Qinglin Yang, M.D., Ph.D.

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CURRICULUM VITAE

QINGLIN YANG TITLE AND AFFILIATION: Associate Professor of Nutrition Sciences Department of Nutrition Sciences University of Alabama at Birmingham 1675 University Blvd, Webb 435 Birmingham, AL 35294-3360 Phone: 205-996-6023 Fax: 205-934-7049 E-mail: qyang@uab.edu EDUCATION: 1996-2000 Division of Molecular Cardiovascular Biology, Department of Pediatrics,

Cincinnati Children’s Hospital Medical Center Research Foundation, Cincinnati, OH.

Postdoctoral Training Advisor: Jeffrey Robbins, Ph.D. 1993-1996 Washington State University, Pullman, WA. Ph.D. (Cardiovascular Physiology) Advisor: Bryan K. Slinker, DVM, Ph.D. 1991-1992 University of Montana, Missoula, MT. Master of Pharmacy Advisor: Craig A. Johnston, Ph.D. 1986-1989 Guang Zhou University of Traditional Chinese Medicine, Guang Zhou,

Guang Dong Province, P.R. China Master of Medicine (Pediatrics) Advisor: Professors Bingnan Li and Yongchang Wu 1979-1984 Guang Zhou University of Traditional Chinese Medicine, Guang Zhou,

Guang Dong Province, P.R. China Bachelor of Medicine (Medicine) PROFESSIONAL EXPERIENCE: 03/2008-present Associate Professor (with tenure), Department of Nutrition

Sciences, School of Health Professions, University of Alabama at Birmingham, AL

03/2008-present Member, Clinical Nutrition Center, University of Alabama at

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Birmingham, Birmingham, AL 08/2008-present Senior Scientist, Diabetes Research and Training Center,

University of Alabama at Birmingham, Birmingham, AL 03/2008-present Scientist, Comprehensive Diabetes Center, University of Alabama

at Birmingham, Birmingham, AL 03/2008-present Adjunct Associate Professor, Cardiovascular Research Institute,

Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA. USA

12/2005-present Visiting Professor, The Cardiovascular Center, TongJi Hospital,

Huazhong University of Science and Technology, Wuhan, China. 07/2006-02/2008 Associate Professor of Biochemistry (with series I). Cardiovascular

Research Institute, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA. USA

11/2000-06/2006 Assistant Professor of Biochemistry. Cardiovascular Research

Institute, Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA.

10/1996-10/2000 Postdoctoral Research Fellow. Division of Molecular

Cardiovascular Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center Research Foundation, Cincinnati, OH.

1995 Teaching Assistant. Department of Veterinary and Comparative

Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, WA.

01/1993-07/1996 Graduate Research Assistant. Department of Veterinary and

Comparative Anatomy, Pharmacology, and Physiology. Washington State University, Pullman, WA.

03/1991-12/1992 Research Assistant. School of Pharmacy and Allied Health

Sciences, University of Montana, Missoula, MT. 07/1989-12/1990 Pediatrician in Xin Hui TCM Hospital, Xin Hui City, Guang Dong,

China 07/1984-09/1986 Physician in Xin Hui TCM Hospital, Xin Hui City, Guang Dong

Province, China

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MEMBERSHIP OF ACADEMIC SOCIETIES: American Association for the Advancement of Science Premium professional member of American Heart Association The Academy of cardiovascular research Excellence (founding member) American Physiology Society The Endocrine Society Honors: 1991: Pharmacy Awards, School of Pharmacy and Allied Health Sciences,

University of Montana 1998-2000: Post-doctoral fellowship, American Heart Association, Ohio Affiliate. 2003-2007: Scientist Development Award, American Heart Association, National Center. 2004: First place winner of Outstanding Early-career Investigator Award, American Heart Association Manuscript Reviewer: American Journal of Physiology Heart and circulation Cardiovascular Research Circulation Expert Review of Cardiovascular Therapy Journal of Molecular and Cellular Cardiology Acta Pharmacologica Sinica Vascular Pharmacology Journal of Nutrition Biochemistry Journal of Cardiovascular Pharmacology Journal of Cardiothoracic-Renal Research Pharmacogenomics Clinical and Experimental Pharmacology and Physiology Journal of Pharmacy and Pharmacology Lab Investigation Nutrition Research Editorial Board Member: 2005- Journal of Cardiothoracic-Renal Research 2009- World Journal of Cardiology Grant reviewer 2005: Ad hoc member of NHLBI ZHL1 CSR-G: K01 and T32 applications 2005: Swiss National Science Foundation

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2006: China Natural Science foundation 2007: Member of NIH NCCAM Review Special Panel 2008: -Member of NIHLBI special review committee for program project application

-Member of AHA Cardiac Biology/Regulation, Region II 2009: -Member of NIHLBI special review committee for program project grant

-Member of AHA Cardiac Biology/Regulation, Region II -Member of NIHLBI CTRIP review panel -Member of NIHLBI special review committee for Program project Grant

Funds:

Finished:

Post-doctoral Fellowship (9804505, Qinglin Yang): Mouse model of familial hypertrophic cardiomyopathy with myosin binding protein C mutations, American Heart Association, Ohio Affiliate $30,000/year 1998-2000 NIH/NHLBI: MSM Cardiovascular Center of Excellence, UH1-HL03676 (PI: Gary Gibbons) $100,000 11/01/2000-06/30/2005 Beginning Grant-in-Aid: (PI: Qinglin Yang): AHA Southeast Affiliate Structure/Function of Cardiac Myofibril Protein Phosphorylation $100,000 07/01/2001-06/30/2003 NIH/NIGMS (Pilot project leader: Qinglin Yang): PKA regulatory subunits in heart function regulation $156,200 01/01/2002-12/31/2004 NIH/NIGMS: S06GM08248 (Subproject leader: Qinglin Yang): The Cardiac Renin-Angiotensin System and Ischemic Tolerance of Hypertrophied Myocardium $438,400 08/01/2002-07/31/2006 Scientist Development Award (0430265N) (PI: Qinglin Yang): AHA National Center Function of Myosin Binding Protein C in Heart $260,000 (Direct costs) 01/01/04-12/30/2007 Roles of PPARdelta in cardiac hypertrophy and heart failure

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NIH/NIGMS-MBRS subproject (S06GM08248): (Subproject leader: Qinglin Yang) $1,064,000 08/01/2006-07/31/2010 Acquired mtDNA depletion and nucleoside reverse transcriptase inhibitors 1 R01 HL079867-01A2 (PI: William Lewis, Emory University, Atlanta, GA) $100,000 09/01/2006-08/30/2011 Current- PPARγ signaling pathway in cardiac hypertrophy and failure 1R01HL085499-01 (PI: Qinglin Yang) $1,750,000 08/01/2006-07/31/2011 Regulation of myocardial lipid and energy homeostasis 1R01 HL084456-01A1 (PI: Qinglin Yang) $1,750,000 01/15/2007-12/31/2011 Effects of Salacia oblonga root extract on cardiac hypertrophy 1 R21 AT003734-01A1 (PI: Qinglin Yang) $385,000 09/01/2007-08/30/2010 (no cost extension) Role of microRNAs in the regulation of PPARγ (supplement to 1R01HL085499-01 (PI: Qinglin Yang) $196,000 010/15/2008-12/31/2011 Others: T32HL072757-06 (Allison) 04/15/03 – 03/31/09 NIH/NHLBI $213,062 (Annual Direct cost) UAB Statistical Genetics Post-Doctoral Training Program The training program aims to develop independent investigative skills in the development, evaluation, and application of advanced statistical genetics methods. Role: Support faculty PENDING R01 HL080017-05 (PI: Yiu-Fai Chen, PhD) ANP Modulates Cardiac Remodeling via Cardiac Fibroblasts

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NIH/NHLBI 12/01/2009-11/30/2014 NCCAM: Purdue-UAB Botanicals Center for Dietary Supplements Research Project 2 Mechanisms by which kudzu root extract alters glucose metabolism and homeostasis in mouse models of metabolic syndrome (Project leader: J Michael Wyss) T32HL79888 (Allison, PhD) NIH/NHLBI $176,404 (Annual Direct cost) UAB Biostatistics Pre-Doctoral Training Program The program aims to develop independent investigative skills in the development, evaluation, and application of advanced statistical methods. Applied experience is provided via co-mentorship by UAB's well established NHLBI-funded investigators. Role: Support faculty T32 HL007457 (Suzanne Oparil, MD) NIH/NHLBI Mechanisms of Hypertension and Cardiovascular Diseases 07/01/2011 to 06/30/2016 Role: Mentor 1 R01 HL104109-01 (PI: Qinglin Yang) NIH/NHLBI The role of LXR signaling in cardiac pathophysiology 07/01/2010-06/30/2015 Peer review Publications: 1) Slinker BK, Stephens RL, Fisher SA and Yang Q. Immediate-early gene responses to different cardiac loads in the ejecting rabbit left ventricle. Journal of Molecular and Cellular Cardiology. 28, 1565-1574. 1996. 2). Q. Yang, R. L. Stephens, J. W. Harding and B. K. Slinker: Angiotensin IV involvement in the mechanically induced Immediate-early gene expression in the isolated rabbit heart. Regulatory Peptides 71, 175-183,1997. 3). Q. Yang, A. Sanbe, H. E. Osinska, R. Klevisky, T. E. Hewett, and J. Robbins: A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy. J. of Clinical Investigation 102, 1292-1300, 1998. (Rapid publication). 4). Q. Yang, A. Sanbe, H. E. Osinska, R. Klevisky, T. E. Hewett and J. Robbins: In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy. Circulation Research 85 (9): 841-847, 1999. (On the cover).

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5). Q. Yang, T. E. Hewett, R. Klevisky, A. Sanbe, Xuejun Wang and J. Robbins: PKA dependent phosphorylation of Cardiac Myosin binding Protein C in transgenic mice. Cardiovascular Research 51(1):80-8, 2001. 6). Q. Yang, Osinska H, R. Klevisky and J. Robbins: Phenotypic deficits in mice expressing a Myosin Binding Protein C lacking the Titin and Myosin binding domains. Journal of Molecular and Cellular Cardiology. 2001 Sep;33(9):1649-58 8). Cheng LH, Ding GL, Qin QH, Xiao Y, Woods D, Chen YE, Yang Q*. Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes. Biochem Biophys Res Commun. 2004; 313(2):277-86. 9). Cheng LH, Ding LH, Qin QH, Huang Y, Lewis W, He N, Evans RM, Schneider MD, Brako LA, Woods D, Xiao Y, Chen EY, and Yang Q*. Cardiomyocyte-restricted Peroxisome proliferator-activated receptor δ deletion perturbs myocardial fatty acid fatty acid oxidation and leads to cardiomyopathy. Nature Medicine 2004; 10, 1245 – 1250. 10). Yang Q*, Cheng LH: Molecular regulation of lipotoxicity in the heart (Invited review) Drug Discovery Today: Disease mechanisms. 2005; 2(1), 101-107. 11). Huang THW, Yang Q, Harada M, Li GQ, Yamahara J, Roufogalis RD, Li YH: Pomegranate flower improves cardiac fibrosis in Zucker diabetic fatty rats: modulation of multiple pathways. Journal of Cardiovascular Pharmacology. 2005;46(6):856-62. 12). Huang THW, Yang Q, Harada M, Li GQ, Uberai J, Radford J, Yamahara J, Roufogalis RD, Li YH: Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: modulation of PPAR-α-mediated transcription of cardiac fatty acid metabolic genes. Toxicology and Allied Pharmacology. 2006;210 (1-2):78-85. 13). Peng X, Kraus MS, Wei HJ, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng LH, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H and Guan JL: Inactivation of focal adhesion kinase in cardiomyocytes promotes cardiac eccentric hypertrophy and fibrosis in mice. Journal of Clinical Investigation. 2006;116(1):217-227. 14). Pan GD, Huang YZ, Guo LY, Tang JM, Kong X, Yang Q and Wang JN: Construction and identification of α-cardiac myosin heavy chain promoter-driven enhanced green fluorescent protein expression vector. Journal of Yunyang Medical College, 2006; 25 (2): 70-73 15). Ding G, Cheng LH, Qin QH, Frontin SE, Yang Q*: Peroxisome proliferator-activated receptor δ inhibits cardiac TNFα expression in response to inflammatory stimuli. Journal of Molecular and Cellular Cardiology. 2006; 40(6):821-8. (On the cover). 16). Lee J, Hu Q, Nakamura Y, Wang X, Zhang X, Zhu X, Chen W, Yang Q*, Zhang J:

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Open-chest 31P Magnetic Resonance Spectroscopy of Mouse Heart at 4.7 Tesla. Journal of Magnetic Resonance Imaging. 2006 Dec;24(6):1269-76. 17). Li HL, Yin R, Chen D, Liu D, Wang D, Yang Q, Dong YG. Long-Term Activation of Adenosine Monophosphate-Activated Protein Kinase Attenuates Pressure-overload-Induced Cardiac Hypertrophy. Journal of Cellular Biochemistry, 2007;100(5):1086-99. 18). Yang Q* and YH Li: Roles of PPARs on regulating myocardial lipid homeostasis (Invited review). Journal of Molecular Medicine 2007:85(7):697-706. 19). Zhuo ML, Wang D, Cai H, Wang AB, Sun LH, Yang Q, Wei YS, Liu PP, Liu DP: Targeted Cardiac Overexpression of A20 Protects Mice from Acute Myocardial Infarction Through Blocking NF-κB Signaling. Circulation 2007, 115(14):1885-94. 20). Li HL, She ZG, Li TB, Yang Q, Wang YG and Liu DP: Aggravated Cardiac Hypertrophy in Response to Chronic Infusion of Angiotensin II in Mice Overexpression of Myofibrillogenesis Regulator-1. Hypertension 2007 Jun;49(6):1399-408 21). Yang Q*: Chasing Sphingosine 1-phosphate, a lipid mediator for cardiomyocyte survival (Editorial) Cardiovascular Research, 2007, 74(1):4-5. 22). Ding GL, Qin QH, Qin QH, He N, Cheng LH, Francis-David SC, Hou J, Ernest Ricks, Jian Liu and Yang Q*. Adiponectin and its receptors are expressed in cardiomyocytes and regulated by PPARγ. Journal of Molecular and Cellular Cardiology. 2007 Jul;43(1):73-84. 23). Ding G, Fu M, Qin QH, Lewis W, Kim HW, Fukai T, Bacanamwo M, Chen EY, Schneider MD, Mangelsdorf DJ, Evans RM and Yang Q*: Peroxisome Proliferator-Activated Receptor γ is essential in maintaining myocardial redox homeostasis. Cardiovascular Research. 2007, 76(2):269-79 24) Chang L., Zhang JF, Tseng YH, Xie CQ, Ilany J, Bruning J, Sun ZC, Zhu XJ, Cui TX, Youker KA, Yang Q, Kahn R, Chen YE: Rad GTPase deficiency leads to cardiac hypertrophy. Circulation, 2007, 18;116(25):2976-83. 25). Huang THW, He L, Qin Q, Yang Q, Peng G, Harada M, Qi Y, Yamahara J, Roufogalis BD, Li Y: Salacia oblonga amends cardiac hypertrophy in Zucker diabetic fatty rats: modulation of cardiac renin-angiotensin system. Diabetes, Obesity and Metabolism 2008:10 (7): 574-585 26) Li YQ, Yin R, Liu J, Wang PY, Wu SJ, Luo JW, Zhelyabovska O, Yang Q*: Peroxisome Proliferator-activated Receptor δ Regulates Mitofusin 2 Expression in the Heart. Journal of Molecular and Cellular Cardiology 2009:46(6):876-82

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27) Cai J, Yi FF, Yang L, Shen DF, Yang Q, Li A, Ghosh AK, Bian ZY, Yan L, Tang QZ, Li H, Yang XC: Targeted Expression of Receptor-Associated Late Transducer Inhibits Maladaptive Hypertrophy via Blocking Epidermal Growth Factor Receptor Signaling. Hypertension 2009, 53(3): 539-548 28) Rong X, Peng G, Suzuki T, Yang Q, Yamahara J, and Li YH: A 35-day gavage safety assessment of ginger in rats. Regulatory Toxicology and Pharmacology 2009 54(2):118-23. 29) He L, Qi YF, Rong XL, Jiang JM, Yang Q, Yamahara J, Murray M and Li YH: The Ayurvedic antidiabetic medicine Salacia oblonga attenuates renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evidence Based Complementary and Alternative Medicine (In press) 30) Cox KB, Barnes S, Smith M, Liu J, Yang Q, and Wood PA: Cardiac Hypertrophy in Mice with Long-Chain Acyl-CoA Dehydrogenase (LCAD) or Very Long-Chain Acyl-CoA Dehydrogenase (VLCAD) Deficiency, Lab Investigation (Accepted) 31) Wu SJ, Yin R, Ernest R, Li YQ, Zhelyabovska O, Luo JW, Yang YF, Yang Q*: LXRα is a negative regulator of cardiac hypertrophy via suppressing NF-κB signaling. Cardiovascular Research. 2009 Oct 1;84(1):119-26. 32) Li Y, Cheng LH, Qin QH, Liu J, Lo WK, Brako LA and Yang Q*: High fat feeding in cardiomyocyte-restricted PPARδ knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to recue cardiac phenotypes. Journal of Molecular and Cellular Cardiology 2009:47(4):536-43 33) Kohler JJ, Hosseini SH, Cucoranu L, Green E, Kristopher I, Abuin A, Fields E, Hoying A, Russ R, Santoianni R, Olga Zhelyabovska, Yang Q, Lavie A, Lewis W: Thymidylate monophosphate kinase (TMPK): characterization of a novel cardiac targeted overexpression and its relation to mitochondrial nucleotide pools. Lab Investigation (In revision). 34) Wang P, Liu J, Li Y, Wu S, Luo J, Yang H, Subbiah R, Chatham J, Zhelyabovska O, Yang Q*: PPARδ is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart. Circulation Research (In revision) 35) Liang J, Lei TH, Zhou Y, Yang Q, Kolattukudy PE and Fu M: MCPIP1 is a Novel Transcriptional Corepressor of NF-κB. (Submitted) 36) Luo N, Tian L, Liu J, Chung BH, Yang Q, Klein RL, Garvey WT, Fu Y: Macrophage adiponectin expression improves body metabolism in vivo (Submitted) Other publications:

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Q. L. Yang: Study on treating allergic asthma in children with basic asthma formulas. In: Selected works of post-graduate thesis (1989), Guang Zhou College of TCM Press, Guang Zhou, 53. *Corresponding author Conferences: Q. L. Yang, N. A. Irons-Diemert, S. L. Pinkston and C. A. Johnston: Oxytocin-induced stimulation of LH release: dependence on gonadal steroids. 1992, 52nd annual meeting of the Montana Academy of Sciences, Montana State University, Bozeman, MT, MBIN Section, talk #12 pg 17. Q. L. Yang, Irons-Diemert, N., Pinkston, S., and Johnston, C. A.: Influence of gonadal steroids on the oxytocin-induced stimulation of LH. 74th Annual Meeting of Endocrine Society of American, San Antonio, TX, June 24-26, P. 355, Abstract #1213 (1992). C. A. Johnston and Q. L. Yang: Gonadal steroid requirement for the oxytocin-induced stimulation of LH. 75th Annual Meeting of Endocrine Society of American, Las Vegas, NV, June 9-12, P.341. Abstract #1161 (1993). C. A. Johnston and Q. L. Yang: Plasticity of CNS oxytocin neuronal interactions with LHRH: role of gonadal steroids. Society for Neuroscience 19(349.3):847. (1993). Q.Yang, R. L. Stephens and B. K. Slinker: Mechanically-induced immediate-early gene expression in the isolated rabbit heart is partially mediated by angiotensin-II International Society for Heart Research XVIII Meeting-American Section (1996). Q. Yang, H. E. Osinska, R. Klevisky, T. E. Hewett, A. Sanbe and J. Robbins: A mouse model of familial hypertrophic cardiomyopathy. In the Molecular Biology of the Cardiovascular System. Steam Boat Springs, CO. Keystone Symposia, March 28-April 3, 1998. Q. Yang, A. Sanbe, H. E. Osinska, T. E. Hewett, R. Klevisky and J. Robbins: A mouse model of Familial Hypertrophic Cardiomyopathy caused by Myosin Binding protein-C mutation. The 71st Scientific session of American Heart Association annual meeting, November 11, 1998, Dallas Texas. Q. Yang, A. Sanbe, H.E. Osinska, R. Klevisky, T.E. Hewett and J. Robbins: Transgenic mouse model of Familial Hypertrophic Cardiomyopathy linked to cardiac myosin binding protein c lacking the myosin binding domain. In 44th Rachford International symposium, Cincinnati, OH. November 15-16, 1999. Q. Yang, A. Sanbe, H. E. Osinska, R. Klevisky, T. E. Hewett, Thomas Kimble, Sandra Witte, and J. Robbins: Structure-function studies of truncated cardiac myosin binding

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protein C in transgenic mice. Experimental Biology 99’, April 17-21, 1999, Washington DC. Q. Yang, A.Sanbe, and J. Robbins: Structure/function studies of hypertrophic cardiomyopathic mutations in transgenic mice. Molecular Biology of the Cardiovascular System, keystone Symposia, January 12-17, 2000. Snowbird, UT. Smith P, Liu X, Yu J, Cheng LH and Yang Q*: Activation of signal transduction pathways in rat model of chronic left ventricular Failure: Biomedical Research Symposium for Minority Students, October 18-21, 2001, Cancun, Mexico. Yang Q*, Liu X, Smith P, Cheng LH: Upregulation of anti-apoptotic proteins in rat model of chronic left ventricular Failure. Molecular Biology of Heart, keystone Symposia, February 13 - February 18, 2002, Keystone Resort, Keystone, Colorado. Qin Q, Cheng LH, Smith P, Liu X, Xiao Y, Yu J, Yang Q*: Arc Expression in Response to Hypertrophic and Apoptotic Stimuli in Cardiomyocytes in vivo and in vitro. Scientific Conference on Advances in the molecular and Cellular Mechanisms of Heart Failure, August 21-25, 2002, Snowbird Conference Center, Snowbird, Utah. Cheng LH, Qin QH, Ding GL, Floyd D, Smith P and Yang Q*: Cardiac Myosin Binding Protein C Missing the RRTS surface Loop impairs cardiac Relaxation in Transgenic Mice. Symposium on Phenotyping: Mouse Cardiovascular Function and Development, October 10-11, 2002. Cheng LH, Ding GL, Qin QH, Xiao Y, Woods D, Chen YQ, Yang Q*: Peroxisome Proliferator-Activated Receptor δ involves in maintaining energy homeostasis in cardiomyocytes. Scientific Conference on Molecular Mechanisms of Growth, Death and Regeneration in the Myocardium: Basic Biology and Insights into ischemic heart disease and Heart Failure. August 13, 2003-Aug 17, 2003. Snowbird, UT Cheng LH, Ding GL, Qin QH, Xiao Y, Woods D, Chen YQ, Yang Q*: PPARδ Activates Fatty Acid Metabolism in Cardiomyocytes Independent of PPARδ. Hot topics in endocrinology: The role of Nuclear Receptors in cardiovascular disease. October 8-12, 2003. Coronado Island in San Diego, CA Cheng LH, Qin QH, Ding GL, Huang Y, Floyd D, Woods D, Yang Q*: Constantly Phosphorylated Cardiac Myosin Binding Protein C in Transgenic Mouse Heart Enhances Cardiac Performance. The Scientific session 2003 of American Heart Association annual meeting, November 9-12, 2003, Orlando, FL Ding GL, Mou YS, Cheng LH, Qin QH, Wu H, Woods D, Huang Y, Yang Q*: PPARδ Inhibits Cardiac TNFα Expression in Response to Inflammatory Stimuli In Vivo and In Vitro. Scientific session 2003 of American Heart Association annual meeting, November

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9-12, 2003, Orlando, FL. Ding GL, Qin QH, Cheng LH, Huang Y, Woods D and Yang Q*: PPARγ enhances the expression of adiponectin and Adiponectin receptor 2 in the heart. Scientific session 2004 of American Heart Association annual meeting, November 7-10, 2004, New Orleans, LA. L. Cheng, G. Ding, Q. Qin, W. Lewis, N. He, R. M. Evans and Y. E. Chen, and Q. Yang*: Cardiomyocyte-restricted PPARδ deletion leads to myocardial lipid accumulation and dilated cardiomyopathy. 2nd Annual Meeting of Society for heart and vascular metabolism: Paradoxical Role of Lipids in the Heart: From PPARs to Patient Care. Fairmont Le Château Montébello Québec, Canada. September 9-11, 2004 L. Cheng, G. Ding, Q. Qin, Y. Huang, W. Lewis, R. M. Evans, M. D. Schneider, YE Chen and Q. Yang*: Cardiomyocyte-restricted inactivation of Peroxisome proliferator-activated receptor δ causes lipotoxic cardiomyopathy. Scientific session 2004 of American Heart Association annual meeting, November 7-10, 2004, New Orleans, LA. L. Cheng, G. Ding, Q. Qin, Y. Huang, W. Lewis, R. M. Evans, M. D. Schneider, Y. E. Chen, and Q. Yang*: Cardiomyocyte-restricted inactivation of Peroxisome proliferator-activated receptor δ deletion causes lipotoxic cardiomyopathy. 1st Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, July 14-18, 2004 at the Dolce Samaria Lodge in Stevenson, WA. G. Ding, Qin Q, He N, Cheng L, Francis-Davis SC, Yang Q*. Adiponectin is expressed in cardiomyocytes and regulates energy metabolism via activating AMP-activated protein kinase in cardiomyocytes. Scientific session 2005 of American Heart Association annual meeting, November 13-16, 2005, Dallas, TX. Ding G, Fu M, Cheng LH, Qin QH, Huang Y, Lewis W, Fukai T, Chen EY, Mangelsdorf DJ, Schneider MD, Evans RM and Yang Q*.: Peroxisome Proliferator-Activated Receptor γ Is Essential to Maintain Myocardial Redox Homeostasis. 3rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, July 31-Aug 3, 2006 at Keystone, CO. Yang Q*, Ding G, Fu M, Cheng LH, Qin QH, Huang Y, Lewis W, Fukai T, Chen EY, Mangelsdorf DJ, Schneider MD, Evans RM: Peroxisome Proliferator-Activated Receptor γ Is Essential to Maintain Myocardial Redox Homeostasis. Scientific session 2006 of American Heart Association annual meeting, November 12-15, Chicago, IL Cheng LH, Qin QH, Huang Y, Lewis W, Brako LA, Aikhionbare FO, and Yang Q: Overexpression of fatty acid metabolic genes in Peroxisome Proliferator-activated Receptor-δ deficient hearts in response to high-fat feedings. The 4th annual meeting of the Society for Heart and Vascular Metabolism - "CARDIAC ENERGY METABOLISM IN

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HEART FAILURE: FROM CONCEPTS TO THERAPIES", September 6 – 9, 2006, Semiahmoo, WA Yang Q*, Qin Q, Liu J, Li Y, Yin R, Madsen E, Nielsen LB.: Upregulation of lipoprotein secretion: a mechanism to maintain myocardial lipid homeostasis in cardiomyocyte-restricted PPARδ knockout mice? 5th Annual Conference Society for Heart and Vascular Metabolism, Maastricht, the Netherlands. June 18-20, 2007 Yang Q*, Qin QH, Liu J, Liu XW, Wang GM, and Brako LA: Smad1 Signaling is Essential for Adult Hearts and in Protecting the Myocardium to Ischemia/reperfusion Injury: AHA Research Symposium, Orlando, November 3nd, 2007 Qin QH, Cheng LH, Lewis W, Brako LA, Floyd D, and Yang Q*: Mice with cardiomyocyte-restricted Smad4 deletion resist to Angiotensin II induced cardiac hypertrophy. Scientific session 2007 of American Heart Association annual meeting, November 4-7, 2007, Orlando, FL. Qin QH, Liu J, Wang GM, Liu XW, Lewis W, Brako LA, and Yang Q*: Cardiomyocyte-restricted knockout of Smad1 in mice exacerbates myocardial ischemia/reperfusion injury: Scientific session 2007 of American Heart Association annual meeting, November 4-7, 2007, Orlando, FL. Liu J, Wang PY, Cheng LH, Brako FA, Yang Q*. Cardiomyocyte-restricted PPARδ deletion in PPARα null mice leads to cardiac hypertrophy and heart failure. Experimental Biology 2008, April 5-8, San Diego, CA Li YQ, Yin R, Broke LA, Floyd D, Yang Q*. Down-regulation of Mitofusin2, a target gene of PPARδ, disrupts mitochondria network in the hearts of cardiomyocyte restricted PPARδ knockout mice. Experimental Biology 2008, April 5-8, San Diego, CA Qinglin Yang*, Jian Liu, Peiyong Wang, Lawrence A. Brako, Yuquan Li. Deficiency of both PPARδ and PPARα in the heart leads to additional cardiac FAO depression and heart failure in mice. Acta Physiologica Sinica, Volume 60 Supplement 1, October 19, 2008 Peiyong Wang; Jian Liu; Olga Zhelyabovska; Sijie Wu; Yuquan Li; Ramasamy Subbiah; Jinwen Luo; Qinglin Yang*: Cardiac-specific knock-out of PPARδ brings down cardiac metabolism and alters cardiac gene expression. Scientific session 2008 of American Heart Association annual meeting, November 7-12, 2008, New Orleans, LA Wang PY, Liu J, Li YQ, Wu SJ, Luo JW, Li QB, Yang H, Zhelyabovska O, Yang Q*: Peroxisome Proliferator-activated Receptor β/δ is Essential for Mitochondrial biogenesis and function in heart. Basic Cardiovascular Sciences Annual Conference 2009

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Wu SJ, Yin R, Ernest R, Li YQ, Zhelyabovska O, Luo JW, Yang YF, Yang Q*: LXRα is a negative regulator of cardiac hypertrophy via suppressing NF-κB signaling. Basic Cardiovascular Sciences Annual Conference 2009 Liu J, Wang PY, Luo JW, Huang Y, Rammasamy S, Yang H, Li QB, Wu SJ, Zhelyabovska O, Yang Q*: Cardiomyocyte-restricted PPARδ overexpression in adult mice enhances myocardial fatty acid and glucose metabolism, mitochondria biogenesis and anti-oxidant defense. Basic Cardiovascular Sciences Annual Conference 2009 Yang H, Li YQ, Zhelyabovska Q, Fu M and Yang Q*: Mito28 is a novel mitochondrial protein involved in energy metabolisms in cardiomyocytes. Basic Cardiovascular Sciences Annual Conference 2009 Liu J, Zhelyabovska, Qin QH, Wang PY, Yang Q*: Conditional Smad1 knockout in mice leads to cardiac hypertrophy and heart failure. Basic Cardiovascular Sciences Annual Conference 2009 Luo JW, Yang H, Li YQ, Liu J, Zhelyabovska O, Yang Q*: Conditional PPARγ knockout from cardiomyocytes of adult mice disturbs myocardial lipid metabolism. Basic Cardiovascular Sciences Annual Conference 2009 Wang P, Liu J, Li Y, Wu S, Luo J, Yang H, Subbiah R, Chatham J, Zhelyabovska O, Yang Q*: PPARdelta is an essential transcriptional regulator for mitochondrial protection and Biogenesis in adult heart, Scientific sessions, AHA 2009 *Corresponding author Invited Presentations: Cardiac Angiotensin System autoregulation in the heart. TCHRF, Children’s Hospital Medical Center, Cincinnati, OH. March 29, 1996. Mouse Models of Human Familial Hypertrophic Cardiomyopathy with Mutations in Cardiac Myosin Binding Protein C. Division of Cardiology, Department of Pediatrics, Children’s Hospital Medical Center, Cincinnati, OH. April 6, 1998. Structure-function studies of truncated cardiac myosin binding protein C in transgenic mice. Division of Cardiology, Department of Pediatrics, Children’s Hospital Medical Center, Cincinnati, OH. June 7, 1999. In vivo Modeling of Familial Hypertrophic Cardiomyopathy with mutations in cardiac myosin binding protein C. Cardiovascular Research Institute, Department of Surgery, University of Louisville School of Medicine, Louisville, KY. September 24, 1999.

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Transgenic mouse models of FHC linked to truncated forms of cardiac MyBP- C. Department of Physiology and Pharmacology, University of Medicine and Dentistry of New Jersey, Newark, NJ. October 29, 1999. Structure/function studies of cMyBP-C and FHC. Laboratory of Physical Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Methesda, MD. December 10, 1999. Structure/function studies of cMyBP-C with a transgenic approach. Washington State University, Pullman, WA. January 27, 2000. Structure/function studies of cMyBP-C in transgenic mice. Myogen Inc. Westminster, CO. April 21, 2000. Structure/function studies of cardiac MyBP-C in transgenic mice. Cardiovascular Research Center, School of Medicine, University of Wisconsin at Madison, Madison, WI. May 31, 2000. Myosin Binding Protein C in the Heart: from mutations to structural and functional defects, Department of Pathology and Lab Medicine, Emory University, Atlanta, Georgia, September 24, 2002. PPARδ, a critical determinant of Fatty acid metabolism in the heart. Atlanta Vascular Research Organization, Atlanta, GA. February 26, 2004. Cardiomyocyte-restricted inactivation of Peroxisome proliferator-activated receptor δ deletion causes lipotoxic cardiomyopathy. 1st Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, July 14, 2004. Stevenson, WA. Cardiomyocyte-restricted PPARδ deletion leads to myocardial lipid accumulation and dilated cardiomyopathy. 2nd Annual Meeting of Society for heart and vascular metabolism: Paradoxical Role of Lipids in the Heart: From PPARs to Patient Care. Fairmont Le Château Montébello Québec, Canada. September 11, 2004 PPARs in the heart: 14th South Eastern Lipid Research Conference (SELRC), Callaway Gardens, Georgia, September 23-25, 2005 Nuclear receptors, popular targets of medicinal herbs: Guangzhou University of Traditional Chinese Medicine, Guangzhou, China, December 14, 2005 Essential roles of PPARs in heart: The Cardiovascular Center, The 1st Affiliate hospital of San Yet-sen University, Guangzhou, China, December 15, 2005 PPARs, potential therapeutic targets for heart failure: The Cardiovascular Research

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Institute, Guangdong Provincial Hospital, Guangzhou, China, December 16, 2005 PPARγ governs redox homeostasis in the heart: The Cardiovascular Center, TongJi Hospital, Huazhong University of Science and Technology, Wuhan, China. December 21, 2005 PPAR signaling in the heart: The Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC, June 21, 2006. PPARs, essential players in the heart: Cardiology Grand Rounds, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, September 27, 2006 Peroxisome Proliferator-Activated Receptors: Transcriptional Regulators at the Crossroads of Myocardial Metabolisms. Department of Pharmacology, Loyola University Chicago, Maywood, IL, September 28, 2006 PPAR signaling in the heart: transcriptional control of myocardial lipid and redox homeostasis: Department of Pharmacology, Medical College of Georgia, Augusta, GA. October 4, 2006 Peroxisome proliferator activated receptors are transcriptional regulators of myocardial energy and lipid homeostasis: Pioneer Valley Life Sciences Institute, University of Massachusetts Amherst, December 5th, 2006 Peroxisome proliferator activated receptors: essential transcription factors govern myocardial homeostasis: Department of Physiology, Wayne State University, Detroit, MI. December 7, 2006 Transcriptional control of metabolism in heart: Department of Biomedical and Pharmaceutical Sciences, school of Pharmacy, University of Montana, Missoula, March 1st, 2007 Metabolic syndrome and adiposity of the heart: Department of Nutrition Sciences, School of Professional Health, University of Alabama at Birmingham, AL, July 10, 2007 Metabolic disorders of the heart: Department of Medicine and Clinical Science, Kyoto University, Kyoto, Japan, July 13, 2007 Transcriptional regulation of energy and lipid homeostasis of the heart: The Cardiovascular Center, The 1st Affiliate hospital of San Yet-sen University, Guangzhou, China, July 19, 2007 The fuel economy in the progression of heart failure: The Department of Cardiac

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Surgery, Xiangya Hospital, Zhong Nan University, Changsha, Hunan, China, October 27, 2008 PPAR signaling and Fuel economy in the heart: Center of Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, September 18, 2008 Peroxisome-proliferator-activated receptor δ: a key regulator of myocardial metabolic homeostasis. The Vascular Biology & Hypertension Program seminar series. University of Alabama at Birmingham, Birmingham, AL, January 23, 2009 LIPID IN THE HEART: THE IMPORTANCE OF YIN-YANG BALANCE. The Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, February 25, 2009 PPARδ: a potential therapeutic target for cardiovascular disease. The 20th Annual UAB Vascular Biology and Hypertension Symposium, to be held on September 14-15, 2009. the Carraway-Davie House and Conference Center, Birmingham, AL Nuclear receptors in the transcriptional regulation of myocardial lipid and energy homeostasis. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine University of Alabama at Birmingham, Birmingham, AL, October 22, 2009 PPARδ is a key transcriptional regulator of mitochondrial biogenesis and function in the heart. Cardiovascular Research Institute, Wuhan University, Wuhan, China. November 5nd 2009 Nuclear receptors: novel therapeutic targets for the treatment and prevention of heart disease. Novel Therapeutic targets in cardiovascular diseases, BIT’s 1st annual International Congress of Cardiology, December 5-7, 2009, Shanghai, China Teaching Activities: 1995-1996: Teaching Assistant in Physiology course for Veterinary professional students. Veterinary College, Washington State University, Pullman, WA. 2001: Graduate Molecular Biology Course P600: Introduction of Transgenesis in Basic Biomedical Research. Morehouse School of Medicine, Atlanta, GA 30310 2002: Medical Biochemistry Course: Molecular Biochemistry-Signal Transduction, Metabolic Biochemistry-Nucleotide Metabolism, Morehouse School of Medicine, Atlanta, GA 30310 2003: Medical Biochemistry Course: Muscle Contraction and Energy Metabolism Morehouse School of Medicine, Atlanta, GA 30310

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2004: Medical Biochemistry Course: Muscle Contraction and Energy Metabolism Morehouse School of Medicine, Atlanta, GA 30310 2004: Special topic: Cardiovascular biology (Cardiac physiology) Morehouse School of Medicine, Atlanta, GA 30310 2005: Medical Biochemistry Course: Muscle Contraction and Energy Metabolism Morehouse School of Medicine, Atlanta, GA 30310 2005: Cardiovascular biology (Molecular Mechanisms of cardiac diseases) Morehouse School of Medicine, Atlanta, GA 30310 2005: Special topic (Course director): Energy metabolisms and heart disease Morehouse School of Medicine, Atlanta, GA 30310 2006: Medical Biochemistry Course (MEDI 500): Muscle Contraction and Energy Metabolism. Morehouse School of Medicine, Atlanta, GA 30310 2006: Cardiovascular biology PHD706 (Molecular Mechanisms of cardiac diseases) Morehouse School of Medicine, Atlanta, GA 30310 2006: Special topic (Course director): Energy metabolisms and heart disease. Morehouse School of Medicine, Atlanta, GA 30310 2007: Medical Biochemistry Course (MEDI 500): Muscle Contraction and Energy Metabolism. Morehouse School of Medicine, Atlanta, GA 30310 2007: Cardiovascular biology PHD706 (Molecular Mechanisms of cardiac diseases). Morehouse School of Medicine, Atlanta, GA 30310 2007: Special topic (Course director): Energy metabolisms and heart disease. Morehouse School of Medicine, Atlanta, GA 30310 2008: Special topic (Course director): Energy metabolisms and heart disease. Morehouse School of Medicine, Atlanta, GA 30310 2009: NTR 779: Obesity in the XXI Century: Obesity and cardiovascular disease Department of Nutrition Sciences, University of Alabama at Birmingham, AL 2009: NTR 618/718, Nutritional Biochemistry, Department of Nutrition Sciences, University of Alabama at Birmingham, AL Administrative services: 2001: Organizer of CVRG Seminar series, Cardiovascular Research Institute,

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Morehouse School of Medicine, Atlanta, GA 30310 2002: Graduate program Strategic Planning Committee Organizer of CVRG Seminar series, Morehouse School of Medicine, Atlanta, GA 30310 2003: Graduate program Strategic Planning Committee, Morehouse School of Medicine, Atlanta, GA 30310 2004: Graduate program Strategic Planning Committee, Morehouse School of Medicine, Atlanta, GA 30310 2008-present: Faculty Affair Committee, School of Health Profession, University of Alabama at Birmingham, Birmingham, AL 35294 2009-present: Graduate committee, Department of Nutrition Sciences, School of Health Profession, University of Alabama at Birmingham, Birmingham, AL 35294 2009-present: Steering Committee, the Center for Cardiovascular Biology (CCVB), University of Alabama at Birmingham, Birmingham, AL 35294 Ph.D. Graduate committee: Morehouse School of Medicine Shana Benton (Morehouse School of Medicine) Kristina Keys (Morehouse School of Medicine) Ernest Ricks (Morehouse School of Medicine) Qingbao Li (Cardiac surgery, College of Medicine, Shan Dong University, Jinan, China) Jinwen Luo (Cardiac Surgery, Department of Cardio-thoracic surgery, The Second

Xiangya Hospital, Central South University, Changsha, China) Sijie Wu (Cardiac Surgery, Department of Cardio-thoracic surgery, The Second

Xiangya Hospital, Central South University, Changsha, China) University of Alabama at Birmingham: Grace Walton (Department of Nutrition Sciences, University of Alabama at Birmingham) Lab members: Past: Undergraduate students: Patrick Smith (2001-2002), Morehouse College James Nichols, Morehouse College David Woods, Morehouse College Sonya E. Frontin, Spelman College, Atlanta, GA Andrew L. Reed, Jr., Morehouse College, Atlanta, GA

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Graduate students: Isfahan Chambers (PhD student) Ernest Ricks (PhD student) Qingbao Li Sijie Wu Jingwen Luo Post-doctoral fellows and Technicians: Past: Guoliang Ding, MD, PhD Current position: Assistant Professor, Department of Pediatrics, Emory University, Atlanta, GA Puthenpura. T. Boban, Ph.D. Current position: Lecturer, Govt College Kariavattom Kariavattom PO, Trivandrum, Kerala, India Xiaowei Liu Current position: Senior Scientist, Morehouse School of Medicine, Atlanta, GA Yuquan Li, Ph.D. Current position: Associate Professor, Department of Anatomy, The Second Military Medical University, Shanghai, China Ran Yin, MD, PhD Current position: Cardiologist, Jiangxi University, China Qingbao Li, MD, Ph.D., Cardiac surgeon, ShanDong University, Jinan, China Qinglu Li, BS Current position: Scientist, Department of Medicine/Cardiology, University of Minnesota, Twin Cities, MN Lihong Cheng, MD, MS Current position: Post-doctoral fellow, Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA Yao Huang, MS Current position: Research assistant: Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA Qianhong Qin, MD, Current position: Research Specialist Lead, Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA

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Zongxian Jiao, MD, Ph.D. Current position: Post-doctoral fellow, Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA Guangming Wang, Ph.D. Current position: Post-doctoral fellow, Neurosciences Institute, Morehouse School of Medicine, Atlanta, GA Wendy Pang Current position: unknown Ramasamy Subbiah, Ph.D. Current position: Post-doctoral fellow, Temple University, Philadelphia, PA Current: Graduate Students (sponsor partly by Department of Education, China): Jinwen Luo Sijie Wu Research Technician: LaShonda R. Silmon Research Assistant: Huan Yang Post-doctoral fellow and research associates: Natasha Browner, PhD Peiyong Wang, MD, PhD Jian Liu, MD, PhD Olga Zhelyabovska, Ph.D. Lan He, MD, PhD Yiqun Zhou, PhD Teayoun Kim, PhD