Cutaneous Manifestations of Systemic Disease Holly Edmonds, MD Chief Resident Department of...
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Cutaneous Manifestations of Systemic Disease
Holly Edmonds, MDChief Resident
Department of Dermatology
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Brief Review of terminology…
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Zits???
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Red Rash???
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“Nasty… just call the derm service and get a consult!”
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You have to learn the language!
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Description of a skin lesion:
Type
Shape
Arrangment
Distribution
OH!!! DATS what that rash is!!!
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TYPE
Primary lesion
Secondary lesion
Color
Palpation
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MACULE/PATCH
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PLAQUE
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PAPULE
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NODULE
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VESICLE/BULLA
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PUSTULE
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WHEAL
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SCALE
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CRUST
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LICHENIFICATION
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EROSION
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ULCER
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ATROPHY
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EXCORIATION
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FISSURE
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SCAR
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Color
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Color
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Color
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Palpation
Consistency – Firm, Soft, Fluctuant, Boardlike
Temperature deviation (hot or cold)
Mobility
Presence of tenderness
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Margination
Ill-defined
vs.
Well-defined
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SHAPE
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SHAPE
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SHAPE
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SHAPE
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SHAPE
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ARRANGEMENT
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ARRANGEMENT
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ARRANGEMENT
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ARRANGEMENT
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ARRANGEMENT
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DISTRIBUTION
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DISTRIBUTION
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DISTRIBUTION
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DISTRIBUTION
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Cutaneous Manifestations
Diabetes Mellitus Renal DiseaseGastrointestinal disordersRheumatologic diseaseHepatitis CThyroid diseaseParaneoplastic diseaseNutritional disease
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Diabetes Mellitus
Acanthosis Nigricans
Diabetic Dermopathy
Bullosis Diabeticorum
Necrobiosis Lipoidica
Diabetic Foot Ulcers
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Acanthosis Nigricans
African Americans and Hispanics > Caucasians
Associated with obesity, insulin resistance
Hyperpigmented velvety plaques of the flexures
Genetic sensitivity of the skin to hyperinsulinemia
Malignant form a/w gastric ACA
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Acanthosis Nigricans
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Acanthosis Nigricans
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Diabetic Dermopathy
AKA “shin spots” or pigmented pretibial papules
Most common cutaneous manifestation of diabetes
Benign asymptomatic red brown macules on shins
No treatment needed
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Diabetic Dermopathy
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Bullosis Diabeticorum
Rapid onset painless, tense blisters on hands and feet
Trauma and microvascular disease may play a role
Spontaneous healing in 2-5 weeks
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Bullosis Diabeticorum
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Necrobiosis Lipoidica
20-35% of patients with NLD have diabetes, only about 1-3% of diabetics have NLDStart as red-brown papules and progress to well defined yellow-brown atrophic plaques with irregular violaceous borders and telangiectasias. Shins #1 site. Ulceration in 35%. Glucose control will not clear NLD
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Necrobiosis Lipoidica Diabeticorum
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Diabetic Eruptive Xanthomas
Seen in uncontrolled diabetes, hypertriglyceridemia
Sudden crops on firm, non-tender yellow papules with a red rim on extensors
Control glucose and lipid reduction will reduce lesions
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Diabetic Eruptive Xanthomas
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Diabetic Neurotropic Ulcers
Peripheral neuropathy leads to unnoticed trauma
Vascular complications may lead to ulcers and complicate ulcer healing
Risk of amputation goes up 8x once these develop
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Diabetic Neurotropic Ulcers
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Renal disease
Pruritis
Perforating dermatosis
Calciphylaxis
Nephrogenic Fibrosing Dermopathy
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Pruritis
Most common cutaneous manifestation of renal disease
Seen in both peritoneal and hemodialysis patients
Unknown mechanism, unsatisfactory therapy- UVB helps the most
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Pruritis
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Perforating Disorder
Acquired Perforating Dermatosis of ESRD
Umbilicated papules/nodules with central hyperkeratotic core
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Perforating dermatosis
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Perforating dermatosis
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Calciphylaxis
Painful purpuric plaques and retiform purpura
More proximal lesions = poorer prognosis
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Calciphylaxis
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Nephrogenic Fibrosing Dermopathy
Woody, indurated plaques with peau d’orange appearance
Usually spares the face, palms, soles
Associated with gadolinium contrast for MRIs
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Nephrogenic Fibrosing Dermopathy
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Gastrointestinal disorders
Henoch Schonlein Purpura
Dermatitis Herpetiformis
Inflammatory Bowel Disease
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Henoch Schonlein Purpura
Palpable purpura, urticaria, necrotic ulcers on buttocks, distal legs
Symmetric
IgA vasculitis
GI symptoms + arthritis, long term concern for hypertension and renal involvement
Usually under 20, following an URI
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HSP
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HSP
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Dermatitis Herpetiformis
Symmetric, grouped vesicles on extensors
Very pruritic!
All patients have gluten-sensitive enteropathy, only 20% symptomatic
Associated with HLA-DQ2, Hashiomoto’s thyroiditis, lymphoma, IDDM
Cutaneous findings are due to autoantibodies to epidermal transglutaminase
Treatment- rapidly responsive to dapsone
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Dermatitis Herpetiformis
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Inflammatory Bowel Disease
Crohn’s and Ulcerative Colitis
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Oral Crohn’s
• Linear ulcerations, cobblestoned oral
mucosa
• UC may have aphthous ulcers that develop as
IBD flares
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Metastatic Crohn’s• See fissures and
fistulas with Crohn’s
• Metastatic Crohn’s are
nodules, plaques and ulcerations
usually in intertriginous
areas which can mimic erythema
nodosum
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Erythema Nodosum• Tender red nodules on
anterior lower legs, precedes or occurs with
IBD flares, UC more common
• Most EN is idiopathic, also can be related to oral
contraceptives or abx, preceding strep or mycobacterial infxn
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Pyoderma Gangrenosum
• More common in UC• Papules, pustules, hemorrhagic blisters enlarge and ulcerate with dusky
undermined edges• Frequently on legs or around stoma sites• Treat with steroids, often gets better as IBD gets better
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Rheumatologic Disorders
Lupus Erythematosis
Dermatomyositis
Reiter’s Disease
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Lupus Erythematosis
Classification:– Systemic Cutaneous Lupus (SLE)– Subacute Cutaneous Lupus (SCLE)– Discoid Lupus (DLE)– Neonatal Lupus
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SLE
+ANA
+Sm and dsDNA
Butterfly Rash
Poikiloderma
Photodistrubited erythematous, papular scaling eruption sparing knuckles.
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SLE
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SLE
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SLE
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Dermatomyositis
Poikiloderma favoring scalp, periocular (Heliotrope rash), and extensor skin sites Nailfold telangiectasiasGottron’s papules
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Dermatomyositis(periungal telangiectasias, gottrons
papules)
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Reiter’s Disease
Urethritis, arthritis, ocular findings, and oral ulcers in addition to psoriasiform skin lesions. Keratoderma blenorrhagicum (feet)Balanitis circinata (penis)
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Reiter’s DiseaseKeratoderma Blenorrhagicum
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Reiter’s Disease(balanitis circinata)
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Hepatitis C virus
Porphyria Cutanea Tarda
Lichen Planus
Pruritis
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Porphyria Cutanea Tarda
Vesicles and bullae on sun-exposed areas, scarring with milia
Hypertrichosis
Fragile skin with sclerodermoid changes
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PCT
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PCT(hypertrichosis)
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Lichen Planus
Purple, pruritic, polygonal papules
Koebner phenomenon
Wickham’s striae
50% with mucosal involvement
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Lichen Planus
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Mucosal Lichen Planus
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Pruritis
Excoriations, lichenification, and prurigo nodularis
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Prurigo Nodularis
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Pruritis
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Thyroid disease
Graves disease
Hyperthyroidism
Hypothyroidism
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Graves Disease
Thyroid dermopathy (pretibial myxedema)
Symmetric, non-pitting yellow-brown waxy papules/plaques
Due to increased hyaluronic acis in dermis
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Thyroid Dermopathy
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Hyperthyroidism
Warm, moist skin
Flushing, palmar erythema
Associated with reversible alopecia and vitiligo
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Vitiligo
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Hypothyroidism
Dry, cool skin
Generalized myxedema
Yellow hue from carotenemia
Purpura from delayed wound healing
Alopecia, madarosis
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Carotenemia
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Paraneoplastic Disorders
Acanthosis Nigricans
Dermatomyositis
Cushing’s Disease
Sign of Lesser-Trelat
Paraneoplastic Pemphigus
Hypertrichosis Lanuginosa
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Acanthosis Nigricans
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Cushing’s syndrome(buffalo hump and striae)
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Sign of Lesser-Trelat
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Erythema Gyratum Repens(associated with cancers above diaphragm)
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Hypertricosis Lanuginosa Acquisita
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Nutritional Disorders
1. Marasmus
2. Kwashiorkor
3. Pellagra
4. Scurvy
5. Zinc deficiency
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Marasmus
Marasmus = protein/calorie malnutrition.
Cutaneous Manifestations:– Emaciation with thin, lax, and wrinkled skin.– Fine scaling with hyperpigmentation.– Follicular hyperkeratosis– Purpura– Thin hair and nails.
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Marasmus
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Marasmus
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Kwashiorkor
Decreased protein intake
Dyschromia (irregular pigment)
Hypopigmentation.
Superficial desquamation with areas of erosion (flaky paint)
Petechia/purpura
Thin hair/nails
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Kwashiorkor
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Kwashiorkor
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Pellagra
Niacin deficiency (Vit B3)
Triad of dermatitis, diarrhea, dementia
Photosensitive eruption around neck known as “Casal’s necklace”
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Pellagra
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Pellagra
Casal’s neckace
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Scurvy
Vitamin C deficiency
Follicular hyperkeratosis with corkscrew hairs
Perifollicular hemorrhage
Gingival hypertrophy with erosive bleeding gums.
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Scurvy
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Zinc Deficiency
Acquired
-deficient intake, high fiber intake, malabsorption
Inherited (acrodermatitis enteropathica) zinc deficiency
-defect in intestinal absorption of zinc
Dermatitis, diarrhea, alopecia
Periorificial and acral distribution
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Acrodermatitis Enteropathica
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Acrodermatitis Enteropathica
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A couple of randoms you should know…
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Sarcoidosis
Multisystem granulomatous disease
Skin affected in 20-35%
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Neurofibromatosis
Von Reckinghausen’s disease
Autosomal dominant
Neurofibromin gene, Chr 17
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Tuberous Sclerosis
Autosomal Dominant
Hamartin and Tuberin (TSC 1 and 2)
MR, Seizures (variable)
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QUIZ TIME!!!
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Very itchy.
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Lichen Planus (HCV)
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Anterior lower leg
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Necrobiosis Lipoidica (DM)
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?
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Pyoderma Gangrenosum (IBD)
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?
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Porphyria Cutanea Tarda
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?
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SLE
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Basal Cell Carcinoma
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Nodulocystic Acne
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Xanthelasma
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Herpes Labialis
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Nevus Sebaceous