CURRICULUM VITAE Revised: 6/12/2018

1. Name: Kelly Rowe Bijanki, PhD

2. Office Address: Brain Health Center Emory University School of Medicine

3. Email Address: kbijank@emory.edu 4. Citizenship: U.S.A. 5. Current Titles and Affiliations:

a. Academic appointments:

Assistant Professor, Department of Neurological Surgery, Emory University School of

Medicine, March, 2018 - present

b. Secondary Appointments: Assistant Professor, Department of Psychiatry and Behavioral Sciences, Emory

University School of Medicine, August, 2017 - present.

Adjunct Assistant Professor, Department of Neurosurgery, University of Iowa Carver

College of Medicine, January, 2014 - present

c. Clinical Appointments:

Clinical Neuroimaging Lead for Intracranial Monitoring Epilepsy Service, Department of Neurosurgery, Emory University School of Medicine, September 2016 – present.

6. Education:

2007 BA/BA Biology, Psychology, Truman State University, John J. Rutter, Ph.D. 2011 PhD Neuroscience, University of Iowa, David J. Moser, PhD.

7. Postgraduate Training:

2011-2014 T32 NRSA Post-doctoral Fellowship in Clinical

Neurobiology and Human Neuroimaging, University of Iowa

Carver College of Medicine, Departments of Psychiatry and

Neurosurgery, Nancy C. Andreasen, MD/PhD

2014-2016 Post-doctoral Fellowship in Neuromodulation, Emory University

School of Medicine, Departments of Psychiatry, Neurosurgery,

and Neurology, Helen S. Mayberg, MD

2016-2018 (expected) Master’s of Science in Clinical Research, Emory University.

8. Committee Memberships: a. Institutional

TL1 Post-doctoral Fellowship Grant Review Committee, 2018

Chair, Neuroimaging Seminar Committee, Emory University, 2014-2015

Chair, Psychiatry Imaging Seminar Committee, University of Iowa, 2011-2013

Chair, Neuroscience Seminar Committee, University of Iowa, 2010-2011

Member, Neuroscience Seminar Committee, University of Iowa, 2009-2011

Member, Brain Awareness Week Committee, University of Iowa, 2007-2010

9. Peer Review Activities:

a. Manuscript Reviews (number of reviews)

Journal of Affective Disorders (1) 2017-present Psychoneuroendocrinology (1) 2016-present Neuropsychology (21) 2010-present American Journal of Psychiatry (1) 2011-present PLOS One (2) 2011-present Journal of Clinical and Experimental Neuropsychology (8) 2011-present

10. Editorial Contributions:

Editorial Assistantship, Neurobiology, Reference Module in Biomedical Sciences, Elsevier 2014.

11. Honors and Awards:

2018, University Research Committee, Biological and Life Sciences Research Award

2016, American Epilepsy Society Junior Investigator Research Award Finalist

2016, Brain Research Foundation Seed Grant Southeast Finalist

2016, Emory Postdoctoral Symposium Outstanding Oral Presenter Award

2011, Society for Neuroscience Postdoctoral Fellow Travel Award 2009, Graduate Research Conference, Biological and Health Sciences Award 2005, Summer Undergraduate Research Grant, Truman State University

2003, President’s Leadership Scholarship, Truman State University

12. Society Memberships:

2016-present International Neuropsychological Society (INS) 2016-present American Epilepsy Society (AES) 2016-present Society for Biological Psychiatry (SOBP) 2016-present American Society for Stereotactic and Functional Neurosurgery (ASSFN) 2013-present World Society for Stereotactic and Functional Neurosurgery (WSSFN) 2011-present International Society of Vascular Behavioral and Cognitive Disorders 2009-present American Academy for the Advancement of Science (AAAS)

2008-present Cognitive Neuroscience Society (CNS) 2007-present Society for Neuroscience (SFN)

13. Formal Teaching:

a. Medical Student Teaching: 2009: Teaching Assistant – University of Iowa Carver College of

Medicine, Medical Neuroscience Course. Taught graduate and medical

students in laboratory section of medical neuroscience, including

dissection of post-mortem brain tissue and preparation of laboratory

examinations (Approximately 2 hours preparation and 4 hours delivery

per week).

2017: Guest Instructor – Emory University School of Medicine, Neural

Function course. Taught neuroanatomy to first-year medical students in

laboratory section, including surface and dissections of post-mortem brain

tissue (Approximately 2 hours preparation and 2 hours delivery).

2017: Guest Instructor – Emory University School of Medicine,

Neuroanatomy Module of Gross Anatomy course. Taught neuroanatomy

to second-year medical students in laboratory section, including sulcal

and gyral organization, functional anatomy, brainstem and ventricular

systems, and live dissections of post-mortem brain tissue (Approximately

2 hours preparation and 2 hours delivery per week for two weeks).

2017: Special Lecturer – Emory University School of Medicine, MD 515

Neural Function course. Taught spinal cord and cerebellar anatomy,

circuitry, function, and syndromes to second-year medical students in

didactic course (6 hours preparation, 2 hours delivery).

b. Residency Programs:

2018: Guest Instructor – Emory University School of Medicine,

Department of Psychiatry Residency Program, PGY-1 and PGY-4

“Particle to Professor” lecture series. Gave overview of psychiatric

neuromodulation as a research avenue and future area of engagement

for practicing psychiatrists (4 hours preparation, 90 min delivery).

c. PhD Programs:

2009: Teaching Assistant – University of Iowa Department of Biology,

Fundamental Neurobiology Course. Instructed discussion section in fundamental

neurobiology, designed weekly quiz materials, assisted with grading of essay and

short answer examinations (Approximately 4 hours preparation and 6 hours

delivery per week).

d. Undergraduate: 2006-2007: Teaching Assistant – Truman State University Department of

Biology, Physiology Course. Assisted in assembling course materials, grading

examinations, running physiology laboratory section (Approximately 4 hour

preparation and 4 hour delivery per week).

2010: Invited Lecturer – University of Iowa Department of Psychology,

Introduction to Clinical Psychology Course. Taught lecture on major

psychological considerations in the elderly, focusing on dementia and depression

to approximately 220 undergraduate psychology students (Approximately 3 hour

preparation and 2 hour delivery).

e. Formal Training in College Teaching; Seminar in College Teaching (Fall 2011) Teaching and Learning in Higher Education Course (Fall 2012)

Teaching Practicum in College Teaching Course (Fall 2012)

14. Supervisory Teaching:

a. Mentorship:

Taylor Shade, undergraduate student, 2017-present. Supervised summer research in

the lab. Camille Steger, undergraduate student, 2015-present. Supervised participation in the

Scholarly Inquiry and Research at Emory (SIRE) program, oversaw development of a research project and corresponding poster presentation.

Eddie Valentin, graduate student, 2014-2015. Advised on the development of a Ph.D.

dissertation research project and corresponding manuscript. Currently

defending dissertation.

Brendan Hodis, medical student, 2012-2014. Advised on development of two

manuscripts, applications to graduate school and M.D./Ph.D. programs.

Currently a resident in Radiology at The University of Iowa.

Emily Harlynn, post-baccalaureate student, 2012-2014. Advised on

development on one manuscript and applications to clinical psychology

programs. Currently in nursing school at Marquette University, pursuing

Neurosurgery OR nursing specification.

Meredith Hoyland, undergraduate student, summer 2012. Oversaw research on

neuroimaging in schizophrenia, and a research project in atherosclerotic vascular

disease. Currently pursuing Ph.D. in Psychology and Neuroscience at Baylor

University.

Katie Leick, medical student, summer 2011. Taught principles and techniques of

diffusion tensor imaging, troubleshooting with data processing and analysis.

Currently a resident in General Surgery at The University of Iowa.

Joshua Timpe, medical student, summer 2010. Taught principles and techniques

of diffusion tensor imaging, assisted in data analysis, reviewed poster and

manuscript. Currently an Assistant Professor in Emergency Medicine at the

Medical College of Wisconsin.

Adam Ruggle, medical student, 2009. Oversaw research on use of selective

serotonin reuptake inhibitor medications in patients with Huntington’s disease.

Currently a resident in Psychiatry at the University of Arizona - Phoenix

College of Medicine.

15. Lectureships and Invited Seminars

a. National and International

“Diffusion Tensor Imaging in the Atherosclerotic Brain: Implications for Depression and

Cognition”. International Society of Vascular Behavioural and Cognitive Disorders

Congress, Lille, France, September 2011.

“In Search of Neurobiological Correlates To Depression: Electrical Stimulation of

the Amygdala”, World Society for Stereotactic and Functional Neurosurgery

Quadrennial Congress, Tokyo, Japan, May 2013.

“Electrical Stimulation of the Dorsal Cingulum Elicits Euphoria and Positive Emotional

Bias”. International Neuropsychological Society Invited Lecture, New Orleans,

Louisiana, February 2017.

“Where do we go from here? Developing the sEEG platform for discovery and validation

of novel neuromodulation targets”. Visiting Professorship, Baylor College of

Medicine, Center for Advanced MRI Seminar Series, Houston, Texas, March

2018.

b. Institutional

“Diffusion Tensor Imaging”, Department of Psychiatry Imaging Seminar, University

of Iowa Carver College of Medicine, June 2011 and June 2012. Taught class

of post-doctoral fellows, graduate students, and faculty members on the use

of diffusion tensor imaging in psychiatric illness.

“Diffusion Tensor Imaging and Depressive Symptoms in Vascular Disease”,

Department of Psychiatry Research Rounds, University of Iowa Carver College

of Medicine, December 2011. Presented findings from Ph.D. thesis for the faculty

and students of the Department of Psychiatry.

“Brain structural correlates of depression and schizophrenia: potential targets for

neurosurgical intervention”, Department of Neurosurgery, University of Iowa

Carver College of Medicine, February 2012. Presented current research

and ideas for expansion of deep brain stimulation therapy for the treatment

of auditory hallucinations in schizophrenia.

“Electrical stimulation transiently induces affective bias and startle response changes:

implications for emotion mapping in epilepsy”, Department of Neurosurgery

Grand Rounds, Emory University, May 2016. Presented findings from KL2

application and postdoctoral research.

16. Abstract Presentations at Conferences ASSFN2018

1. Bijanki, K.R., Manns, J.R., Gale, J.T., Choi, K.S., Inman, C.S., Pedersen, N.P.,

Mayberg, H.S., Drane, D.L., Willie, J.T. Dorsal anterior cingulum bundle stimulation: impacts on anxiety, affect, and pain. American Society for Stereotactic and Functional Neurosurgery, Denver, Colorado, June 2018

2. Bijanki, K.R., Manns, J.R., Choi, K.S., Inman, C.S., Pedersen, N.P., Drane, D.L., Mayberg, H.S., Willie, J.T., Use of continuous focal stimulation of the dorsal

anterior cingulate white matter to produce euphoria and anxiolysis without sedation in an epilepsy patient undergoing awake craniotomy. World Society for Stereotactic and Functional Neurosurgery, Berlin, Germany, June 2017.

3. Bijanki, K.R., Willie, J.T., Mayberg, H.S., Fiedorowicz, J.G., Kovach, C.K., Inman, C.S., Crowell, A.L., Gross, R.E., Drane, D.L., Electrical stimulation to the cingulate cortex and amygdala drive shifts in affective bias across patient populations. Translational Science, Washington DC, April 2017.

4. Bijanki, K.R., Mayberg, H.S., Kovach, C.K., Inman, C.S., Crowell, A.L., Gross, R.E., Drane, D.L., Willie, J.T., Affective bias is sensitive to acute electrical stimulation of two limbic regions: subcallosal cingulate white matter and amygdala. Society for Neuroscience, San Diego, CA November 2016.

5. Bijanki, K.R., Kovach, C.K., Mayberg, H.S., Inman, C.S., Crowell, A.L., Gross,

R.E., Willie, J.T., Novel test of affective bias is modulated by both subcallosal cingulate and amygdala deep brain stimulation. American Society for Stereotactic and Functional Neurosurgery, Chicago, IL, June 2016.

6. Bijanki, K.R., Crowell, A.L., Kovach, C., Tiruvadi, V., Waters, A., Veerakumar, A., Dension, L., Mayberg, H.S., Affective biasing is sensitive to discontinuation of chronic deep brain stimulation to the subcallosal cingulate white matter. Society

of Biological Psychiatry, Atlanta, GA, April 2016.

7. Crowell, A.L., Inman, C., Bijanki, K.R., Veerakumar, A., Denison, L., Riva-Posse, P., Hamann, S., Garlow, S.J., Mayberg, H.S., Effect of Subcallosal Cingulate Deep Brain Stimulation on Resting Heart Rate Variability. Society of Biological Psychiatry, Atlanta, GA, 2016.

8. Waters, A., Choi, K.S., Tiruvadi, V., Veerakumar, A., Bijanki, K.R., Crowell, A.,

Riva-Posse, P., Mayberg, H.S., Cortical Evoked Response To Subcallosal Cingulate Deep Brain Stimulation For Treatment Resistant Depression. Society of Biological Psychiatry, Atlanta, GA, 2016.

9. Veerakumar, A., Tiruvadi, V., Waters, A., Bijanki, K., Crowell, A., Riva-Posse, P., Mayberg, H.S., Broadband Power Spectral Density (PSD) Changes Observed In Local Field Potentials (LFP) During Subcallosal Cingulate Deep Brain

Stimulation (SCC-DBS) for Treatment Resistant Depression (TRD). Society of Biological Psychiatry, Atlanta, GA, 2016.

10. Inman, C.S., Bijanki, K.R., Bass, D.I., Manns, J.R., Gross, R.E., Hamann, S., Willie, J.T., Effects of brief electrical stimulation to the amygdala in humans on memory for neutral stimuli. Cognitive Neuroscience Society, New York, NY, 2016.

11. Parker, K.L., Kim, Y., Kelly, R., Ewald, V.A., Han, Y., Bijanki, K.R., Andreasen,

N.C., Narayanan N.S., A neurophysiologic basis for the therapeutic potential of cerebellar stimulation on cognition in schizophrenia. Society for Neuroscience,

Chicago, IL, 2015.

12. Bijanki, K.R., Matsui, J.T., Mayberg, H.M., Magnotta, V.A., Arndt, S., Johnson, H.J., Nopoulos, P., Paradiso, S., McCormick, L.M., Fiedorowicz, J.G., Epping, E.A., Moser, D.J., Low fractional anisotropy of the right ventral anterior cingulate related to depressive symptoms in atherosclerotic vascular disease. American College of Neuropsychopharmacology Annual Meeting, Hollywood, Florida, 2013.

13. Bijanki, K.R., Kovach, C., McCormick, L.M., Kawasaki, H., Wemmie, J., Dlouhy, B., Howard, M.A., In search of neurobiological correlates to depression: electrical stimulation of the amygdala. World Society for Stereotactic and Functional

Neurosurgery Meeting, Tokyo, Japan, 2013.

14. Rowe, K.C., Magnotta, V.A., Matsui, J.T., Vitense, K., Axelson, E., Brumm, M., Arndt, S., Paradiso, S., Nopoulos, P., and Moser, D.J., Relationships among white matter health, depression, and cognition: A diffusion tensor imaging study. Cognitive Neuroscience Society Conference, Chicago, IL, 2012.

15. Rowe, K.C., Magnotta, V.A., Matsui, J.T., Vitense, K., Axelson, E., Brumm, M., Arndt, S., Paradiso, S., Nopoulos, P., and Moser, D.J., Diffusion tensor imaging in the atherosclerotic brain: implications for depression, processing speed, and attention. Society for Neuroscience Conference, Washington, DC, 2011; International Society of Vascular Behavioral and Cognitive Disorders Conference, Lille, France, 2011.

16. Rowe, K.C., Vitense, K., Axelson, E., Magnotta, V.A., Nopoulos, P, and Moser, D.J., Diffusion Tensor Imaging: revealing hidden connections between vascular disease, emotion, and cognition. University of Iowa Neuroscience Research Week, 2011.

17. Epping, E.A., Mills, J., Smith, M.M., Beglinger, L.J., Rowe, K.C., Fiedorowicz, J.G., Paulsen, J.S., and the PREDICT-HD Investigators of the Huntington Study

Group. Depression in Prodromal Huntington Disease. Huntington Study Group Conference, 2010.

18. Timpe, J., Rowe, K.C., Matsui, J.T., Magnotta, V.A., and Denburg, N.L. White matter integrity as measured by diffusion tensor imaging distinguishes between impaired and unimpaired older adult decision-makers. University of Iowa Medical

Student Research Day, 2010.

19. Moser, D.J., Rowe, K.C., Magnotta, V.A., Haynes, W., Nopoulos, P. Cerebral

White Matter Volume is Associated with Forearm Vascular Function in Elderly Men with Vascular Disease. American College of Neuro- Psychopharmacology Conference, Miami Beach, FL, 2010.

20. Rowe, K.C., Paulsen, J.S., Langbehn, D.R., Duff, K., Beglinger, L.J., Wang, C., Mills, J., Fiedorowicz, J., Epping, E., and Moser, D.J. SSRI usage in Prodromal

Huntington Disease. Jakobsen Graduate Conference, Iowa City, IA, 2010.

21. Rowe, K.C., Langbehn, D.R., Duff, K., Beglinger, L.J., Wang, C., Moser, D.J.,

O’Rourke, J.J.F., Stout, J., Queller, S., Paulsen, J.S., and the Predict-HD investigators of the Huntington Study Group. Self-Paced Timing Task Detects Subtle Changes in Pre-Diagnosed Huntington Disease. World Congress on Huntington Disease, Vancouver, Canada, 2009.

22. Rowe, K.C., Langbehn, D.R., Duff, K., Beglinger, L.J., Wang, C., Moser, D.J., O’Rourke, J.J.F., Stout, J., Rao, S., Queller, S., Paulsen, J.S., and the Predict-HD investigators of the Huntington Study Group. Self-Paced Timing Task in Pre-diagnosed Huntington’s disease. Cognitive Neuroscience Society Conference, San Francisco, CA, 2009

23. Rowe, K.C., Beglinger, L., Wang, C., Langbehn, D., Duff, K., Paulsen, J.S., and

the Predict-HD Investigators of the Huntington Study Group. Antidepressant use in Predict-HD: Patterns of use relevant to “Naturalistic” drug studies. Huntington Study Group Clinical Research Symposium, Tampa, FL, 2008.

24. Rowe, K.C., Paulsen, J., Nopoulos, P., Beglinger, L., Johnson, H., Magnotta, V., Pierson, R., Langbehn, D., Aylward, E. White Matter Volume in Pre-diagnosed Huntington’s Disease. Society for Neuroscience Conference, Washington, DC, 2008.

25. Wang, Q., Rowe, K.C., Green, S. P-75NTR signaling promotes IHC-SGN

synapse regeneration after excitotoxic trauma. Auditory Research Organization Conference, 2007.

17. Research focus: My primary research interest explores the neurobiological, behavioral,

and electrophysiological correlates of human behavior and psychopathology,

particularly related to the effects of neuromodulation on affective neural circuit function

and implications for our understanding of the circuit across psychiatric and neurological

patient populations.

18. Patents and Intellectual Property:

1. U.S. Patent App. No. 62/554,551 (pending). A method of electrically stimulating the dorsal anterior cingulum bundle to reduce anxiety, reduce pain, facilitate cognitive performance, and elicit spontaneous laughter, smiling, and euphoria. Inventors: Bijanki, K.R., Willie, J.T., Inman, C.I., Pedersen, N.P.

19. Grant Support:

a. Active support:

i. Federally funded: Bijanki (PI) Pending NIH K01-A1 MH116364 $696,000 total directs The human amygdala in social processing: circuits, physiology, behavior, and neuromodulation. The goal of this project is to provide critical training in electrophysiology, and to test the scientific premise that the amygdala is directly and causally involved in depression and social processing. Role: Principal Investigator Bijanki and Willie (MPI) Pending NIH R21-A1-NS104953 $429,000 total directs Novel strategies for mapping the emotional neural circuitry using human brain stimulation. This research seeks to gain a better understanding of the emotional correlates to limbic brain stimulation. We aim to use this information to help develop better methods to anticipate and prevent neuropsychiatric complications following brain surgery for epilepsy. Role: Principal Investigator

Bijanki (PI) 08/01/16-07/31/18 NIH KL2TR000455. $255,535 total directs Affective bias as a biomarker for neuropsychiatric complications following neurological surgery for epilepsy. This project examines whether there are neuropsychological and behavioral correlates to limbic stimulation that can be used to predict and prevent neuropsychiatric complications following resective or ablative neurosurgery for epilepsy.

Role: Principal Investigator, KL2 Scholar

Mayberg (PI) 07/31/18-07/31/22 NIH UH3NS103550. $1,118,820 total directs Electrophysiological Biomarkers to Optimize DBS for Depression. This project is to develop and test objective methods for reliable device configuration in individuals being treated with deep brain stimulation to the subcallosal cingulate for treatment refractory depression, by optimizing stimulation parameters with respect to human functional anatomy and key electrophysiological variables.

Role: Research Faculty Mayberg (PI) 04/01/05-06/30/19 R01MH073719-06 $814,365 total directs

Testing an Imaging Biomarker for Treatment Stratification in Major Depression. This project tests the efficacy of a novel imaging biomarker developed to stratify patients into two subtypes that predict the likelihood of remission to monotherapy with cognitive behavioral therapy (CBT) or escitalopram (sCIT)--two first-line treatments for MDD.

Role: Research Faculty

Drane (PI) 01/07/14-30/04/19 R01NS088748-01 $634,658 total directs Dissecting the Cognitive Roles of Hippocampus, Other Temporal Lobe Structures. This project compares the cognitive outcome of patients undergoing standard open resections versus a

novel, minimally invasive laser ablation technique that is exquisitely restricted to the hippocampus and amygdala. As open resections affect a broader range of temporal lobe white matter and structures, this study will determine whether the hippocampus and amygdala have an essential role in cognitive processes.

Role: Research Faculty

ii. Privately funded: Bijanki (PI) 05/01/18-04/30/19 University Research Council Biological and Health Sciences Grant $27,699 total directs Developing emotional stimulation mapping to predict postoperative depression in epilepsy patients. The goal of this study is to utilize electrical brain stimulation to predict postoperative depression in neurosurgery patients undergoing destructive interventions for medically intractable epilepsy (Emory University).

Role: Principal Investigator Wolf, S. (PI) 05/01/18-04/30/21 Microtransponder Inc. Pivotal Trial $261,625 total directs A Pivotal Randomized Study Assessing Vagus Nerve Stimulation (VNS) During Rehabilitation for Improved Upper Limb Motor Function After Stroke (VNS-REHAB). The aim of the study is to pair vagus nerve stimulation (VNS) with rehabilitation motor tasks in subjects with upper extremity ischemic stroke deficits and to compare this to individuals who undergo motor rehabilitation therapy without VNS pairing. Our preclinical studies have demonstrated that VNS during a motor task induces significant reorganization of the rat motor cortex (Porter et al., 2011). In addition, our ongoing animal studies demonstrate that VNS during movement improves the motor deficit in at least two stroke models (see above in Preclinical Studies); two pilot human studies confirm this benefit.

Role: Research Faculty

b. Previous Support

i. Federally funded: Howard (PI) 09/15/12-08/14/14 5R01 DC004290-14 $574,051 total directs

Human Auditory Cortex Physiology. The goal of this project is to understand the functional organization and connections of those areas of human cerebral cortex that are engaged in sound processing by combining anatomical and functional MRI methods with direct cortical electrophysiological recordings and electrical stimulation techniques in awake, behaving human subjects undergoing clinical evaluation of intractable epilepsy (University of Iowa).

Role: Post-doctoral Fellow Andreasen (PI) 12/15/11-08/14/14 T32 MH019113-22 $231,555 total directs Research Training in the Major Psychoses and Clinical Neurobiology.

The goal of this project is to provide training in translational clinical neuroscience, focusing on neuroimaging and cognitive neuroscience related to major mental illness (University of Iowa).

Role: Post-doctoral Fellow

Moser (PI) 06/15/09-12/15/11 5R01 AG030417-05 $469,862 total directs

Vascular Function, Cognition, and Brain MRI in Atherosclerotic Vascular Disease. The goal of this project is to determine the relationship between vascular function and specific MRI-based brain measures (both cross-sectionally and longitudinally) in patients with atherosclerotic vascular disease, and to conduct a pilot study on vascular function and MRI- based brain measures in healthy comparison participants (University of Iowa).

Role: Graduate Student

Tranel (PI) 09/07/99-30/06/09 5T32NS007421-09 $204,000 total directs

Neuroscience Training Program. This training award provides support for broad-based, fundamental, predoctoral (pre-thesis) training in neuroscience (University of Iowa).

Role: Graduate Student

ii. Privately Funded

Bijanki (PI) 10/01/14-09/30/15 YIG-0-015-13 American Foundation for Suicide Prevention $39,866 total directs Direct electrical stimulation of the amygdala: Impact on suicidal ideation, depression, and anxiety. The goal of this study is to utilize electrical brain stimulation to map the function of the amygdala in awake, behaving human research participants, focusing on implications for patients with major mental illness (Emory University and University of Iowa).

Role: Principal Investigator Bijanki (PI) 10/1/12-10/1/13

University of Iowa PET Imaging Center Pilot Grant $9,000 total directs

Pilot Scans for O15-PET examination of deep brain stimulation effects on cerebral blood flow.

This pilot funding supported the collection of ON and OFF stimulation neuroimaging for 10 patients receiving deep brain stimulation for treatment-refractory obsessive-compulsive disorder (University of Iowa).

Role: Principal Investigator

19. Bibliography: (ORCID: 0000-0003-1624-8767)

1. Published and accepted research articles:

1. Inman, C.S., Bijanki, K.R., Bass, D.I., Gross, R.E., Hamann, S., Willie, J.T.

(2018). Human amygdala stimulation effects on emotion physiology and

emotional expression. Neuropsychologia.

2. Inman, C.S.*, Manns, J.R.*, Bijanki, K.R., Bass, D.I., Hamann, S., Drane, D.L.,

Fasano, R., Kovach, C.K., Gross, R.E., Willie, J.T. (2017). Direct Electrical

Stimulation of the Amygdala Enhances Event-Specific Declarative Memory in

Humans. Proceedings of the National Academy of Sciences. (* co-first authors).

3. Li, T., Horta, M., Mascaro, J., Bijanki, K., Arnal, L.H., Adams, M., Barr, R.G.,

Rilling, J.K. (2017). Explaining individual variation to paternal brain response to

infant cries. Physiology and Behavior.

4. Bijanki, K.R., Matsui, J.T., Mayberg, H.S., Magnotta, V.A., Arndt, S., Johnson,

H.J., Nopoulos, P., Paradiso, S., McCormick, L., Fiedorowicz, J.G., Epping, E.A.,

Moser, D.J. (2015). Depressive symptoms related to low fractional anisotropy in

the right ventral anterior cingulate in older adults with atherosclerotic vascular

disease. Frontiers in Human Neuroscience. 9(408) DOI:

10.3389/fnhum.2015.00408. PMID: 26236221.

5. Bijanki, K.R., Hodis, B., Magnotta, V.A., Zeien, E., Andreasen, N.C. (2015).

Effects of age on white matter integrity and negative symptoms in schizophrenia.

Schizophrenia Research 161(1): 29-35. DOI: 10.1016/j.schres.2014.05.031.

PMID: 24957354

6. Bijanki, K.R., Hodis, B., Brumm, M., Harlynn, E, McCormick, L.M. (2014). Hippocampal

and subcallosal cingulate atrophy in psychotic depression. PLoS ONE 9(10): e110770.

DOI: 10.1371/journal.pone.0110770. PMID: 25338068.

7. Bijanki, K.R., Kovach, C., McCormick, L.M., Kawasaki, H., Dlouhy, B., Feinstein, J.,

Jones, R.D., Howard, M. (2014). Case report: Stimulation of the right amygdala

produces transient changes in affective bias. Brain Stimulation 7(5): 690-693. DOI:

10.1016/j.brs.2014.05.005. PMID: 24972588.

8. Epping, E.A., Mills, J.A., Beglinger, L.J., Fiedorowicz, J.G., Craufurd, D., Smith, M.M.,

Groves, M., Bijanki, K.R., Downing, N., Williams, J.K., Long, J.D., Paulsen, J.S., and

the PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2013).

Characterization of depression in prodromal Huntington disease: the PREDICT-HD

study. Journal of Psychiatric Research, 47(10) 1423-1431. DOI:10.1016/j.jpsychres.

2013.05.026. PMID: 23790259.

9. Bijanki, K.R., Arndt, S., Magnotta, V.A., Nopoulos, P., Paradiso, S., Matsui, J.T.,

Johnson, H.J., Moser, D.J. (2013). Characterizing white matter health in atherosclerotic

vascular disease. Psychiatry Research: Neuroimaging, 214(3): 389-394. DOI:

10.1016/j.pscychresns.2013.07.011 PMID: 24144509.

10. Bijanki, K.R., Stillman, A.N., Arndt, S., Magnotta, V., Fiedorowicz, J.G., Haynes, W.,

Matsui, J.T., Johnson, H.J., W., Moser, D.J. (2013). White matter fractional anisotropy

is inversely related to anxious symptoms in older adults with atherosclerosis.

International Journal of Geriatric Psychiatry, 28(10): 1069-1076. DOI: 10.1002/gps.

3930. PMID: 23348834.

11. Beglinger, L.J., Prest, L., Mills, J.A., Paulsen, J.S., Smith, M., Gonzalez-Alegre, P.,

Rowe, K.C., Nopoulos, P., Uc, E.Y. (2012). Clinical predictors of driving status in

Huntington disease. Movement Disorders. 27(9):1146-52. DOI: 10.1002/mds.25101.

PMID: 22744778.

12. Stillman, A.N., Rowe, K.C., Arndt, S., Moser, D.J. (2012). Anxious symptoms and

cognitive function in non-demented elderly adults: an inverse relationship. International

Journal of Geriatric Psychiatry, 27(8): 792-798. DOI: 10.1002/gps.2785. PMID:

21919061.

13. Timpe, J.C., Rowe, K.C., Matsui, J.K., Magnotta, V.A., Denburg, N.L. (2011). White

matter integrity, as measured by diffusion tensor imaging, distinguishes between

impaired and unimpaired older decision-makers. Journal of Cognitive Psychology 23 (6

SI) 760-767. PMID: 24976948

14. Rowe, K.C., Paulsen, J.S., Langbehn, D.R., Wang, C., Mills, J., Beglinger, L.J., Smith,

M.M., Epping, E.A., Fiedorowicz, J., Duff, K., Ruggle, A., Moser, D.J., and the PREDICT-

HD Investigators of the HSG. (2012). Patterns of Serotonergic Antidepressant Usage in

Prodromal Huntington Disease. Psychiatry Research, 196(2-3) 309-314. DOI:

10.1016/j.psychres.2011.09.005. PMID: 22397915.

15. Downing N., Smith M.M., Beglinger L.J., Mills J., Duff K., Rowe K.C., Epping E.,

Paulsen J.S., and the PREDICT-HD Investigators of the HSG. (2012). Perceived Stress

in Prodromal Huntington Disease. Psychology & Health, 27(2) 196-209. DOI:

10.1080/08870446.2010.529141. PMID: 21623544.

16. O’Rourke, J.J.F., Beglinger, L.J., Smith, M.R., Mills, J., Moser, D.J., Rowe, K.C., Langbehn, D.R., Duff, K., Stout, J.C., Harrington, D.L., Carlozzi, N., Paulsen, J.S., and

the PREDICT-HD Investigators of the Huntington Study Group. (2010). Cognitive,

Motor, and Psychiatric Contributions to the Trail Making Test in Prodromal Huntington Disease: Contributions of Disease Progression to Test Performance. Journal of Clinical

and Experimental Neuropsychology, 33 (5) 567-579. DOI: 10.1080/13803395. 2010.541228. PMID: 21302170.

17. Rowe, K.C., Paulsen, J.S., Langbehn, D.R., Duff, K., Beglinger, L.J., Wang, C.,

O’Rourke, J.J.F., Stout, J., Moser, D.J., and the PREDICT-HD Investigators of the

Huntington Study Group. (2010). Self-Paced Timing Detects and Tracks Change in

Prodromal Huntington Disease. Neuropsychology, 24, 435-442. DOI: 10.1037/

a0018905. PMID: 20604618.

b. Manuscripts Submitted and Under Review: 1. Bijanki, K.R., Manns, J.R., Choi, K.S., Inman, C.S., Pedersen, N.P., Drane, D.L., Gross,

R.E., Willie, J.T. (under review). Case study: Deep brain stimulation of cingulum bundle evokes laughter and reduces intraoperative anxiety. Journal of Clinical Investigation.

2. Waters, A., Choi, K.S., Tiruvadi, V., Veerakumar, A., Bijanki, K.R., Crowell, A.,

Riva-Posse, P., Mayberg, H.S., (under review). Cortical Evoked Response To

Subcallosal Cingulate Deep Brain Stimulation For Treatment Resistant

Depression. NeuroImage.

3. Waters, A., Veerakumar, A., Choi, K.S., Howell, B., Tiruvadi, V., Bijanki, K., Crowell, A.L., Riva-Posse, P., Mayberg, H.S. (under review). Test-retest reliability of a stimulation-locked evoked response to deep brain stimulation in subcallosal cingulate for treatment resistant depression. Human Brain Mapping

4. Rilling, J.K., Li, T., Horta, M., Mascaro, J., Bijanki, K., Adams, M., Barr, R. (under

review). Effects of the Period of PURPLE Crying program on paternal subjective

evaluations and neural responses to infant crying. Psychoneuroendocrinology.

5. Veerakumar, A., Tiruvadi, V., Waters, A., Bijanki, K., Crowell, A., Riva-Posse, P.,

Mayberg, H.S. (under review). Broadband Power Spectral Density (PSD)

Changes Observed In Local Field Potentials (LFP) During Subcallosal Cingulate

Deep Brain Stimulation (SCC-DBS) for Treatment Resistant Depression (TRD).

Journal of Neuroscience.

c. Manuscripts in Preparation

1. Isbaine, F., Bijanki, K.R., Koch, P., Hariprasad, R., Gross, R.E., Willie, J.T., Gale,

J.T. (in preparation). Accuracy and precision (AC-PC) toolbox: presentation and

statistical analysis for assessing 2d and 3d measurements for neurosurgical

procedures. Neuroimage.

2. Bijanki, K.R., Kovach, C.K., Inman, C.S., Crowell, A.L., Gross, R.E., Drane, D.L.,

Willie, J.T., Mayberg, H.S. (in preparation). Affective bias is sensitive to DBS for

depression across the first 6 months of therapy and during blinded

discontinuation. Biological Psychiatry.

3. Bijanki, K.R., Van Rooij, S., Jovanovic, T, Inman, C.S, Willie, J.T. (in

preparation). Right amygdala ablation reverses chronic PTSD in epilepsy surgical

patients. Nature Neuroscience.

4. Crowell, A.L., Inman, C., Bijanki, K.R., Veerakumar, A., Denison, L., Riva-Posse,

P., Hamann, S., Garlow, S.J., Mayberg, H.S. (in preparation). Effect of

Subcallosal Cingulate Deep Brain Stimulation on Resting Heart Rate Variability.

Journal of Affective Disorders.

d. Book Chapters

1. Bezchlibnyk, Y.B., Cheng, J., Bijanki, K.R., Mayberg, H.S., and Gross, R.E. (2018).

Subgenual Cingulate Deep Brain Stimulation for Treatment-Resistant Depression. In: Neuromodulation: Comprehensive Textbook of Principles, Technologies, and Therapies (Second Edition), Eds. Krames, E.S., Peckham, P.H., and Rezai, A.R.