B. Mathes

Webinar, July 1 2014

DaNa2.0 – Communication platform for safety research on nanomaterials

Supported by Supported by

DECHEMA - Link between disciplines and organisations

Non-profit scientific-technological society

More than 5,800 members (including more than 650 companies)

Honorary service of far more than 1,000 high-ranking experts from research institutions and industry

About 100 working groups on scientific issues

Together with DECHEMA Ausstellungs-GmbH we are the organizers of ACHEMA, the world forum for the process industry

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History

2002 • Discussion in DECHEMA

workgroups

2005 • Announcement of BMBF*

funding

2006 • Project

2009 • Project

2013 • Project

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Nanomaterial safety research in Germany

*BMBF = German Federal Ministry of Education and Research

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Roots of DaNa2.0

Project NanoCare (2006 – 2009) - largest project on (human-)toxicology of nanomaterials - 11 “on the market” substances examined (19 variations)

- Public dialogue:

• Website: www.nanoobjects.info: Knowledge Base Nanoparticles (today: nanoobjects)

- SOPs (standard operation procedures) introduced

• For nanomaterials • Reproduceable • Available at www.nanoojects.info

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German national funding (2008 ff)

BMBF* funding actions (2008) - NanoCare (this time as the name

of a funding action) Human toxicology of

nanomaterials - NanoNature Nanomaterials for and

in Nature (Ecotoxicology) 18 projects and 1 accompanying: DaNa – „Database Nanomaterials“ (i.e. DaNa1.0)

*BMBF = German Federal Ministry of Education and Research

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DaNa

Motivation for the knowledge base

Nanotechnology in applications and consumer products

Different nanomaterials used (individual and in combinations)

When in textiles, food supplements, cosmetics:

Safety concerns

among consumers

Source: Nature

Target groups

Interested laymen

Journalists

Politicians

NGOs

Scientists but „non-toxicologists“

Complete content is available in German and English

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Picture: http://www.target-catalogue.com

Aims of DaNa/DaNa2.0

Central component of DaNa:

Communication of research on safety of nanomaterials

• Website (German/English) • Brochure, Flyer • Other Media (lectures, …)

No active research but assessment of literature and projects

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Central issues of DaNa/DaNa2.0

Impartial information on nanomaterials for objectification of public discussion

Support of German funded projects e.g. project information, SOP template, cluster meetings, …

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Website www.nanoobjects.info

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Correlation Materials ↔ Application

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Correlation Materials ↔ Application

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Material + application specific information

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Material + application specific information

In-depth information on each nanomaterial

Material / Applications Exposure / Uptake / Behaviour Human toxicology / Eco-toxicology

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1 summary

2 main results known in the field

3 Link to scientific literature

Increasing depth of details

Nanotoxicology literature

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Increasing numbers of publications

# of Nanotoxicology Papers published per year. Columns for 2010 and 2011 were added by H.F.Krug and C.Steinbach. (modified from original: C.L. Haynes: The emerging field of nanotoxicology. Anal. Bioanal. Chem 398, 587-588, 2010).

Usability of nanotoxicology papers

An actual publication showed: for titaniumdioxide only ~32%, and for Zinkoxide even only 13%

of the published data are suitable for risk assesment

(Hristozov et al. 2012).

Today about 2000 publications / year => in maximum ~600 useable!

Need to be sorted out!

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pdf form for download

Example project page http://www.nanoobjects.info/en/projects

Development of a harmonized SOP template

Glossary german/ english

FAQ

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Risk assessment for nanomaterials

What is risk?

Risk = f (Exposure; Hazard)

Exposure Hazard Risk

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Risk assessment for nanomaterials

Important • Hazard potentials and exposure

have to be determined case-bycase

• Conclusions by analogy for substance characteristics not possible

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Short risk assessment for nanomaterials TiO2 (nano) in sunscreens Positive prospects: - effective sunblock - yearly tens of thousands

skin cancer diagnoses less

Negative prospects: - permeation into the body - negative impact of nano

particles in human body

Conclusion: - better sun protection - good protection via healthy skin - more information needed for injured skin

Real: - good protection via healthy

skin

Real: - better sun protection - less use of chemical UV

block substances

Still open - epidemiology of incidence of

skin cancer by TiO2-sunscreens

Still open - research with injured skin

Direct link to Consumers

Contact: dialog@nanopartikel.info

Contact!

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Dr. Björn Mathes DECHEMA e.V. +49 69 7564 365 mathes@dechema.de www.nanoobjects.info @nano_info