Danone tony mateos

March 2012

DANONE RESEARCH Perspectiva para construir cienciaJA Mateos 26 marzo 2012

Danone Research General Presentation - External Communication Direction

April 2011

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DANONE RESEARCHNuestra misión:

Aportar salud a través de los alimentos a la mayor parte de

población posible

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Gobernanza Corporativa de DANONE

(2nd version in 2009)

Download:

www.danone.com

Cinco Compromisos en la Carta de Salud

– Proponer soluciones en nutrición que se ajusten a necesidades, recomendaciones nutricionales, sabores e ingresos locales

– Desarrollar productos con beneficios para la salud científicamente probados

– Informar al consumidor claramente, objetivamente y con publicidad responsable

– Promover dietas y estilos de vida saludables

– Enfrentarse a retos sociales relacionados con la salud y la nutrición

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DANONE' health and nutrition commitments are defined in a Food, Nutrition & Health Charter, the second version of which was published in 2009 and launched on the occasion of the 19th International Congress of Nutrition in Bangkok. It concerns Danone's four divisions.


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Convicción

El alimento es el mayor vector de ayuda a la

población para construir y

preservar su capital salud

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Food is one of the main vectors, among others like lifestyle & environment, which helps people build and preserve their health capital.


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Desórdenes mayores de salud vinculados con la alimentación

MalnutritionCardiovascular

17 MILLION DEAD/YEAR

923 MILLION UNDERNOURISHED

Diabetes

> 20 between 10 and 19< 9

Obesity

300 MILLION PEOPLE

360 MILLION PEOPLE BY 2030

Sources:WHO/FAO

2008

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...But, chronic pathologies connected with malnutrition and poor life hygiene are on the rise. Food abundance, but also food scarcity can lead to malnutrition, deficiencies, pathologies...Anecdotes:Malnutrition and non-infectious pathologies may coexist in a same country, and ever in a same family.Obesity concerns 300 million people in the world, according to the WHO, and can lead to diabetes and cardiovascular diseases.Diabete Mellitus (type II) should have doubled by 2030, reaching 360 million people (WHO).Cardiovascular diseases kill 17 million people each year (WHO).Malunutrition: 923 million undernourished in 2007 (FAO).

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Eating better, eating well

BRINGING HEALTH THROUGH FOOD TO AS MANY PEOPLE AS POSSIBLE: ACTION PRIORITIES

BRINGING HEALTH THROUGH FOOD TO AS MANY PEOPLE AS POSSIBLE: ACTION PRIORITIES

BETTER EATING HABITS

BALANCED PRODUCTSPORTFOLIO

TARGETEDHEALTHEFFECT

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2

1

Efficient and relevanthealth offer

A legitimaleproductin nutrition

Danone CBU responsible actor

Tres prioridades

– Educación y apoyo para promover mejores hábitos alimentarios

– Adaptar el perfil nutricional de los alimentos a necesidades específicas

– Ofrecer productos con efectos sobre objetivos específicos de salud

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Three priorities express the great nutritionnal and public health challenges of today and DANONE has a role to play:1. Contributing to the well-being and the balanced diet of consumers by influencing eating habits through education and coaching.2. Adapting food's nutritional profile to the specific needs of given population.3. Offering products with specific and targeted effects to help build people's health capital, optimise their organic functions and improve their quality of life.


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DANONE aporta salud en todos los estadíos de la vida

Envejecer bienConstruyendo capital salud

ESTADIOS VIDA

NU

TR

ICIO

N E

SP

EC

IFIC

A /

N

EC

ES

IDA

DES

SA

LU

D

Desarrollo cerebralAlergias

Desarrollo sabor

Evitar Carencias Mantener independencia

MantenimientoPrevenciónALTO

BAJO

Preservación del capital salud

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!: Water is only represented in the adulthood, but is obviously accompanies consumers at every life stages.


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…con portfolio de productos focalizados en beneficios sobre la

salud

FalteringGrowth

Growth

Bone Health

Alzheimer*

Enhanced recovery

Cardiovascular health

Immune function

Digestive function

Replenishment

Elimination

Metabolic control

WeightManagement

COPD

Epilepsy

Oncology

Independance

Glucose control

CREDIBILITY RELEVANCE

EFFICACITY

Allergy

* Under development

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Some information on some products of the chart:Growth:- Blédilait 2ème âge: infant formula (liquid or powder form) for children aged from up to 6 months in France.Faltering growth:- Infatrini: food for special medical purpose for use under medical supervision. It is a nutritionally complete, energy dense, ready to use feed for the dietary management of infants (from birth up to 18 months or 8 kg in body weight) with faltering growth.- Nutrini: food for special medical purposes for use under medical supervision. It is a nutritionally complete 1 kcal/ml tube feed for the dietary management of disease related malnutrition in children aged 1-6 years or 8-20 lg in body weight.Metabolic control:- PKU Anamix: an amino acid based phenylalanine-free powdered infant formula for the dietary management of infants with phenylketonuria (PKU, a genetic disorder in which the body can't process phenylalanine (Phe), an aminoacid present in almost foods. If the Phe level gets too high, it can damage the brain and cause severe mental retardation. - PKU Anamix junior: Phe-free drink mix for the dietary management of children (1-10 years) with PKU.Glucose control:- Diasip:Food for special medical purposes fou use under medical supervision. Diasip is a nutritionally complete, ready-to-drink milkshake style supplement, deisgned for the dietary management of patients with diabetes and impaired glucose tolerance;Allergy:- Neocate: amino-acid based complete infant formula for diatery management of infants allergic to milk or proteins.COPD (Chronic Obstructive Pulmonary Disease):- Respifor: it is a little drink specifically designed for COPD patients to provide the right balance of energy and nutrition.Oncology:- Forticare: it is a food fro special medical purposes for use under medical supervision. Forticare is a nutritionzlly complet, high energy, high protein, ready to drink milk shake style nutritional supplement which is enriched with n-3 fatty acids, antioxidants and fibre for the dietary management of cachexia in oncology patients.Epilepsy:- Ketocal: a nutritionally complete, powdered product, which can be used to administer the classical (4:1) Ketogenic diet for children over 1 year of age.Alzheimer(under development): -Souvenaid (under development): multi-nutrient drink designed to improve cognitive function.


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… a través de cuatro líneas de negocio con buena posición en

el mercado

BABY NUTRITION3.3 bln €*

20%+8.9%

Nº 1 in Europe,Nº 2 Worldwide

WATERS2.9 bln €*17%+5.3%Nº 2 Worldwide

MEDICAL NUTRITION

1.05 bln €*6%

+9%Nº 1 in Europe,nº 3 Worldwide

FRESH DAIRYPRODUCT9.7 bln €*57%+6.5%Nº 1 Worldwide

2010

* Key figures 2010

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Danone's main competitors per division:- Fresh Dairy Products: Yoplait with €3.5bln(€9,7 bln for Danone)- Waters: Nestlé (no. 1 worldwide with €9bln/ Danone: €2.9bln)- Baby Nutrition: Nestlé, no. 1 worldwide- Medical Nutrition: Abbott, Nestlé, Fresenius


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Comunidad para la Investigación y el

DesarrolloCompromiso entre las cuatro divisiones


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1200 R&D expertos en el mundo

Más de 500 científicos: nutricionistas, fisiólogos, inmunólogos, neurólogos, microbiólogos, biólogos moleculares, bioquimicos, expertos en análisis sensorial, especialistas en seguridad alimentaria, en comportamiento del consumidor, doctores e ingenieros

2 Centros I&D de referencia:•Daniel Carasso Centre (F)•Centre for Specialised Nutrition (NL)

Más de 200 convenios de colaboración científica en el mundo

Comunidad Danone para la Investigación

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F. DAIRY PRODUCTS

WATERS

BABY NUTRITION

MEDICAL NUTRITION

DANIEL CARASSO CENTRE, PALAISEAU

CENTRE FOR SPECIALISED NUTRITION, WAGENINGEN

Comunidad Danone para la Investigación

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Danone Research vistazo 2011

Headcount

1200 (dairy, nutrition)

PhD

171

R&D Budget

209 M€

PublicacionesIn journals 90

In congress 47

Estudios clínicos activos

108

PatentesDeposits (43)

Patent portfolio (448)

* Key figures 2010


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Foco en áreas clave de conocimiento

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Nuestro core cientifico

Sensory & Behavior Science

Human nutrition& physiology

Clinical research

Water & Hydration Science

Immunology

Neurosciences

Food design

Milk & Dairy ingredients

Packagingmaterials

Gut, Microbiology & Microbiota

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7 ámbitos estratégicos en que somos “science makers/integrators”

NUTRIENT PROFILINGDevelop nutritional targets / nutrient profiling systems that account for local diversity and metabolic effect of our products

RESPONSABILIDAD NUTRICIONALValorise and reinforce the nutritional responsibility of our formulations

SITUACIONES EN NUTRICION & ALIMENTOSTo propose relevant products and services based on public health stakes, epidemiological data and consumer perceptions

EVALUACIÓNTo propose science-based tools to measure food and drink intakes and nutritional status

SERVICIOSTo develop « integrated » services to Danoners and consumers

Health @ Work

IMPACTO EN EL COMPORTAMIENTO ALIMENTARIO

Define key criteria and conditions for a favorable impact of our products on eating behaviours

SUPERIORIDAD NUTRICIONALDefine & animate the conditions for the nutritional superiority of Danone products

NutriPlanet

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Nuestro core científico

Intestino, Microbiología & Microbiota&

Probióticos

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Microbiota Intestinal: Un ecosistema microbioano

complejo

PREBIOTICS

Non-digestible food ingredients that stimulate the growth and/or activity of specific bacteria in the

intestinal microbiota

PROBIOTICS

Live microorganisms which when administered in

adequate amounts confer a health benefit on the host

(FAO-WHO)

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Our digestive system contains a microbiota which is essential for a good digestion.Pre- and probiotics can optimize the good working of this system :-either by interacting with the gastro-intesinal tract- or by interacting with the intestinal microbiota, which will interact with the tract.Therefore there is a complex network of interactions between man, his intestinal flora, prebiotics and probiotic bacteria.Anecdotes:- Danone has been studying probiotics since 1919.- The intestinal folds cover an area as big as 2 tennis courts (400m²).- 70% of the immune system is located in the gut.- The intestine harbours 10^14 bacteria: 10 times more cells than human cells in the body.- Greater than 1,000 different species of bacteria make up the intestinal flora.- Approximately, 1kg of bacteria is contained in a human adult intestine.- 3.3 million bacterial genes in the gut: it is 150 times more than in the human genome.3,3 millions de gènes bactériens dans l'intestin : 150 fois plus que dans le génome humain.


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Desde la bacteria láctica al desarrollo de productos para ofrecer beneficios en salud

SELECCION PROBIÓTICOS &

CARACTERIZACION

CARACTERIZACION FUNCIONAL

PROPAGACION Y FORMULACION

PRODUCTO

DEMOSTRACION EFECTO

Estudios clínicos beneficios específicos

SeguridadCrecimientoAcidificación

Supervivencia

Beneficio específico tests para nutrición y

salud Conocimiento en

microbiota intestinal…

Utilización industrialcepas

Know-how tecnológico: Proceso

& Organolepsia…

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From strains selection to the effect demonstration, R&D teams masters all steps.Comments:Knowledge in gut microbiota: there is an interaction between the gut, the microbiota and biotics. By understanding the gut function, we can easelier study health benefits and identify markers on which we should work to innovate.We have 4,100 different strains coming from biodiversity contained in Danone Bacterial Bank, which forms a huge product innovation potential.

Author - Date creation – Document title Confidentiality mention

Total of 91 scientific communications published in 2011

As attendee: 29 congresses Presentations (poster and/oral com presentation): 44 congresses

2010 : 91 congresses participation (46 as attendee and 45 for presentation)

Scientific Communications

Nb Articles

Mean Impact Factor

3,45,0 6,4

2009 2010 2011

Congresses Participation

Un vistazo sobre Comunicaciones Científicas (Lácteos)2011

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30

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Published articles from 2009 to 2011


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Nuestra competencia científica

Investigación Clinica

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Nuestra competencia científica

• Definición estudios clínicos– Ensayos llevados a cabo en humanos para

desarrollar conocimiento biológico y médico

• Porqué hacemos estudios clínicos?– Para demostrar

– los beneficios en la salud de nuestras marcas funcionales

– y generar evidencia científica

• Golden standards – ICH-GCP, ISO 9001

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Key-message: clinical research in nutrition is a key skill to scientifically demonstrate health benefits of our functional brands.Associated messages:definition of a clinical study,why doing clinical studies,Clinical studies are supported by golden standards.Anecdotes:Studies are conduted in partnership with a diversity of external experts (scientists, research organisations, etc.) whose expertise has been recognised by the relevant scientific authorities.Clinical studies are conducted according to the highest scientic quality standards; the International Conference of Harmonisation (ICH)- WHO Good Clinical Practice (GCP) standards.


23Danone Research General Presentation - External Communication Direction

April 2011

Generar evidencia científica

MEDIANTE CRO (CONTRACT RESEARCH ORGANIZATION)

DISEÑOS INNOVADORES

COMITE ETICO EVALUACION

FASE EXPERIMENTAL HECHA EN HOSPITALES O CLINICAS

Validated scientific evidence

Study report

Statistical analysis

Control of the data

Biological analysis

Production of batches

(products)

Study document

writing

Choice of partners

Choice of products

Protocoland design

of the study

Submission of the project to

the health authorities

Recruitment of volunteers

and study implemen-

tation

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Key-message: Clinical studies in nutrition are specific, and especially the accentuated steps (boxes 1, 2, 5, 7, 9).Production of batches (control and active products) must take into account shelf-lives and dispatching of products on a worlwide scale (developed during the Fresh Dairy Product Pilot's visit).


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Trabajamos con expertos reconocidos

en el mundo

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Institut Pasteur - France: 4 collaboration focuses: bacterial infection resistance , intestinal homeostasis, inflammation modulation response (vaccination), genetic profile analysis

INRA- France: European Project MetaHIT: characterization of the genes and bacterial functions of the human intestinal microbiota

Washington University in St Louis - USA: novel investigations of the impact of intestinal microflora on metabolism & health

Red científica de colaboración sobre microbiota intestinal

Más de 200 colaboraciones científicas en el mundo.

prebióticos, probióticos, microbiota intestinal , nutrición, salud huesos, salud cardiovascular, inmunología, neurociencias, etc.


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Nuestro modelo de innovación


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Nuestro modelo de innovación

ConsumidorBeneficios salud

Relevancia

EficaciaMarcado

res

Visualisación beneficio

Ingredientes, Cepas

Producto

Nutrición & Eficacia en la salud

Estudios con

producto

Efecto clínico

científico

LIDERA I+D

MARKETING + I+D

LIDERAN CONSUMIDORES Y

EXPERTOS

LIDERA MARKETING

SOPORTE I+D

CREDIBILIDAD RELEVANCIA

EFFICACIA

360° ConsumerCommunication

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We have a unique innovation model which starts and ends with consumer.R&D leads some steps: from relevant efficacy markers identification to the demonstration of our products' effects.


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Con respeto a las escificidades locales


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Fórmulas adaptadasal contexto local

FOCO en “DANONINO” adaptado para deficiencias en micronutrientes

DANONINO / SPAIN

Ca, Vit. D

GERVAIS AUX FRUIT / FRANCE

Ca, Vit. D

DANONKI / POLANDCa, Vit. D

RASTISHKA / RUSSIA

Ca, Vit. D, Iodine

FRUCHTZWERGE / GERMANY

Ca, Vit. D

PETIT DANINO / TURKEYCa, Vit. D

DAN-O-NINO / USA

Ca, Vit. D

DANONINO / MEXICO

Ca, Vit. D, Zinc

DANONINHO / BRAZIL

Ca, Vit. E, D, Fer, Zinc, Phosphore

DANONINO / ARGENTINACa, Vit. A, B9, D, Zinc, Fer

DANONINO / SOUTH AFRICACa, Vit. D

DANONINO / ALGERIACa, Vit. D

PETIT DANONE / JAPAN

Ca, Vit. D

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The amount of added vitamins and minerals covers at least 15%of the RDA.As a dairy product, Danonino naturally contains vitamins B2, B12, and Phosphorus.According to countries and specific local nutritional needs, Danonino is enriched in calcium from 20% up to 40% of the RDA.

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Responsabilidad medioambiental

Cinco prioridades

– Reducir la huella de carbono un 30% en 2012

– Proteger los recursos acuíferos y reducir nuestro consumo

– Idear como transformar los deshechos en packaging

– Dar soporte a una eco-agricultura

– Proteger y restaurar la biodiversidad

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The environmental responsability is also part of DANONE's DNA. Indeed, it is our mission to bring health through food to as many people as possible, and that means preserving and renewing resources. Moreover, healthy food requires healthy ingredients.Since 1990s, DANONE has formalized its commitments.The group defines 5 priorities for action with among other things an ambitious objective : reducing our carbon footprint by 30% in kilos by 2012.It includes 3 areas:- reliable measurements of carbon emissions (work with PricewaterhouseCoopers to develop a method which can be reliably audited)- reducing emissions (notably via packaging with more recycled PET: the first bottle with 100% rPET was launched in 2009 in Mexico)- carbon offsets (creation of the Danone Fund for Nature which identifies and finances projects contributing to CO2 absorption).The Group do not act alone but with recognized partners : RAMSAR, Ademe, INRA, Carbon trust, ...


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DANONE RESEARCHen el corazón de la misión del Grupo

APORTAR SALUD A TRAVÉS DE LOS ALIMENTOS A LA MAYOR PARTE DE POBLACIÓN POSIBLE

Muchas graciasjose-

[email protected]

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