DETOXIFICATION AND CANCER The role of chelation and detoxification in the treatment and prevention of cancer

Detoxification

What are you detoxifying & why?

Detoxification Pathways

• Drainage vs. elimination

• Drainage- from the organ/matrix to the circulation system

• Elimination- From the circulation system out via the GI Tract, urination, breathing (lungs), skin, & other excretions

Chelation & Detoxification Principles

• Patient’s Health• Patient’s Disease• Timing - Seasons• Complexity of Toxic State

Detox Philosophy

• Antidote• Transformation• Acceptance• Freedom

Detox Principles & Philosophy• Understand the difference between drainage and

elimination and how to support both

• Initial preparation - assessment, strategy & planning with emphasis on seasonal timing

• Utilize appropriate support structure and tools

• Construct realistic goals and proceed slowly

Detox Principles & Philosophy

Follow up program:• Maximize benefits of detoxification• Smooth transition after detoxification

Freedom - the concept of loosening our grip:• Mentally/Emotionally/Spiritually: supports overall

detox• Physiologically: releasing the toxins from organs &

tissues• Grasping & letting go• Expanding while detoxifying

The Detoxification Cycle

• Liver as the starting point• Follow circulation• Lungs• Heart/brain• Gastrointestinal tract• Systemic - joints, etc.• Elimination or… back to the liver or other tissues

Tools in Detoxification• Diet• Nutritional supplements• Botanicals• Acupuncture & Moxibustion• Heat therapies - Infra red saunas• Purging - colonics, enemas, washes• Intra venous therapies• Lymph drainage• Meditation

• Body/Mind Connection

Detoxification Diet

• High fiber• High greens• Help elimination - liver & large intestines• Catabolic• Organic• Modify as needed

Heavy Metal Detoxification Principles

• Go slow

• Appropriate timing

• Avoid fasting or radical low protein diets while detoxifying heavy metals

• Supplement with minerals

• Support the body in the process

• Have a long term maintenance plan

Chelation Guidelines: A Multi-step Graduated Program

• Start by Chelating from the blood & GI Tract• Once total body burden has decreased, enhance

chelation & add organ specific detoxification • Support drainage, elimination mechanisms &

pathways• Support body’s system• Minimize side effects & aggravations• Gentle & gradual chelation is almost always

preferable

Detoxification Supplements

• Modified Citrus Pectin/Alginate complex

• Medicinal Mushrooms - balanced, multi-nutrient type formulations

• Alpha Lipoic Acid, sulfured amino acids, others

• Digestive support - herbs, enzymes, probiotics

EDTA, DMSA & DMPS Used for Provocation

• Sometimes called a "challenge" or "provoked" heavy metals test.

• The ability of EDTA, DMSA or DMPS to mobilize heavy metals stored in body tissues (& therefore not typically present in the circulation) increases the excretion of heavy metals in the urine, leading to more accurate identification of total heavy metal toxicology than hair or blood tests alone.

• This must be performed by trained medical practitioners, with timed urine collections sent out to a specialized laboratory for analysis.

Safe Natural Chelation

Natural Chelators• More recently natural chelating agents have also been

discovered, such as the use of pectins after the Chernobyl disaster in 1986.

• Includes polyuronide soluble fibers (Modified Citrus Pectin & kelp alginates), Vitamin C, natural thiol compounds & sulfur containing amino acids, kelp derived alginates & even herbs such as cilantro/coriander (Coriandrum sativum). • These have properties that bind with metallic ions so that the ion is held by

several chemical bonds. This renders it much less chemically reactive, producing a complex that is water soluble allowing it to be excreted harmlessly by the body.

Natural Chelation is Significantly Safer• Alpha Lipoic Acid (ALA): Rare cases of allergic reaction. Other possible

side effects include headache, muscle cramps, & a feeling of “pins & needles” in the body. Not to be used in initial state of chelation.

• Vitamin C: Rare cases of gastrointestinal complaints. These side effects normally stop as soon as high potency intake is reduced or stopped.

• Modified Citrus Pectin: No known adverse effects other than occasional loose stools.

• Alginates: No documented adverse effects

Modified Citrus Pectin (MCP) in Chelation and Detoxification• Clinical data indicates that MCP functions as a gentle chelator of

heavy metals. • The detoxification properties have been confirmed in clinical trials &

case studies.• MCP has shown in clinical studies to increase the urinary excretion of

toxic metals such as lead, cadmium, arsenic & mercury. • Long-term use of this gentle safe chelator could effectively reduce

the body burden as shown in a clinical trial. • The ability of MCP and modified Alginates to remove heavy metals &

environmental toxins on an ongoing basis has been shown to be of significant clinical benefit in multiple case studies.

Chemical Properties of Alginates & Pectin

O

Ar

Ar

Ar

Rh

Rh Rhamnose

Ar Arabinose

Neutral Sugars

O

O

C

OHO

OO

C

OHO

O

O

C

OHO

O

O

C

OHO

O

O

C

OHO

O

O

C

OHO

O

O

C

OO

CH3

O

O

C

OHO

GalaturonicAcid Group

Esterified Galacturonic

Acid

Citrus Pectin Chemical Structure

OHHO

OHHO

OH OHHO HO

OH OH OHHOHOOH HO OH

Pectin has neutral sugar chains that branch off from the mainchain of galacturonic acid. Some of the galatcuronic acid groups have an additional methyl group (CH3-) associated with them.This is called esterification and it reduces chelation potential.

Alginates have a similar linear structure to pectin without the neutral sugar side branches. Instead of galacturonic acid, alginate is made up of trepeating blocks of mannuronic and guluronic acid.

A class of complex polysaccharide compounds known as polyuronides. Polyuronides are long chains of repeating sugar acid groups such as galacturonic acid (pectin) or mannuronic & guluronic acid (alginates). Polyuronides are proven chelators of toxic metals, pesticides & herbicides, and have been used in humans exposed to lead & radioactive metals as well as in the clean-up of environmental pollution for over 40 years.

Chelation “Egg Box” Theory

PCC chain (comprised of alginate or pectate)

In solution, the long fiber chains stack together in groups forming pockets where metal cationscan complex with the fiber. This stackedformation is sometimes referred to as an "eggbox confirmation".

lead (Pb2+)mercury (Hg2+)

cadmium (Cd2+)

Once the metals are bound to the fiber they can easily be removedfrom the body via the urine orfeces.

Mechanism of ActionMetal Complex Formation

Polyuronides form stacks in solution in what is known as an “egg box” structure. Each pocket of the “egg carton” contains a positively charged ion to balance the negatively charged chains. Normally the positive ions are sodium & potassium. However, toxic metals especially lead, mercury, cadmium, & radioactive metals have a higher affinity for polyuronides than the essential ions like calcium, magnesium, & potassium. Toxic metal ions become trapped in the “egg box” structure & are eliminated from the body.

Stage I Detoxification

During the first stage of detoxification, avoid introducing agents that can penetrate into the tissues & bind heavy metals to them.

The concern is that they can pull heavy metals including mercury from the circulation into the tissues, especially the brain.

Stage I Detoxification Continued• First chelate using MCP, or Modified Citrus Pectin/Alginate

complex to slowly reduce the overall heavy metal burden on the tissue level for 2-4 weeks.

• During the initial chelation stage, higher dosages of such a combination are needed.

• For maintenance & long term prevention, lower dosages are sufficient. Due to ongoing exposure to heavy metals such as lead & mercury, there is great benefit to using such a preparation on a long term basis.

• Modified Citrus Pectin/Alginate complex provides on-going gentle chelation systemically in the blood stream as well as in the digestive tract.

The Effect of Modified Citrus Pectin on the Urinary Excretion of Toxic MetalsEliaz I, Hotchkiss AT, Fishman ML, Rode D.3Amitabha Medical Clinic & Healing Center, Sebastopol, California, USA. Eastern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Wyndmoor, PA 19038,3University of California, Davis, CA, USA. Phytother Res. 2006 20(10):859-64.

• Methods: Prior to oral administration of MCP, the subjects collected a 24 hour urine sample for baseline measurements. Twenty four hour urine samples were also collected on day one & day six. The subjects ingested 15 grams of Modified Citrus Pectin (MCP) each day for five days & 20 grams on day six. Urine samples were analyzed by ICP-MS (inductively coupled plasma-mass spectrophotometer).

• Results: Lead, mercury, cadmium & arsenic increased significantly in urine analysis.

• Essential minerals were not changed significantly.• No side effects were reported.

Results: Modified Citrus Pectin & Urinary Excretion of Toxic Elements - Day One

Urinary Excretion of Elements - Day One(Percent Change from Day Zero)

Al Sb As Cd Pb Hg Sn-50

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Results – Day One

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Results: Modified Citrus Pectin & Urinary Excretion of Toxic Elements - Day Six

Urinary Excretion of Elements - Day Six(Percent Change from Day Zero)

Al Sb As Cd Pb Hg Sn

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Results – Day Six

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Results Summary• In the first 24 hours of MCP administration the urinary excretion of

arsenic increased significantly (30% over baseline/day zero, p<0.05).

• In this same period, the excretion of mercury & cadmium approached significance (50% & 130% over baseline respectively; p<0.1). On day six, urinary excretion was significantly increased for cadmium (50% over baseline, p<0.05) with tin approaching significance (130% approached significance; p < 0.1).

• In addition, lead showed a dramatic increase in excretion (460% over baseline) with p=0.05

• No significant changes in the excretion of Al, Ca, Cu, Mg, Zn, Fe, Se, Pt, Be, Bi, Tl, Th, U & Sb were observed.

• No Side effects were reported.

Modified Citrus Pectin Decreases the Total Body Burden: A Pilot Human Clinical trial

Eliaz I. Amitabha Medical Clinic & Healing Center, Sebastopol, California, USA.EcoNugenics, Santa Rosa, California, USA. 228th ACS National Meeting, Philadelphia, PA. 2004.

• Methods: Oral intake 5 g Modified Citrus Pectin/3x day for 4-10 months. Base line body burden and change measured with DMPS challenge (250mg i.v. followed by 6 hr. urine collection).

• Results: All subjects showed significant decrease in Mercury levels. Average decrease was 62.17%, ranging between 38.13% & 74.83% (p=0.0313).

• No significant side effects were noted.

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Patient A Patient B Patient C Patient D Patient E

67.90%72.80%

38.10%

74.80%

57.30%

Percent Reduction in Mercury from Baseline • MCP was effective in

decreasing the total body burden of Mercury in all subjects.

• MCP is a promising systemic gentle chelator of heavy metals that can be used on an on going basis.

Percent Reduction in Mercury from Baseline

10 months 4.5 months 6 months4 months 6.5 months

Study Conclusion

MCP Intervention Individual Results

The Role of Modified Citrus Pectin as an Effective Chelator of Lead in Children Hospitalized with Toxic Lead Levels

Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, Eliaz I.Children’s Hospital, Zhejiang University, School of Medicine, Hangzhou, Republic of China, Centrax International, Inc, San Francisco, California, USA. Eastern Regional Research Center, Agricultural Research Services, US Department of Agriculture, Wyndmoor, Pennsylvania, USA. EcoNugenics, Inc. Santa Rosa, California, USA. Altern Ther Health Med. 2008 14(4):34-8.

Lead in 24 Hour Blood Serum

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30

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60

1 2 3 4 5 6 7

P Value = 0.0016

Figure 1 Blood serum lead concentration (ug/dL) measured in blood serum by GFAAS before (Blue) and after (Red) Modified Citrus Pectin treatment (5 grams three times daily) in 7 hospitalized children 5-12 years of age. No side effect reported.

Lead in 24 Hour Urine Excretion

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20

40

60

80

100

120

140

1 2 3 4 5 6 7

P Value = 0.0007

Figure 2 Lead levels (µg/dL) measured in 24-hour urine excretion by GRAS before (Blue) and after (Yellow) Modified Citrus Pectin treatment (5 grams three times daily) in 7 hospitalized children 5-12 years of age. No side effects reported.

Stage II DetoxificationSupport heavy metal discharge and purge heavy metals while the body is going through a detoxification process. We can foster this process by:

• Removal & excretion of heavy metals from the tissue.• Preventing re-absorption of heavy metals secreted via the bile

to the gut. • Binding circulating heavy metals, neutralizing & preventing re-

absorption in the gut. • Aiding the liver & the detoxifying enzymes in the body, support

drainage & elimination.• Supporting the body’s energy/vitality/strength to allow the body

to “follow through” & successfully chelate the heavy metals.• Supporting tissues where the chelation process can create side

effects, such as the brain.

Stage II Supplementation: Detox Complete

• Poly botanical/thiols/nutrient formula is the second stage in a unique, two-part integrated detoxification system that broadens the gentle systemic chelation process.

• Designed as a complimentary formula to be used after 2-4 weeks of gentle chelation with Modified Citrus Pectin/Alginate complex.

• Poly botanical/thiols/nutrient formula supports detoxification by addressing multiple facets of chronic heavy metal toxicity.

• It fosters systemic chelation by providing a comprehensive combination of vitamins, nutrients & herbs that support detoxification from the tissues & organs and aids in liver detoxification, promoting elimination through both the bile/intestines & the urinary tract.

Stage II Supplementation: Detox Complete

Eliaz, I, Weil, E, Wilk, B. Amitabha Medical Clinic & Healing Center, Sebastopol, California, USA. EcoNugenics, Santa Rosa, California, USA.Forsch Komplementmed. 2007 Dec;14(6):358-64.

Integrative Medicine & the Role of Modified Citrus Pectin/Alginates in Heavy Metal Chelation & Detoxification - Five Case Reports

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74%

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83%

Percent Decrease in Heavy Metals Pb = Lead, Hg = Mercury, (Mo) = Months 75% Average Decrease, P Value = 0.026

Pb (3Mo) Pb (6Mo) Hg (6Mo) Hg (6Mo) Hg (6Mo) Hg (12Mo)

Five Case Reports: Results

Detoxification Guidelines• Start by Chelating from the blood & GI Tract

• Once Total Body Burden has decreased, enhance chelation & add organ specific detoxification

• Support drainage, elimination mechanisms & pathways

• Support body’s system

• Minimize side effects & aggravations

• Gentle & gradual chelation is almost always preferable

Detoxification Summary• Define your goals - patient & practitioner

• Proper timing

• Multi faceted program

• Post detoxification follow up

• Repeat cleanse during spring & fall

• Evaluate success - physical, emotional & mental/psychological/spiritual

LINKS BETWEEN CANCER AND DENTAL HEALTH

Specific Dental Risk Factors in Cancer

• Root Canals• Mercury amalgam fillings• Infection• Inflammation

Links between Cancer and Dental Health

• Research shows generalized links between periodontal disease and certain cancers

• Traditional Chinese Medicine demonstrates relationships between teeth and organ systems

Relationships between teeth and organs

Periodontal Disease Linked to:• Cancer• Systemic Inflammation• Heart Disease• Diabetes• Autoimmune Disease• Osteoporosis• Allergies• Lung Conditions• Obesity• Other conditions

PERIODONTAL DISEASE, INFLAMMATION AND CANCER

Research Highlights

The Association of Dental Plaque with Cancer Mortality in Sweden

• Objectives: To study whether the amount of dental plaque, which indicates poor oral hygiene and is a potential source of oral infections, correlates with premature death from cancer.

• Methods: Prospective cohort study. 1390 randomly selected healthy young Swedes followed from 1985 to 2009.

Soder B, Yakob M, et al. Dept. of Dental Medicine, Karolinska Institutet, Huddinge, Sweden BMJ Open 2012;2;e001083. doi:10.1136/bmjopen-2012-001083

The Association of Dental Plaque with Cancer Mortality in Sweden

Results: 4.2% of participants died during the study. Amount of dental plaque between those who died and those who survived was statistically significant with 1.79 times the overall risk of death via scattered malignancies in men and breast cancer in majority of women.

Conclusion: Increased amount of dental plaque may be associated with increased cancer mortality. Further studies are warranted.

Soder B, Yakob M, et al. Dept. of Dental Medicine, Karolinska Institutet, Huddinge, Sweden BMJ Open 2012;2;e001083. doi:10.1136/bmjopen-2012-001083

Chronic Periodontitis and the Incidence of Head and Neck Squamous Cell Carcinoma

• Objective: To assess the effect of chronic periodontitis on head and neck squamous cell carcinoma (HNSCC).

• Methods: 473 HNSCC patients studied btw 1999-2005. Periodontitis measured by alveolar bone loss (ABL).

• Results: Each millimeter of ABL was associated with >4-fold increase risk of HNSCC. Chronic periodontitis may be an independent risk factor for HNSCC.

Tezal M, et al. Depts. Oral Diagnostic Sciences, Oral Biology, Social and Preventive Medicine, Otolaryngology, S.U.N.Y. New York, USA Cancer Epidemiol Biomarkers Prev 2009 18;2406.

Periodontal Disease May Associate with Breast Cancer

• Objective: To evaluate the association between periodontal disease, missing molars and breast cancer.

• Methods: Prospective study of 3,273 subjects ages 30-40 at baseline.

• Results: Chronic periodontal disease accompanied by missing molars associates statistically with increased incidence of breast cancer.

Soder B, et al. Dept. of Dental Med., Division of Periodontology, Karolinska Institutet, Huddinge, Sweden. Breast Cancer Res Treat. June 2011; 127(2):497-502

A Review of the Relationship Between Tooth Loss, Periodontal Disease, and Cancer

• Objectives: A review of 18 published studies demonstrating relationships and possible mechanisms of action between tooth loss, periodontal disease and various cancers. Controlled for smoking, demographics and other possible confounding factors.

Meyer M, et al. Harvard School of Public Health Dept. of Epidemiology, Boston, MA. USA Cancer Causes Control 2008 19:895-907

SummaryRelationships between teeth and organs

Relationships between periodontal disease, inflammation and cancer

Relationships between heavy metal toxicity, inflammation and cancer

Natural agents with anti-inflammatory/anti-microbial/anti-cancer properties:

• Modified Citrus Pectin• Tibetan Herbal Formula• Honokiol• Vitamin D3