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Transcript of D ] } G µ ] ] À ] ( } ] ^ } v v v o Ç ] } ( o oweb.mit.edu/smart/research/biosym/Rohit...
![Page 1: D ] } G µ ] ] À ] ( } ] ^ } v v v o Ç ] } ( o oweb.mit.edu/smart/research/biosym/Rohit Karnik.pdf · Created Date: 12/29/2010 8:42:39 AM](https://reader033.fdocuments.us/reader033/viewer/2022052000/6012a8d6cdd08c66ca67db50/html5/thumbnails/1.jpg)
Biography:
RohitRohitKarnikisad’ArbeloffAssistantProfessorofMechanicalEngineeringattheMassachusesInstuteofTechnology.Heholdsabachelor’sdegreefromtheIndianInstuteofTechnology,Bombay,wherehewasarecipientoftheInstuteSilverMedal.HeobtainedhisPhDundertheguidanceofProf.ArunMajumdarfromtheUniversityofCaliforniaatBerkeleyin2006,wherehestudiedtransportinnanofluidicsystemsanddevelopeddevicesfornanofluidicflowcontrol,biosensing,andpaern-ing.HewasapostdoctoralassociateinthelaboratoryofProf.RobertLangeratMITfromfrom2006to2007.HejoinedtheDepartmentofMechanicalEngineeringatMITasAssistantProfessorinFall2007,wherehisresearchisfocusedonmicrofluidicandnanofluidictransportanddevicesforapplicaonsinseparaons,sensing,andanalysis.
Abstract:
MulpleMulplesample-processingstepspresentachallengefordevelopmentoflow-complexitymicrofluidicdevices.Inthistalk,Iwilldiscussnewapproachesthathavethepotenaltodirectlyseparate,enrich,oranalyzecellswithminimalornosampleprocessingrequirements.Weshowthatasymmetricreceptorpaernsthatpermittransientcell-surfacemolecularinteraconscanbeusedtodirectthetrajectoriesofcellsflowingthroughmicrofluidicdevices,withoutcapturingthecells.Thiseffectmimicscellrolling,aphysiologicalphenomenonthatplaysacricalroleincellhomingininthevasculature.Similarly,wedemonstrateasimplemicrofluidiccircuitforself-sorngofsoparclesandcellsbasedonthehydrodynamicresistanceinducedbythecellsinmicrofluidicchannels.Theseapproachesallowthedesignofdevicesforconnuous-flow,label-freeseparaonofcellsbasedonsurfacereceptorexpression,size,anddeformability.Suchdevicesmaybeusefulforbloodcounts,diagnosisofsepsisandmalaria,isolaonofcirculangcells,andotherapplicaons.
Speaker:
RohitKarnik
MicrofluidicDevicesforDirectSeparaonandAnalysisofCells
Date:5January2011,WednesdayTime:3.00pm-4.00pmVenue:NUSLectureTheatre31,S16,Level3,ScienceDrive1
[email protected],3January2011.
