Department of Pediatrics Newsletter Summer...

D E P A R T M E N T O F P E D I A T R I C S N E W S L E T T E R

I S S U E N U M B E R 1 0 S P R I N G / S U M M E R 2 0 0 8H T T P : / / W W W. P E D I AT R I C S . M E D . U B C . C A /

Contents Department Head’s Message 2

Administration News 3

Resident’s Review 3 Education Program Updates 4-5 Medical Students Update 6 Resident Awards 6-7 Management of Pain & Anxiety in the ED 8-9 Emeritus Happenings 10-11

Faculty Awards 2007 12-13 UBC MD Undergraduate Admissions - What’s New 14-15 Child Health in South Africa 16-17

The Relationship Between Child Psychiatry and Pediatrics 17-18

Academic Highlight - Stress and Neuro- Development in Children born pre-term 20

Announcements 21-24 FOM Quarter Century Celebration 25 Recognition Dinner 2008 26-33 FOM Academic Gowns Reception 35-36 In Memorium 37 Current Publications 40-48


D E P A R T M E N T O F P E D I A T R I C S P A G E 2

Hypothermia Therapy for Cardiac Arrest in Pediatric

Patients

Hutchison JS, Doherty DR, Orlowski JP, Kissoon N.

Cardiac arrest is associated with high morbidity and mortality in children. Hypothermia therapy has theoretical benefits on brain preservation and has the potential to decrease morbidity and mortality in children following cardiac arrest. The American Heart Association guidelines recommend that it should be considered in children after cardiac arrest. Methods of inducing hypothermia include simple surface cooling techniques, intravenous boluses of cold saline, gastric lavage with ice-cold normal saline, and using the temperature control device with extracorporeal life support. We recommend further study before a strong recommendation can be made to use hypothermia therapy in children with cardiac arrest.

Pediatr Clin North Am. 2008 Jun; 55(3):529-544.

Department Head’s Message

Dr. Bob Armstrong

Pediagogue is a publication of the Department of Pediatrics 4480 Oak St., Rm 2D19, Vancouver, BC V6H 3V4

Editor and Design: Georgia Petropoulos Any opinions expressed by authors of articles in Pediagogue are the authors’ opinions alone

and do not represent the philosopy or opinions of the Department of Pediatrics

Through this Spring edition of Pediagogue I want to wish all of you a very relaxed and regenerative summer season (that is if summer ever arrives!) We are entering a very important period for the Department and I hope you will have the renewed energy for success as we look forward. In July of 2010, I will have completed my second term as Head of the Department and Chief of Pediatrics. I will need to personally reflect on these past ten years and think about what I want to do next. There are of course a few things that still have to be finished during the course of the next two years!

However, the process for department reflection must start in the early Fall when we return from summer holidays. We need to step back and summarize what has been achieved and develop a strategic plan for moving forward that will help to frame the search for the next Head of the Department. Fortunately, this will coincide with an updated strategic plan for the BC Children’s Hospital as President Larry Gold works with us to renew our vision for the BC Children’s Hospital. So, we will go through a department strategic plan this Fall to be completed by December.

In the Spring of 2009, Dean Gavin Stuart and President Larry Gold will conduct an external review of the Department. A lot of work goes into the report for this review and the review itself, as the Department has

the opportunity to provide input to the search committee that will be charged with recommending the candidate for Head and Chief. Gavin and Larry will establish the search committee by the Spring of 2009 with the expectation that the search will be completed and the candidate selected in time to start work on July 1, 2010.

There are many things that should have or could have happened during my tenure and I can think of several thousands of wasted hours that we have spent on things that should have been much simpler and would have allowed us to move forward in a more efficient and bolder manner. I am of course aware of this reality and take responsibility for it. My hope, however, is that the Department is better positioned for the next ten years, and with your leadership and support the next head will have greater success!

The role of Head is not always easy but it is very satisfying and rewarding. In the end it is about leadership, not simply “administration”. I hope those of you with an interest in taking on the challenge will step up to be considered and that we all work hard to locate potential external candidates.

Once again I wish you and your families a relaxing and enjoyable summer.

Dr. Armstrong can be reached at [email protected]


N E W S L E T T E R I S S U E 1 0 S P R I N G / S U M M E R 2 0 0 8P A G E 3

Marcelle Sprecher

Acting Director of Administration

Administration News Residents’ ReviewPediatric Chief Residents’ News

Dr. Alexandra Zorzi, Pediatric Chief Resident

The Pediatric residents are very pleased to be welcoming 12 new pediatric residents July 1st 2008. CARMs was a huge success and I would like to take this opportunity to thank everyone who helped contributed to the interview process.

The pediatric residents have designed a new case based approach to their academic half day, held weekly on Tuesday afternoons. This new format is resident driven and has allowed for a clinically based approach to pediatric teaching and resident learning. Celebrate Research Day, which was held on March 14th, showcased resident research. Congratulations to Drs. G. Cuvellier and Kevin Harris, winners in the fellow and resident research competitions held that day! We are pleased to announce that at the National Pediatric Research Competition held on May 8th in Winnipeg, Manitoba, Dr. Kevin Harris won in the Resident Category I Research Competition.

In March, the annual Pediatric Resident Spring Retreat was held with a focus on professional development and transitioning to pediatric practice. Congratulations to our 4th year residents who completed the OSCE portion Royal College Exam on May 15th.

Dr. Druker and I are looking forward to working on a Global Child Health curriculum for residents. The Brighter Smiles program continues to grow, with Drs. Morrison Hurley Shreya Moodley traveling to Uganda this June. We are looking to continue to expand our affiliation with the Red Cross Hospital in South Africa and Sydney Children’s Hospital with resident exchange programs.

Lastly, I would like to thank Drs. Mona Singal and Jeff Bishop for all their work and dedication as our chief residents. They have significantly contributed to the education and well being of the pediatric residents, and I look forward to continuing on in this tradition.

Alexandra Zorzi, MD, Pediatric Chief Resident

Dr. Zorzi can be reached at: [email protected]

“All this will not be finished in the first hundred days. Nor will it be finished in the first thousand days, nor in the life of this administration, nor even perhaps in our lifetime on this planet. But let us begin.” John Fitzgerald Kennedy; 35th President of the USA

What an apt quote to describe life in administration land and perhaps in the work that you do as well.

Many times it may be difficult to stay the course when the path is not clear or the ending seems elusive. But that is exactly the time that we need to hold to the bigger vision of what we are trying to accomplish. That is why we set visions – to set us on the path and give us the strength to continue to pursue them to their end.

Likewise, many times we may put off starting a task or a project because it seems daunting or unreachable.

I note that under John F. Kennedy’s administration a moon landing was achieved based on a determined vision and unyielding energy.

What is your vision for what you want to do? What is our collective vision for the Department of Pediatrics to which we need to lend our determination and energy?

Let us begin!



Education Program Updates Sylvia Wu, Manager, Education

Spring marks the final months of training for our graduating residents and fellows. It is a busy period for Education with many activities geared toward graduation, along with Orientation and Curriculum Planning for the new academic year. In April, the undergraduate and postgraduate OSCEs were held; Education hosted a combined postgraduate and undergraduate Curriculum Retreat at the end of May; the Long Case Examinations were conducted on June 3 for our year three residents; and, on June 4, the SSR and Fellows Academic Half Day was presented. Next on the list is the June 23 CPS Conference taking place in Victoria. UBC Pediatrics will be hosting Program Directors from across the country at this event.

The time has come again to celebrate the graduation of our residents and fellows and to recognize their achievements over the past year. The Graduation and Awards Ceremony took place on June 12, 2008, at the Pan Pacific Hotel Vancouver. After such a busy spring for all our trainees, faculty and staff in Education, we welcomed the opportunity to relax and recognize our efforts. A highly accomplished and talented group of residents and fellows was honoured this year. Our first-year residents provided the perfect finale to our evening. Memories of their video skit will bring forth laughter for many years to come.

Congratulations to all of our

graduating trainees and award recipients. It has been an exciting

and eventful year. Best wishes to all of you as you continue with your academic and clinical pursuits.

The awards presented during the evening are as follows:

SSR and Fellowship Award Presented by Dr. Walter Duncan, Program Director, Division of Cardiology and Graduation Banquet Speaker

Dr. Quynh Doan and Dr. Geoffrey CuvelierLaura MacRae Award

Resident Awards Presented by Dr. Jenny Druker, Director, Pediatric Residency Program:

Drs. Mona Singal and Jeffrey BishopChief Pediatric Resident Award

Dr. Jacob RozmusOutstanding Senior Resident

Dr. Kathy WongOutstanding Junior Resident

Dr. Jeffrey BishopSenior Resident, Teaching

Dr. Abdullah Al AbbasSenior Resident, Teaching

Dr. Alexandra ZorziUBC Resident Research Award

Drs. Shelina Jamal and Christina BiggRecognition for Academic Half Day

Dr. Alexandra ZorziBC Pediatrics Society Resident Prize: Child Advocacy Award for First Nations Children in BC

Dr. Bob Armstrong

Dr. Walter Duncan

Dr. Jenny Druker and Dr. Alex Zorzi

cont’d on p. 5



Dr. Jeffrey BishopBC Pediatrics Society Resident Prize: Child Advocacy Award for Outstanding Leadership and Innovation in Pediatric Medicine and Knowledge Transfer

Dr. Jeffrey BishopUBC Pediatrics: Award of Excellence for Outstanding Leadership and Innovation in Pediatric Medicine

Dr. Shreya MoodleyUBC Brighter Smiles Program Award of Recognition as Pediatric Resident Coordinator for Brighter Smiles BC and Brighter Smiles Africa Program

Dr. Nicole RadziminskiUBC Brighter Smiles Program Award of Excellence for Promotion of Global Citizenship in the Brighter Smiles Africa Program

Dr. Jacob RozmusUBC Brighter Smiles Program Award of Excellence for Contribution to the Diabetic Screening Project, BC First Nations Children

Dr. Alexandra ZorziUBC Pediatrics: Award of Excellence for Outstanding Presentation at the Western Scientific Pediatric Society meeting in Carmel, CA, February 2008

Awards presented by Dr. Alexandra Zorzi, Chief Resident:Dr. Peter LouieBest Hospital Based Pediatrician

Dr. Frank JagdisBest Community Based Pediatrician

Dr. Kimberley Myers, CardiologyOutstanding Clinical Fellow

NephrologyBest Service Award

Dr. Walter DuncanTeacher of the Year Award

Dr. Shawn GeorgeRookie of the Year Award

Dr. Jennifer DrukerThe Golden Rattle

Dr. David SpeertThe Ivory Tower Award

Dr. Glenn RobertsonWyeth Excellence in Teaching Award

Awards and accomplishments noted at banquet but presented elsewhere:

Alexandra ZorziCFRI 2008 Award for Outstanding Achievement by a ResidentDrs. Jane Ng and Kevin Harris

Education Updates

CPS Advocacy Grant 2008

Drs. Nicole Radziminski and Karen TrudelCPS Hillman International Child Health Award 2007

Dr. Kevin Harris20th Annual National Pediatric Resident and Fellow Research Competition

Now that we’ve had a chance to look back on 2007/08 and take a

moment to appreciate our successes, we can look forward to a new academic year.

Orientation is scheduled for July 2--a full day for our new residents, SSRs and Fellows -- designed to help prepare trainees for their time with us. To welcome the new trainees to their programs, we have the annual Summertime Garden Party and BBQ on July 20. This is a special day in which fellows, residents, faculty and staff, along with their family members, have a chance to relax and enjoy the sunshine together. On behalf of the faculty and staff members in Education, we wish everyone a wonderful summer.

cont’d from p. 4



Medical Students’ Update

Students Interested in Pediatrics (SIPs), is a UBC Medicine Club that was founded by Joanne Yeung, one of UBC Pediatrics own residents. This year is its second year of operation, coordinated by two UBC fourth year medical students, Tram Nguyen and Shalea Piteau. The purpose of SIPs is to serve as a resource for students interested in paediatrics and to foster a relationship with pediatricians in the community and with pediatric residents. We provide information on careers in pediatrics and we teach about and participate in child advocacy. This year SIPs held monthly events which hosted many honourable speakers, generating plenty of interest amongst the medical students. Some of our events included Adolescent Night, International Night, Life of a Resident Night, Developmental Pediatrics Night, and visits to Canuck Place. SIPs is still growing and developing a network of paediatricians, residents, and medical students. We want you to share your expertise with us and teach medical students how wonderful it is to be a pediatrician. We even want to hear about the difficult times. If you are interested in sharing some of your experiences with us or you have a great idea for an event to teach students about pediatrics or child advocacy, please contact us. The coordinators for 2008/2009 are Esther Lee (UBC Med 2009, [email protected]) and Jessica Fry (UBC Med 2010, [email protected]).

We look forward to the many exciting events this year and learning more about a career in paediatrics! Shalea Piteau, Queen’s University Pediatrics PGY1 in 2008

Dr. Karen Trudel Awarded the Hillman International

Child Health Grant

Dr. Karen Trudel

Dr. Shalea Piteau

The Don & Elizabeth Hillman International Child Health Grant was created by the International Child Health Section of the Canadian Paediatric Society (CPS) with the underlying philosophy of promoting international health opportunities for residents and fellows. The section has established four grants, awarded annually, to be used towards completing a paediatric elective in developing countries.

In a few months, Dr. Karen Trudel will be heading to South Africa for a long-awaited 12-month elective. She will be working as a supernumerary registrar at the Red Cross War Memorial Children’s Hospital in Cape Town from November 2008 to October 2009. Dr. Trudel will spend three months on each of the following services: the General Pediatrics Ward, the PICU, NICU, and the Emergency Department. In doing so, she will be following the footsteps of Drs. Dan Tzse, Elizabeth Grant, and Nicole Radziminski, all graduates of our program, who have been involved with the Red Cross

during the past five years. This represents a tremendous learning opportunity for Canadian residents, as it provides exposure to diseases not commonly seen in North America, as well as to International Child Health issues in general.

As Dr. Trudel prepares for a career in critical care, she sees this elective as an excellent opportunity which will also allow her to gain valuable experience treating actuely ill children.

She looks forward with anticipation to beginning her elective at Red Cross and in the process, also discovering Cape Town and and the surroundings! Dr. Trudel is particularly grateful for the financial support provided by the CPS and the Don & Elizabeth Hillman International Child Health Grant.

Dr. Trudel can be reached at: [email protected]



Dr. Alexandra Zorzi receives Award of Excellence for Outstanding Presentation at

the Western Scientific Pediatric Society Meeting in Carmel, CA:

“Prevalence of Metabolic Syndrome in Canadian First Nations Children

Living on the Remote Pacific Coast”

The communities of Hartley Bay (Gitga’at), Kitkatla (Gitkxaahla) and Port Simpson (Lax Kw’alaams) have a long-standing relationship with BC Children’s Hospital through the Brighter Smiles program. Following the identification by the Brighter Smiles team of unsuspected type 2 diabetes in one of the children, these three Tsimshian Nation communities requested

diabetes screening for all of their children, all of whom have at least two major risk factors. In adults, type 2 diabetes is closely associated with dyslipidemia and cardiovascular disease (CVD). The coexistence of central obesity and at least two additional components (high blood pressure, high triglyceride level, low HDL-cholesterol level, high fasting glucose) is referred to as the “metabolic syndrome”. The purpose of this study was to determine the prevalence of obesity, metabolic syndrome and its components (including glucose intolerance) in children living in three remote Tsimshian Nation communities of British Columbia. The research team was led by Dr. Panagiotopoulos and included a pediatric resident, a laboratory technician to spin and aliquot blood samples, and a nurse experienced in performing oral glucose tolerance tests. These data were presented at the Western Scientific Pediatric Research Meeting held in Carmel, California this past February. A poster presentation at the Canadian Pediatric society meeting this June will present final data. To summarize, 19% of children were overweight and 26% were obese. The overall rate of metabolic syndrome was 4.1% (8/194); however, the prevalence in overweight/obese children was 9.1% (8/88). In overweight/obese children, 40% had one component of metabolic syndrome and 25% had two. The high prevalence rates of the components of the metabolic syndrome as well as overweight/obesity documented in these Canadian Tsimshian Nation children raise concerns about their future diabetes and cardiovascular disease risk.

This research has provided the impetus for these communities to implement lifestyle-modification programs to modify their cardiovascular and diabetes risk. Currently, Dr. Zorzi is evaluating the Action Schools! BC program, modified for First Nations children, as a school based physical activity and

nutrition education program to address the identified health needs of these Tsimshian Nation children living on the remote Pacific Coast. The preliminary data will be presented at the American Diabetes Association scientific meeting held in June 2008. Dr. Zorzi expresses her gratitude to Dr Dina Panagiotopoulos, The Lawson Foundation, The Canadian Council of Learning and the communities of Hartley Bay, Kitkatla and Port Simpson for supporting this research. Dr. Zorzi can be reached at [email protected]

Dr. Alexandra Zorzi



Management of Pain and Anxiety in the Emergency Department

Ran D. Goldman, MD, FRCPC Division Head and Medical Director Division of Pediatric Emergency Medicine

Children experience a wide variety of acute, recurrent and chronic pain. In a recent study, almost all (96%) of Canadian children reported acute pain over a period of a month before the study. In the Emergency Department (ED), pain is one of the most common complaints. Today, it is clear that pain has a negative impact on all quality of life aspects for children and it imposes a significant burden on society. Furthermore, studies demonstrate that infants and children who endure pain, in particular, pain related to medical procedures, retain a ‘memory’ to pain and respond negatively to future pain experiences. The Emergency Department setting is unique in many ways. Health care providers work in an environment of uncertainty until a diagnosis is made, and diagnosis and treatment need to be performed quickly in order to manage acute and critical illness. Furthermore, the currently evident overcrowding of Emergency Departments around the country present new challenges in managing children in a timely manner. These are some of the reasons pain management in the ED was under-recognized for many years. Other barriers to analgesia in the ED include health

care providers’ perceptions that have accumulated over the years. These include assumptions that

“children do not feel as much pain as adults”, “the procedure is short and providing analgesia will take longer”, “opioid analgesia can cause dependence” and others.Over the past two decades, research in the area of pediatric pain, largely from Canadian universities and specifically from BC Children’s and the Child and Family Research Institute helped to mitigate these misconceptions and promote analgesia for chronic and acute pain in children. Only recently are children visiting the ED setting benefiting from these changes by receiving analgesia, sedation and measures to reduce anxiety, especially during procedures. Assessment of Pain

One of the difficulties in determining the need for analgesia is the compelling need to determine the level of pain. Validating previously developed pain scales, and creation of new scales that are age and development appropriate are very helpful in the hospital setting for children presenting with chronic or acute pain. However, more work is needed in order to determine

the reliability in the hectic and sometimes chaotic environment of the Emergency Department. Non-Pharmacological Management

Children feel anxiety with any injury, pain and procedure they are going through. Child life specialists are members of the team providing emotional support to children and families in the emergency. They facilitate preparation and educate children about medical experiences through developmentally appropriate activities such as play. Before and during medical procedures, child life specialists help reduce anxiety by teaching children how to engage in coping techniques such as muscle relaxation, deep breathing exercises, and distraction. Predominantly, these interventions are considered for invasive and/or painful procedures such as intravenous catheter insertion and blood work and can encompass both active and inactive forms. Active forms of distraction engage the child in the play, while inactive approaches reflect the child’s passive response which usually entails observing the activities presented by the child life specialist.

cont’d on p. 9



New Routes of Analgesia There are numerous pharmacological measures to provide analgesia, from acetaminophen and ibuprofen to opioid medications such as morphine and fentanyl. The ED physicians are equipped with very potent options for analgesia, however, many of these medications are administered intravenously, necessitating an intravenous line, and may carry a higher risk of adverse events if given IV. Other routes of administration such as intravenous and sub-lingual administration of drugs are finding their way into the ED armamentarium. Intranasal administration of preparations has been known for thousands of years and was used to “cleanse the body”. Recent research has shown the benefit of using intranasal administration of midazolam for sedation and ketamine, morphine and fentanyl for analgesia. Sub-lingual and buccal administration of drugs has also been shown effective, utilizing the rich blood supply in the mucosal surface and bypassing absorption through the gastrointestinal system.

Topical Analgesia

One of the most advanced areas that pain management has experienced in the ED setting is the use of topical anesthetics. EMLA dominated topical application of lidocaine for

years. New preparations are now available including liposomal lidocaine, vapocoolant spray, lidocaine with faster onset of action, and amethocaine. A combination of pharmacologic analgesia with mechanical penetration of the skin with ultrasound, small electric current (iontophoresis) and heating patches have increased the potency of these drugs. The most recent advancement in this area is a futuristic looking “gun” that triggers passage of high speed gas that pushes lidociane powder into the skin and anesthetizes the skin in seconds.

The Emergency Department at BC Children’s Hospital is part of the significant revolution in the area of pain management and children arriving with injury or pain to the

ED these days are receiving much more analgesia than in the past. With continued technological and pharmacological advances, enhanced understanding of the pain process and improved education to parents and health care providers, we may one day witness the “painless ED”. Dr. Goldman can be reached at [email protected].

cont’d from p. 8


D E P A R T M E N T O F P E D I A T R I C S P A G E 1 0

Emeritus Happenings

Those of us with pediatric medically related backgrounds in British Columbia, and having reached senior status, continue to meet twice yearly for a luncheon at the Royal Vancouver Yacht Club in Vancouver. Most attendees have worked or continue to work in or out of Children’s Hospital in pediatrics or a related medical specialty. Pediatric surgeons, pediatric anesthetists and pediatric pathologists all participate, as do pediatricians from around the province. This year, May 30th was our spring luncheon date, and a few new invitees are now on the list, having reached that magical age of 60 which makes them eligible for participation. The response to the initial invitation can vary, as most physicians retire at 65 or older now, and not at the invitation age of 60. Some physicians start attending the luncheon immediately, recognizing the unique opportunity to see former teachers, mentors and others in a very pleasant social setting. Others wait until after their actual retirement to attend, finding that work demands limit their availability for a mid-day function on a Friday.

The luncheon provides an opportunity to be informed about Children’s hospital activities, to hear about pediatric planning in the province and catch up on the activities of many pediatricians and related health professionals, many of whom send along personal information when attendance is not possible. Dr Rob Hill, who retired as Pediatric Department

head just over 20 years ago, continues to be the chief organizer and planner of the senior’s group.

In previous Emeritus Happenings columns, I have attempted to provide a perspective on some of the attitudes and activities involved in the practice of pediatrics in the past. For this column, I have taken a lighter approach. In relationship to this intent, I have always felt that the day-to-day activities of a physician can provide a virtual gold mine of information for articles or stories if a physician is so inclined. Strange and interesting episodes occur to all of us in practice, sometimes at the most unlikely of times.

Over the years I have submitted many medical short stories for publication. The following story, published in the humour magazine “Stitches” eight years ago, may have some interest for this readership. This particular patient visit actually occurred over 30 years ago at the Vancouver General Hospital. I did not make this story up:

What follows actually happened, and in exactly the way I describe. The name of this child has been forever imprinted in my mind. The story went as follows:

It was a routine pediatric office visit by a new patient, a baby of about two months of age, accompanied by an attractive and somewhat serious single mother of approximately 20 years of age.

Taking a medical history was not a

significant undertaking, but there were some unusual features to this male child’s presentation, not the least of which was his chosen name. The mother had a last name of Vickery, which by itself wasn’t unusual, but she’d named her son “Hickory”. Hickory Vickery was now in my office.

Noting that this was many years ago, I had a stronger and much more naïve opinion at that point about my potential influence on a new parent.

I made what I thought was a rather obvious suggestion. “I think you should perhaps consider getting married “. (I wouldn’t say this today because it is now considered very politically incorrect, but at the time… well, I said it! I believe that we all make mistakes once in a while.)

“Why?” she asked. “Your son is going to have a difficult time unless his last name is changed,” I said. “Why?” she again replied.

I found myself at a loss for words. She sincerely did not see anything the matter. Perhaps her mother had never read her nursery rhymes. After a brief period of reflection, I thought a bit of humour might add some insight.

“ I’m going to tell you a joke.” I said.She immediately developed a suspicious look on her face but nevertheless was prepared to listen. (The reader must realize that I had not ingratiated myself to her with my negativity about her son’s name.”)

David Smith, MD, FRCPC

cont’d on p. 11


N E W S L E T T E R I S S U E 1 0 S P R I N G / S U M M E R 2 0 0 8P A G E 1 1

A book review by Dr. Judith G. Hall

Review of “Jack McCreary: Paediatrician, Pedagogue, Pragmatist, Prophet”

Author: Robert Hill, BM, BCh, FRCP(C); Tantalus Research Limited, Vancouver, BC, 2006

Jack McCreary was no ordinary person, but rather a visionary who first saw the need for interdisciplinary training and care, as well as the importance of research and preventative care, long before others.

Rob Hill, known to many of us as a multi-talented pediatric administrator, has uncovered his hidden talent as a careful medical historian. Rob went through reams of letters, documents, correspondence, minutes, and archives to be able to detail (in the most readable manner) the experiences that shape the man, and probably helped to form his concepts of a university teaching hospital, the cooperation of the health sciences, and the organization of medical care.

It is pleasurable to read this book because Rob puts in so many personal and “of the time” details—from the official opening of the Health Centre for Children by Prince Philip to the opening of the McCreary Centre. You will enjoy reliving some of the events that brought pediatricians in British Columbia to where we are today.

I urge you to obtain a copy of this wonderful book by sending a cheque in the amount of $25.00 to Georgia Petropoulos, ([email protected]) at: Department of Paediatrics, The University of British Columbia, Room 2D19, 4480 Oak Street, Vancouver, BC V6H 3V4.

Judith G. Hall, OC, MDProfessor Emerita of Pediatrics and Medical GeneticsThe University of British Columbia

Dr. Jack McCreary, Paediatrician, Pedagogue,

Pragmatist, Prophet

written by Dr. Robert Hill

“ This is an old story about a doctor,” I said. Now holding her interest, and after a pause for dramatic effect, I began. “Every day this doctor, after work, would go into a bar and ask for an unusual drink consisting of a daiquiri with a hickory nut in it.”

“He did this every day, and everyone knew about the doctor’s unusual habit.” “One day he walked into the bar and asked for a beer. The bartender looked very surprised and asked. “Don’t you want your hickory daiquiri, Doc?”

A brief silence followed my story.

“That’s not funny!” said Miss Vickery.

I have no idea what subsequently happened to this mother and her son, which is probably just as well. God only knows what I might say to them today, and she probably still hasn’t forgiven me for my original comments or for telling her a really bad medical joke.

I think in retrospect my problem with her choice of names was derived from the wording of the original nursery rhyme itself. The expression,

“hickory dickery doc,” is almost sacred and it’s that word “doc” on the end that really makes it significant for a physician.

“Hickory Vickery, Doc.” It doesn’t sound right. Imagine a lifetime trying to deal with it. It just would not work for me!

David F. Smith MD Dr. Smith can be reached at: [email protected].

cont’d from p 10



Department of Pediatrics Faculty Awards 2007

Name Awarding Body Name of Award

Dr. Anne Antrim Partners in Care Family Advisory/ Award of DistinctionClinical Assistant Professor Committee BCCH and BCCF

Dr. Robert W. Armstrong SFU Alumni Association SFU Outstanding Alumni Award Associate Professor & Head for Professional Achievement

Dr. Keyvan Hadad Department of Family Practice Postgraduate Teaching AwardClinical Assistant Professor Greater Vancouver Program, UBC

Dr. Keyvan Hadad Department of Family Practice Postgraduate Teaching Award Clinical Assistant Professor, International Medical Graduate Program

Dr. Martin Hosking Partners in Care Family Advisory Family Centred Care AwardClinical Associate Professor Committee/BCCH and BCCF

Dr. Morrison Hurley Residency Program Golden Rattle AwardClinical Professor Dr. Tobias Kollmann Canadian Health Clinician-Scientist Career AwardAssistant Professor Program

Dr. Andrew Macnab, Professor Western Society for Pediatric Research President USA

Dr. Andrew Macnab, Professor American Federation for Scholar Medical Research

Dr. Andrew Macnab, Professor Western Society for Pediatric Research, Distinguished Service Award USA

Dr. Andrew Macnab, Professor Gi’gat First Nation Award of Excellence

Dr. Andrew Macnab, Professor Canadian Academy of Health Sciences Fellowship

Dr. Andrew Macnab, Professor NW Urological Association, USA Henry Cooper Research Award

Dr. Daniel Metzger, Clinical Professor Partners in Care Family Advisory Family Centred Care Award Committee/BCCH and BCCF Dr. Naomi Paice Dept. of Pediatrics Residency Program Teacher of the Year Award Clinical Assistant Professor

cont’d on p 13



Dr. Constadina Panagiotopoulos Dept. of Pediatrics Residency Program Ivory Tower Award for excellenceClinical Assistant Professor in resident teaching and rese

Dr. Min Phang Dept. of Pediatrics Residency Program Hospital-Based PediatricianClinical Assistant Professor Teaching Service Award

Dr. Julie Prendiville Partners in Care Family Advisory Family Centred Care Award Clinical Professor Committee BCCH and BCCF

Dr. Ralph Rothstein, Professor Faculty of Medicine Career Award for Excellence in Clinical Teaching

Dr. David Scheifele, Professor Canadian Pediatric Society Alan Ross Award for Outstanding Achievement

Dr. Richard Schreiber, Clinical Professor Canadian Pediatric Society ”Reach for the Top” Award second best abstract - 84th Annual CPS Meeting Dr. David Speert, Professor Sauder Family Foundation and Sauder Professorship International Forest Products Ltd.

Dr. Laura Stewart Partners in Care Family Advisory Award of Distinction Clinical Associate Professor BCCH and BCCF

Dr. Cherrie Tan-Dy Pediatrics Residency Program Community-Based PediatricianClinical Assistant Professor Teaching Service Award

Dr. Glen Ward Pediatrics Residency Program Community-Based PediatricianClinical Assistant Professor Teaching Service Award

Dr. David Wensley American Thoracic Society Special Recognition for work onClinical Professor and Division Head The Assembly on Pediatrics developmental and maintenance of Division of Respiratory Medicine “Ped-Lung” listserve - a global forum for children’s lung health

Name Awarding Body Name of Award

Department of Pediatrics Faculty Awards 2007



Many members of the Department of Pediatrics are involved in the MD Undergraduate Program in several different roles. In Admissions, we are fortunate to have several Pediatricians on our Admissions committees and other Pediatricians who form part of our interviewer pool.

Last year, we became one of the largest MD admissions processes in North America when

we expanded the Class of 2011 to 256 seats across three distributed sites. Currently, 192 students enter the Vancouver Fraser Medical Program (VFMP), 32 enter the Northern Medical Program (NMP) and 32 enter the Island Medical Program (IMP). During this cycle, we had a record number of over 1800 applicants for these coveted seats.

MD Undergraduate Admissions is continually evaluating policies and procedures, and we research nearly every aspect of the selection process. We have a comprehensive website, as well as a brand-new state-of-the-art online application and interview booking system, which went live this year.

The admissions process is based on the Faculty of Medicine mission and goals and is designed to select well-rounded medical students from a variety of backgrounds who are motivated, mature, and have a genuine concern for human welfare. Above all else, MD Undergraduate Admissions gives careful consideration to applicants, without regard to age, gender, sexual orientation, race, ancestry, color, place of origin, family status, physical or mental disability, political belief, religion, marital or economic status.

Our Admissions team is currently distributed between the three sites. As a large and innovative distributed program, with multiple home sites, our admissions procedures are complex, yet thorough and fair. We have four committees that are involved with Admissions, each having unique functions. They are the Admissions Policy Committee, Admissions Selection Committee, Northern Medical Program Admissions Subcommittee and the Aboriginal Admissions Subcommittee.

This year was a particularly exciting time for Admissions as we switched from the panel interview to the Multiple Mini-Interview (MMI) model. This is a well-researched method of interviewing pioneered by McMaster University in 2001. The MMI is based on the OSCE examination and is gaining global popularity across health care disciplines. We interviewed

UBC MD Undergraduate Admissions - What’s New? Dr. Michael Clifford Fabian, Associate Dean, UBC MD Undergraduate Program, Admissions Clinical Assistant Professor, Departments of Pediatrics and Surgery, UBC Faculty of Medicine

University of Victoria - Island Medical Program (IMP)

University of British Columbia - Vancouver-Fraser Medical Program (VFMP)

Dr. Michael Clifford Fabian

cont’d on page 15



close to 650 applicants over two weekend periods. Our interviewer pool was made up of clinicians, academics, community members, and for the first time, senior medical students. Applicants went through a cycle of ten

stations, with each station lasting ten minutes.

The Northern Medical Program, in collaboration with the Northern Medical Program Admissions Subcommittee and other relevant stakeholders, is always reviewing processes in place to recruit and retain physicians for the North. We also have an Aboriginal pre-admissions program in place to help recruit prospective Aboriginal medical students.

We value each and every person who contributes in a myriad of ways to help us in the selection our future physicians.

Michael Clifford Fabian FRCPC(Peds) FRCSC(Otol) FACS Associate Dean, MD Undergraduate Program – AdmissionsClinical Assistant Professor, Departments Pediatrics and SurgeryFaculty of Medicine, UBC

University of Northern British Columbia - Northern Medical

Program (NMP)

cont’d from p. 14

Balding for Dollars is an event which was initiated by parents and hospital staff touched by childhood cancer and blood disorders with a view to raising community awareness for childhood cancer and blood disorders; to provide funding in support of the oncology program at BC Children’s Hospital, and to support children and their families during and after treatment. Balding for Dollars has grown from being a one day event where people gathered pledges and in return shaved their head in support of the mandate “bald is

beautiful”, to many events held in communities throughout British Columbia. This year, Dr. Rod Rassekh, Oncologist and Clinical Professor with the Division of Hematology/Oncology/BMT at BC

Children’s Hospital, collected donations while participating at the 8th Annual Balding for Dollars Event which took place on April 26, 2008 at BC Children’s Hospital. With the support of donors, Rod has raised well over $5,000 to help kids with cancer and blood disorders! Congratulations, Rod and thank you to all our donors!

8th Annual Balding for Dollars Event - April 26, 2008

Dr. Rassekh with patients and their families

Dr. Rod Rassekh

Georgia Petropoulos, Communications Coordinator, Department of Pediatrics



Child Health in South Africa: Designing a transdisciplinary study

Two-year old Abou’s mother brings him to the hospital. He weighs just 6 kg, and he is coughing, his mouth coated with thrush, too weak to eat or fight when an IV is started; he lies limply in his mother’s arms. Despite our efforts, he dies – just one of 10,600,000 children under the age of 5 who die annually, which leads us to ask “why did this child die?” The reasons are complex and straight forward at the same time. The intersection of

poverty, malnutrition/food insecurity, weak health care systems, and delayed presentation to hospital are all to blame. And yet it is more complex then that; some children from very difficult backgrounds do rather well despite the challenges they are faced with. Many illnesses occur for no obvious reason and are therefore impossible to predict and prevent. Members of the Division of Infectious and Immunological Diseases in the Department of Pediatrics are part of an exciting and historic tri-university collaboration, between

UBC, the University of Cape Town and Stellenbosch University, endeavoring to further examine some of these questions. We are in the “pre-pilot” phase of planning a very large 20-year birth cohort study to identify the genetic, environmental and psychosocial factors which predispose to potentially fatal disease in childhood.

Large scale birth cohorts underway in a number of developed-world settings will not answer the questions of interest to children in low

and middle income countries. In fact, only about 10% of the medical research resources are focused on the needs of the poorest 90% of the world’s population. The Cape Town – Vancouver collaboration is one of several research groups trying to address this so-called “10-90 gap” to assure that ongoing medical research benefits the most vulnerable. Armed with the new knowledge from our major ambitious and unique study, we hope to devise effective strategies to address major problems of childhood mortality.

The Drakenstein sub-district of Western Cape province has an intersection of impoverished people living in challenging conditions with a lack of clean water, overcrowding, malnutrition and a generalized HIV epidemic within the proximity of several very strong universities having local scientific sophistication. The university laboratory facilities have the ability to undertake sophisticated laboratory studies such as molecular infectious disease studies, and genomic studies.

Laura Sauve, MD, FRCPC, FAAP, DTM&H Clinical Assistant Professor, Department of Pediatrics, Division of Infectious and Immunological Diseases, Vaccine Evaluation Centre

cont’d on p. 17



As a fully collaborative partnership, we set guiding principles early on, including placing emphasis on local community consultation, engagement, capacity building and benefit, guidance by South African ethical standards, and academic capacity building and benefit. The pilot study will focus on respiratory wellness with the aim of decreasing childhood morbidity and mortality and our goal is to develop a harmonized platform of clinical, genetic, environmental and biobehavioural data to facilitate ongoing and future studies and international collaboration.

As a junior faculty member with mentorship from Drs. David Speert and David Scheifele, I arrived at UBC’s Department of Pediatrics in September 2007 to establish my research career focusing on the world’s most vulnerable children and infectious causes of childhood mortality. In addition to the Drakenstein Child Health Study, I am developing research interests in the health of newly arrived refugees and vaccinology.

Prior to arriving in Vancouver, I spent a year working with the Baylor Pediatric AIDS Initiative in Burkina Faso, working with American and Burkinabé colleagues to establish a pediatric HIV clinic in Bobo Dioulasso, a city of 600,000 in one of the world’s poorest countries. The experience was challenging, humbling and at times frustrating, but ultimately rewarding and it has encouraged me to continue to work in this field. Dr. Sauve can be reached at [email protected].

Reflections on the Relationship between Child Psychiatry

and Pediatrics

Derryck H. Smith, M.D., F.R.C.P.(C) Clinical Professor, Department of Psychiatry, UBC Former Head, Department of Psychiatry, C&W

I welcome the opportunity to reflect on the relationship between child psychiatry and pediatrics. I have recently stepped down as Head of the Department of Psychiatry, and this has given me the opportunity to reflect back on the accomplishments of the last 25 years; that we have jointly accomplished between the two departments in forwarding the issue of children’s mental health. When I first arrived at BC Children’s Hospital in 1985, the Department of Psychiatry had three psychiatrists; ten beds for children, and a very small outpatient department. As of today, there are 26 psychiatrists associated with our department; we have 33 to 36 beds and the largest outpatient clinic in the hospital. This growth is not surprising, given that approximately 20% of all children and teens qualify for a psychiatric diagnosis.

Increasingly, psychiatrists are conceptualizing their field of practice as working with primary disorders of the brain. There is no doubt that autism; mood disorders; anxiety and schizophrenia just to name a few conditions are indisputably disorders of the human brain. We share our interests in brain functioning not just with pediatrics; but also with neurology,

sleep disorders and neurosurgery andd neuroimaging. The challenge is to not forget that the child has an emotional and social context, which sometimes impact negatively and sometimes positively on the underlying brain disorder.

Our partnership with pediatrics has been cemented and enhanced over the past number of years. The majority of our referrals come from hospital and community-based pediatricians. Some of our specialty clinics such as the ADHD service could not function without a close relationship with community-based pediatricians. We need to rely primarily on pediatricians to provide the mental health services that our patients require. There are simply not enough child psychiatrists to meet the mental health needs of children in our province.

cont’d from p. 16

cont’d on p. 18



Our Eating Disorders Program is probably the best example of a fully working partnership with Pediatrics. Teenagers, predominantly young women with the debilitating disorders associated with anorexia and bulimia, have always benefited from a team based treatment approach involving pediatrics and psychiatry; not to mention our other partners, psychology, social work and nutritionists. Personally, I think that team management of patients is the service delivery model that we should be aiming for in the future. Ideally, pediatricians and for that matter, community-based family doctors should have ready access to a collaborative relationship with a child psychiatrist and increasingly focus on multi-disciplinary clinics within the hospital.

What does the future hold? Functional brain imaging and pharmaco genetics will become increasingly important. The service delivery challenge for both pediatrics and psychiatry is to make our expertise readily available to children, wherever they live in BC; through telehealth, distance education and outreach.

I want to acknowledge the effective leadership and strong support that Psychiatry has enjoyed over the years from the heads of the Department of Pediatrics; Drs. Rob Hill, Judy Hill and currently Bob Armstrong. Dr. Smith can be reached at: [email protected] Tel: 604-879-2200 505-805 West BroadwayVancouver, BC V5Z 1K1

Press Release - April 1, 2008

Canadian Child & Youth Health Coalition endorses the

Leitch report

Toronto, ON – April 1, 2008 -- Dr. Bob Armstrong and Ms. Marilyn Booth, Co-Chairs of the Canadian Child and Youth Health Coalition (CCYHC) welcomed the release last week of Reaching for the Top: A Report by the Advisor on Healthy Children and Youth. The report, prepared by Dr. K. Kellie Leitch, Advisor on Healthy Children and Youth to Federal Minister of Health Tony Clement, and based on extensive nation-wide consultation, provides five key recommendations to improve the health and wellness of Canada’s children and youth. The report can be viewed on the Health Canada website.

The Coalition applauds the initiative of the federal government in taking an important leadership role in providing a platform for defining the pressing health issues facing Canada’s children and youth and for identifying solutions to address key areas of concern. The Coalition welcomes the call for greater national collaboration contained in Dr. Leitch’s report and strongly encourages the Minister to move forward on the specific recommendations put forward.

The health of our children and youth is a reflection of the health of our nation as a whole. Serious childhood conditions often track into adulthood and represent significant future impact on our health care system and on our overall success as a nation. Any investment in the health of Canada’s children is a wise investment in the future of the country.

Dr. Leitch’s recommendations focus on significant child and youth health issues such as injury prevention, childhood obesity and mental health services. In addition, Dr. Leitch has recommended a longitudinal study that will help us to understand the health status of Canada’s children and environmental factors that impact their health. This information is critical to guide public policy and clinical practice.

The fifth key recommendation is focused on the creation of a National Office of Child and Youth Health with a permanent advisor. This recommendation would ensure that the Federal Minister of Health and the Government of Canada are well informed about the health of our youngest citizens and the steps that must be taken to continue to improve their health and wellbeing.

The report indicates that, despite our prosperity, Canada ranks 12th out of 21 wealthy countries in the United Nations’ rankings of child well being. We clearly can do better and the Government of Canada has a central role to play in helping to ensure that we make real progress in improving child and youth health and that every child, no matter where they live in Canada, has access to these benefits.

cont’d on p. 19

cont’d from p. 17



Established in 2004, the Canadian Child & Youth Health Coalition is a collaboration of eight major national organizational and program members working together with a common vision to advance the cause of child and youth health and health care in Canada. By engaging a broad range of constituents and stakeholders across the continuum of child and youth health, the Coalition is addressing priority issues, bringing together the collective expertise required to formulate, facilitate, implement and evaluate national initiatives and programs.

Bob ArmstrongCo-Chair, Canadian Child & Youth Health Coalitionand Director, Associate Professor & Chair, Department of PaediatricsUniversity of British Columbia

Marilyn BoothCo-Chair, Canadian Child & Youth Health Coalitionand Executive Director, Provincial Council for Children’s Health (Ontario)

On behalf of the CCYHC members: Canadian Association of Paediatric Health Centres (CAPHC)Canadian Child Health Clinician Scientist Program (CCHCSP)Canadian Family Advisory Network (CFAN) Council of Canadian Child Health Research (CCCHR)Maternal, Infant, Child, & Youth Research Network (MICYRN)National Infant, Child, & Youth Mental Health Consortium (The Consortium)Paediatric Chairs of Canada (PCC)Pediatric Surgical Chiefs of Canada (PSCC)

cont’d from p. 18

A Superhero Department

The Department of Pediatrics - A Superhero Department: The BC Children’s Hospital Foundation has launched the largest capital campaign in BC history to support the construction of a new acute care children’s health care facility on the Oak Street site, the relocation of Sunny Hill to the Oak Street site and the support of child health services around the province. With the help of the Foundation, we have made it easy for you to contribute. Simply click on the following link: www.bcchf.ca/superherodepartment,and you will be taken to the “Superhero Department” website where you will see a number of options for your consideration.

For those individuals in the matching program, there are a number of matches still left. A $10K contribution is matched through the Foundation with an additional $10K and this amount can be designated to the priorities of the donor. As an added incentive, the Department will hold a draw for two additional $10K awards to be added to the Foundation match; names will be drawn from division where at least one individual is contributing to th matching fund program over the course of the capital campaign.

Any contribution is welcome, and the message is not so much the amount of support by faculty and staff, but the number of people who make a commitment.

Dr. Glenn Robertson with patient Emily



Survival of extremely preterm infants has increased significantly in recent years; however the prevalence of developmental problems in this vulnerable population remains unchanged. A vast amount of literature describes poorer cognition, behavior and academic achievement of preterm children, however, little is known about the etiology or mechanisms. In a multidisciplinary research program, Ruth Grunau and colleagues are investigating neonatal pain-related stress as one potential mechanism for altered neurodevelopment in preterm infants.

In a longitudinal study funded from 2001-2013 by the National Institute of Child Health and Human Development, National Institutes of Health USA (NICHD/NIH), Ruth Grunau, Principal Investigator and the following Co-investigators at UBC: Joanne Weinberg PhD, Neuroscientist; Michael Whitfield MD FRCP(C), Neonatologist; Steven Miller MD FRCP(C), Pediatric Neurologist; Adele Diamond, PhD, Cognitive Psychologist; Angela Devlin PhD, Geneticist; Anne Synnes MD FRCP(C), Neonatologist; Tim Oberlander MD FRCP(C), Developmental Pediatrician; Alfonso Solimano MD FRCP(C), Neonatologist; Rollin Brant PhD, Statistician; and at Simon Fraser University: Urs Ribary PhD, Neuroscientist; Hal Weinberg PhD, Neurophysiologist; Mario Liotti MD, PhD, Neurologist; Dan Weeks PhD, Psychologist, are following a prospective cohort of preterm and full-term infants who are now school-age.

Pain-related stress in infants born at extremely low gestational age is developmentally “unexpected” and occurs at a time of very rapid brain development and programming of stress systems. In the first phase of this longitudinal project, pain reactivity in the neonatal intensive care unit (NICU) was addressed, then biobehavioural reactivity, arousal regulation, attention and cognition in preterm and term born infants, as well as maternal interaction and parenting stress, in home visits at 3 and 6 months corrected age (CA), and lab visits at 8 and 18 months CA.

It is well-established that early environmental stress impacts learning and behavior long-term, and that cortisol levels (either too low or too high) affect cognitive functions and memory. One important finding from phase one was that basal cortisol levels were down-regulated in early infancy, followed by up regulation at 8 and 18 months corrected age, in infants born ≤ 28 weeks gestation compared to more mature preterm and full term infants. This altered pattern of endogenous cortisol suggests one potential mechanism for later problems in neurodevelopment and behavior in extremely preterm infants.

Building on this earlier work, the next phase is to examine whether high cortisol levels persist to school-age, to compare cortical processing in preterm and full-term children using brain imaging (magnetoencephaolography and magnetic resonance imaging), and to relate stress-sensitive neurodevelopment (attention, visual memory, executive function, behavior) to cortisol levels and cortical processes. Thereafter will be an examination as to whether genetic variants in the serotonin transporter modulate relationships between early stress and later stress-sensitive function, and whether gene expression of the glucocorticoid receptor is altered due to neonatal pain/stress, and if maternal factors moderate this process.

In another longitudinal cohort, building on a CIHR study headed by Steven Miller, with new CIHR funding 2008-2013, Ruth Grunau, Principal Investigator and Co-investigators Steven Miller, Joanne Weinberg, Anne Synnes, Michael Whitfield, Rollin Brant, are evaluating whether neonatal stress and brain development (MRI), interactively or independently impact neurodevelopment at 18 and 3 months CA, and whether maternal interaction and parenting stress moderate these relationships. Dr. Grunau can be reached at [email protected].

Academic Highlight: Stress and Neurodevelopment in Children Born very Preterm

Ruth E. Grunau, PhD, RPsych, Pediatric Psychologist, Professor, Division of Neonatology, Department of Pediatrics, Distinguished Scholar, CFRI



Announcements

Dr. Cherrie Tan-Dy has accepted the position of Year 3 Clerkship Director for the Island Medical Program. Dr. Tan-Dy is the co-director of the Neonatal Intensive Care Unit at Victoria General Hospital and has been involved with the Island Medical Program students as the Pediatric Discipline Specific site Leader for the past two years. As well as teaching students, Dr. Tan-Dy mentors residents and has twice received the Community Pediatrician Award granted by BC Children’s Hospital Paediatric residents to the most outstanding teacher. We are delighted that she will continue to work with us in further developing and enhancing the

clerkship experiences.

Dr. Tan-Dy received her medical degree from Boston University School of Medicine and after a paediatric residency at the Children’s Hospital in Los Angeles she moved to the Hospital for Sick Children in Toronto where she was a Clinical Fellow in Neonatal-Perinatal Medicine. After moving to Victoria in January 2004 to work in neonatology at VGH, Dr. Tan-Dy was also appointed Clinical Assistant Professor at UBC. She is principal investigator on several research projects and her love of learning and teaching is evident in everything she does. In Dr. Tan-Dy’s own words: “ ... in time, the most important goal of a teacher and a physician is that we are able to provide outstanding, compassionate, state-of-the-art care to every patient everyday and to demonstrate that commitment to our students. These efforts benefit people beyond the time that we practice medicine, beyond the patients that we serve today and beyond even our lifetime.” Dr. Tan-Dy will fully assume her responsibilities on July 1, 2008. Dr. Tan-Dy’s office will be located at VGH.

Welcome, Dr. Tan-Dy!

Dr. Cherrie Tan-Dy

Congratulations to Dr. Jane Ng and Dr. Kevin Harris, recipients of the 2008 Canadian Pediatric Society’s Resident Advocacy Grant. Their project, entitled “Improving Nutrition in Children of Vancouver’s Downtown Eastside”, won the national grant competition and has been awarded $10,000 for the upcoming year. Established in 2004, the Resident Advocacy Grant supports paediatric residents in developing, planning and implementing a community-based research or advocacy project in child and youth health. Awarded annually by the Canadian Paediatric Society’s Residents Section and supported through an unrestricted grant from Wyeth Pharmaceuticals, this grant hopes to encourage paediatric residents to develop and implement advocacy initiatives. Congratulations! Dr. Harris can be reached at [email protected] and Dr. Ng can be reached at: [email protected]

Dr. Kevin Harris and Dr. Jane Ng

Year 3 Clerkship Director Island Medical Program

Canadian Pediatric

Society Resident

Advocacy Grant



UBC Faculty of Medicine Clinical Faculty Award

for Excellence in Teaching

This year, we are proud to anounce that Dr. Adam Cheng, with the Department of Emergency Medicine and Dr. Min Sen Phang, Department of Pediatrics, were recipients of the UBC Faculty of Medicine Clinical Faculty Award for Excellence in Teaching. The Award recognizes extraordinary members of the Faculty of Medicine who have made innovative or extrordinary contributions at UBC in the area of teaching. Dr. Cheng’s academic interests include resucitation education and simulation. He is the leader of the Pediatric Simulation Program which has expanded over the past one and a half years to involve various divisions at BC Children’s Hospital. Since its inception one year ago, the simulation program has taught over 250 residents, nurses and staff the crucial resuscitation, teamwork, leadership and communication skills needed to save lives. The program will begin to offer Simulation based CME courses to the rest of the province as it expands and grows. Dr. Cheng’s research focuses on examining the value of simulation and scripted debriefing in improving educational outcomes for health care professionals. This multicenter trial, led by BC Children’s Hospital and involving eleven pediatric centers across North America, is being funded by the American Heart Association, who hope to incorporate the product of this research into the next version of the PALS course and textbook.

Announcements, cont’d

Dr. Adam Cheng

Dr. Min Sen Phang

Modern technology has swept the practice of medicine forward at a pace unimaginable even a mere 20 years ago. With it, the importance of the clinical skills of interview and physical examination seems to have been undermined. Dr. Phang’s primary goal in teaching is to bring the focus back to clinical skills - not only to teach these skills, but also to instill their importance into the mindset of medical students, residents and nurses at every available opportunity. Another one of his goals is to make use of every opportunity during contacts with medical students, residents and nurses to teach around the clinical setting.

Ultimately, the knowledge base that a young practitioner needs to acquire is so vast that teachers can only cover a fraction of it. Dr. Phang’s third teaching goal is to train students and young physicians to think effectively around problems, to ask questions and to find the answers to problems. His fourth goal which follows, is to cultivate a culture of curiosity and inquisitiveness. Young clinicians should

be taught and constantly reminded not to be afraid to ask questions, and to not hesitate to utilize research techniques to discover the right answer and finally, to not accept the status quo as the ultimate truth. As a pediatrician, Dr. Phang expresses that everything he does, every clinical decision he makes, every skill he possesses, and every principle or philosophy he adheres to, has been shaped by highly committed and skilled teachers who have taught him along the way. Their influence has been long lasting. From his learning experiences, it is clear that in order to produce physicians of the highest caliber for the future, clinician teachers need to collectively contribute to their teaching and provide role models at every opportunity and to the best of their ability. Dr. Phang arrived at BCCH in 1989 where he completed three years of neonatal fellowship training in the “SCN”. He completed his Canadian residency training in 1992 and worked in the Special Care Nursery from 1992 - 1993. Dr. Phang joined the group practice of Drs. Thiessen, Ebelt, Riddell and Hailey (at that time) in 1993, and has been working with the group ever since, with 75% of his time spent at BCWH in newborn care and in general pediatrics at BCCH.



On May 8, 2008, The Manitoba Institute of Child Health and The University of Manitoba Department of Pediatrics & Child Health presented The 20th Annual Pediatric Resident and Fellow Research Competition.

Dr. Kevin Harris competed in the Resident Category I Research Competition, presenting: “The Effect of School-Based Physical Activity Interventions on Body Mass Index in Children: Implications for Prevention and Treatment of Childhood Obesity”. He was awarded The Children’s Hospital Foundation Award for Pediatric Resident and Fellow Research Competition - Resident Category. Congratulations to Dr. Harris!


Dr. Kevin Harris

Paediatric Chairs of Canada (PCC)

2008 Paediatric Academic Leadership

- Clinical Practitioner Award

We are pleased to announce that Dr. Paul Thiessen is the Paediatric Chairs of Canada recipient of the 2008 Paediatric Academic Leadership - Clinical Practitioner Award.

Over the last ten years, the Paediatric Chairs of Canada (PCC) has promoted the development of excellence and leadership within specific career paths. The health of children and youth is dependent upon leadership in each of the roles of clinician practitioner (teacher), clinician educator, clinician investigator and in association with these roles, the provision of administrative leadership. In 2007, to recognize, support and promote these roles among academic paediatricians, the Paediatric Chairs of Canada established PCC’s Annual National Paediatric Leadership Awards Program. The Paediatric Academic Leadership - Clinical Practitioner Award is focused on the clinician whose clinical practice has served as an outstanding environment for the education of trainees and the advancement of practice through knowledge translation and dissemination and leadership within the discipline. Dr. Thiessen’s career contributions have been truly remarkable, innovative, and varied and he has demonstrated enormous leadership and administrative abilities at local, provincial and national levels. Through this award, the Paediatric Chairs of Canada recognizes Dr. Thiessen’s achievements as a community-based pediatrician; a medical doctor, a child health advocate, a scholar, and educator. The PCC also recognizes his exemplary work and achievements in “Partrners in Care” - recognizing his vision and implementation of a true family centred care milieu. Dr. Thiessen feels very privileged to be a pediatrician at C&W, and he thoroughly enjoys the various areas of clinical care and teaching activities in which he is involved.

Dr. Thiessen is a member of a collegial and supportive six person general pediatric consulting practice, and is also the Medical Director of the Intermediate Nursery at BC Women’s Hospital and the Spinal Cord Clinic at

Dr. Paul Thiessen

cont’d on p. 24



Canadian Child Health

Clinician Scientist

Program

The Western Canada Canadian Child Health Clinician Scientist Program Western Mini-Symposium took place this year from May 22 - 24, 2008 at the Banff Centre in Alberta.

Drs. Kevin Harris and Jane Ng, Pediatric Residents III were invited to attend the program.

The purpose and focus of the two day event was to discuss the importance of knowledge translation in our research and to identify strategies for implementation. Trainees brought a brief presentation of their research with a view towards facilitating a discussion regarding knowledge translation specific to their research. The mini-symposium also provided trainees with the opportunity to meet with site leaders to discuss their work.

BC Children’s Hospital. He has a keen interest in medical education, and particularly enjoys interactions with trainees at all levels of their medical training. He serves as Chair of the Annual Meetings Committee of the Canadian Pediatric Society, and finds it stimulating and challenging to help organize the annual national meetings. Dr. Thiessen has also participated in international medical projects, including those in the Ukraine, Honduras, India and Uganda. He feels that these foreign experiences have powerfully shaped his weltanschauung, and given him a deep sense of gratitude for the privilege of practicing pediatrics in a first world setting. Dr. Thiessen can be reached at [email protected].


cont’d from p. 23

2008 Award for

Outstanding Achievement

by a Resident

The Selection Committee for the Child & Family Research Institute Trainee Research Awards Program is pleased to extend congratulations on the selection of Dr. Alexandra Zorzi, Pediatric Chief and Resident, Year III as the 2008 recipient of the award for Outstanding Achievement by a Resident. The Award recognizes the outstanding achievement of a Resident who has demonstrated originality, research ability and a capacity for critical thinking, indicating that the individual holds promise for becoming a contributing member in the scientific community. The Award was presented at the 2008 Student Research Forum Reception, held on Thursday, June 19, 2008 in the Auditorium of the CFRI.

Congratulations, Dr. Zorzi!



Dr. Bob Armstrong, Dr. Rob Hill, and Dean Gavin Stuart

The following Department of Pediatrics Faculty and Staff members were recognized:

Ms. Maureen Campbell - 25 yearsDr. Jim Jan - 39 yearsDr. Heather Louie - 25 yearsDr. Peter Malleson - 25 yearsDr. Andrew Murray - 31 yearsDr. John Smyth - 25 years

Congratulations to all!

Dr. Bob Armstrong, Dr. John Smyth, Dr. Jim Jan

From left to right: Dr. Bob Armstrong, Dr. Rob Hill, Dr. Jim Jan, Dr. Heather Louie, Dr. Andrew Murray, Dr. John Smyth and

Dean Gavin Stuart

25 Year Club Celebration Dinner

May 5, 2008

The UBC 25 Year Club was established in 1971 by President Walter Gage to recognize non-faculty staff with 25 years of uninterrupted or accumulated service. In 2004, the club began recognizing active staff who have reached the additional milestone of 35 years of service. An Annual Dinner is held to recognize staff and it has become a wonderful opportunity for new, active and retired members to keep in touch with each other and the university in a warm, celebratory environment. This year, Wendy Cannon and Janette King of the Department of Pediatrics were inducted into the 25 Year Club. In her role as Scholarly Activities Co-coordinator for the Department of Pediatrics, Wendy assists others with knowledge transfer and mentors students in the pursuit of excellence. In doing so, she hopes to promote ‘global citizenship’

– a goal to which she personally aspires. Outside of work, Wendy enjoys various creative endeavors including photography and writing.

Janette is a Research Technician with the Nutrition & Metabolism Research Program headed by Dr. Sheila Innis. Outside of the lab, Janette tries to get away from the scientific. Her interests include photography, reading, music, cooking and discovering the wonderful province of B.C. Janet is also a long-time writer of poetry and creative non-fiction, a historical novel reviewer.

Faculty of Medicine Quarter Century Celebration April 2, 2008

On April 2, 2008, the Faculty of Medicine recognized a combined total of over 100 faculty and staff members who have contributed more than 25 years of service to the Faculty of Medicine and who were still active in 2007.

Department of Pediatrics Faculty members Dr. Rob Hill with 45 years of service and Dr. J. Michael Stephenson with 40 years of service were honoured as well.

Georgia Petropoulos Communications Coordinator, Department of Pediatrics



Department of Pediatrics Recognition Dinner 2008 April 3, 2008

On Thursday, April 3, 2008, The Department of Pediatrics hosted a Recognition Dinner at the University Golf Club, in honour of Sharon Toohey, Past President, BCCH and Sunny Hill Health Centre for Children, and three Department of Pediatrics Faculty members: Dr. Alexander Ferguson, Professor and previous Head, Division of Allergy, Dr. Morrison Hurley, Clinical Professor, Division of Nephrology and Dr. Aubrey Tingle, President & CEO, Michael Smith Foundation for Health Research and Professor of Pediatrics. It was a special evening with attendance by many faculty members as well as PHSA Executive members.

Mrs. Sharon Toohey Dr. Alexander (Sandy) Ferguson

Dr. Aubrey Tingle Dr. Morrison Hurley

cont’d on p. 27




Department of Pediatrics Recognition Dinner 2008

conti’d on page 28

Guests enjoy the Reception featuring music by the Musical Occasions Duo; Guitarist Don Hlus and Violinist Patricia Armstrong




Dr. Bob Armstrong is MC while guests enjoy the evening.

cont’d on page 29




Mr. Larry Gold, Incoming President, BC Children’s Hospital, is welcomed.

Dr. Ralph Rothstein presents for Mrs. Sharon Toohey

cont’d on p. 30




Mrs. Sharon Toohey responds

Dr. Anne Junker presents for Dr. Aubrey Tingle

cont’d on p. 31




Dr. Tingle responds

cont’d on p. 32




Left: Dr. Phil Ashmore, Pediatric Surgeon with Mrs. Sharon Toohey; Top Right: Dr. George Mackie, UBC Deputy Provost;

Middle Right: Mr. John Andruchak, VP, Clinical & Support Services, PHSA and Dr. David Hardwick, Special Advisor on Planning, UBC Medicine Dean’s Office

cont’d on p. 33




Dr. Alison Buchan, Senior Associate Dean of Research UBC Faculty of Medicine

from L to R: Mr. Michael Marchbank, Executive VP, Quality Management, Performance, Improvement & Innovation, PHSA, Dr. Ran Goldman, Division Head & Medical Director, Division of Pediatric Emergency Medicine, Mr. Brian Schmidt, Senior VP,

Provincial Services, Population and Public Health, PHSA, Dr. Stuart Macleod, VP, Academic Liaison and Research Coordination, Executive Director, CFRI and Assistant Dean, Research, UBC Faculty of Medicine

photography courtesy of Ian Durning, C&W Media Services



The Department of Pediatrics Malpractice Cup - April 11, 2008

2008 Department of Pediatrics Malpractice Cup - Team Photo

There was a lot of excitement in the air as the teams took to the ice for the seventh annual Malpractice Cup. Both teams had some new faces, with a lot of skill on both sides of the ice. Dr Jim Potts had taken on the role of coaching the staff team, the Pedihatricks, and had his work cut out for him. The fans were there to see Rosy Wang, the Staphylocidal goalie, just nine weeks after delivering her son.

The residents came out flying and had a 2-0 lead early in the game. The staff team was slow to get going but had tied the game at the end of two periods at 2-2. The trainee team kept coming with lots of pressure in front and took at 3-2 lead in the 3rd period. Due to a few penalties, the Pedihatricks were able to tie the game. This was a blow to the Staphylocidal team and the Pedihatricks went on to score 2 more goals, winning 5-3. It was the first victory for the staff team since 2004.

Dr. Shubhayan Sanatani, Assistant Professor, Division of Cardiology



Faculty of Medicine Academic Gowns Reception May 20, 2008

On May 20, 2008, Dean Gavin Stuart hosted the Academic Gowns dinner reception to recognize Faculty of Medicine members who have been promoted to either Clinical Professor or Professor in the previous year. Each individual being honoured was presented with an Academic Gown for their achievements by their Department Head and the Dean.

This year, we are proud to announce that the following Department of Pediatrics Faculty members were honoured at the Academic Gowns Reception: Dr. Daniel Metzger, Clinical Professor, Dr. Timothy Oberlander, Professor and Dr. John Wu, Clinical Professor.

After completing his fellowship in Pediatric Endocrinology at the University of Virginia, Dr. Metzger arrived at UBC in 1994. He works in the Endocrinology & Diabetes Unit at BC Children’s Hospital, with an emphasis on the care of children with diabetes. His research interests center around the etiology and prevention of type 1 diabetes in children, and he collaborates on multicentre clinical studies and with local basic-science researchers. His other clinical interests focus on the integration of databases and the internet into clinical care and the education of professionals, patients

and caregivers. Dr. Metzger has developed a close affiliation with the Canadian Diabetes Association and has been the Medical Director of their diabetes camp in BC for the past 10 years. Dr. Tim Oberlander is a Clinician-Scientist Developmental Pediatrician. He graduated from Queen’s University medical school, and completed a residency program in pediatrics after which, he completed a developmental pediatrics fellowship at Montreal Children’s Hospital, and additional fellowship training in Child Development and Pediatric Pain Management at Children’s Hospital in Boston. He began with the Department of Pediatrics in 1993.

From left to right: Dean. Gavin Stuart, Dr. Daniel Metzger, Dr. Ralph Rothstein

from left to right: Dean Gavin Stuart, Dr. Tim Oberlander, Dr. Ralph Rothstein

cont’d on p. 36




As a clinician at BC Children’s Hospital, Dr. Oberlander treats children with complex pain, and children with developmental disorders related to prenatal drug and alcohol exposure. Dr. Oberlander is involved in teaching in the Brain and Behavior block and subspecialty resident training in Developmental Pediatrics. As a researcher, he seeks to understand how early adverse social experience affects child development. His research extends from “cell to society” and ranges from studies at the genetic level to studies of behavioral outcomes at the population level reflecting the everyday world in which children live. His work includes investigations of how prenatal exposure to psychiatric medications and depressed mothers’ mood affect the developing child, studies of how responses to early stress sets up a life course of health or disease and studies of pain in children with developmental disabilities.

Dr. John Wu joined UBC and the BC Children’s Hospital in July 1993 after completing his research fellowship at the Hospital for Sick Children in Toronto. His primary interests are in bleeding disorders such as hemophilia, and in hemoglobinopathies such as thalassemia and sickle cell disease. He has worked with his division to build a provincial comprehensive care program in these areas and is involved with the drafting of national standards of care. He is also extensively involved in patient advocacy groups for these conditions. He was also the Royal College of Physicians and Surgeons of Canada examiner for Hematology. Dr. Wu participates in collaborative research nationally with both clinicians and basic scientists, in particular, with those at the Center for Blood Research, UBC.

Faculty of Medicine Academic Gowns Reception May 20, 2008

from left to right: Dean Gavin Stuart, Dr. John Wu, Dr. Ralph Rothstein

cont’d from p. 35



In Memorium

It is with great sadness that we experienced the untimely and accidental death of Dr. Basil Boulton at age 69.

Basil was a caring Pediatrician, a leader and innovator who put the needs of children ahead of personal gain. He served on Esquimalt Council. Basil was compassionate and loved nothing more than meeting with people and providing help where he could. He was involved in ongoing initiatives for the rights and health of children: Children’s Charter of Health Rights, and a pilot project to support the mental health of children in schools. He was inspired by the vision of Nakita Sekhon, who at age 14 began her work towards founding an orphanage in India. A naturalist and island boy at heart, Basil felt at home on the water and happiest at his Ruxton Island retreat.

Basil received his medical degree from the University of British Columbia and established a pediatric consulting practice in Victoria in 1969 until he retired from active practice in 2004. He since continued his work to improve the health care of children. In 1977, supported by medical colleagues and the public, Basil led a campaign to improve pediatric and maternity services, which were split between two major hospitals in Victoria. The result was a single, well-equipped, and staffed, integrated unit at Victoria General Hospital. This endeavour was broadened to include all community child health services with the release of the influential 1980 report on child health care in the Capital Region, which he co-authored with former deputy health minister James Mainguy. Basil has served on the board of the Greater Victoria Hospital Society and the BC Medical Association, and on various Victoria and provincial committees and organizations. He sat on the BC Medical Association Council of Health Promotion and the Child and Youth Health Committee. He was also an elected councilor for the Township of Esquimalt. At the time of his death, Boulton was developing both a bill of rights for children’s health and a pilot program in the schools combining a mental-health team, medical team and educators to better support children.

In addition to his service at home, Basil volunteered internationally. As a member of the Christian Medical Society, he worked with the Cuban Ministry of Health and Cuban doctors to improve the health and welfare of children in that country. Basil was very dedicated to his family and is survived by Marilyn, his wife of 46 years, children Chris, Mary, Tim and Robin; young friend, Mbala; grandchildren Adam, Carlin, Sara, Mara, Martin, Daytona, Sasha, Keetah and Theo; sisters Helen, Meg and Betty; and brothers Nelder and Eric. Basil’s family members have recently established the Dr. Basil Boulton Memorial Scholarship. Dr. Boulton was a strong supporter of the Island Medical Program. This scholarship will be awared to a third or fourth year medical student in the Island Medical Program, having an interest in pediatrics and/or international health. Basil will be greatly missed by family, friends and colleagues.

Dr. Basil Cartwright Boulton; March 6, 1938 - January 3, 2008

Dr. Basil Boulton



Upcoming Conferences and Events

September 7-9 Canadian Academy of Child and Adolescent Psychiatry’s 28th Annual Conference, Vancouver, B.C. Web: http://www.cacap-acpea.org/onottaca/doc.nsf/doc/ProfDev_Conf.cm October 2nd - 4th, 2008 - Childhood & Adolescent Obesity 2008 Conference, Vancouver, BC. Please visit: http://www.interprofessional.ubc.ca/Obesity_Conference.htm. This conference brings together an interdisciplinary group of professionals who work in the field of childhood and adolescent obesity or are confronted with this growing problem. Register before the Early Bird Deadline of September 8, 2008 to take advantage of the reduced rates. You can through the online registration website at http://www.peopleware.net/index.cfm?eventDisp=IPE%2EMAR09&subeventdisp=IN9553.

October 5, 6, and 7, 2008: Seventh North American SBS Conference - Westin Bayshore Hotel and Convention Centre, Vancouver, BC The Conference program is designed for medical, law enforcement, social work, legal professions, family members and victim advocates. Web site: http://www.dontshake.ca/news/news.php?id=13 October 17-18, 2008 5th Annual Paediatric Emergency Medicine Conference (PEM) Designed for physicians and nurses involved in managing the sick child, this conference will provide up-to-date management of common paediatric emergencies. Small group breakouts and workshops will promote interaction and individualized attention with the opportunity to practice procedures and clinical skills.

October 19-22, 2008: CAPHC 2008 Annual Conference - Transforming Services for Children and Youth: Turning our Thinking Inside Out. Call for posters deadline date is May 30, 2008. Early Bird Registraiton is September 8, 2008. Web Site: www.caphc.org.

November 13, 2008 Update in Child and Adolescent Psychiatry, 19th Annual Update in Child Psychiatry. Presentations and interactive workshops will be given by expert faculty in the Division of Child Psychiatry and will provide a current update on Child and Adolescent Psychiatry topics in a practical, hands-on format, based on the multi-disciplinary learner’s needs. Location: The Hospital for Sick Children, Toronto, Ontario Contact: Telephone: (416) 813-7530 e-mail: [email protected] November 15, 2008 - SickKids Heart Transplant Program and The Labatt Family Heart Centre presents: “Caring for Children after a Heart Transplant: A Symposium for Health Professionals” More information to follow; Contact: [email protected] March 11 - 14, 2009: The 3rd International Conference on Fetal Alcohol Spectrum Disorder: Integrating Research, Policy, and Promising Practice Around the World: A Catalyst for Change, Victoria Conference Centre, Victoria, BC. Please visit http:www.interprofessional.ubc.ca/FASD09.htm for details.



A record number of runners and walkers braved the cold temperatures on Sunday, April 20th, 2008 for the 24th Annual Vancouver Sun Run.

The Department of Pediatrics formed its own team for BC Children’s Hospital and several

faculty members and residents joined the team. Included were: Dr. Jennifer Druker, Pediatric Residency Program Director, Cardiologist, Dr. Shu Sanatani, and Dr. Jane Hailey with the Division

of General Pediatrics.

Residents included Dr. Tammie Dewan, Dr. Alexandra Faber, Dr. Deepak Manhas, Dr. Jonathan Sam and Neurology Fellow, Dr. Jayasri Srinivasan. Everyone did very well and it was an excellent experience.

We look forward to having a record number of faculty, trainees and staff join next year’s team!

Vancouver Sun Run 2008 - BC Children’s Hospital Team

Dr. Jane Hailey

Dr. Shu Sanatani

Dr. Jennifer Druker

Dr. Deepak Manhas



Selected Faculty and Trainee Publications

(Medline Search -January - June 2008)

Pediatrics. 2008 Feb;121(2):e215-22. Fathers’ experiences in the neonatal intensive care unit: a search for control. Arockiasamy V, Holsti L, Albersheim S.

Dev Med Child Neurol. 2008 Apr;50(4):244.The first meta-analysis of randomized controlled surgical trials in cerebral palsy. Armstrong RW.

FEMS Immunol Med Microbiol. 2008 Jan 30 Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection. Burgess TS, Hirschfeld AF, Tyrrell GJ, Bettinger JA, Turvey SE. Cancer Chemother Pharmacol. 2008 Apr 9 Population pharmacokinetics of imatinib mesylate and its metabolite in children and young adults. Menon-Andersen D, Mondick JT, Jayaraman B, Thompson PA, Blaney SM, Bernstein M, Bond M, Champagne M, Fossler MJ, Barrett JS. Obesity (Silver Spring). 2008 Jan;16(1):202-4.GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise. Chanoine JP, Mackelvie KJ, Barr SI, Wong AC, Meneilly GS, Elahi DH. Bellemain A, Collet JP, Montalescot G. New antiplatelet drugs, Presse Med. 2008 Jun;37(6 Pt 2):1055-68.2008 Apr 29. French.

Bertrand ME, Collet JP, Montalescot G. Non-ST-segment elevation acute coronary syndromes: an algorithm for decision. Eur Heart J. 2008 Jan;29(2):279-80. Samadi A, Le Feuvre C, Allali Y, Collet JP, Barthélémy O, Beygui F, Helft G, Montalescot G, Metzger JP. Medium-term survival after primary angioplasty for myocardial infarction complicated by cardiogenic shock after the age of 75 years.Arch Cardiovasc Dis. 2008 Mar;101(3):175-80. Child Neurol. 2008 May 12. Quality of Life and Seizure Outcome After Vagus Nerve Stimulation in Children With Intractable Epilepsy. Sherman EM, Connolly MB, Slick DJ, Eyrl KL, Steinbok P, Farrell K. Mol Genet Metab. 2008 Apr 28. Partial trypsin digestion as an indicator of mis-folding of mutant alanine:glyoxylate aminotransferase and chaperone effects of specific ligands.Study of a spectrum of missense mutants.Coulter-Mackie MB, Lian Q Clin Biochem. 2008 Feb 7 Mutation-based diagnostic testing for primary hyperoxaluria type 1: Survey of results. Coulter-Mackie MB, Lian Q, Applegarth DA, Toone J, Waters PJ, Vallance H. Kuhle S, Spavor M, Massicotte P, Halton J, Cherrick I, Dix D, Mahoney D, Bauman M, Desai S, Mitchell LG. Prevalence of post-thrombotic syndrome following asymptomatic thrombosis in survivors of acute lymphoblastic leukemia. J Thromb Haemost. 2008 Jan 11





Paulus S, Dobson S. Human papillomavirus vaccines: who should get them and why? Adv Exp Med Biol. 2008;609:145-53. Snape MD, Perrett KP, Ford KJ, John TM, Pace D, Yu LM, Langley JM, McNeil S, Dull PM, Ceddia F, Anemona A, Halperin SA, Dobson S, Pollard AJ. Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trial.JAMA. 2008 Jan 9;299(2):173-84. Ogilvie GS, Remple VP, Marra F, McNeil SA, Naus M, Pielak K, Ehlen T, Dobson S, Patrick DM, Money D. Intention of Parents to have male children vaccinated with the HPV vaccine. Sex Transm Infect. 2008 Apr 29. Cardiol Young. 2008 Apr 14;:1 Left ventricular diverticulum in an infant with pentalogy of Cantrell. Duncan AW, Mawson JB, Duncan WJ. J Cell Sci. 2008 Mar 1;121(Pt 5):664-74. Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer. Astanehe A, Arenillas D, Wasserman WW, Leung PC, Dunn SE, Davies BR, Mills GB, Auersperg N. Goldman RD, Dolansky G, Rogovik AL. Predictors for admission of children with periorbital cellulitis presenting to the pediatric emergency department.Pediatr Emerg Care. 2008 May;24(5):279-83.

J Pediatr. 2008 Apr;152(4):521-6, 526.e1-4. Potential interactions of drug-natural health products and natural health products-natural health products among children. Goldman RD, Rogovik AL, Lai D, Vohra S.

Mater A, Shroff M, Al-Farsi S, Drake J, Goldman RD. Test characteristics of neuroimaging in the emergency department evaluation of children for cerebrospinal fluid shunt malfunction.CJEM. 2008 Mar;10(2):131-5.

Clin J Pain. 2008 Jan;24(1):11-5. Predictors for opioid analgesia administration in children with abdominal pain presenting to the emergency department.Goldman RD, Narula N, Klein-Kremer A, Finkelstein Y, Rogovik AL. Pediatric Research in Emergency Therapeutics (PRETx) Program Holsti L, Grunau RE, Oberlander TF, Osiovich H. Clin J Pain. 2008 Jan;24(1):83-88. Is It Painful or Not?: Discriminant Validity of the Behavioral Indicators of Infant Pain (BIIP) Scale.

Hassall E. Talk is cheap, often effective: symptoms in infants often respond to non-pharmacologic measures. J Pediatr. 2008 Mar;152(3):301-3.

Hassall E, Owen D. Long-Term Use of PPIs in Children: We Have Questions. Dig Dis Sci. 2008 Apr;53(4):1158-1160. Epub 2008 Feb 8. Horvath GA, Stockler-Ipsiroglu SG, Salvarinova-Zivkovic R, Lillquist YP, Connolly M, Hyland K, Blau N, Rupar T, Waters PJ.Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: Evidence of a phenotypic continuum between dominant and recessive forms. Mol Genet Metab. 2008 Feb 12.





J Perinatol. 2008 Mar 27 Severe retinopathy of prematurity and visual outcomes in British Columbia: a 10-year analysis. Schiariti V, Matsuba C, Houbé JS, Synnes AR.

Perinatol. 2008 Feb 21 Perinatal characteristics and parents’ perspective of health status of NICU graduates born at term. Schiariti V, Klassen AF, Houbé JS, Synnes A, Lisonkova S, Lee SK. J Neurosurg Pediatrics. 2008 Apr;1(4):A353. Atypical presentation of Basal Ganglia germ cell tumors in children. Steinbok P, Almubarak S, Gan P, Hendson G, Poskitt K, Nadel H, Goddard K, Hukin J.

Cancer. 2008 Feb 15;112(4):892-9. Carboplatin hypersensitivity reaction in pediatric patients with low-grade glioma: a Canadian Pediatric Brain Tumor Consortium experience. Lafay-Cousin L, Sung L, Carret AS, Hukin J, Wilson B, Johnston DL, Zelcer S, Silva M, Odame I, Mpofu C, Strother D, Bouffet E. Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, Ont., [email protected]

Pediatr Emerg Care. 2008 Jan;24(1):9-15. A consensus-established set of important indicators of pediatric emergency department performance. Hung GR, Chalut D. Pediatr Nephrol. 2008 May;23(5):835-839. Simultaneous occurrence of atypical hemolytic uremic syndrome and acute lymphoblastic leukemia: a case report and literature review. Sinha R, Alabbas A, Dionne JM, Hurley RM. Postgrad Med J. 2008 Jan;84(987):56. Posterior reversible encephalopathy syndrome in SLE nephritis. Sinha R, Hurley RM. Innis SM, Davidson AG. Cystic Fibrosis and Nutrition: Linking Phospholipids and Essential Fatty acids with Thiol Metabolism. Annu Rev Nutr. 2008 May 22.

Innis SM, Friesen RW. Essential n-3 fatty acids in pregnant women and early visual acuity maturation in term infants.Am J Clin Nutr. 2008 Mar;87(3):548-57.

Oztek FZ, Ipsiroglu O, Mueller T, Aufricht C. Eur J Pediatr. 2008 Mar 20 Outcome after renal transplantation in children from native and immigrant families in Austria. Department of Pediatrics, Medical University of Vienna, Vienna, Austria. Amre DK, Mack DR, Israel D, Morgan K, Krupoves A, Costea I, Lambrette P, Grimard G, Deslandres C, Levy E, Seidman EG.Inflamm Bowel Dis. 2008 Mar 31 Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn’s disease in Canadian children using a gene-wide haplotype-based approach. Department of Pediatrics, University of Montreal, Montreal, Canada. Can J Gastroenterol.2008 May;22(5):485-9.Low prevalence of Helicobacter pylori infection in Canadian children:A cross-sectional analysis.Segal I, Otley A, Issenman R, Armstrong D, Espinosa V, Cawdron R, Morshed MG,Jacobson K.





Goodman KJ, Jacobson K, Veldhuyzen van Zanten S Can J Gastroenterol. 2008 Mar;22(3):289-95.Helicobacter pylori infection in Canadian and related Arctic Aboriginal populations.

Pinsk V, Jacobson K. Response to dr. Rashid and colleagues. Am J Gastroenterol. 2008 Jan;103(1):243-4.

Wu X, Vallance BA, Boyer L, Bergstrom KS, Walker J, Madsen K, O’Kusky JR, Buchan AM, Jacobson K. Saccharomyces boulardii ameliorates Citrobacter rodentium-induced colitis through actions on bacterial virulence factors. Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G295-306. Can J Gastroenterol. 2008 Mar;22(3):289-95. Wasdell MB, Jan JE, Bomben MM, Freeman RD, Rietveld WJ, Tai J, Hamilton D, Weiss MD J Pineal Res. 2008 Jan;44(1):57-64. A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities.

Hutchison JS, Doherty DR, Orlowski JP, Kissoon N. Hypothermia Therapy for Cardiac Arrest in Pediatric Patients.Pediatr Clin North Am. 2008 Jun;55(3):529-544.

Kissoon N, Rimensberger PC, Bohn D. Ventilation Strategies and Adjunctive Therapy in Severe Lung Disease.Pediatr Clin North Am. 2008 Jun;55(3):709-733.

Nielsen AL, Hilwig H, Kissoon N, Teelucksingh S. Discrete event simulation as a tool in optimization of a professional complex adaptive system. Stud Health Technol Inform. 2008;136:247-52.

Choong K, Kissoon N. Vasopressin in pediatric shock and cardiac arrest. Pediatr Crit Care Med. 2008 May 19.

Kissoon N, Adderley R. Noninvasive ventilation in infants and children. Minerva Pediatr. 2008 Apr;60(2):211-8.

Spenceley N, Skippen P, Krahn G, Kissoon N. Continuous central venous saturation monitoring in pediatrics: a case report. Pediatr Crit Care Med. 2008 Mar;9(2):e13-6.

Sullivan KJ, Kissoon N, Gauger C. Nitric oxide metabolism and the acute chest syndrome of sickle cell anemia. Pediatr Crit Care Med. 2008 Mar;9(2):159-68.

Kissoon N, Syed N, Campbell B. Silence and the physician executive. Physician Exec. 2008 Mar-Apr;34(2):40-2.

Kissoon N. Pediatric critical care transport: Diagnostic uncertainty-no worries, resource limitation-worry*. Pediatr Crit Care Med. 2008 Jan;9(1):116-7.

Kochanek PM, Kissoon N. PCCM moves to online-only publication of case reports. Pediatr Crit Care Med. 2008 Jan;9(1):1.





Nestle Nutr Workshop Ser Pediatr Program. 2008;61:183-95. Induction of antigen-specific immunity in human neonates and infants. Wilson CB, Kollmann TR. Departments of Immunology and Pediatrics, University of Washington, Seattle, WA, USA. Lavoie, P. Mol Endocrinol. 2008 Apr 3 Developmental Dependence on NurRE and EboxNeuro for Expression of Pituitary POMC. Lavoie PL, Budry L, Balsalobre A, Drouin J. Laboratoire de génétique moléculaire, Institut de recherches cliniques de Montréal (IRCM)

J Inherit Metab Dis. 2008 Apr 4 The relation of cerebrospinal fluid and plasma glycine levels in propionic acidaemia, a ‘ketotic hyperglycinaemia’ Scholl-Bürgi S, Korman SH, Applegarth DA, Karall D, Lillquist Y, Heinz-Erian P, Davidson AG, Haberlandt E, Sass JO.

Rural Remote Health. 2008 Apr-Jun;8(2):882. 3-year results of a collaborative school-based oral health program in a remote First Nations community. Macnab AJ, Rozmus J, Benton D, Gagnon FA. Pharmacoeconomics. 2008;26(6):477-495.Guidelines for Conducting Pharmaceutical Budget Impact Analyses for Submission to Public Drug Plans in Canada. Marshall DA, Douglas PR, Drummond MF, Torrance GW, Macleod S, Manti O, Cheruvu L, Corvari R.

Arthritis Rheum. 2008 Feb 15;59(1):65-72. Asking the experts: Exploring the self-management needs of adolescents with arthritis. Stinson JN, Toomey PC, Stevens BJ, Kagan S, Duffy CM, Huber A, Malleson P, McGrath PJ, Yeung RS, Feldman BM. Ivanova L, Butt MJ, Matsell DG. Mesenchymal transition in kidney collecting duct epithelial cells. Am J Physiol Renal Physiol. 2008 May;294(5):F1238-48.

Am J Physiol Renal Physiol. 2008 May;294(5):F1238-48. Mesenchymal transition in kidney collecting duct epithelial cells. Ivanova L, Butt MJ, Matsell DG.

Am J Physiol Renal Physiol. 2008 Mar 5 Mesenchymal Transition in Kidney Collecting Duct Epithelial Cells. Ivanova L, Butt MJ, Matsell DG.

Am J Kidney Dis. 2008 Mar;51(3):435-44.Albuminuria and estimated GFR 5 years after Escherichia coli O157 hemolytic uremic syndrome: an update. Garg AX, Salvadori M, Okell JM, Thiessen-Philbrook HR, Suri RS, Filler G, Moist L, Matsell D, Clark WF. Am J Kidney Dis. 2008 May 1. CKD Following Kidney Transplantation in Children and Adolescents. White CT, Schisler T, Er L, Djurdjev O, Matsuda-Abedini M.

Evid Rep Technol Assess (Full Rep). 2008 Feb;(164):1-131. Utility of monitoring mycophenolic acid in solid organ



transplant patients.Oremus M, Zeidler J, Ensom MH, Matsuda-Abedini M, Balion C, Booker L, Archer C,Raina P.Br J Psychiatry. 2008 May;192:338-43. Effects of timing and duration of gestational exposure to serotonin reuptake inhibitor antidepressants: population-based study. Oberlander TF, Warburton W, Misri S, Aghajanian J, Hertzman C.

Birth Defects Res B Dev Reprod Toxicol. 2008 Feb;83(1):68-76. Major congenital malformations following prenatal exposure to serotonin reuptake inhibitors and benzodiazepines using population-based health data. Oberlander TF, Warburton W, Misri S, Riggs W, Aghajanian J, Hertzman C.

Clin J Pain. 2008 Jan;24(1):83-8. Is it painful or not? Discriminant validity of the Behavioral Indicators of Infant Pain (BIIP) scale. Holsti L, Grunau RE, Oberlander TF, Osiovich H. Ivanova L, Butt MJ, Matsell DG. Mesenchymal transition in kidney collecting duct epithelial cells. Am J Physiol Renal Physiol. 2008 May;294(5):F1238-48.

Am J Physiol Renal Physiol. 2008 May;294(5):F1238-48. Mesenchymal transition in kidney collecting duct epithelial cells. Ivanova L, Butt MJ, Matsell DG.

Am J Physiol Renal Physiol. 2008 Mar 5 Mesenchymal Transition in Kidney Collecting Duct Epithelial Cells. Ivanova L, Butt MJ, Matsell DG.

Am J Kidney Dis. 2008 Mar;51(3):435-44.Albuminuria and estimated GFR 5 years after Escherichia coli O157 hemolytic uremic syndrome: an update. Garg AX, Salvadori M, Okell JM, Thiessen-Philbrook HR, Suri RS, Filler G, Moist L, Matsell D, Clark WF. Am J Kidney Dis. 2008 May 1. CKD Following Kidney Transplantation in Children and Adolescents. White CT, Schisler T, Er L, Djurdjev O, Matsuda-Abedini M.

Evid Rep Technol Assess (Full Rep). 2008 Feb;(164):1-131. Utility of monitoring mycophenolic acid in solid organ transplant patients.Oremus M, Zeidler J, Ensom MH, Matsuda-Abedini M, Balion C, Booker L, Archer C,Raina P.

Br J Psychiatry. 2008 May;192:338-43. Effects of timing and duration of gestational exposure to serotonin reuptake inhibitor antidepressants: population-based study. Oberlander TF, Warburton W, Misri S, Aghajanian J, Hertzman C. Early Human Experience Unit, CCCHR

Birth Defects Res B Dev Reprod Toxicol. 2008 Feb;83(1):68-76. Major congenital malformations following prenatal exposure to serotonin reuptake inhibitors and benzodiazepines using population-based health data. Oberlander TF, Warburton W, Misri S, Riggs W, Aghajanian J, Hertzman C.

Clin J Pain. 2008 Jan;24(1):83-8. Is it painful or not? Discriminant validity of the Behavioral Indicators of Infant Pain (BIIP) scale. Holsti L, Grunau RE, Oberlander TF, Osiovich H.







Circulation. 2008 Apr 22;117(16):2162-7. Hands-only (compression-only) cardiopulmonary resuscitation: a call to action for bystander response to adults who experience out-of-hospital sudden cardiac arrest: a science advisory for the public from the American Heart Association Emergency Cardiovascular Care Committee. Sayre MR, Berg RA, Cave DM, Page RL, Potts J, White RD Osteoarthritis Cartilage. 2008 May 19. Interleukin-1 inhibits osmotically induced calcium signaling and volume regulation in articular chondrocytes. Pritchard S, Votta BJ, Kumar S, Guilak F.

Davie JR, He S, Li L, Sekhavat A, Espino P, Drobic B, Dunn KL, Sun JM, Chen HY, Yu J, Pritchard S, Wang X. Nuclear organization and chromatin dynamics - Sp1, Sp3 and histone deacetylases. Adv Enzyme Regul. 2008 Mar 13.

Stuart-Buttle CE, Smart CJ, Pritchard S, Martin D, Welch IM. Desmoplastic small round cell tumour: A review of literature and treatment options. Surg Oncol. 2008 Jan 9;

Theopold C, Pritchard S, McGrouther DA, Bayat A. Keloid scar harbouring malignant blue naevus emphasises the need for excision biopsy and routine histology. J Plast Reconstr Aesthet Surg. 2008 Jan 7.

Cancer Genet Cytogenet. 2008 Apr 15;182(2):84-94. Screening for submicroscopic chromosomal rearrangements in Wilms tumor using whole-genome microarrays. Rassekh SR, Chan S, Harvard C, Dix D, Qiao Y, Rajcan-Separovic E. Pediatr Blood Cancer. 2008 Feb;50(2 Suppl):447-50; discussion 451. Children’s Oncology Group (COG) Nutrition Committee. Rogers PC, Melnick SJ, Ladas EJ, Halton J, Baillargeon J, Sacks N; Children’s Oncology Group (COG) Nutrition Committee.

Heart Rhythm. 2008 May;5(5):639-42. Outcome of the Fidelis implantable cardioverter-defibrillator lead advisory: a report from the Canadian Heart Rhythm Society Device Advisory Committee. Krahn AD, Champagne J, Healey JS, Cameron D, Simpson CS, Thibault B, Mangat I, Tung S, Sterns L, Birnie DH, Exner DV, Parkash R, Sivakumaran S, Davies T, Coutu B, Crystal E, Wolfe K, Verma A, Stephenson EA, Sanatani S, Gow R, Connors S, Paredes FA, Essebag V

J Invasive Cardiol. 2008 May;20(5):212-6. Invasive measurements of atrioventricular conduction parameters prior to and following ventricular septal defect closure with the amplatzer device. Kramoh EK, Dahdah N, Fournier A, Sanatani S, Hosking M, Miró J. Pediatric Cardiology, Sainte-Justine Hospital, Montreal, Quebec, Canada.

Sanatani S, Duncan W, Chan S. The Challenge of Diagnosing Arrhythmogenic Right Ventricular Cardiomyopathy in the Young. Pediatr Cardiol. 2008 Apr 22.

Sanatani S, Wilson G, Smith CR, Hamilton RM, Williams WG, Adatia I. Sudden unexpected death in children with heart disease.Congenital Heart Dis. 2006 May;1(3):89-97. Pediatr Infect Dis J. 2008 Feb;27(2):112-8. The epidemiology of children hospitalized with herpes zoster in Canada: Immunization Monitoring Program, Active (IMPACT), 1991-2005. Wootton SH, Law B, Tan B, Mozel M, Scheifele DW,



Halperin S; IMPACT Investigators. Eur J Pediatr Surg. 2008 Apr;18(2):111-6. European biliary atresia registries: summary of a symposium. Petersen C, Harder D, Abola Z, Alberti D, Becker T, Chardot C, Davenport M, Deutschmann A, Khelif K, Kobayashi H, Kvist N, Leonhardt J, Melter M, Pakarinen M, Pawlowska J, Petersons A, Pfister ED, Rygl M, Schreiber R, Sokol R, Ure B, Veiga C, Verkade H, Wildhaber B, Yerushalmi B, Kelly D. Department of Pediatric Surgery, Medical School Hannover, Hannover, Germany.

Hasosah M, Lemberg DA, Skarsgard E, Schreiber R. Congenital short bowel syndrome: a case report and review of the literature. Can J Gastroenterol. 2008 Jan;22(1):71-4. Griffith LM, Pavletic SZ, Lee SJ, Martin PJ, Schultz KR, Vogelsang GB. Chronic Graft-versus-Host Disease--implementation of the National Institutes of Health Consensus Criteria for Clinical Trials. Biol Blood Marrow Transplant. 2008 Apr;14(4):379-84.

Barbaric D, Corthals SL, Jastaniah WA, Asalanian S, Shimizu H, Reid GS, Schultz KR. Detection of WT1-specific T cells in paediatric acute lymphoblastic leukaemia patients in first remission. Br J Haematol. 2008 Apr;141(2):271-3. J Pain Symptom Manage. 2008 Mar;35(3):235-8. Haloperidol as a palliative anti-emetic in a toddler: an evidence base challenge. Siden HB. Air Med J. 2008 Mar-Apr;27(2):91-8. Air medical evacuation in patients with airleak syndromes. Kaczala GW, Skippen PW.

Pediatrics. 2008 Feb;121(2):e233-8. Prevention and 18-month outcomes of serious pulmonary hemorrhage in extremely low birth weight infants: results from the trial of indomethacin prophylaxis in preterms. Alfaleh K, Smyth JA, Roberts RS, Solimano A, Asztalos EV, Schmidt B; Trial of Indomethacin Prophylaxis in Preterms Investigators. J Clin Microbiol. 2008 Apr;46(4):1470-3. Differential mucoid exopolysaccharide production by members of the Burkholderia cepacia complex. Zlosnik JE, Hird TJ, Fraenkel MC, Moreira LM, Henry DA, Speert DP. Mol Genet Metab. 2008 Feb 12 Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: Evidence of a phenotypic continuum between dominant and recessive forms. Horvath GA, Stockler-Ipsiroglu SG, Salvarinova-Zivkovic R, Lillquist YP, Connolly M, Hyland K, Blau N, Rupar T, Waters PJ.

Huemer M, Födinger M, Bodamer OA, Mühl A, Herle M, Weigmann C, Ulmer H, Stöckler-Ipsiroglu S, Möslinger D. Total homocysteine, B-vitamins and genetic polymorphisms in patients with classical phenylketonuria. Mol Genet Metab. 2008 Jan 11 J Perinatol. 2008 Mar 27 Severe retinopathy of prematurity and visual outcomes in British Columbia: a 10-year analysis. Schiariti V, Matsuba C, Houbé JS, Synnes AR.







Houghton KM, Tucker LB, Potts JE, McKenzie DC.Fitness, fatigue, disease activity, and quality of life in pediatric lupus. Arthritis Rheum. 2008 Apr 15;59(4):537-45.

Tucker L, Uribe A, Fernández M, Vilá L, McGwin G, Apte M, Fessler B, Bastian H, Reveille J, Alarcón G. Adolescent onset of lupus results in more aggressive disease and worse outcomes: results of a nested matched case-control study within LUMINA, a multiethnic US cohort (LUMINA LVII). Lupus. 2008;17(4):314-22. J Immunol. 2008 Jun 1;180(11):7764-7773. Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease. Blohmke CJ, Victor RE, Hirschfeld AF, Elias IM, Hancock DG, Lane CR, Davidson AG, Wilcox PG, Smith KD, Overhage J, Hancock RE, Turvey SE.

FEMS Immunol Med Microbiol. 2008 Jan 30 Commonly invasive serotypes of Streptococcus pneumoniae trigger a reduced innate immune response compared with serotypes rarely responsible for invasive infection. Burgess TS, Hirschfeld AF, Tyrrell GJ, Bettinger JA, Turvey SE. Cell Microbiol. 2008 Apr 23 Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection. Valdez Y, Diehl GE, Vallance BA, Grassl GA, Guttman JA, Brown NF, Rosenberger CM, Littman DR, Gros P, Finlay BB.

Infect Immun. 2008 Apr;76(4):1410-22. Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium. Khan MA, Bouzari S, Ma C, Rosenberger CM, Bergstrom KS, Gibson DL, Steiner TS, Vallance BA.

PLoS Pathog. 2008 Apr 4;4(4):e1000036. A novel secretion pathway of Salmonella enterica acts as an antivirulence modulator during salmonellosis. Gal-Mor O, Gibson DL, Baluta D, Vallance BA, Finlay BB.

Gastroenterology. 2008 Mar;134(3):768-80. Comment in: Gastroenterology. 2008 Mar;134(3):872-5. Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis. Grassl GA, Valdez Y, Bergstrom KS, Vallance BA, Finlay BB. Ghia JE, Galeazzi F, Ford DC, Hogaboam CM, Vallance BA, Collins SM.

Role of M-CSF dependent macrophages in colitis is driven by the nature of the inflammatory stimulus. Am J Physiol Gastrointest Liver Physiol. 2008 Jan 17; White AP, Gibson DL, Grassl GA, Kay WW, Finlay BB, Vallance BA, Surette MG. Aggregation via the rdar morphotype is not a virulence adaptation in Salmonella enterica serovar Typhimurium. Infect Immun. 2008 Jan 14; Hines-Thomas M, Kaste SC, Hudson MM, Howard SC, Liu WA, Wu J, Kun LE, Shulkin BL, Krasin MJ, Metzger ML.Comparison of gallium and PET scans at diagnosis and follow-up of pediatric patients with Hodgkin lymphoma. Pediatr Blood Cancer. 2008 Apr 21;

Department of Pediatrics Newsletter Summer...

Documents

Transcript of Department of Pediatrics Newsletter Summer...