Dietary bioactives, polyphenols and potential health ... · Dietary bioactives, polyphenols and...
Transcript of Dietary bioactives, polyphenols and potential health ... · Dietary bioactives, polyphenols and...
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Dietary bioactives, polyphenols and potential health
effects: facts, fiction and the future…
Daniele Del Rio
The Laboratory of Phytochemicals in Physiology, LS9 InterLab Group Department of Food Science, University of Parma, Italy
The Need for Nutrition Education/Innovation Programme (NNEdPro)
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Dietary fiber?Phytochemicals!
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Main sources ?
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They prevent!!?
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But the best comes from Japan!
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They prevent!
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No they don’t!
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Or maybe yes!
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No, no, they don’t!
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BIOAVAILABILITY & METABOLISM
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TIM
E
SMALL INTESTINE
KIDNEY
LIVER
COLON
POLYPHENOL
TISSUE
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A FEW PLANT POLYPHENOLS
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Chocolate?
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You fancy a coffee?
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J. Agric. Food Chem., 2014, 62 (28), pp 6535–6538 DOI: 10.1021/jf5024615
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We are trying to change the paradigm!
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Work out more physiological models!
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Synthesising metabolites that are not commercially available!
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Study the interactions of phenolic
metabolites with drugs!
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Identify new and emerging targets!
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Copyright © 2015 by the American Society of Nephrology
TMAO
CARDIOVASCULAR RISK
FACTORS
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Modified from Curr Opin Lipidol. 2014 Feb; 25(1): 48–53.
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TMAO
POLYPHENOLS
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We are working in humans, with a
multiplicity of approaches….
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