Disease systems biology
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Transcript of Disease systems biology
![Page 1: Disease systems biology](https://reader036.fdocuments.us/reader036/viewer/2022062703/554e89cdb4c90526358b4943/html5/thumbnails/1.jpg)
Lars Juhl Jensen
Disease Systems Biology
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protein networks
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cellular signaling
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Horn, Schoof et al., in preparation, 2012
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sequence motif atlas
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functional associations
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Szklarczyk, Franceschini et al., Nucleic Acids Research, 2011
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computational predictions
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experimental data
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curated knowledge
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confidence scores
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orthology-based transfer
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Franceschini, Szklarczyk, Frankild et al., Nucleic Acids Research, 2013
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functional modules
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Palleja et al., in preparation, 2012
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literature mining
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~22 million abstracts
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~4 million full-text articles
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comprehensive lexicon
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co-mentioning
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proteins
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compartments
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compartments.jensenlab.org
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tissues
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tissues.jensenlab.org
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diseases
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diseases.jensenlab.org
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diseases.jensenlab.org
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behavioral phenotypes
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diseases.jensenlab.org
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medical data mining
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electronic health records
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Jensen et al., Nature Reviews Genetics, 2012
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structured data
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Jensen et al., Nature Reviews Genetics, 2012
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unstructured data
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patient stratification
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Roque et al., PLoS Computational Biology, 2011
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comorbidity
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Roque et al., PLoS Computational Biology, 2011
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disease trajectories
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Jensen et al., in preparation, 2012
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pharmacovigilance
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Eriksson et al., in preparation, 2012
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conferences
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questions?