Virus DNA VIRUS Herpes Virus (8 type) Icosahedral capsid enclosed in lipoprotein envelope Tegument: amorphous proteinaceous material lying between envelope and capsid Genome = single molecule of linear, ds-DNA

Herpes simplex 1 / Cold sores (fever blisters, Herpes labialis) Portal of entry- Respiratory tract or conjunctiva Intranuclear eosinophillic inclusion bodies Lungs- multinucleated giant cells Virus enters sensory nerve endings- Latent infection of dorsal ganglia Herpes simplex 2 common STD itching and throbbing in the genital area, blisters Varicella-Zoster Virus Transmission respiratory aerosols direct contact with skin lesions viremia chicken pox reactivation shingles

Chicken Pox VESICLE dew-drop on rose pedal lesion small red spots Becomes pustular & crusts over, forming scab Lesions begin on scalp, spread over the face & neck to trunk Shingles (Herpes zoster Recurrent infection) Latent phase In dorsal root ganglion cranial nerve ganglia (CN V) Painful vesicular lesions having a erythematous base develop along the nerve dermatome Cytology : Presence of Cowdry Type A intranuclear Inclusion Bodies Tzanck smears from base of vesicles reveal multinucleated giant cells (syncytia formation) Herpes genital : acyclovir 1000 mg/hari (5x200 mg/hari) Valacyclovir 1000mg/hari (2x500mg/hari) Herpes zoster : acyclovir 4000 mg/hari (5x800 mg/hari) Valacyclovir 1000-3000 mg/hari (3x2 tablet @500mg)

Epstein-Barr Virus (EBV) / Infectious Mononucleosis (kissing disease) / Burkitt's lymphoma Types of infection multiplication infection: epithelial cells latent infection: B lymphocytes transforming B cell contain EBV FATIGUE, high fever, exudative pharyngitis and tonsilitis Lymphademopathy - lymph node swelling Occasional rash Lab Lymphocytosis : Atypical Lymphocytes or Downey Cells Serology: Heterophile Ab (+) Human Cytomegalovirus (HCMV) HCMV is the most common intrauterine viral infection Microencephaly Intracerbral calcifications Hepatosplenmegaly Rash Cytology Cytomegalic cell Enlarged cell in which nucleus contains a dense, central, basophilic intranuclear inclusion body Owls Eye POXVIRIDAE Variola virus / Small Pox Eradicated all around the world replicates in the CYTOPLASM Molluscum Contagiosum Benign epidermal tumor Papules & nodules on skin, have central casseous plug that can be squeezed out on trunk, genitalia, proximal extremities