated esophagus,
residual material.
� Inflammation and
ulceration ulceration
� Stasis - candida
infection.
� The LES does not
open spontaneously,
traversed easily with
gentle pressure
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MANOMETRY
� Elevated resting
LES pressure
� Incomplete LES
relaxationrelaxation
� Peristalsis — or
simultaneous
contractions
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�A barium swallow -
diagnostic accuracy is
approximately 95%
�Absence of peristalsis
� In some patients,
spastic contractions
in the esophageal
body ("vigorous"
achalasia)
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PATHOPHYSIOLOGY
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�Chagas disease (Trypanosoma cruzi) can
result in a loss of intramural ganglion
cells leading to aperistalsis and
incomplete LES relaxation
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Malignancy - most common cause of pseudoachalasia
� Invasion of the esophageal neural plexuses directly, or part of a paraneoplastic of a paraneoplastic syndrome.
� Other tumors -esophagus, lung, lymphoma and pancreatic carcinoma
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TREATMENT
1. Medical
2. Pneumatic Baloon
DilatationDilatation
3. Surgery
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MEDICAL THERAPY
� Nitrates and calcium channel blockers relax the smooth muscle of the LES.
� Pharmacotherapy is often ineffective, and associated with side effects.associated with side effects.
� Used primarily for patients who are unwilling or unable to tolerate more effective invasive forms of therapy.
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BALLOON DILATATION
Weaken the LES by tearing its muscle
fibers.
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OESOPHAGUS
� Dilatation with mercury filled dilators & polyethylene balloons(pneumatic)
� Complications; GIT bleeding, intramural haemorrhage, perforation
� Response to pneumatic dilatation 32%-98%, most studies 60%-80%
� Remission is not durable; 60% are symptom free for 1 year, with recurrence in 50% of these patients in 5 yearswith recurrence in 50% of these patients in 5 years
� Surgery
� Heller's Myotomy. Open or laparoscopic
� Laparoscopic technique first described in 1991, little morbidity, shorter hospital stay, and earlier return to daily activities
� Overall mortality rate <2%
� Most troublesome complication after surgery is GORD, therefore myotomy is performed in conjunction with antireflux procedure.
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SURGERY
� Surgical myotomy - may provide a more
permanent solution
� For the high-risk patient, a trial of BTX is a
reasonable approachreasonable approach
� For most younger patients, a laparoscopic
myotomy offers the best chance for a single
permanent procedure
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SURGERY
� Heller's Myotomy. Open or laparoscopic
� Laparoscopic technique first described in 1991, little morbidity, shorter hospital stay, and earlier return to daily activities
� Overall mortality rate <2%Overall mortality rate <2%
� Most troublesome complication after surgery is GERD, therefore myotomy is performed in conjunction with antireflux procedure.
� For most younger patients, a laparoscopic myotomy offers the best chance for a single permanent procedure
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MODIFIED HELLER APPROACH
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Esophageal Perforation
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ESOPHAGEAL PERFORATION
� Iatrogenic 75%
� endoscopy #1 cause
� Non-Iatrogenic
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IIATROGENICATROGENIC CCAUSESAUSES
1. Rigid or flexible endoscopy (diagnostic)
2. Dilatation of an esophageal stricture
3. Dilatation of achalasia
4. Removal of a foreign body4. Removal of a foreign body
5. Intubation for the relief of disphagia
6. Sclerotherapy of esophageal varices
7. Laser therapy of a tumor
8. Anaesthesiology (attempt of intubation)
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NON-IATROGENIC CAUSES
1. spontaneous rupture (emetogenic) Boerhaave’s
syndrome
2. barotrauma (blunt trauma) of the chest
3. penetrating trauma
4. Swallowed foreign body4. Swallowed foreign body
5. corrosive injuries
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The cardinal symptoms The cardinal symptoms ::
�� cervical or thoracic paincervical or thoracic pain
�� difficulty in swallowingdifficulty in swallowing�� difficulty in swallowingdifficulty in swallowing
�� feverfever
�� subcutaneous or mediastinal subcutaneous or mediastinal emphysemaemphysema
�� epigastric painepigastric pain
�� right or left pleural effusionright or left pleural effusion
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DDIAGNOSTICIAGNOSTIC PROCEDUREPROCEDURE
1. plain film of the neck and
chest (air in the soft tissues,
ptx, hydro ptx)
contrast swallowing (water-2. contrast swallowing (water-
soluble, diluted barium)
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MMANAGEMENTANAGEMENT
Individualized , according to :
1. Preoperative condition of the patient
2. The site, size and extent of the perforation
3. The presence of systematic sepsis3. The presence of systematic sepsis
4. The nature of any associated intrinsic esophageal
disease
5. The lenght of delay in diagnosis and treatment
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PPRINCIPLESRINCIPLES OFOF MMANAGEMENTANAGEMENT
1. Withhold of oral intake
2. Not to swallow even the saliva
3. Broad spectrum i.v. Antibiotics3. Broad spectrum i.v. Antibiotics
4. Restoring intravascular volume
5. Tube decompression of the
stomach
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SURGERY
� Emergency closure of perforation and drainage is
the standard treatment.
� After 24 hours repair of the perforation is
frequently not feasible the esophagectomy is the
procedure of choice depending on the general procedure of choice depending on the general
condition of the patient
� Patients selected for non-operative treatment
should have minimal symptoms and minimal
signs of local sepsis, no evidence of subcutaneous
emphysema and underlying esophageal
pathology.