Héctor H. Valdivia, M.D., Ph.D.Frank N. Wilson Professor of Cardiovascular Medicine

Professor of Molecular and Integrative PhysiologyCo-Director, Center for Arrhythmia Research

North Campus Research ComplexUniversity of Michigan

2800 Plymouth Ave., 26-235NAnn Arbor, MI 48109

734-647-4001hvaldiv@umich.edu

Education and Training: 1978-1984 Doctor of Medicine. National University of Mexico, School of Medicine, Mexico City.1984-1988 Ph.D. in Biochemistry. National University of Mexico and Baylor College of Medicine.

Academic and Administrative Appointments:1980-1986 Teaching Instructor: Department of Biochemistry, School of Medicine, National

Autonomous University of Mexico (UNAM), Mexico City.1986-1989 Research Associate: Department of Molecular Physiology and Biophysics, Baylor

College of Medicine, Houston, TX. 1989-1992 Associate Scientist: Department of Physiology, University of Wisconsin School of

Medicine, Madison, WI.1992-1994 Research Assistant Professor: Department of Physiology, University of Maryland

Medical School, Baltimore, MD. 1994-1999 Assistant Professor: Department of Physiology, University of Wisconsin Medical

School, Madison, WI.1999-2004 Associate Professor: Department of Physiology, University of Wisconsin Medical

School, Madison, WI.2004-2010 Professor & Vice-Chair: Department of Physiology, University of Wisconsin Medical

School, Madison, WI.2010-2011 Professor. Department of Cell & Regenerative Biology, University of Wisconsin

Medical School, Madison, WI.2012-present Professor. Department of Internal Medicine. Adjunct Professor of Molecular and

Integrative Physiology. University of Michigan, Ann Arbor, MI.2012-present Co-Director. Center for Arrhythmia Research, Cardiovascular Center, Department of

Internal Medicine, University of Michigan, Ann Arbor, MI.

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Research interests:My research interests lie in the field of Cardiovascular Electrophysiology and Pharmacology.

The long-term goal of my laboratory is to contribute to elucidate the molecular and cellular mechanisms that control the heart beat in normal and pathological settings. We are presently focused on determining the role of Ca2+ release channels/ryanodine receptors (RyR) of sarcoplasmic reticulum in excitation-contraction (e-c) coupling of the heart in health and disease. We are conducting three main projects, appropriately funded by the NIH, that use a combination of biochemical, electrophysiological, immunological, Ca2+ imaging and gene-manipulating techniques to elucidate the structural and functional properties of RyRs at the molecular, cellular and whole heart level.

Grants: Active: NIH RO1. “Cytosolic Calcium Sweeper of Ventricular Myocytes”. H.H. Valdivia, P.I.

$1,550,000 (total costs) for the period 7/01/2014 to 6/30/2018. Active: American Heart Association Predoctoral Fellowship. Francisco Alvarado, Mentee. $65,000

for the period 7/1/2014 to 6/30/2016. Active: American Heart Association Postdoctoral Fellowship. Roberto Ramos, PhD, Mentee.

$92,000 for the period 7/1/2014 to 6/30/2016. Active: NIH RO1. “Ryanodine receptors, Calcium-dependent arrhythmias, and HCM” H.H. Valdivia,

P.I. $1,550,000 (total costs) for the period 4/1/2015 – 3/30/2019. Pending: NIH R01. “Natural Peptide Ligands of Ryanodine Receptors: Physicochemical Properties

and Antiarrhythmic Effect”. H.H. Valdivia, P.I. $2,521,362 (total costs) for the period 2/1/2017-1/31/2022

Completed: NIH RO1. “Calcins as membrane-permeable ligands of RyRs”. H. H. Valdivia, P.I.

$1,550,000 (total costs) for the period 7/01/2011 to 4/1/2015. Completed: MTRAC Award. “Antiarrhythmic drugs based on natural peptides”. Héctor H Valdivia,

P.I. $27,000 for the period 7/1/2014 to 7/30/2015. Completed: NIH PO1. “Calcium Triggered Arrhythmias and Sudden Cardiac Death”. R.L. Moss,

P.I., (H.H. Valdivia, P.I. of Sub-Project 1). $1,890,000 (Project 1, only) for the period 7/01/2009 to 6/30/2014.

Completed: NIH RO1. “Mechanisms of RyR2-triggered Arrhythmias”. H. H. Valdivia, P.I. $1,250,000 for the period 7/01/2009 to 6/30/2014.

Completed: Cardiovascular Research Training Award. Michelle Capes, P.I. $45,000 for the period 7/1/2010 to 6/30/2012.

Completed: American Heart Association Predoctoral Fellowship. Randall Loaiza, P.I. $60,000 for the period 7/1/2010 to 6/30/2012.

Completed: NIH RO1. "TRIP3 channels in human melanoma". V. Setaluri, P.I., (H.H. Valdivia, Collaborator with 10% effort). $1,250,000 for the period 4/1/2007 to 3/30/2011.

Completed: NIH RO1. "Sorcin modulation of cardiac E-C coupling". H. H. Valdivia, P.I., $1,250,000 for the period 4/1/2004 to 3/30/2010 (includes a 1-year no cost extension).

Completed: American Heart Association Predoctoral Fellowship. Michelle Capes, P.I. $60,000 for the period 7/1/2008 to 6/30/2010.

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Completed: Supplement to NIH RO1. "β-adrenergic regulation of cardiac ryanodine receptors". H.H. Valdivia, P.I., Michael Hoffman, trainee. $120,000 for the period Feb 1, 2005 to Aug 31, 2007.

Completed: NIH RO1. "β-adrenergic regulation of cardiac ryanodine receptors". H. H. Valdivia, P.I., $1,520,000 for the period 9/1/2004 to 8/31/2008.

Completed: Program Project Grant, NHLBI of the NIH: “Regulation of Contraction in Myocardium”. Richard L. Moss, P.I., H. H. Valdivia, P. I. of project 2. $1,250,000 for the period 6/1/00 to 10/30/05 (Project # 2, only).

Completed: American Heart Association Postdoctoral Fellowship. Angélica Rueda, P.I. $121,000 for the period 1/1/2003 to 1/1/2006.

Completed: Training Program in Translational Cardiovascular Sciences. Postdoctoral Fellowship. Emily F. Farrell. $38,000 for the period 8/23/2004 to 8/22/2005.

Completed: NIH RO1. “Modulatory Mechanisms of Ryanodine Receptor Adaptation”. H. H. Valdivia, P.I. $1,550,000 (total costs) for the period 11/1/00 to 8/31/04.

Completed: Training Program in Translational Cardiovascular Sciences. Predoctoral Fellowship. Beth Olbinski. $21,000 for the period 9/1/2003 to 8/31/2004.

Completed: American Heart Association Predoctoral Felloship. Emily F. Farrell, P.I. $50,000 for the period 7/1/2002 to 7/1/2004.

Completed: NIH RO1. “Alterations in the dyad cleft in failing cardiomyocytes”. R. Haworth, H. H. Valdivia and T. Kamp, Co-PIs. $1,875,000 for the period 9/1/98 to 8/31/03.

Completed: American Heart Association Scientist Development Award. Andrew J. Lokuta, P.I. $260,000 for the period 7/1/98 to 6/30/02.

Completed: American Heart Association Predoctoral Fellowship. Xinsheng Zhu, P.I. $36,000 for the period 8/1/00 to 7/31/02.

Completed: Established Investigator of the American Heart Association. “Molecular Determinants of Excitation-contraction coupling”. H. H. Valdivia, P.I. $330,000 for the period 1/1/98 to 12/31/01.

Completed: NIH RO1. “Modulatory Mechanisms of Ryanodine Receptor Adaptation”. H. H. Valdivia, P.I. $630,000 (total costs) for the period 3/1/96 to 3/30/00.

Completed: NIH Program Project Grant. Project #3 “Actions of adenosine in normal and ischemic myocardium”, R. M. Mentzer and H. H. Valdivia, Co-project leaders. $810,000 (total costs) for the period 1/1/95 to 12/31/99.

Completed: American Heart Association Grant-in-Aid (National Office).“Dynamic Response of Cardiac Ryanodine Receptors to Calcium and Phosphorylation”, H. H. Valdivia, P.I. $120,000 for the period 7/1/95 to 6/30/98.

Completed: American Heart Association Scientist Development Award, "Role of Ryanodine Receptors in Excitation-Contraction Coupling", H. H. Valdivia, P.I. $275,000 for the period 7/1/92 to 6/30/97.

Completed: American Heart Association Grant-in-Aid (National Office) "Toxins of excitation-contraction coupling". H. H. Valdivia, P.I. $120,000 for the period 7/1/91 to 6/30/94.

Declined: KO2 Scientist Development Award from the National Institute of Health (Heart, Lung and Blood Institute). H. H. Valdivia, P.I. Declined to accept the Established Investigator Award of the American Heart Association.

Honors and Awards:

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Cystic Fibrosis Foundation Fellowship, 1989-1991. Scientist Development Award, American Heart Association, 1992 - 1997. Medal “Gabino Barreda” 1990 for Outstanding Students (Graduate Program), National

Autonomous University of Mexico. Committee Member of the Biophysical Society Congress, 1993 and 1994. Reviewer for Biophys J, Circ Res, J Biol Chem, Proc Nat Acad Sc USA, Am J Physiol, J Gen Physiol, J

Physiol (Lond), J Mol Cell Cardiol, Cell Calcium, others. Winner of the 1998 Society of Latin American Biophysicists (SOBLA) Prize for the Best Paper from

a Young Latin American Scientist. Established Investigator of the American Heart Association, 1998-2002. Session leader. Gordon Research Conference on "Skeletal Muscle: Excitation-contraction

Coupling", 2003. New London, NH. Course Director. Physiology 720, for Medical Students. University of Wisconsin School of

Medicine & Public Health. Madison, Wi. Session leader. Gordon Research Conference on "Skeletal Muscle: Excitation-contraction

Coupling", Les Diablerets, SWITZERLAND, June 2012. Fulbright Specialist. A five-year, renewable appointment to impart university-level courses

abroad, sponsored by the Fulbright Foundation. 2014-2019. Fulbright Scholar. Three-week theoretical and practical course: “Role of Ryanodine Receptors in

Physiological and Pathophysiological Settings”. La Plata, ARGENTINA. April 2014. Visiting Professor. Department of Physiology and Biophysics, Universidad de La Plata, ARGENTINA.

April 2014. Keynote speaker. 10th Chinese Congress on Calcium Signaling. Yichun, CHINA. Visiting Professor. Instituto de Biotecnología, Universidad Nacional Autónoma de México,

MEXICO. February 2015. Chair-elected. Gordon Research Conference on Muscle: Excitation-Contraction Coupling. Newry,

Maine, June 2015. Keynote speaker. 68th Congress of the Mexican Physiological Society. San Miguel Allende,

MEXICO. Fulbright Scholar. Four-week theoretical and practical course: “Function and Regulation of

Ryanodine Receptors in Physiological and Pathophysiological Settings”. Center for Advanced Studies, México City. MEXICO. February 2016.

Chair. Gordon Research Conference on Muscle: Excitation-Contraction Coupling. Les Diablerets, Switzerland, June 2017.

Memberships in Professional Societies:Biophysical Society, U.S.A., since 1987.American Heart Association Basic Science Council, since 1995.Society of Latin American Biophysicists (SOBLA), since 1994.International Society for Heart Research, since 2005.American Society of Experimental Biology, since 2006. Heart Rhythm Society, since 2012.

Editorial Positions, Boards, and Peer-Review Service:

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Peer Reviewer for the American Heart Association Wisconsin and Northland Affiliate, 1997-1999. Peer Reviewer for the American Heart Association National Office, Cell Transport and Metabolism

Study Section, 1996 - 2000. Standing Member, NIH Study Section MDCN-4. (Molecular, Developmental and Cellular

Neurobiology) Feb. 1999 – Feb. 2003. Program Project Grant Reviewer, NIAMD of the NIH. January 2001 and June 2001. PPG reviewer, NHLBI of the NIH. June 2002, Feb 2007, and Sept 2010. Ad hoc reviewer. NHLBI of the NIH. August 2002, March 2005, Aug 2010. Managing Editor. Frontiers in Bioscience. (http://www.bioscience.org). 2002-present. Permanent member, NIH study section ESTA (Electrical Signaling & Transmission Arrhythmia) Oct.

2006-Oct 2010. Editorial Board Member, Journal of Biological Chemistry. July 2007-2013. Editorial Board Member, Circulation Research July 2009-present. Investigador Nivel 3. Sistema Nacional de Investigadores, CONACyT, México. 2010-present. Chair, NIH Special Emphasis Panel, ZRG1-MOSS Study Section, Sept 2010. Chair, NIH Special Emphasis Panel, ZRG1-CVRS Study Section, January 2011. Chair, NIH Special Emphasis Panel, ZRG1-CVRS-E Study Section, November 2011. Permanent Member, NIH study section SMEP (Skeletal Muscle & Exercise Physiology). Oct 2011-

Oct 2017. Mentor, RO1 Boot Camp. University of Michigan, Ann Arbor. June 2012 to present. Ad hoc reviewer. NHLBI of the NIH. Special Emphasis Panel, April 2013. Ad hoc reviewer. Fellowship Review Panel for Musculo-skeletal, Oral and Skin Sciences (MOSS)

section of the NIH. March 24-25, 2015. Ad hoc reviewer. Board of Scientific Counselors, National Institute of Aging of the NIH. October

2015. Scientific Advisory Board Member, International Academy of Cardiology. Nov 2015-present.

Peer Reviewer for International Organizations: COLCIENCIAS, Consejo Nacional de Ciencias de Colombia ANII - Agencia Nacional de Investigación e Innovación de Uruguay ANR – Agence Nationale de la Recherche Francaise BHF – British Heart Foundation CFI – Canadian Foundation for Innovation HFSP – Human Frontiers Science Program SIIS – Societá Italiana de Investigazione Scientifica SNF – Swiss National Foundation ISF – Israel Science Foundation

Teaching:National University of Mexico 1980-1985 Instructor of Biochemistry (1st year Medical Students, 40-45 enrolled/semester)1985-1986 Lecturer of Biochemistry (1st year Medical Students, 48-50 enrolled/semester).

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University of Maryland-Baltimore 1992-1994 Seminar coordinator and discussion leader. Department of Physiology.

University of Wisconsin-Madison Oct.-Dec 1996 Lecturer: Physiology 335. Cardiovascular, Respiratory, Renal and Digestive

Systems (Undergraduate students. 526 enrolled).Feb.-May 1997 Lecturer: Physiology 901. Seminar Series: Excitation-contraction Coupling

(Graduate students. 5 enrolled). 1995-present Mentor, Undergraduate Independent Research Project: Paul R. Sander, Robert

B. Brusky, José Olvera, Molly Stepnick, Stacy Edling, Joshua Balts, Rory Makielski, Michael Tran, Holli Loomans. Undergraduate students. Various laboratory Projects.

Oct.-Dec 1999 Lecturer: Physiology 335. Cardiovascular, Respiratory, Renal and DigestiveSystems (Undergraduate students. 410 enrolled).

Feb-May 2001 Lecturer: Physiology 335. Cardiovascular, Respiratory, Renal and DigestiveSystems (Undergraduate students. 220 enrolled).

April 2002 Lecturer: Physiology 720. Digestive System Module (Medical School students, ~160 enrolled each year)

April 2003 Lecturer: Physiology 720. Digestive System Module (Medical School students, ~160 enrolled each year)

April 2004. Lecturer: Physiology 720. Digestive System Module (Medical School students, ~160 enrolled each year)

March-April 2004. Lecturer: Physiology 553. Heart Failure and Cardiac Excitation-contraction Module (Undergraduate students. 15 enrolled).

July 2004. Lecturer: Physiology 335. Cardiovascular, Respiratory, Renal and DigestiveSystems (Undergraduate students: 85 enrolled).

April 2005. Lecturer: Physiology 720. Digestive System Module (Medical School students, ~160 enrolled each year).

April 2006. Lecturer: Physiology 720. Digestive System Module (Medical School students, ~160 enrolled each year).

January 2007 Lecturer: Physiology 720. Muscle Physiology Module (Medical School students, ~160 enrolled each year)

April 2007 Lecturer: Physiology 720. Digestive System Module (Medical School students, ~160 enrolled each year).

January 2008 Lecturer: Physiology 720. Muscle Physiology Module (Medical School students, ~160 enrolled each year)

April 2008 Lecturer: Physiology 720. Digestive System Module (Medical School students, ~160 enrolled each year).

Sept 2008. Lecturer, Anatomy 710. Muscle Physiology Module (Medical School students, ~160 enrolled each year).

Feb.-May 2009 Course Coordinator: Physiology 901. Seminar Series: Store-operated Calcium Entry. (Physiology Graduate students. 4 enrolled).

Feb. 2009. Lecturer, Physiology 720. Digestive System Module (Medical School students, ~160 enrolled each year).

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Nov-Dec. 2009 Lecturer, Anatomy 710. Muscle Physiology Module (Medical School students, ~160 enrolled each year).

April 2010. Lecturer, Physiology 720. Digestive System Module (Medical School students, ~178 enrolled each year).

Nov-Dec 2010 Lecturer, Anatomy 710. Muscle Physiology Module (Medical School students, ~178 enrolled each year).

Jan-May 2011 Course Director, Physiology 720. (Human Physiology for 1st. year Med Students, 180 enrolled each year).

University of Michigan-Ann Arbor Nov. 2012 Lecturer. Lecture series: “Origin and conduction of the cardiac electrical

impulse” Cardiovascular Center of the University of Michigan. Course for EP Fellows (14 enrolled).

Nov. 2014 Lecturer. Lecture series: “Origin and conduction of the cardiac electrical impulse” Cardiovascular Center of the University of Michigan. Course for EP Fellows (14 enrolled).

June 2012-present Mentor, RO1 Boot Camp 1.0 and 2.0. University of Michigan. June 2012 to present.

Past and current trainees:Students: Carolina Arévalo. Graduate student of the Department of Physiology, UW-Madison. 1994-1998.

“Structural and functional analogies between Imperatoxin A and the II-III loop of the skeletal dihydropyridine receptor”. (Mentor and Thesis Committee member). She is today a Scientist in the University of Guatemala.

Ramki Nagarash. Graduate student, Department of Poultry Science, UW-Madison. 1995-1997. “effects of moniliformin, a fungal toxin, on the intracellular Ca2+ homeostasis of cardiac cells”. (Co-Mentor and Thesis Committee member). He is today a laboratory Scientist in a private research company in New York.

Xinsheng Zhu. Graduate student. Department of Physiology, UW-Madison. 1997-present. “Structure and function of ryanodine receptors of striated muscle” (Mentor). Currently Instructor in Harvard Medical School, Boston, MA.

Paul R. Sander (“Regulation of ryanodine receptors by sorcin”), Robert B. Brusky (“Effect of phosphorylation on the function of ryanodine receptors”) and Molly Stepnick (“Ligand-receptor interactions of the calcium release channel”). Undergraduate students. 1995 to 1998. UW-Madison. Independent Research Work. (Mentor).

José Olvera, Carlos Márquez and Tyanna Burroughs. Undergraduate students of the Minority Research Apprentice Program, UW-Madison. Summer fellowships 1996, 1997 and 1998, respectively. (Mentor).

Marchelle D’anna, Nicole Morales and John Rodríguez. Undergraduate students of the NASA Sharp Research Program. Summer fellowships 1996, 1997 and 1998, respectively. (Mentor). They are presently post-doctoral fellows in different Universities.

My Yang. Undergraduate student of the Chancellor Scholar Program. Mentor since 1997. Graduated from UW-Madison. Currently a fourth-year medical student at the UWSMPH.

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Emily F. Farrell. Graduate student of the Department of Physiology, UW-Madison. January 2000 to Sept 2007. (Mentor). Presently a post-doctoral fellow in the UWSMPH.

Beth Olbinski. Graduate student of the Department of Physiology. UW-Madison. March 2001 to Sept. 2008. (Mentor). Presently Instructor in the Department of Physiology of UW-Madison.

Hui Yu. Graduate student of the Department of Physiology, UW-Madison. March 2002 to Aug 2004. (Mentor). Presently in the University of Singapore.

Michael S. Hoffman. MD-PhD Student, UW-Madison. June 2003 to Aug 2003. (Mentor) and Sept 2004 to 2005 (Advisor). Presently in the School of Veterinary Medicine.

Joshua Balts and Emily Church. Undergraduate students of UW-Madison (Advisor). Sept 2007 to Sept 2008. Currently in Medical School (Balts) and Rush University (Church).

Michelle E. Capes. Graduate Student, Department of Physiology, UW-Madison. January 2006 to present (Thesis Director). Presently in my lab.

Randall Loaiza. Graduate Student, Department of Physiology, UW-Madison. July 2007 to present (Thesis Director). Presently in my lab.

Michael Oldenburg. Medical Student, Shapiro Scholar, UW-Madison. June-August 2009. (Mentor). Presently in Medical School.

Jonathan Hernández. Graduate student of Physiology, UW-Madison. Aug. 2010-present. (Thesis Director). Presently in my lab.

Francisco Alvarado. Graduate student of Molecular and Integrative Physiology, University of Michigan-Ann Arbor. Aug. 2011-present. (Thesis Director). Presently in my lab.

Xi Chen. Graduate student of Molecular and Integrative Physiology, University of Michigan-Ann Arbor. Aug. 2011-present. (Thesis Director). Presently in my lab.

Liang Xiao. Graduate student of the Second Military School, Shanghai, China and of the Graduate Program in Molecular and Integrative Physiology, University of Michigan-Ann Arbor. Nov. 2012-present. (Thesis Director). Presently a postdoctoral fellow in Shanghai, CHINA.

Peter Warren, BSc. Pre-medical school graduate student, aspiring MD/PhD student. (Mentor). Presently in medical school.

Sharon Szabo & Edgar Ocotl. Undergraduate Summer Research Program (SURP) students. (Mentor). Summer of 2016. Presently in my lab.

Post-doctoral: Andrew J. Lokuta, PhD. Assistant Scientist. 1994-present "Effect of cyclic ADP-ribose in sea urchin

egg ryanodine receptors". (Mentor). Currently Instructor in the Department of Physiology, UW-Madison.

Bradley J. Martin, PhD. Postdoctoral Fellow. 1996-1998. “Ryanodine receptor alterations in stunned myocardium”. (Mentor). Program Director, Michigan Life Sciences Translation and Commercialization Program, University of Michigan. Ann Arbor, MI.

Ming-Tao Jiang, PhD. Research Associate. 1996-present. “Sarcoplasmic reticulum calcium transport in heart failure”. (Mentor). Presently a Research Assistant Professor at Medical College of Wisconsin, Milwaukee, WI.

Hirochika Komai, PhD. Associate Scientist. 1996-present. “Effect of volatile anesthetics on calcium transport metabolism”. (Mentor). Presently retired.

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Timothy Connelly, MD. Assistant Professor. 1994-1996. “Photoactivatable ryanodine and the kinetics of blockade of cardiac ryanodine receptor”. (Collaborator). Presently an Associate Professor at St. Mary’s Hospital in Madison.

Georgina Gurrola, PhD and Fernando Zamudio, PhD. Visiting Scientists 1996-1997, 2003-2004, and 2012-2013. “Molecular determinants of excitation-contraction coupling”. (Collaborator). Drs. Gurrola and Zamudio are Associate and Assistant Professor, respectively, of the Department of Protein Structure and Molecular Recognition in Cuernavaca, Mexico.

Prakash Narayan, PhD. Research Associate. 1996-1997. “Effect of diacylglycerol derivatives on the intracelular calcium transients of cardiac cells”. (Co-Mentor). Currently a Research Assistant Professor in the Department of Surgery, University of Kentucky, Lexington, KY.

Anaid Antaramian, PhD. Research Associate. 2000-2002. “Structural domains of ryanodine receptors critical for calcium modulation”. (Mentor). Presently an Associate Professor at UNAM-Querétaro.

Angélica Rueda, PhD. Research Associate. 2002-2007. "Role of sorcin in excitation-contraction coupling of smooth muscle". (Mentor). Presently an Assistant Professor in CIVESTAV, México City, México.

Emily F. Farrell, PhD. Research Associate, 2004-present. “Sorcin modulation of cardiac excitation-contraction coupling” (Mentor). Presently a Postdoctoral Fellow in the Department of Medicine, UW-Madison.

Gerardo García-Rivas, PhD. Research Associate, 2006-2008. “Molecular mechanisms of Ca2+-dependent arrhythmias in animal models of heart failure”. (Mentor). Presently an Assistant Professor in the Tecnológico de Monterrey, Monterrey, México.

Carolina Moller, PhD. Assistant Scientist, 2010-2011. “Calcins as membrane-permeable ligands of Ryanodine Receptors”. (Mentor). Presently at the University of Florida.

Michelle E. Capes, PhD. Postdoctoral fellow, Department of Physiology, UW-Madison. May 2010 to Jan 2012. (Mentor). Presently a Research Associate at the University of Wisconsin-Madison..

Emmanuel Camors, PhD. Associate Scientist Intermediate, Department of Internal Medicine, Center for Arrhythmia Research, UM-Ann Arbor. May 2011 to present. (Mentor) Presently a postdoctoral fellow at the Cleveland Clinic, in Cleveland, OH.

Vandana Verma, PhD. Associate Scientist, Department of Internal Medicine, Center for Arrhythmia Research, UM-Ann Arbor. (Mentor) Presently in my lab.

Randall Loaiza. Research Associate, Department of Internal Medicine, UM-Ann Arbor. January 2012-present. Presently in my lab.

Yanting Zhao, PhD. Research Associate, Department of Internal Medicine, UM-Ann Arbor. November 2012-present. Presently in my lab.

Roberto Ramos-Mondragón, PhD. Research Associate, Department of Internal Medicine, UM-Ann Arbor. January 2013-2016. Presently a Research Associate at the University of Michigan.

Carmen R. Valdivia, MD, Associate Scientist, Department of Internal Medicine, Center for Arrhythmia Research, UM-Ann Arbor. (Mentor). January 2013-present. Presently in my lab.

Julieta Palomeque. MD. Visiting Professor from Universidad de La Plata, Argentina. Department of Internal Medicine, Center for Arrhythmia Research, UM-Ann Arbor. (Collaborator). July 2014- July 2015. Presently a Professor at the Universidad de La Plata.

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Angélica Rueda, PhD. Visiting Professor from CINVESTAV, México. Department of Internal Medicine, Center for Arrhythmia Research, UM-Ann Arbor. (Collaborator). July 2016- July 2017. Presently in my lab.

Supervised Staff: Nancy A Benkusky. Senior Laboratory Specialist, 2002-2011. (Employer). Presently in the

Department of Biochemistry, Univ. of Wisconsin. Craig Weber. Laboratory Specialist, 2005-2009. (Employer). Presently in the Univ. of Arizona-

Tucson. Joseph Sherman. Laboratory Specialist, 2006-2008. (Employer). Presently a Medical School Student

at Rush University (Chicago). Holli Loomans. Laboratory Specialist, 2009-2010. (Employer). Presently in the Physical Therapy

Masters Program of Houston Medical Center (Houston). Jessica Felton. Research Assistant. Aug 2010-2011. (Employer). Presently in the Department of

Neuroscience, Univ. of Wisconsin-Madison. Fang Liu. Associate Laboratory Specialist, 2011-2012. (Employer). Presently at the UW-Madison. Gaoussou Diarra. Associate Laboratory Specialist, 2011-2012. (Employer). Presently at the UW-

Madison. Li Cong. Assistant laboratory Specialist. 2012-2013. (Employer). Presently in my lab. Yan Chen. Assistant laboratory Specialist. 2013-present. (Employer). Presently in my lab. Sharon Szabo. Student hourly. 2015-present. (Employer). Presently in my lab. Dawn Henderlong. Student hourly. 2015-present. (Employer). Presently in my lab.

Thesis Committee: Anthony Tu. UTMB, Dept of Physiology and Biophysics. 1993-1996. (Thesis Committee) Andrew Lokuta. UMAB, Department of Biochemistry. 1993-1994. (Thesis Committee)

University of Wisconsin-Madison Carolina Arévalo. Department of Physiology. 1994-1998. (Main Thesis Advisor) Jeffery Morrissette. Department of Physiology. 1994-1996. (Thesis Committee) Xinsheng Zhu. UW-Madison, Department of Physiology. 1997-2002 (Main Thesis Advisor) Seth Robia. Department of Physiology. 1998-2002. (Thesis Committee) Thomas Nabhani. UI-Chicago, Department of Physiology. 1998-2003. (Thesis Committee) Valentin Robu. Department of Physiology. 1999-2003. (Thesis Committee) Risa Cohen. Department of Physiology. 1996-2003. (Thesis Committee). Emily Farrell. Department of Physiology. 2000-2005 (Main Thesis Advisor). Srinivasan P Venkatachalan. Department of Physiology. 2004-2009. (Thesis Committee). Amanda Farley. Department of Physiology. 2005-2009. (Thesis Committee). Beth Altschafel. Department of Physiology. 2004-2010 (Thesis Advisor). Brett Colson. Department of Physiology. 2006-2010. (Thesis Committee). Eric Lin. Department of Physiology. 2007-2011. (Thesis Committee). Jason Foell. Department of Medicine. 2007-2011 (Thesis Committee) Erick Schmuck. Department of Physiology. 2007-2010 (Thesis Committee)

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Debbie Capes. Department of Physiology. 2008-2012 (Thesis Committee) E. Michelle Capes. Department of Physiology. 2006-2011 (Main Thesis Advisor). Daryl O. Nelson. Department of Anatomy. 2008-2013 (Thesis Committee). Matthew Brody. Department of Anatomy. 2009-2013 (Thesis Committee). Mathew Locher. Department of Physiology. 2010-2012 (Thesis Committee). Peter Chen. Department of Physiology. 2006-2011 (Thesis Committee). Randall Loaiza. Department of Physiology. 2007-2012 (Main Thesis Advisor). Jonathan Hernández. Department of Physiology. 2010-2016 (Main Thesis Advisor).

University of Michigan Yangyang Bao. Department of Pharmacology. 2013-present (Thesis Committee). Xi Chen. Department of Molecular & Integrative Physiology. 2012-present (Main Thesis

Advisor). Francisco Alvarado. Department of Molecular & Integrative Physiology. 2012-present

(Main Thesis Advisor). Amelia Glazier. Department of Molecular & Integrative Physiology (Thesis Committee). Liang Xiao. Second Military Medical School, Shanghai, CHINA. Nov. 2012-Jan. 2015

(Thesis Co-Advisor).

Committee, Organizational, and Volunteer Service:Institutional: Grant Proposal Reviewer, Howard Hughes Scholar Fellowships, University of Wisconsin-Madison,

1997 and 1998. Mentor for Chancellor Scholars, NASA-Sharp Minority Students, and Research Apprentice

Program Students, 1997-Present. Interview Committee, UWSMPH, 1999-present. Member of the Search and Screen Committee for Associate Dean for Faculty. Nov. 1999 to March

2000. Admissions Committee Member, Graduate Program of Physiology, Department of Physiology.

2000 to 2004. Steering Committee Member, Medical Scientist Training Program, School of Medicine, 2001 to

2004. Admissions Committee Member, Medical Scientist Training Program, School of Medicine, 2001 to

2005. Faculty Senator, Department of Physiology, School of Medicine, January 2004-July 2007. Committee Member, Campus Diversity Recruiting and Retention, UW-Madison. May 2005-May

2007. Committee Member, Physiology Graduate Program External Review, UW-Madison, October 2005. Grant proposal reviewer. Wisconsin Institute of Discovery. February 2007. Director, Cardiovascular Research Center Conferences. July 2006-2012. Chair, Centennial Scholars Committee, Sept. 2008-2012. UW School of Medicine and Public Health Admissions Committee Member (Non-Resident

section), Sept. 2009-2012.

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Course Director, Physiology 720, (Human Physiology for 1st year Medical School students). August 2010-January 2012.

RO1 Boot Camp Mentor. University of Michigan Medical School. Six mentees under my supervision (and Dr. Robert Bartlett’s) to write and submit a RO1 proposal to NIH. Feb 2013-Feb 2014.

Chair, Search Committee for Endowed Chair in Cardiovascular Physiology. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor.

RO1 Boot Camp Mentor. University of Michigan Medical School. Six mentees under my supervision (and Dr. Daniel Lawrence’s) to write and submit a RO1 proposal to NIH. Feb 2014-Sept. 2015.

RO1 Boot Camp Mentor. University of Michigan Medical School. Six mentees under my supervision (and Dr. Eugene Chen’s) to write and submit a RO1 proposal to NIH. Feb 2015-Sept. 2016.

Consulting Positions: Consultant, Procter & Gamble Pharmaceuticals, 2003-2005.

Visiting Professorships, Seminars, and Extramural Invited Presentations:NATIONAL: Research Presentation: “Phosphorylation of airway epithelium chloride channels”. Second North

American Cystic Fibrosis Conference. Orlando, FL. October 1988. Department of Biophysics and Membrane Biochemistry of Merck Sharp and Dohme. Seminar

“Reconstitution and phosphorylation of chloride channels from airway epithelium” Rahway, NJ. June 1989.

Research presentation: “Mg2+ regulation of chloride channels from bovine airway epithelium” Third North American Cystic Fibrosis Conference. Tarpon Springs, FL. October 1989.

Seminar: “Abnormal regulation of ryanodine receptors in human malignant hyperthermia”. Department of Anesthesiology, University of Utah, Salt Lake City, UT. March 1992.

Invited speaker: “Scorpion toxins as novel ligands of ryanodine receptors” Department of Biological Chemistry of Burroughs-Wellcome Pharmaceutical Co., Research Triangle Park, NC. May 1992.

Seminar: “Novel ligands of ryanodine receptors”. Department of Physiology, University of Maryland Medical School, Baltimore, MD. February 1993.

Invited speaker: “Novel pharmacological ligands of ryanodine receptors”. 209th American Chemical Society Congress, San Diego, CA. March 1993.

Seminar: “Rapid adaptation of ryanodine receptors: regulation by Mg2+ and phosphorylation”. Department of Physiology, Loyola University, Chicago, IL. February, 1995.

Seminar: “Response of ryanodine receptors to rapid Ca2+ stimuli”. Department of Physiology and Biophysics, The Chicago Medical School, Chicago, IL. October 1995.

Héctor H. Valdivia July 2012 P a g e | 12

Research presentation: “Ryanodine receptor kinetics in response to fast Ca2+ stimuli”. 68th

Congress of the American Heart Association, Anaheim, CA. November 1995. Department of Molecular Physiology and Biophysics. Seminar “Molecular determinants of

excitation-contraction coupling”, Southwestern Medical Center, Dallas, TX. October 20, 1997. XX Meeting of the International Society for Heart Research. Invited speaker in the Symposium

“New Frontiers in Cardiovascular Research”. Ann Arbor, MI, August 11, 1998. Seminar: “Molecular determinants of excitation-contraction coupling in skeletal muscle”.

Department of Physiology and Biophysics, Rush University, Chicago, IL. October 5, 1998. Chairman of the Platform Session: Ryanodine receptors structure and function. 43rd Biophysical

Society Congress, Baltimore, MD, Feb. 17, 1999. Seminar: “Molecular determinants of excitation-contraction coupling in skeletal muscle”.

Department of Physiology and Biophysics, University of Illinois at Chicago. March 2, 1999. Seminar: “Region of the dihydropyridine receptor critical for activation of ryanodine receptors”.

Laboratory of Cardiovascular Science, NIH, Baltimore, MD. March 18, 1999. Seminar: “How do ryanodine receptor channels turn off?” Department of Molecular Physiology &

Biophysics, Baylor College of Medicine, Houston, Tx. May 9th, 2000. Invited speaker: Gordon Research Conference on “Muscle: excitation-contraction coupling”. New

London, NH, June 12, 2000. Seminar: “Activation of ryanodine receptors by Imperatoxin A”. Department of Molecular

Physiology & Biophysics, University of New York, Rochester, NY. Jan. 13th, 2001. Invited speaker: "Role of ryanodine receptors in heart failure". XIX Congress of the International

Society of Heart Research, Madison, Wi July 2002. Invited speaker: Gordon Research Conference on "Cardiac Regulatory Mechanisms". New London,

NH, August 4, 2002. Seminar: "Sorcin and ryanodine receptors in heart failure". Department of Physiology, Texas Tech

University, Lubbock, Tx. August 28, 2002. Seminar: "Sorcin and ryanodine receptors in heart failure". Department of Physiology, Loyola

University, Maywood, IL, October 23, 2002. Seminar: "Abnormal Ca2+ release, but normal ryanodine receptors, in heart failure". Procter &

Gamble Pharmaceuticals, Cincinnati, Ohio, Feb. 19, 2003. Session Leader: "Accessory Proteins of Ryanodine Receptors". Gordon Conference on Skeletal

Muscle: Excitation-contraction Coupling. New London, NH, June 8-13, 2003. Invited Speaker: "Ryanodine Receptors in Heart Failure". Heart Failure Society of America

Conference. Las Vegas, NV, Sept. 23, 2003. Seminar: "Sorcin modulation of cardiac E-C coupling". University of Washington at Seattle. Feb.

24, 2004. Seminar: “Modulation of cardiac excitation-contraction coupling by sorcin”. Department of

Physiology and Molecular Biophysics, Ohio State University. June 11, 2004. Seminar: “Modulation of Cardiac Ryanodine Receptors by Sorcin”. Department of Pharmacology

and Molecular Genetics, University of Cincinnati, Nov 2, 2005.

Héctor H. Valdivia July 2012 P a g e | 13

Seminar: “Sorcin and other quenching mechanisms of CICR”. Department of Physiology and Mol Biophysics, University of Medicine and Dentistry of New Jersey, Nov. 4, 2006.

Seminar: “Cell-penetrating scorpion peptides”. Department of Pharmacology and Physiology of University of Arizona, Phoenix, AZ. March 22, 2007.

Invited Speaker: “Molecular Mechanisms of Ryanodine Receptor-Initiated Arrhythmias”. Experimental Biology Congress. San Diego, CA, April 9, 2008.

Late-breaking Science Presenter: “Intact -adrenergic response and progression towards heart failure in mice with genetic ablation of a major PKA site in the cardiac ryanodine receptor”. Congress of the International Society for Heart Research. Cincinnati, OH, June 13, 2008.

Invited Speaker. “Controversies on Ryanodine Receptor Regulation”. Satellite Meeting, Biophysical Society Congress. Boston, MA, Feb. 2009.

Oral Presenter: “A CPVT-associated RYR2 mutation produces a highly arrhythmogenic phenotype”. Biophysical Society Congress. Boston, MA, Feb. 2009.

Invited Speaker: “Increased ventricular automaticity in mice with genetic ablation of Sorcin, a Calcium binding protein that modulates excitation-contraction coupling”. Calcium Symposium. Merced, CA. March 2010.

Invited Speaker: “Mutations in the ryanodine receptor associated with ventricular arrhythmias and sudden death”. University of Iowa, Iowa City, IA, May 2010.

Invited Speaker: “Sorcin, a Calcium binding protein that modulates excitation-contraction coupling in heart”. George Washington University, Washington DC. Sept. 2010.

Invited Speaker: “Increased ventricular automaticity in mice with ablation of sorcin, a calcium binding protein that modulates excitation-contraction coupling in heart”. Center for Arrhythmia Research, University of Michigan, Ann Arbor, Nov. 2010.

Invited Speaker: “Arrhythmia Mechanisms in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia”. CCV Conference, UW-Madison, Dec. 2011.

Invited Speaker: “Arrhythmia Mechanisms in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia”. CVC Conference, UM-Ann Arbor. April 2012.

Invited Speaker: “Mutations in the Ryanodine Receptor Associated with Ventricular Arrhythmias and Sudden Cardiac Death”. Gordon Research Conference on Cardiac Regulatory Mechanisms. New London, NH. June 2012.

Invited Speaker: “Mutations in the Ryanodine Receptor Associated with Ventricular Arrhythmias and Sudden Cardiac Death”. Department of Molecular Biophysics and Physiology, Louisville, KY. October 2012.

Invited Speaker: “State of ryanodine receptor regulation in 2012”. American Heart Association Scientific Sessions, Los Angeles, CA, November 2012.

Invited speaker: “Calcium-dependent arrhythmias and ryanodine receptors”. Doris Day Institute of Cardiology, Ohio State University, Columbus, OH. April 2013.

Invited speaker: “Marching to the beat of the calcium drum: ryanodine receptor mutations associated with ventricular fibrillation and sudden death”. Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, VA. May 2013.

Héctor H. Valdivia July 2012 P a g e | 14

Invited speaker: “Regulation of the heart beat at supraphysiological pacing”. World Congress of the International Society for Heart Research. San Diego, CA, July 2013.

Invited speaker: “Marching to the beat of the calcium drum: mechanisms of cardiac arrhythmias in mice with gain- and loss-of-function ryanodine receptor mutations”. Cardiac Physiome Workshop, Bar Harbor, Maine. October 2013.

Invited speaker: “Natural Peptides as Antiarrhythmic Therapy for Calcium-dependent Arrhythmias”. Gordon Research Conference on Muscle: Excitation-contraction Coupling. Newry, Maine, June 2015.

Ross McIntire Lecturer: “Natural Peptides as Antiarrhythmic Therapy for Calcium-dependent Arrhythmias”. University of Nebraska, Omaha. April 7, 2016.

INTERNATIONAL: Invited speaker: “Abnormal regulation of ryanodine receptors in human malignant

hyperthermia”. VII International Congress in Neuromuscular Diseases, Munich, GERMANY. September 1990.

Invited speaker: “Pharmacological regulation of ryanodine receptors of striated muscle”. VII International Congress of the Pan-American Biochemical Societies, Ixtapa, MEXICO. September 1992.

Invited speaker: “Activation of ryanodine receptors by flash photolysis of caged calcium”. XXIII Congress of the Mexican Physiological Society, Acapulco, MEXICO, August 1993.

Invited speaker: “Regulation of ryanodine receptor by calcium and accessory proteins”. XXXIX Congress of the Mexican Physiological Society, Puebla, MEXICO. September 1996.

Invited speaker in the Symposium “Dynamics of Contraction in Cardiac and Skeletal Muscle”, National University of Mexico, MEXICO, April 1997.

Invited speaker in the Symposium “Single Cell Techniques in Signal Transduction Research”, FEBS Advance Course. Leiden, THE NETHERLANDS. May 3-10, 1997.

III Congress of the Iberoamerican Society of Biophysicists. September 20 to 25, 1997. Buenos Aires, ARGENTINA. Winner of the Award “Best Paper from a Young Latin American Scientist”.

International Heart Research Conference. Invited speaker in the Symposium “Calcium in small quarters - Microdomain Ca2+ signaling in the control of cardiac contraction”. Rhodes, GREECE, May 28, 1998.

Invited speaker. VI National Meeting of the Mexican Society of Arterial Hypertension. President-Intercontinental Hotel. Mexico City, MEXICO. May 25 1998.

XVIII Congress of Nephrology. Plenary conference on “Molecular basis of cardiac hypertrophy”. National Institute of Cardiology, Mexico City, MEXICO, July 17 of 1998.

International Meeting “Pathophysiology of Stunning, Hybernation and Preconditioning". Taormina, Sicily, ITALY. October 17-19, 1998. Winner of the Young Investigator Travel Prize.

Invited speaker. “Regulación de los receptors de rianodina por fosforilación y defosforilación” XXXII National Congress of the Mexican Biochemistry Society. November 1-3, 1998. Merida, MEXICO.

Héctor H. Valdivia July 2012 P a g e | 15

Invited speaker. International Meeting: “Channel pathophysiology”. November 13-14, 1998. University of Concepción and University of Chillán, CHILE.

Invited speaker. II Symposium on Muscle Physiology. School of Medicine, National University of Mexico. Mexico City, MEXICO, November 16-19, 1998.

Seminar: “Mecanismos que cierran el receptor de rianodina cardiaco”. CINVESTAV del IPN, Mexico City, MEXICO. April 12th, 2000.

Seminar: “Modulación del receptor de rianodina por factores citosólicos”. Universidad Autonoma de San Luís Potosí, MEXICO. April 16th, 2000.

Seminar: “Determinantes moleculares del acoplamiento excitación-contracción en músculo esquelético y cardíaco”. Instituto de Biotecnología, Cuernavaca, MEXICO, June 13th, 2001.

Seminar: "Sorcin and ryanodine receptors in heart failure". INSERM U-309, Montpellier, FRANCE, September 15, 2002.

Seminar: "Sorcin and ryanodine receptors in heart failure". Universitá "La Sapienza", Rome, ITALY. September 20, 2002.

Invited speaker: "Sorcin and ryanodine receptors in heart failure". Symposium on Calcium Signaling in skeletal, cardiac and smooth muscle. National University of Mexico, Mexico City. MEXICO, May 7, 2003.

Invited Speaker: "Sorcin modulation of cardiac E-C coupling". Calcium Signaling Workshop. Marbella, CHILE. Sept. 30, 2003.

Seminar: "Bases Moleculares de la Insuficiencia Cardiaca". University of Bio-Bio, Chillán, CHILE. Oct. 6, 2003.

Plenary Session speaker: "Bases moleculares de la insuficiencia cardiaca". National Institute of Cardiology. Mexico City, MEXICO. April 20, 2004.

Invited Speaker: "β-adrenergic modulation of cardiac ryanodine receptors". Scandinavian Physiological Society. Lundsbrun, SWEDEN, May 9, 2004.

Invited speaker: "β-adrenergic modulation of cardiac ryanodine receptors". International Society for Heart Research, Latin American Section Congress. Iguazú, ARGENTINA, Aug. 4, 2004

Invited speaker: "β-adrenergic modulation of cardiac ryanodine receptors". International Society for Heart Research, International Congress. Brisbane, AUSTRALIA Aug. 18, 2004.

Invited speaker: "Modulación del Receptor de Rianodina por Proteínas Accesorias”. Primer Congreso Unido de Sociedades Biomédicas Argentinas. Mar del Plata, ARGENTINA. Nov. 20, 2004.

Seminar: Modulación del receptor cardíaco de rianodina por sorcina”. La Plata, ARGENTINA, Nov. 24, 2004.

Symposium: “Peptide Toxins of Ryanodine Receptors”. 1st International Meeting on “Novel Therapeutics for Heart Disease”. Herzliya, ISRAEL. January 20-24, 2006.

Invited speaker. XVI Congress of the International Society for Heart Research. Toronto, CANADA, June 2006.

Invited speaker: “Péptidos penetrantes de membrana: nuevos mecanismos para matar a una célula”. Instituto de Neurobiología. Querétaro, MEXICO. June 2, 2006.

Héctor H. Valdivia July 2012 P a g e | 16

Invited speaker: “Novel mechanisms to kill a cell: the cell-penetrating properties of selected scorpion toxins”. International Meeting of the Protein Society. Acapulco, MEXICO, Nov. 10, 2007.

Honorary Speaker: “Mutaciones en el Receptor de Ryanodina que Provocan Arritmias Cardiacas”. (In Spanish) Universidad de Bío-Bío, Chillán, CHILE. December 4, 2008.

Lecturer: Mini-Course on Muscle Physiology and Physiology of Exercise. Universidad del Bío-Bío, Campus Chillán, CHILE. December 5, 2008.

Invited Speaker: “Cardiac Ryanodine Receptors and Catecholaminergic Polymorphic Ventricular Tachycardia”. International Congress on Meso-Science. Kyoto, JAPAN. January 2009.

Invited Speaker: “Calcins: high affinity scorpion peptides targeted against ryanodine receptors”. International Congress of Toxinology. Recife, BRAZIL. March 2009.

Lecturer: Mini-Course “Biodiversity in Toxins: Tools for Biological Research and Drug Development”. University of Brasilia, BRAZIL. March 23-28, 2009.

Plenary Lecturer: “Ryanodine receptor mutations associated with ventricular arrhythmias and sudden death” Congreso de Cardiología del Tec de Monterrey, Monterrey, MEXICO, August 2009.

Invited Speaker: “Increased ventricular automaticity in mice with genetic ablation of Sorcin, a Calcium binding protein that modulates excitation-contraction coupling”. V International Congress on Calcium Binding Proteins. Pucón, CHILE. November 2009.

Invited Speaker: “Mutaciones en el receptor de rianodina asociadas con ventricular arritmias y muerte súbita”. Instituto de Biotecnología, UNAM, Cuernavaca, MEXICO March 2010.

Invited Speaker: “Mutaciones en el receptor de rianodina asociadas con arritmias ventriculares y muerte súbita”. Instituto de Fisiología, UNAM, Mexico City, MEXICO April 2010.

Invited Speaker: “Toxinas de alacrán dirigidas al receptor de rianodina: nueva (e ingeniosa) manera de matar a una célula”. CINVESTAV, Mexico City, MEXICO March 2010.

Invited Speaker: “Increased ventricular automaticity in mice with ablation of sorcin, a calcium binding protein that modulates excitation-contraction coupling in heart”. II Congress on Cardiology, Monterrey, MEXICO August, 2010.

Invited Speaker: “Calcinas – Ligandos permeables del Receptor de Rianodina”. Instituto de Biotecnología, UNAM. Cuernavaca, Morelos, MEXICO August 31, 2011.

Invited Speaker: “Arrhythmia Mechanisms in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia”. South China Cardiology Congress, Guangzhou, CHINA. April 2012.

Invited Speaker: “Arrhythmia Mechanisms in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia”. Department of Physiology, University of Calgary, CANADA, May 2012.

Session Leader: “Cardiac Excitation-Contraction Coupling” Gordon Research Conference on Muscle: E-C coupling. Les Diablerets, SWITZERLAND. June 2012.

Invited Speaker: “Calcium-dependent arrhythmias in a mouse model of CPVT”. XXVI Congress of the Federation of European Physiological Societies, Santiago de Compostela, SPAIN. Sept. 2012.

Invited Speaker: “Mutaciones en el Receptor de Ryanodina Asociadas con Arritmias Ventriculares y Muerte Súbita”. IV Congreso de Cardiología, Monterrey, Nuevo León, MEXICO. October 2012.

Héctor H. Valdivia July 2012 P a g e | 17

Fulbright Specialist. Three-week theoretical and practical course: “Function and regulation of Ryanodine Receptors in Physiological and Pathophysiological Settings”. La Plata, ARGENTINA. April 2014.

Invited speaker: “Calcium-dependent arrhythmias due to ryanodine receptor dysfunction”. University of Peking, Beijing, CHINA. July 2, 2014.

Keynote Speaker: “Marching to the beat of the calcium drum: mechanisms of cardiac arrhythmias in mice with ryanodine receptor gain- and loss-of-function mutations”. 10th Chinese Symposium on Calcium Signaling. Yichun, Jiangxi Province, CHINA. July 3-6, 2014.

Invited speaker: “Propiedades antiarrítmicas de calcinas, una familia de péptidos derivada de veneno de escorpiones”. Instituto de Biotecnología, UNAM. Cuernavaca, MEXICO. February 2015.

Keynote speaker: “Arrhythmogenic Mechanisms in Cathecolaminergic Polymorphic Ventricular Tachycardia”. Conference of the European Working Group of Cardiac Electrophysiology. Milan, ITALY, June 23, 2015.

Invited speaker: “Arrhythmogenic Mechanisms in Cathecolaminergic Polymorphic Ventricular Tachycardia”. Department of Physiology, University of Bern, SWITZERLAND. June 26, 2015.

Invited speaker: “Anti-arrhythmic Properties of Natural Peptides that target Ryanodine receptors”. Center for Cell Signaling and Cardiovascular Physiology, Université du Paris-d-Sud, Paris, FRANCE, June 30, 2015.

Keynote speaker: “Mecanismos que generan arritmias en Taquicardia Ventricular Polimórfica y Catecolaminérgica”. Conferencia de la Sociedad Mexicana de Fisiología, San Miguel Allende, MEXICO, September 8, 2015.

Invited speaker: “Péptidos naturales y agonistas del receptor de rianodina con propiedades anti-arrítmicas”. Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, MEXICO, September 10, 2015.

Invited speaker: “Increased ventricular automaticity in mice with genetic ablation of Sorcin, a Ca2+

binding protein that modulates excitation-contraction coupling in heart”. Institute for Translational Research, Imperial College, London, ENGLAND, October 1, 2015.

Fulbright Specialist. Four-week theoretical and practical course: “Función y regulación del Receptor de Rianodina en la fisiología y patología cardiaca”. CINVESTAV, México City; MEXICO. February 2016.

Invited speaker: “Péptidos naturales y agonistas del receptor de rianodina con propiedades anti-arrítmicas”. CINVESTAV, México City; MEXICO. February 20, 2016.

Invited speaker: “Péptidos naturales y agonistas del receptor de rianodina con propiedades anti-arrítmicas”. Instituto de Cardiología, México City; MEXICO. February 22, 2016.

Invited speaker: “Regulation and Dysregulation of Ryanodine Receptors”. World Congress of the International Society for Heart Research. Buenos Aires, ARGENTINA. April 18, 2016.

Invited speaker: ”Scorpions, snakes, insecticides and coffee: insights into the genesis of ventricular arrhythmias” Sudden Death Symposium – Insespital, Bern, SWITZERLAND. October 20, 2016.

University of Wisconsin - Research Presentations:

Héctor H. Valdivia July 2012 P a g e | 18

Department of Physiology, Medical School. Physiology Department Seminar Series. December 14 1995, December 10, 1997, and October 23, 1998.

Department of Physiology, Medical School. Graduate Students Semi-annual meeting. November 1994.

Department of Surgery, UW-Hospital. Department of Surgery Seminar Series. February 1995. Cardiovascular Research Center, Medical School. Heart Failure Journal Club. December 3, 1998,

and April 6, 2000. Cardiovascular Research Conference Series. “The Failing of E-C coupling in Heart Failure”.

December 12th, 2000 and January 16th, 2001. Faculty Presentations. Department of Physiology. “Sorcin modulation of cardiac e-c coupling”.

June 2004. Faculty Presentations. Department of Physiology. “Cell-penetrating peptides and Ryanodine

Receptors”. September 2006. Lecture, National Youth Leadership Forum. “Physiology of Muscle”. HSLC, July 12, 2009. Department of Physiology. “Scorpion Toxins with Cell-penetrating capacity: new (and ingenious)

ways to derange Ca2+ homeostasis”. May 2010.

University of Michigan - Research Presentations: Department of Molecular and Integrative Physiology. Seminar: “Calcins as membrane-permeable

ligands of Ryanodine Receptors” September 2011. Cardiovascular Medicine Grand Rounds. Seminar: “Arrhythmogenic Mechanisms in Mice with

Catecholaminergic Polymorphic Ventricular Tachycardia”. April 2012. Cardiac Electrophysiology course for CVC Fellows: Cellular mechanisms of Ca2+-dependent

arrhythmias. November 2012. Cardiac Electrophysiology course for CVC Fellows: Ionic basis of Sinoatrial node action potential.

November 2013. Cardiac Electrophysiology course for CVC Fellows: Ionic basis of Sinoatrial node action potential.

November 2014. Department of Internal Medicine Grand Rounds. Seminar: “Natural Peptides that target

ryanodine receptors with anti-arrhythmic properties”. July 24, 2015. Center for Arrhythmia Research Seminars: “Natural Peptides as Antiarrhythmic Therapy for

Calcium-dependent Arrhythmias”. December 4, 2015. Grand Rounds Seminars, Frankel CVC: ”Scorpions, snakes, insecticides and coffee: insights into the

genesis of ventricular arrhythmias” . May 2016.

Patents: Pluripotent Stem Cells for Drug Induced Myopathy and Malignant Hyperthermia. K. Hogan and

H.H. Valdivia, applicants. 31543/US-1/PRO Antiarrhythmic Drugs based on Natural Peptides. H.H. Valdivia and Liang Xiao, applicants.

Bibliography:Google Scholar: http://scholar.google.com/citations?user=yebc6A8AAAAJ&hl=en # of citations to date: 6784.

Héctor H. Valdivia July 2012 P a g e | 19

h-index: 45i10-index: 90

Refereed Journal Papers & Reviews:1. Valdivia HH, Dubinsky WP, Coronado R (1988). Reconstitution and Phosphorylation of Chloride

Channels from Airway Epithelium. Science 242:1441-1444.

2. Valdivia HH, Smith JS, Martin BM, Coronado R, Possani LD (1988). Charybdotoxin and Noxiustoxin, two homologous peptide inhibitors of the K (Ca) channel. FEBS Letters: 226:280-284.

3. Valdivia HH, Coronado R (1989). Inhibition of Dihydropyridine-sensitive Calcium Channels by the Plant Alkaloid Ryanodine. FEBS Letters 244:333-337.

4. Prestipino G, Valdivia HH, Liévano A, Darszon A, Ramírez A, Possani LD (1989). Purification and Reconstitution of Potassium Channel Proteins from Squid Axon Membranes. FEBS Letters 250:570-574.

5. Valdivia HH, Coronado R (1990). Internal and External Effects of Dihydropyridines in the Calcium Channel of Skeletal Muscle. J Gen Physiol 95:1-27.

6. Valdivia CR, Valdivia HH, Potter BL, Coronado R (1990). Calcium Release by 1,4,5-Triphosphorothioate in Triad Junctions of Skeletal Muscle. Biophys J 57:1233-1243.

7. Valdivia HH, Valdivia CR, Ma J, Coronado R (1990). Direct Binding of Verapamil to the Ryanodine Receptor of Skeletal Muscle. Biophys J 58:471-481.

8. Coronado R, Kawano S, Lee C, Valdivia C, Valdivia HH (1990). Planar Bilayer Recording of Ryanodine Receptors of Sarcoplasmic Reticulum. Meth Enzymol 207:699-707.

9. Valdivia HH, Hogan K, Coronado R. (1991) Altered binding site for Ca2+ in the ryanodine receptor of human malignant hyperthermia. Am J Physiol 261 (Cell Physiol. 30):C237-C245.

10. McPherson PS, Kim YK, Valdivia HH, Knudson CM, Takekura C, Franzini-Armstrong C, Coronado R, Campbell KP (1991) The Brain Ryanodine Receptor: a Caffeine-sensitive Calcium Release Channel. Neuron 7:17-25.

11. Valdivia HH, Fuentes O, El-Hayek R, Morrissette J, Coronado R (1991). Activation of the Ryanodine Receptor Calcium Release Channel of Sarcoplasmic Reticulum by a Novel Scorpion Venom. J. Biol Chem 266:19135-19138.

12. Valdivia HH, Kirby MS, Lederer WJ, Coronado R (1992). Scorpion Toxins Specifically Targeted Against the Calcium Release Channel of Cardiac and Skeletal Muscle. Proc Natl Acad Sc (USA) 89:12185-12189.

13. Valdivia HH, Martin BM, Escobar L, Possani LD (1992). Noxiustoxin and Leiurustoxin III, Two Homologous Peptide Inhibitors of Ca-dependent K+ Channels. Biochem Internat 27:953-962.

14. El-Hayek R, Parness J, Valdivia HH, Coronado R, Hogan K (1992). Dantrolene and Azumolene Inhibit [3H]PN200-110 Binding to Porcine Skeletal Muscle Dihydropyridine Receptor. Biochem Biophys Res Commun 187:894-900.

Héctor H. Valdivia July 2012 P a g e | 20

15. Kim Y-K, Valdivia HH, Marion EB, Anderson P, Coronado R (1992). High molecular weight proteins in the nematode C. elegans bind [3H]ryanodine and form a large conductance channel. Biophys J 63:1379-1384.

16. El-Hayek R, Valdivia C, Valdivia HH, Hogan K, Coronado R (1993). Activation of the calcium release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine. Biophys J 65:779-789.

17. Fuentes O, Vaughan D, Valdivia C, Coronado R, Valdivia HH, (1994). Calcium Dependent Block of Ryanodine Receptor Channel of Skeletal Muscle by Direct Binding of Calmodulin. Cell Calcium 15:305-316.

18. Valdivia HH, Martin B, Ramirez A, Fletcher P, Possani LD (1994). Isolation and pharmacological characterization of four novel Na channel-blocking toxins from the scorpion C. noxius. Biochem J 116:1383-1391.

19. O'Brien J, Valdivia HH, Block B (1995). Physiological differences between the and ß ryanodine receptors of fish skeletal muscle. Biophys J 68:471-482.

20. Valdivia HH, Kaplan JL, Ellis-Davies GCR, Lederer WJ (1995). Rapid adaptation of cardiac ryanodine receptors: modulation by Mg2+ and phosphorylation. Science 267:1997-2000.

21. Cheng H, Fill M, Valdivia HH, Lederer WJ (1995). Models of Ca2+ release channel adaptation. Science 267:2009-2010.

22. Lokuta AJ, Rogers TB, Lederer JW, Valdivia HH (1995). Modulation of cardiac ryanodine receptors by a phosphorylation/dephosphorylation mechanism. J Physiol (Lond) 487(3):609-622.

23. El-Hayek R, Lokuta AJ, Arévalo C and Valdivia HH (1995). Peptide Probe of Ryanodine Receptor Function. J Biol Chem 270:29696-28704.

24. Zamudio F, Gurrola GB, Arévalo C, Sreekumar R, Walker J, Valdivia HH, Possani LD (1997). Primary structure and synthesis of Imperatoxin A (IpTxa), a peptide activator of Ca2+ release channels/ryanodine receptors. FEBS Letters 405:385-389.

25. Zamudio F, Conde R, Arévalo C, Becerril B, Valdivia HH, Possani LD (1997). The mechanism of blockade of ryanodine receptor channel by Imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperator. J Biol Chem. 272:11886-11894.

26. Gómez AM, Valdivia HH, Cheng H, Lederer M, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ (1997). Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science 276:800-806.

27. Xiao R-P, Valdivia HH, Bogdanov K, Valdivia C, Lakatta E, Cheng H (1997). Termination of Ca2+

induced Ca2+ release by the immunophilin FK506-binding protein. J Physiol. (Lond) 500:343-354.

28. Valdivia C, Hegge JO, Lasley RD, Valdivia HH, Mentzer R (1997). Ryanodine receptor dysfunction in porcine stunned myocardium. Am J Physiol 273: (Heart Circ. Physiol. 42):H796-H804.

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29. Lokuta AJ, Meyers MB, Sander PR, Fishman G, Valdivia HH (1997). Modulation of cardiac ryanodine receptors by sorcin. J Biol Chem 272:25333-25338.

30. Martin BJ, Valdivia HH, Bünger R, Lasley RD, Mentzer RD, Jr. (1998) Pyruvate augments calcium transients and cell shortening in rat ventricular myocytes. Am J Physiol 274 (Heart Circ. Physiol. 43):H8-H17.

31. Trypathy A, Resch W, Xu L, Valdivia HH, Meissner G (1998). Imperatoxin A induces subconductance states in Ca2+ release channels (ryanodine receptors) of cardiac and skeletal muscle. J Gen Physiol 111:679-690.

32. Narayan P, Valdivia HH, Mentzer RM, Jr, Lasley RD (1998). Adenosine A1 receptor stimulation antagonizes the negative inotropic effects of the PKC activator dioctanoylglycerol. J Mol Cell Cardiol 30:913-921.

33. Lokuta AJ, Beltrán C, Darszon A, Valdivia HH (1998). Detection and functional characterization of ryanodine receptors of sea urchin eggs. J Physiol (Lond.) 510:155-164.

34. Lasley RD, Martin BJ, Valdivia HH, Mentzer RM Jr, Bunger R. (1998) Metabolic inotropy and calcium transients in isolated rat cardiomyocytes. Ann. N. Y. Acad. Sci. 853:308-10.

35. Valdivia HH, Possani LD. (1998) Scorpion peptides as probes of ryanodine receptor structure and function. Trends in Cardiovascular Medicine 8:111-118.

36. Valdivia HH (1999). Modulation of intracellular calcium levels in heart by sorcin and FKBP12, two accessory proteins of ryanodine receptors. Trends Pharmacol Sc 19:479-482.

37. Gurrola GB, Arévalo C, Sreekumar R, Lokuta AJ, Walker JW, Valdivia HH (1999). Activation of ryanodine receptors by Imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor. J Biol Chem 274:7879-7886.

38. Zhu X, Gurrola G, Jiang MT, Walker JW, Valdivia HH (1999). Conversion of an inactive cardiac dihydropyridine receptor II-III loop segment into forms that activate skeletal ryanodine receptors. FEBS Letters 450:221-226.

39. Samsó M, Trujillo R, Gurrola GB, Valdivia HH, Wagenknecht T (1999) Three-dimensional location of the Imperatoxin A binding site on the ryanodine receptor. J Cell Biol 146:493-499.

40. Shtifman A, Ward CW, Wang J, Valdivia HH, Schneider MF (2000) Effects of Imperatoxin A on local sarcoplasmic reticulum Ca2+ release in frog skeletal muscle. Biophys J 79:814-827.

41. Hayek SM, Zhu X, Bhat MB, Zhao J, Takeshima H, Valdivia HH, Ma J. (2000). Biochemical and functional characterization of a Ca2+ regulatory domain of the skeletal muscle ryanodine receptor. Biochem J 351:57-65.

42. Li PL, Tang WX, Valdivia HH, Zou AP, Campbell WB (2001). cADP-ribose activates reconstituted ryanodine receptors from coronary arterial smooth muscle. Am J Physiol (Heart Circ Physiol) 280(1):H208-215.

43. Valdivia HH (2001). Cardiac ryanodine receptors and accessory proteins. Augmented expression does not necessarily mean big function. Circ. Res. 88:134-136.

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44. Simeoni I, Rossi D, Zhu X, Garcia J, Valdivia HH, Sorrentino V. (2001) Imperatoxin A (IpTxa) from Pandinus imperator stimulates [3H]ryanodine binding to RyR3 channels. FEBS Letters 508(1):5-10.

45. Shtifman A, Ward CW, Yamamoto T, Wang J, Olbinski B, Valdivia HH, Ikemoto N, Schneider MF. (2002) Interdomain Interactions within Ryanodine Receptors Regulate Ca2+ Spark Frequency in Skeletal Muscle. J Gen Physiol 119:15-32.

46. Lokuta AJ, Komai H, McDowell TS, Valdivia HH (2002) Functional properties of ryanodine receptors from rat dorsal root ganglia. FEBS Lett 511:90-96.

47. Nabhani T, Zhu X, Simeoni I, Sorrentino V, Valdivia HH, Garcia J (2002) Imperatoxin A enhances Ca2+ release in developing skeletal muscle containing ryanodine receptor type 3. Biophys J 82:1319-1328.

48. Terentyev D, Viatchenko-Karpinski S, Valdivia HH, Escobar AL, Gyorke S. (2002) Luminal Ca2+

controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes. Circ Res 91:414-20.

49. Jiang MT, Lokuta AJ, Farrell EF, Wolff MR, Haworth RA, Valdivia HH (2002) Abnormal Ca2+

release, but normal ryanodine receptors, in canine and human heart failure. Circ Res 91:1015-22.

50. Plank DM, Yatani A, Ritsu H, Witt S, Glascock B, Lalli MJ, Periasamy M, Fiset C, Benkusky N, Valdivia HH, Sussman MA. (2003) Calcium dynamics in the failing heart: restoration by β-adrenergic receptor blockade. Am J Physiol [Heart Circ Physiol]. 285(1):H305-15.

51. Balijepalli RC, Lokuta AJ, Maertz NA, Buck JM, Haworth RA, Valdivia HH, Kamp TJ. (2003) Depletion of T-tubules and specific subcellular changes in sarcolemmal proteins in tachycardia-induced heart failure. Cardiovasc Res. 59(1):67-77.

52. Farrell EF, Antaramian A, Rueda A, Gómez AM, Valdivia HH (2003) Sorcin inhibits calcium release and modulates excitation-contraction coupling in the heart. J Biol Chem 278:34660–34666.

53. Bers DM, Eisner DA, Valdivia HH (2003) Sarcoplasmic Reticulum Ca2+ and Heart Failure. Roles of Diastolic Leak and Ca2+ Transport. Circ Res 93:487-490.

54. Zhu X, Ganta J, Walker JW, Allen PD, Valdivia HH (2003). The calmodulin binding domain of skeletal ryanodine receptor behaves as a self-modulatory domain. Cell Calcium 35:165-177.

55. Zhu X, Zamudio FZ, Olbinski BA, Possani LD, Valdivia HH. (2004) Activation of skeletal ryanodine receptors by two novel scorpion toxins from Buthotus judaicus. J Biol. Chem. 279:26588-96.

56. Kiarash A, Kelly CE, Phinney BS, Valdivia HH, Abrams J, Cala SE (2004). Defective glycosylation of calsequestrin in heart failure. Cardiovasc Res. 63:264-72.

57. Tester DJ, Spoon DB, Valdivia HH, Makielski JC, Ackerman MJ (2004). Targeted mutational analysis of the ryr2-encoded cardiac ryanodine receptor in sudden unexplained death: a molecular autopsy of 49 medical examiner/coroner’s cases. Mayo Clin Proc. 79:1380-1384.

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58. Farrell EF, Antaramian A, Benkusky N, Zhu X, Rueda A, Gomez AM, Valdivia HH. (2004). Regulation of cardiac excitation-contraction coupling by sorcin, a novel modulator of ryanodine receptors. Biol Res. 37(4):609-12.

59. Valdivia HH, Farrell EF, Antaramian A, Benkusky NA, Rueda A, Gómez AM (2004). Sorcin and ryanodine receptors in heart failure. J Muscle Res Cell Motil. 25(8):605-7.

60. Benkusky NA, Farrell EF, Valdivia HH (2004). Ryanodine receptor channelopathies. Biochem Biophys Res Commun 322:1280-5.

61. Lokuta AJ, Maertz NA, Meethal SV, Potter KT, Kamp TJ, Valdivia HH, Haworth RA (2005) Increased Nitration of Sarcoplasmic Reticulum Ca2+-ATPase in Human Heart Failure. Circulation 111:988-995.

62. Zhu X, Bernecker OY, Manohar NS, Hajjar RJ, Hellman J, Ichinose I, Valdivia HH, Schmidt U (2005). Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handing and shortening in sepsis. Critical Care Medicine 33(3):598-604.

63. Zhu X, Altschafl BA, Hajjar RJ, Valdivia HH, Schmidt U. (2005) Altered Ca2+ sparks and gating properties of ryanodine receptors in aging cardiomyocytes. Cell Calcium 37(6):583-91.

64. Pereira L, Matthes J, Schuster I, Valdivia HH, Herzig S, Richard S, Gómez AM. (2006). Mechanisms of [Ca2+]i Transient Decrease in Cardiomyopathy of db/db Type 2 Diabetic Mice. Diabetes 55(3):608-15.

65. Meethal SV, Potter KT, Redon D, Munoz-Del-Rio A, Kamp TJ, Valdivia HH, Haworth RA. (2006) Structure-function relationships of Ca2+ spark activity in normal and failing cardiac myocytes as revealed by flash photography. Cell Calcium 41(2):123-34.

66. Rueda A, Song M, Stefani E, Toro L, Valdivia HH. (2006) Sorcin modulation of Ca2+ sparks in rat vascular smooth muscle cells. J Physiol (Lond) 576:887-901.

67. Brickson SL, Fitzsimons D, Pereira L, Hacker TA, Valdivia HH, Moss RL. (2007) In vivo left ventricular functional capacity is compromised in CMyBP-C null mice. Am J Physiol (Heart Circ Physiol). 292(4):H1747-54

68. Tocchetti CG, Wang W, Froehlich JP, Huke S, Aon MA, Wilson GM, Di Benedetto G, O'Rourke B, Gao WD, Wink DA, Toscano JP, Zaccolo M, Bers DM, Valdivia HH, Cheng H, Kass DA, Paolocci N (2007) Nitroxyl Improves Cellular Heart Function by Directly Enhancing Cardiac Sarcoplasmic Reticulum Ca2+ Cycling. Circ Res. 100(1):96-104.

69. Yuan Q, Fan GC, Dong M, Altschafl B, Diwan A, Ren X, Hahn HH, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW 2nd, Wang HS, Valdivia HH, Chu G, Kranias EG. (2007) Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation 115(3):300-9.

70. Valdivia HH (2007) One gene, many proteins. Alternative splicing of the ryanodine receptor gene adds novel functions to an already complex channel protein. Circ Res. 100(6):761-3.

71. Altschafl BA, Beutner G, Sharma VK, Sheu SS, Valdivia HH (2007) The mitochondrial ryanodine receptor in rat heart: A pharmaco-kinetic profile. Biochim Biophys Acta 1768(7):1784-95.

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72. Benkusky NA, Weber CS, Scherman JA, Farrell EF, Hacker TA, Powers PA, Valdivia HH (2007) Intact -adrenergic response and unaltered progression towards heart failure in mice with genetic ablation of a major PKA phosphorylation site in the cardiac ryanodine receptor. Circ Res 101(8):819-29. PMID: 17717301

73. Franceschini S, Ilari A, Verzili D, Zamparelli C, Antaramian A, Rueda A, Valdivia HH, Chiancone E, Colotti G. (2008) Molecular basis for the impaired function of the natural F112L sorcin mutant: X-ray crystal structure, calcium affinity, and interaction with annexin VII and the ryanodine receptor. FASEB J. 22(1):295-306. PMID: 17699613

74. MacDonnell S, García-Rivas G, Kubo H, Chen X, Scherman JA, Valdivia HH, Houser SR (2008) Adrenergic Regulation of Cardiac Contractility Does Not Involve Phosphorylation of the Cardiac Ryanodine Receptor at Serine 2808. Circ Res. 102(8):e65-72. PMC2652487

75. Valdivia HH, Houser SR (2008) Response to: Ca2+-calmodulin-dependent protein kinase phosphorylation of ryanodine receptor may contribute to the -adrenergic regulation of myocardial contractility independently of increases in heart rate. Circ Res. 3;103(1):e10-12. NIHSID: NIHMS #70600.

76. Schwartz E, Capes M, Possani LD, Valdivia HH. (2009) Purification, amino acid sequence determination and pharmacological characterization of Hadrucalcin, a novel member of the calcin family of scorpion toxins that target ryanodine receptors. Brit J Pharmacol. 157:392-403. PMC2707986

77. Gómez AM, Rueda A, Sainte-Marie Y, Zhu X, Perrier E, Perrier R, Richard R, Jaisser F, Valdivia HH, Bénitah JP. (2009) Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with FKBP12.6 down regulation. Circulation 119:2179-2187. PMID: 19364981

78. Shen J, Yu WM, Brotto M, Scherman JA, Guo C, Stoddard C, Nosek TM, Valdivia HH, Qu CK. (2009) Deficiency of MIP phosphatase induces a muscle disorder by disrupting Ca2+ homeostasis. Nat Cell Biol. 11(6):769-76. PMC2693472

79. Devi S, Kedlaya R, Maddodi N, Bhat KM, Weber CS, Valdivia HH, Setaluri V. (2009) Calcium homeostasis in human melanocytes: role of transient receptor potential melastatin 1 (TRPM1) and its regulation by ultraviolet light. Am J Physiol Cell Physiol. 297(3):C679-87. PMC2740396.

80. Valdivia HH. (2009) Take it to heart: myostatin inhibition, mighty mouse and the quest for a competitive edge. J Physiol. 587(Pt 21):5005. PMID: 19880873. PMC2790238

81. Gurrola GB, Capes EM, Zamudio FZ, Possani LD, Valdivia HH (2010) Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca2+ Release Channels/Ryanodine Receptors. Pharmaceuticals 3, 1093-1107. PMID: 20668646. PMC2910439

82. Wang H, Viatchenko-Karpinski S, Sun J, Györke I, Benkusky NA, Kohr MJ, Valdivia HH, Murphy E, Györke S, Ziolo MT (2010) Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation. J Physiol. 588(Pt 15):2905-17. PMID: 20530114. PMC2956906

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83. Romero-Suarez S, Shen J, Brotto L, Hall T, Mo C, Valdivia HH, Andresen J, Wacker M, Nosek TM, Qu CK, Brotto M. (2010) Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis. Aging 2(8):504-513. PMID: 20817957. PMC2954041

84. Touchberry CD, Bales IK, Stone JK, Rohrberg TJ, Parelkar NK, Nguyen T, Fuentes O, Liu X, Qu CK, Andresen JJ, Valdivia HH, Brotto M, Wacker MJ. (2010) Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptor. J Biol Chem. 285(51):40312-21. PMID: 20947503. PMC3001011

85. Altschafl BA, Arvanitis DA, Fuentes O, Yuan Q, Kranias EG, Valdivia HH. (2011) Dual role of Junctin in the regulation of ryanodine receptors and calcium release in cardiac ventricular myocytes. J Physiol. 589:6063-80. PMC3286686.

86. Capes EM, Loaiza R, Valdivia HH (2011). Ryanodine Receptors. Skeletal Muscle 1:18-31. PMID: 21798098. PMC3156641

87. Zhang H, Makarewich C, Kubo H, Wang W, Duran J, Li Y, Berretta R, Koch WJ, Chen X, Gao E, Valdivia HH, Houser SR. (2012) Hyperphosphorylation of the Cardiac Ryanodine Receptor at Serine 2808 Is Not Involved in Cardiac Dysfunction After Myocardial Infarction. Circ Res. 110:831-840. PMC3322671

88. Ullrich ND, Valdivia HH, Niggli E. (2012) PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. J Mol Cell Cardiol. 53(1):33-42. PMC3674825

89. Valdivia HH (2012). Ryanodine receptors and heart failure: phasing out S2808 and “criminalizing” S2814. Circ Res. 110(11):1398-402. PMC3386797

90. Loaiza R, Benkusky N, Powers PP, Hacker T, Noujaim S, Ackerman MJ, Jalife J, Valdivia HH (2013) Heterogeneity of Ryanodine Receptor Dysfunction in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 112(2):298-308. PMC3549355.

91. Quintero-Hernández V, Jiménez-Vargas JM, Gurrola GB, Valdivia HH, Possani LD (2013) Scorpion venom components that affect ion-channels function. Toxicon. 76:328-42. PMC4089097

92. Liu B, Ho HT, Velez-Cortes F, Lou Q, Valdivia C, Knollmann B, Valdivia HH, Gyorke S (2014). Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca2+-dependent cardiomyopathy by exacerbating diastolic Ca2+ release. J Physiol. 592:1957-73. PMID: 24445321

93. Zhao YT, Valdivia HH (2014). Ca2+ nanosparks: shining light on the dyadic cleft but missing the intensity of its signal. Circ Res. 114(3):396-398. PMC3960500

94. Escobar AL, Valdivia HH. (2014) Cardiac alternans and ventricular fibrillation: a bad case of ryanodine receptors reneging on their duty. Circ Res. 114(9):1369-71. PMC4040960

95. Camors E, Valdivia HH. (2014) CaMKII regulation of ryanodine receptors and Inositol trisphosphate receptors. Front. Pharmacol. 5(101):1-13. PMC4021131

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96. Gao J, Xu D, Sabat G, Valdivia H, Xu W, Shi NQ (2014) Disrupting KATP channels diminishes the estrogen-mediated protection in female mutant mice during ischemia-reperfusion. Clin Proteomics. 11(1):19-28. PMC4047774

97. Rueda A, de Alba-Aguayo DR, Valdivia HH (2014) [Ryanodine receptor, calcium leak and arrhythmias]. Arch Cardiol Mex. 84(3):191-201. Spanish. PMID: 25103920

98. Zhao YT, Valdivia CR, Gurrola GB, Hernández JJ, Valdivia HH (2015) Arrhythmogenic mechanisms in ryanodine receptor channelopathies. Sci China Life Sci. 58(1):54-8. PMID: 25480325.

99. Kalbitz M, Grailer JJ, Fattahi F, Jajou L, Herron TJ, Campbell KF, Zetoune FS, Bosmann M, Sarma JV, Huber-Lang M, Gebhard F, Loaiza R, Valdivia HH, Jalife J, Russell MW, Ward PA (2015). Role of extracellular histones in the cardiomyopathy of sepsis. FASEB J. 2015; 29(5):2185-93. PMID: 25681459

100. Valdivia HH (2015) Mechanisms of cardiac alternans in atrial cells: intracellular Ca2+ disturbances lead the way. Circ Res. 116(5):778-80. PMID: 25722439

101. Tong CW, Wu X, Liu Y, Rosas PC, Sadayappan S, Hudmon A, Muthuchamy M, Powers PA, Valdivia HH, Moss RL. (2015) Phosphoregulation of Cardiac Inotropy via Myosin Binding Protein-C During Increased Pacing Frequency or β1-Adrenergic Stimulation. Circ Heart Fail. 8(3):595-604. PMID: 25740838

102. Zhao YT, Valdivia CR, Gurrola GB, Powers PP, Willis BC, Moss RL, Jalife J, Valdivia HH. Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function. Proc Natl Acad Sci USA. 2015; 112(13):E1669-77. PMCID: PMC4386375

103. Marmugi A, Parnis J, Chen X, Carmichael L, Hardy J, Mannan N, Marchetti P, Piemonti L, Bosco D, Johnson P, Shapiro AM, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Thorens B, Valdivia HH, Rutter GA, Leclerc I. (2016) Sorcin links pancreatic β cell lipotoxicity to ER Ca2+ stores. Diabetes. 65(4):1009-21PMID: 26822088

104. Wu Y, Valdivia HH, Wehrens XH, Anderson ME. (2016) A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock. Circ Arrhythm Electrophysiol. 9(2):e003180. PMID: 26857906

105. Xiao L, Gurrola GB, Zheng Y, Valdivia CR, SanMartin M, Zamudio FZ, Zhang L, Possani LD, Valdivia HH (2016). Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands. J Gen Physiol. 147(5):375-94. PMID: 27114612

106. Willis BC, Pandit S, Ponce-Balbuena D, Zarzoso M, Guerrero-Serna G, Limbu B, Deo M, Cammors E, Ramirez RJ, Mironov S, Herron TJ, Valdivia HH, Jalife J (2016) Constitutive Intracellular Na+ Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress than Ventricular Myocytes from Mice with Catecholaminergic Polymorphic Ventricular Tachycardia. Circulation 116.021936. [Epub ahead of print] PMID: 27169737

Book chapters (refereed):

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1. Valdivia HH, Coronado R. Dihydropyridine Pharmacology of the Reconstituted Calcium Channel of Skeletal Muscle. In "The Calcium Channel: Structure, Function and Implications". (M. Morad and W.G. Nayler, Eds.) Springer-Verlag, Berlin, 1988.

2. Possani LD, Valdivia HH, Ramirez AN, Gurrola GB, Martin BM. K+ Channel Blocking Peptides Isolated from the Venom of Scorpions. In "Recent Advances in Toxinology Research". (P. Gopalakrishnakone and C. K. Tan, Eds.) Singapore, 1992.

3. Gurrola GB, Valdivia HH. Regulation of ryanodine receptors by scorpion peptides. In “Ryanodine Receptor Structure and Function” (R. Sitsapesan and A. Williams, Eds.). Imperial College Press, London, U.K. 1999.

5. Gurrola GB, Zhu X, Valdivia HH. Scorpion peptides as high-affinity probes of RyR function. In Ryanodine Receptors: structure, function and dysfunction in clinical disease. (XT Wehrens & AR Marks, Eds.) Springer, New York, NY, 2005.

7. Valdivia HH. Ionic basis of sarcoplasmic reticulum ion fluxes in heart muscle. In Cardiac Electrophysiology: from cell to bedside. 6th Ed. (D Zipes and J Jalife, eds.), Saunders, New York, 2013.

8. Alvarado F, Valdivia HH. Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation. In Cardiac Electrophysiology: from cell to bedside. 7th Ed. (D Zipes and J Jalife, eds.), Saunders, New York. In press.

Abstracts: (a total of 285 abstracts in national and international meetings).

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