Detoxification:Theory to Practice

Dawn Zerneke, MBC2/1/15

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DefinitionsToxins are any substances that cause irritation, undermines our health, has harmful effects on the body or overloads our organs

Detoxification is to diminish or remove the toxic quality of a compound

Krohn J, & Taylor F. (2000). Natural Detoxification. A Practical Encyclopedia. Hartley and Marks Publishers Inc., Page 3-6.

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Detoxification is a balancing act

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Prevalence of toxins• 25 percent of the population suffers from heavy metal poisoning.1

• 287 different chemicals were found in the cord blood of babies.2

• Prenatal organophosphate exposure is associated with developmental disorders, a decline in mental development, poor attention skills and hyperactive behavior.3

• 3,100 stock chemical ingredients are not listed on perfume labels and bucketed under the term fragrance4

1. Bennett P., Bland J., Galland L. et al. (2010). Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional Medicine. ISBN: 978-0977371372 , page 275.

2. Houlihan J., Kropp T., Wiles R., Gray S. & Campbell C (2005). Body Burden, The Pollution In Newborns. Environmental Working Group, 1-63.3. Redmond E., Egeston C. & Bralley A. (2012). Low level prenatal exposure to organophosphate pesticides significantly lowers IQ in children.

Townsend Newsletter for Doctors. 4. Sarantis H., Naidenko O.V., Gray S., Houlihan J. & Malkan S. (2010). Not so Sexy: The Health Risks of Secret Chemicals in Fragrance. Breast Cancer

Fund, Commonwealth Environmental Working Group & Campaign for Safe Cosmetics.

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What are toxins?Toxins ExamplesHome Asbestos, formaldehyde, radon, carbon monoxide, furniture, new carpet,

wood heating systems, cleaning and laundry supplies, personal care products, tobacco smoke, molds

Work/Travel/Leisure Occupational exposures, faulty ventilation

Medical Treatments Radiation, chemotherapy, medications, dental work

Food Chemicals from fertilizers and pesticides, bacteria (i.e., E.coli), additives (i.e. MSG, aspartame), preservatives and food packaging

Water and Air Contaminated water, air pollution

Plants and Organisms Poisonous plants, parasites, mold

Chemicals and Toxic Metals Solvents, aluminum, arsenic, cadmium, lead, mercury

Noise, Weather and Altitude Road noise, industrial noise, humidity, cold, heat, mountain sickness

Radiation, Electromagnetic Fields and Geopathic Stress

X-rays, UV rays, Phones, TV’s, Microwaves

Internally produced Hormone imbalance, metabolic waste products, acid/alkaline balance

Mind and body Traumatic events, abuse, stress

Krohn J, & Taylor F. (2000). Natural Detoxification. A Practical Encyclopedia. Hartley and Marks Publishers Inc., Pages 125-252.

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Our bodies response to toxins• Fatigue• Depression• Brain fog/poor memory/confusion• Balance problems• Frequent unexplained headaches• Tremors• Allergies/asthma/sinus problems• Diabetes• Fibromyalgia• Infertility• Chronic infections• Abnormal body odor/bad breath• Brittle nails and hair• Adult acne• Back or joint pain• Food allergies• More…

• Crinnion W. (2010). Clean, Green and Lean. John Wiley & Sons, Inc., Hoboken, New Jersey. ISBN-978-0-470-40923-7, page 15.• Krohn J, & Taylor F. (2000). Natural Detoxification. A Practical Encyclopedia. Hartley and Marks Publishers Inc., Page 6.

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Organs of detoxification

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Factors influencing detoxification

Diet and Lifestyle

Environment

Genetics

Age

Disease

Medications

Gender

Bennett P., Bland J., Galland L. et al. (2010). Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional Medicine. ISBN: 978-0977371372, pages 283-286.

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Detoxification in the body

Institute for Functional Medicine, 2011

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Detoxification assessments• Complete a metabolic

screening assessment • Functional liver

detoxification profile• Heavy metal toxicity

Bennett P., Bland J., Galland L. et al. (2010). Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional Medicine. ISBN: 978-0977371372, pages 366, 551.Krohn J, & Taylor F. (2000). Natural Detoxification. A Practical Encyclopedia. Hartley and Marks Publishers Inc., Page 35-36.

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Detoxification Lifestyle

“A NERD” can assist…

• Avoid exposure• Nutrition• Exercise• Rest• Detoxification

Bennett P., Bland J., Galland L. et al. (2010). Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional Medicine. ISBN: 978-0977371372, page 552.

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Avoid and Remove Toxins Avoid • Garden chemicals• Dry cleaning• Car exhaust• Second-hand smoke• Carbon monoxide

exposure• Radiation• Heavy metal

exposure• Aluminum deodorant• Antacids• Toxic pots and pans

Replace• 1-2 bowel

movements/day• Drink 6-8 glasses of

water• Sweat regularly

(exercise, steam baths, sauna’s)

• Use HEPA filters• Drink filtered water• Exercise, yoga or

lymphatic massage• Buy organic food• Treat gut infections

Bennett P., Bland J., Galland L. et al. (2010). Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional

Medicine. ISBN: 978-0977371372, pages 367.

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Dietary support • Bioflavonoids (i.e. grapes, berries and citrus fruits)• Burdock root• Celery• Chlorophyll• 1 cup of cruciferous vegetables daily (i.e. cabbage,

broccoli, kale, brussel sprouts) • Grape seed• Rosemary• Herbal teas• Sulfur-containing proteins (eggs, whey protein,

onions)• Fiber intake (beans, whole grains, vegetables, nuts,

seeds)• Curcuminoids (turmeric and curry)• Dandelion greens• Fresh vegetable juices (carrots, celery, cilantro,

beets, parsley and ginger)• Garlic (a few cloves/day)• Green tea

Bennett P., Bland J., Galland L. et al. (2010). Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional Medicine. ISBN: 978-0977371372, pages 367.

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Nutritional SupplementsSupplements Recommended Dosage

Alpha-Lipoic Acid 100-600 mg/day

Amino acids (taurine and glycine) 500 mg 2x/day

B-complex vitamins

Bioflavonoids

Carnitine 1000-3000 mg/day

High potency multi-vitamin

Essential fatty acids

Extra buffered vitamin C

Milk thistle 70-210 mg/day

Mixed carotenoids 15,000-25,000 u/day

Molybdenum 50-200 mcg/day

N-acetyl cysteine 500-1000 mg/day

Probiotics

Selenium 200 mcg/day

Zinc 30-50 mg/day

Bennett P., Bland J., Galland L. et al. (2010). Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional Medicine. ISBN: 978-0977371372, pages 367.

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Common Detoxification ApproachesNaturopathic Medicine Survey N=169

Cleansing Foods 91%

Increased fruit and vegetable intake 88%

Vitamin/mineral/antioxidant supplements 85%

Organic foods 85%

Elimination diet 84%

Probiotics 83%

Reduce environmental exposure 81%

Stool bulking agents 79%

Herbs 75%

Sauna 66%

Skin brushing 56%

Allen J., Montalto, MS et., al. (2011). Detoxification in Naturopathic Medicine: A Survey. The Journal of Alternative and Complementary Medicine, 17, 12, pages 1175-1180.

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Detoxification Approaches (cont.)28 Day Program

• Week 1: Eat clean, green and lean• Trash foods that are most toxic (i.e. pesticides)• Reduce and remove energy-zapping foods (i.e.

sugar)• Uncover your weight loss saboteurs (i.e. foods

you crave)• Eat a rainbow of colors• Eat more vegetarian protein sources• Find healthy replacements

• Week 2: Remove toxins from your home • Find and evict hidden enemies• Deep cleaning

• Week 3:Cleanse the body and eliminate toxins • Clean your primary exit route• Optimize your kidney and liver function (i.e. castor oil,

healthy foods)• Detox through your skin (i.e. sauna, skin brushing)• Eat more whole grain brown rice and greens daily

• Week 4: Start using Supplements• Vitamin B1-100 mg, Vitamin B2-50 mg, Vitamin B6-100 mg • Vitamin C-3,000 mg, Vitamin E-400-500 iu• Magnesium-500 mg• Alpha-lipoic acid-50 mg• Fish Oil- 1500 mg• N-acetyl L-cysteine-100 mg• Selenium-200 mcg• Whey protein powder• Chlorophyll• Probiotics• Liquid Life- 1 ounce/day• Ginkgo Biloba-1 capsule• Extracts: broccoli, dandelion, green tea, milk thistle, turmeric,

rooibos• Herbs/spices: Basil, cinnamon, garlic, nutmeg, clove and thyme

Crinnion, 2010

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Detoxification Approaches (cont.)

Peter Bennett, N.D.

7 Day Detox

• Brief fasting (2 days)• Fasting on water, lemon water or herbal tea • Vitamin C (1-4 grams/day)

• Olio antigenic diet (5 days)• Rice, fruit and vegetables

• Whey or rice protein shake 1-2/day during days 3-7• Sauna’s and shower hydrotherapy (daily for a month)• Nutritional supplements (one month)• Sleep 6-7 hours

Bennett P., Bland J., Galland L. et al. (2010). Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional Medicine. ISBN: 978-0977371372, pages 556-562.

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Resources Environmental Working Group

www.ewg.orgNational Library of Medicinehttp://hpd.nlm.nih.gov/

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References:Allen J., Montalto MS., et., al. (2011). Detoxification in Naturopathic Medicine: A Survey. The Journal of Alternative and Complementary Medicine, 17, 12,

pages 1175-1180.

Altinterim B. (2014). Hepatoprotective Effect of Milk Thistle Seed (Silybum Marianum). Near East Medical Journal. http://nemj.neu.edu.tr/en/deve-dikeni-tohumunun-silybum-marianum-karaciger-koruyucu-etkileri/

Barrett K., Barman S., Boitano S. & Brooks H.L. (2010). Ganong’s Review of Medical Physiology, 24th edition. Columbus, OH: McGraw-Hill. ISBN: 978-0071605670.

Bennett P., Bland J., Galland L. et al. (2010). Textbook of Functional Medicine. Gig Harbor, WA: The Institute for Functional Medicine. ISBN: 978-0977371372.

Bland J. (1994). Neurobiochemistry: A New Paradigm for Managing Brain Biochemical

Bland J. (1995). A medical food-supplemented detoxification program in the management of chronic health problems. Alternative Therapies Health Medicine; 1 (5), 62-71. http://www.metaehealth.com/site/office/print.jsp?path=fm_wellness_center/healthy_kitchen&id=3

Brustolin S., Giugliani R. & Felix T.M. (2010). Genetics of Homocysteine Metabolism and Associated Disorders. Brazilian Journal of Medical and Biological Research, 43, 1, 1-7.

Cline, J. (2009). Everyday Toxins, Hawthorn University.

Crinnion W. (2010). Clean, Green and Lean. John Wiley & Sons, Inc., Hoboken, New Jersey. ISBN-978-0-470-40923-7.

Crinnion W. (2010). Organic Foods Contain Higher Levels of Certain Nutrients, Lower Levels of Pesticides and May Provide Health Benefits to the Consumer. Alternative Medicine Review, 15, 1, 4-12. http://www.altmedrev.com/publications/15/1/4.pdf

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References:Curl C., Fenske R. & Elgethun K. (2003). Organophosphorus Pesticide Exposure of Urban and

Suburban Preschool Children with Organic and Conventional Diets. Environmental Health Perspectives, 111, 3, 377-382.

Dadd, D.L. (2008). The Greening of Your Home. Hawthorn University.

Environmental Health and Toxicology, Special Information Services (SIS), United States National Library of Medicine, National Institutes of Health. http://www.sis.nlm.nih.gov/enviro.html

Environmental Working Group. (2014). http://www.ewg.org/

Houlihan J., Kropp T., Wiles R., Gray S. & Campbell C (2005). Body Burden, The Pollution InNewborns. Environmental Working Group, 1-63.

Krohn J, & Taylor F. (2000). Natural Detoxification. A Practical Encyclopedia. Hartley and Marks Publishers Inc.

Lipski, E. (2008). Understanding Liver Detoxification Pathways. Hawthorn University.

Little Y., Semmes B. Correlation of High Sensitivity Creative Protein marker of Inflammation and Metabolic Screening Questionnaire. True North. http://www.truenorthhealthcenter.org/documents/CRPMSQStudy_TrueNorth.pdf

Redmond E., Egeston C. & Bralley A. (2012). Low level prenatal exposure to organophosphate pesticides significantly lowers IQ in children. Townsend Newsletter for Doctors.http://www.townsendletter.com/Jan2012/lowprenatal0112.html

Sarantis H., Naidenko O.V., Gray S., Houlihan J. & Malkan S. (2010). Not so Sexy: The Health Risks of Secret Chemicals in Fragrance. Breast Cancer Fund, Commonwealth Environmental Working Group & Campaign for Safe Cosmetics. http://safecosmetics.org/downloads/NotSoSexy_report_May2010.pdf

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