DNA Viruses Selected RNA Viruses Tobacco Mosaic Virus.
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Transcript of DNA Viruses Selected RNA Viruses Tobacco Mosaic Virus.
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LISTING OF SELECTED VERTEBRATE VIRUS FAMILIES BY MORPHOLOGY
Morphology of Particle
Icosahedral
Irregular
Morphology of Nucleocapsid
Poxviridae (ovoid) Yes
Enveloped
RoundCoronaviridae Yes Helical or tubularParamyxoviridae YesOrthomyxoviridae Yes
Rhabdoviridae (bacilliform)Yes
Filoviridae Yes
Bunyaviridae Yes HelicalArenaviridae Yes Helical
SphericalRetroviridae Yes
Togaviridae Yes T = 4
Flaviviridae Yes T = 3
Adenoviridae No T = 25
Papillomaviridae No P = 7d
Polyomaviridae No P = 7d Parvoviridae No T = 1
Reoviridae No T = 13l
Picornaviridae NoAstroviridae No Not applicable
T = 3
Caliciviridae No Not applicableT = 3
Triangulation Number
Herpesviridae Yes T = 16
Hepadnaviridae Yes Icosahedral T = 3 & 4
Table 2.1
?
Filamentous
Figure Numbers
Not applicable Figures 2.1, 2.5, 2.12Icosahedral Figures 2.1, 2.5, 2.11
Not applicable Figure 2.5
Not applicable Figures 2.5, 2.9Not applicable Figures 2.1, 2.5
Not applicable Figures 2.1, 2.5, 2.7, 2.8
Icosahedral Figures 2.1, 2.5, 2.16Icosahedral Figures 2.5, 2.14, 2.15
Icosahedral Figure 2.5
Dumbbell Figures 2.1, 2.20Coiled helix Figures 2.1, 2.19
Icosahedral? Figures 2.1, 2.17
Helical Figure 2.18Helical Figures 2.1, 2.18
Helical Figure 2.19
a
a,ba,b
c
c
aTwo mirror image structures can be formed using T = 13 or T = 7, a symmetry referred to as “d” or “l”.
cVirions are often pleiomorphic
P = 3 b
Because the subunits are not exactly equivalent, Papillomaviridae , Polyomaviridae, and as well as poliovirus have “pseudo-triangulation numbers” so are referred to as P = 7, P = 7, and P = 3 symmetries respectively.
b
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DNA Viruses
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Selected RNA Viruses
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100 nm
Tobacco Mosaic Virus
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HOOC
2
3
5F
D I BG
HC
NH
E
3
5
55 2
2 2A
A
A
Icosahedral Structure
A T=1 structure with 60 identical subunits Fold of the 8-stranded ß-sandwich
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N(15)
C(361)N (1)C(238)
A. B.
C(349)
N(1)
C.
SV40 VP1 P = 7 Poliovirus 1 VP3 P = 3
Bluetongue virus VP7 T = 13
Capsid Proteins Having a Similar Fold
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Reovirus (Lang) (850Å)
Rotavirus (1000Å)
Herpes Simplex (1250Å) 500Å
Ross River (700Å)
Human papilloma (600Å)Polyoma (495Å)
Poliovirus (320Å)
Human rhinovirus (320Å)
Flockhouse (330Å)
Cowpea mosaic (312Å)
B19 parvovirus (260Å)
Dengue 2 (490Å)
Figure 2.5
Structures
of Viruses
Determined
by Cryo EM
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B.
C.
dsRNA
C C2
B5 A
AA5
B5
C5
C B
B2
A2
C2
5
55
3
ds RNAarm arm
5
A.
Flockhouse Virus (T=3)
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T = 3 Poliovirus Cowpea Mosaic Virus
A
BC L
SVP1
VP2
VP3
Schematic of Three T=3 or P=3 Viruses
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Human
Rhinovirus 14
VP1 = Blue
VP2 = Green
VP3 = Red
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VP1
VP3
VP4
VP2
RNA
5-fold Axis
Drug-binding pocket
VP3-cylinder
D2
ICAM-1
“Canyon”D1
Five-fold Vertex of Rhinovirus Showing Binding of ICAM-1
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Picornaviruses
Bound
To Receptors
PNAS 97:79 (2000)
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Orbivirus Structure
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Structure
of
Adenovirus
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Structure
of
Ross River Virus
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Sindbis Virus Capsid Protease
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Herpesvirus
Schematic of Virion EM of Nucleocapsid
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Retrovirus Structure
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Rhabdoviruses
and
Filoviruses
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Structure of Poxviruses
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Budding
Viruses