1976- !u"a# (!EBOV
*++*- Fruit Bats
,#tibo"ies agai#st Ebo%a
Ebo%a e#e se.ue#ces i# %iver a#" s$%ee#
Fruit bats "o #ot sho' a#& s&m$toms
Best ca#"i"ate to be the reservoir 
More research #ee"s to be "o#e
 
GeographyGeography
/he %i#k bet'ee# huma# i#)ectio# b& the Ebo%a virus a#" their $ro0imit& to $rimates is c%ear
  -Outbreaks occurre" i# cou#tries that house + $erce#t o) the 'or%"2s remai#i#g 'i%" gori%%a a#" chim$a#3ee  $o$u%atio#s
  - /he outbreaks coi#ci"e" 'ith the outbreaks i# 'i%" a#ima%s
- /he same "isti#ct vira% strai#s 'ere iso%ate" i# a#ima% carcasses a#" i# the bo"ies o) those 'ho ha#"%e" those carcasses
 
Stage I (unspecific):
  -"iarrhea4 #ausea a#" vomiti#g4 a#ore0ia
  ab"omi#a% $ai#
  - arthra%gia (#eura%gic $ai# i# joi#ts
  - m&a%gia (muscu%ar $ai# or te#"er#ess4 back $ai#
  - mucosa% re"#ess o) the ora% cavit&4 "&s$hagia ("i))icu%t& i# s'a%%o'i#g
  - co#ju#ctivitis
  - rash a%% over bo"& e0ce$t i# )ace
 
- a#uria (the abse#ce o) uri#e )ormatio#   - hiccu$s
- tach&$#ea (ra$i" breathi#g
55 atie#ts 'ho $rogresse" to $hase t'o EHF a%most a%'a&s "ie (8"ambi et a%4 1999
Late Complications:  -,rthra%gia
- ocu%ar "iseases (ocu%ar $ai#4 $hoto$hobia a#" h&$er%acrimatio#
 
 
EpidemiologyEpidemiology
 Ebo%a Hemorrhagic Fever 'as )irst )ou#" i# 1976  t struck t'o cou#tries 'ithi# that &ear  a !u"a# : i# a to'# ca%%e" 823ara  b Zaire4 #o' k#o'# as the ;emocratic <e$ub%ic o)
=o#go   # these t'o i#sta#ces the morta%it& rate 'as bet'ee#
>+ :9+ Fo%%o'i#g those e$i"emics4 Ebo%a hit ,)rica i# ma#& other
 
i#"ivi"ua%2s bo"& )%ui"s
Ebo%a HF $reve#tio#
 $oster use" i# Aik'it
Controlling the spread of EbolaControlling the spread of Ebola
a Hos$ita%s must )o%%o' $recautio#ar& metho"s4 such as
1 'eari#g g%oves
  * iso%ati#g i#)ecte" i#"ivi"ua%s
  C $ractici#g #urse barrier tech#i.ues
  @ $ro$er steri%i3atio# a#" "is$osa% o) a%% e.ui$me#t
 b Buria%s must be "o#e correct%&
  1 #o 'ashi#g or touchi#g carcass
  * $ut i#to bo"& bags a#" bur& outsi"e cit&
 
Ebo%a-<esto# (<EBOV
MOLECUL! ST!UCTU!EMOLECUL! ST!UCTU!E =haracteri3atio# o) the virus
 :  Or"er Mo#o#egavira%es  :  Fami%& Fi%oviri"ae  :  e#us Ebo%avirus  :  !$ecies Ebo%a-Zaire4 Ebo%a-!u"a#4 Ebo%a-=ote "-voire4 Ebo%a-<esto#
Mor$ho%og& u#"er e%ectro# microsco$e  :  )i%ame#tous4 e#ve%o$e" <8, virus  :  a$$ro0 19 kb i# %e#gth (1 kb D 1+++ <8,
 bases#uc%eoti"es or 6+-+ #m i# "iameter   :  si#g%e-stra#"e"4 %i#ear4 #o#-segme#te"  :  #egative-se#se <8, (e#co"e" i# a C2 to >2 "irectio#  :  a$$ears to have s$ikesG "ue to g%&co$rotei# o#
  outsi"e membra#e
!tructure o) Ebo%a ge#ome a#" $rotei#s
 :  /ra#scribe" i#to sub-ge#omic m<8, $rotei#s 7 structura% a#" 1 #o#structura%
 :  7 structura% $rotei#s  : #uc%eo$rotei# (8
 : @ vira%virio# $rotei#s (VC>4 V@+4 VC+4 V*@
 : g%&co$rotei# (
 :  <8,-"e$e#"e#t <8, $o%&merase ( $rotei#
I  84 VC>4 VC+4 $rotei# re.uire" )or tra#scri$tio# J re$%icatio#
 
Ethi#sEthi#s
Biogeograo$hica% Ethics is "e)i#e" as motivatio#  base" o# i"eas o) right a#" 'ro#g 'he# "ea%i#g 'ith the geogra$hica% "istributio# o) a#ima%s a#"  $%a#ts
/his co#ce$t o) ca# be use" to e0$%ai# the 'or%"2s shocki#g%& sma%% res$o#se to the Ebo%a Virus
 
 become %ess iso%ate" as the threat o)
 bioterrorism %ooms %arge
/he Ebo%a virus is #o' o# the ,G %ist )or
ho$e)u% vacci#atio# "eve%o$me#t
E0$erime#ts have eve# bee# )orme" to sho'