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CURRICULUM VITAE NAME: Andrzej T. Slominski, MD, PhD BIRTHPLACE: Poland CITIZENSHIP: USA MARITAL STATUS: Married to Elizabeth CHILDREN: One son: Radomir, Matthew CORRESPONDENCE: Business: Department of Dermatology, University of Alabama at Birmingham, 1720 2nd Avenue South VH 476C, Birmingham, AL 35294; VA Medical Center, 700 South 19th Street, Birmingham, AL 35233 Phones: 205.934.5245; VA: 205.933.8101 ext. 8625; E-mails: aslominski@uabmc.edu; andrzej.slominski@va.gov Web: http://www.uab.edu/medicine/dermatology/andrzej-t-slominski-m-d-ph-d orcid.org/0000-0001-8963-3995 Research Gate: https://www.researchgate.net/profile/Andrzej_Slominski/info Home: 3500 Redmont Rd, Birmingham, AL 35213; phone/fax: (205)5186346; e-mail: elaslom@bellsouth.net orcid.org/0000-0001-8963-3995 EDUCATION: Graduate/Medical School

Medical University of Gdansk, Poland (9/1973 – 6/1979) MD (with honors) 1979 Medical University of Gdansk, Poland (5/1983) PhD

Clinical Fellowship Dermatopathology, Division of Dermatology and Dermatopathology, Albany Medical Center, Albany, NY (7/96-6/97)

Residency Anatomic Pathology, Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY (7/1/93-6/30/96)

Internship Municipal Hospital, Tczew, Poland (9/1979-9/1980) Postdoctoral Training:

Yale University School of Medicine, Postdoctoral Fellow, Department of Dermatology, New Haven, CT (1/10/85-4/30/89)

UNIVERSITY APPOINTMENTS: 7/2015-present Professor of Pathology, University of Alabama Birmingham 4/2015-present Professor of Dermatology (Endowed), University of Alabama Birmingham 4/2015-present Senior Scientist, Comprehensive Cancer Center, Cancer Chemoprevention

Program, University of Alabama 7/2015-7/2017 Program Director of Dermatopathology Fellowship 7/2014- 4/2015 Cancer Research Committee Member, West Clinic 7/2002-7/2015 Professor of Pathology (tenured on 2003), Department of Pathology and

Laboratory Medicine, University of Tennessee HSC, Memphis, TN 7/2011-4/2015 Professor of Internal Medicine, Department of Internal Medicine, University of Tennessee HSC, Memphis, TN 7/2003-7/2014 Director of Dermatopathology Fellowship at UTHSC 7/2003-4/2015 Full Member of the University of Tennessee Cancer Institute 7/2006-4/2015 Member of CGHS Curriculum Committee 7/2000-7/2002 Associate Professor, Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 11/1997-6/2000 Associate Professor, Department of Pathology, Loyola University Medical Center, Maywood, IL 7/1993-11/1997 Assistant Professor, Department of Pathology and Laboratory

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Medicine, Albany Medical College, Albany, NY 6/1989-6/1997 Assistant Professor, Microbiology, Immunology & Molecular Genetics, Albany

Medical College, Albany, NY 5/1989-6/1990 Associate Investigator, Toolan Institute for Cancer Research,

Bennington, Vermont 1/1985-4/1989 Postdoctoral Fellow, Department of Dermatology, Yale University School of Medicine, New Haven, CT 5/1983-12/1984 Assistant Professor, Department of Biology and Human Genetics, School of Medicine, Gdansk, Poland HOSPITAL PRIVILEDGES: 4/2015-present Pathologist, Birmingham VA Medical Center 4/2015-present Dermatopathologist, Department of Dermatology, University of Alabama 5/2014-5/2015 Regional One Health (previously Regional Medical Center at Memphis), Memphis, TN 5/2004-4/2014 Regional Medical Center at Memphis, Memphis, TN 7/2001-4/2004 Member of Credentialing Committee, University of Tennessee Medical Group 7/2000-4/2004 University of Tennessee Bowld Hospital, Memphis TN (Hospital closed in 2004) 11/1997-6/30/2000 Loyola University Medical Center, Maywood, IL, Department of Pathology, CLINICAL APPOINTMENTS: 4/2015-present Pathologist, Birmingham VA Medical Center 4/2015-present Dermatopathologist, Department of Dermatology, University of Alabama Birmingham 4/2004- 2/2015 Dermatopathologist, UPG, Department of Pathology, UTHSC 5/2014-4/2016 Regional One Health (previously Regional Medical Center at Memphis), Memphis, TN 5/2004-4/2014 Regional Medical Center at Memphis, Memphis, TN 7/2003-7/2014 Director of Dermatopathology Fellowship at UTHSC 7/2001-4/2004 Member of Credentialing Committee, University of Tennessee Medical Group 7/2000-4/2004 Dermatopathologist, UTMG, Department of Pathology, UTHSC 7/1/1998-6/30/2000 Loyola University Medical Center, Maywood, IL, Director of Dermatopathology 7/1998-6/2000 Cardinal Bernardin Cancer Center, Maywood, IL, Member of Melanoma

Multidisciplinary Clinic 7/1998-6/2000 Sun-Belt Melanoma Program (Loyola Medical Center), member 11/1997-6/30/2000 Loyola University Medical Center, Maywood, IL, Department of Pathology,

Dermatopathologist/Anatomic Pathologist BOARD CERTIFICATION (valid indefinitively) Dermatopathology: American Board of Pathology and American Board of Dermatology, 11/15/97 Anatomic Pathology: American Board of Pathology, 6/11/97 MEDICAL LICENSURE: Active: Alabama since 2015, Tennessee since 2000; New York since 1997; DEA, schedules 2-5, Active Inactive: Utah and Illinois; HONORS: 2019 Chair of two sessions: I. Historic and Future Perspective of Vitamin D3, and II. Molecular

Biology of Vitamin D – New Insights in Vitamin D Receptor Function/Structure and Beyond. during Joint International Symposium on Vitamin D in Prevention and Therapy & Biologic Effects of Light. June 5-7, 2019, Schlossberg, Homburg, Germany

2018-2021 Chair of the Continuing Education and Research Committee, American Society of Dermatopathology

2018 Full Member of the World Academy of Sciences

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2017 Co-chair of the concurrent Session UV Response and DNA Repair Melanoma of the International Pigment Cell Conference, Denver, CO, August 27-30, 2017

2017 Invited visiting Professor and Lecturer at the Jagiellonian University, Krakow, May 8-22, 2017 2017 Invited Lecturer at the Medical University of Gdansk, May 2017, Gdansk, Poland 2015-2018 Member of Continuing Education and Research Committee, and the vice-Chair,

American Society of Dermatopathology 2016-2018 Elected Council Member of the Panamerican Society for Pigment Cell Research 2015 Speaker for the GRC on Barrier Function of Mammalian Skin, August 16-21, 2015 at Waterville

Valley, NH: “Cutaneous melatoninergic and secosteroidogenic systems as protectors of epidermal integrity.”

2015 Distinguished Scientist Leadership Society Speaker Series, Amway, Grand Rapids, May 28, 2015: “Ultraviolet, vitamin D, melanin and the skin: What’s new under the sun?

2014-2015 Elected Council Member of the Panamerican Society for Pigment Cell Research 2014 Member of Scientific Advisory Board for XXII International Pigment Cell Conference (IPCC

2014), September 2014, Singapore 2013 Member of the scientific committee for the 18th PASPCR Annual Meeting in Madison, WI,

September, 2013 2013 Co-chair of the Satellite Symposium Dermatoendocrinology, May 7, 2013, to the IID

tricontinental meeting, Edinburgh, Scotland, May 7-11. 2012 Member of the scientific committee for the 17th PASPCR Annual Meeting in Salt Lake City,

Utah, September /October , 2012 2011-2014 Elected Secretary of the International Federation of Pigment Cell Societies 2011 Co- chair of the joint Society for Melanoma Research/Pan-American Society for Pigment Cell

Research session on 11/10 during the 8th International Congress of The Society for Melanoma Research, 11/ 9-11/2011, Tampa, FL

2011 Co-chair of the Session “Neuroendocrinology of pigmentation and MC1R” During XXI International Pigment Cell Conference (IPCC). ‘‘Skin and Other Pigment Cells: Bridging Clinical Medicine and Science’’. 9/20-24, 2011Bordeaux, France.

2011 Member of Scientific Advisory Board for International Society for Pigment Cell Research Meeting in Bordeaux, France 9/ 2011

2010 Member of Scientific Advisory Board for 16th PASPCR Meeting in Vancouver, Canada; 9/10, 2010

2009 Chairman of the Session “Pigment cell Biology of the Hair Follicle” during 15th meeeitng of the European Society for Pigment Cell Research, Munster, Germany, September 21-23, 2009

2009 Chairman of the 15th Annual Meeting of the Panamerican Pigment Cell Society, “ The Pigmentary System: Securing a Place Under the Sun”, September 4-7, 2009, Memphis, TN, USA

2009 Invited Speaker : "Neuroendocrine functions of the skin" of the 2009 US Technical Symposium of The International Society for Bioengineering and Skin Imaging (ISBS), March 19, 2009, Dallas, TX.

2009 Invited Speaker: “Neuroendocrinology of the pigmentary system”, February 25, 2009. Dowling Club Lectures, University of California, Irvine

2008 Co-chair of the Symposium: Sensory functions of cells in stratified epithelia and their response to peripheral stimuli; XIII International Congress of Immunocytochemistry and Histochemistry, August 23-27, 2008, Gdansk, Poland.

2008 Aaron B Lectureship Awarded by the PASPCR for contribution to Pigment Biology and presented on May 12, 2008 during joined conference of the IPCC and IMRC, Sapporo, Japan

2008-2013 Elected Secretary-Treasurer of the Panamerican Society for Pigment Cell Research 2007 Chairperson of the Session "Cell Biology and Pigmentation”, 14th Annual PASPCR meeting

“Pigmentation and Diversity”, September 13-16, Chicago, IL. 2007 Member of the Editorial Board of the Experimental Dermatology 2007 Member of the Editorial Board of the Journal of Pineal Research 2007 Member of the Editorial Board of the Open Endocrinology 2007 Elected Council Member of the Panamerican Society for Pigment Cell Research 2006 Elected Member of Steering Committee of the Society for Melanoma Research 2004 Laureate of the William J. Cunliffe Prize for 2004 for contribution to the Neuroendocrinology of

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the Pilosebaceus Unit. 2004 Chairperson of the Session "Pigmentation" during Conference “Neurobiology of the Skin”,

February 13-15, 2004, Munster, Germany. 2001 Member of Southwest Oncology Group, National Clinical Research Group, San Antonio, Texas 2001 Member of the Scientific Review Board “New Melanoma Treatment?” Neurobiological

Technologies, Inc, CA. 1998 Co-Chairmen of the Conference “Cutaneous Neuromodulation: the Proopiomelanocortin

System” (Chairs: Luger TA, Paus R, Lipton J, Slominski A), September 11-13, 1998, Munster, Germany. The conference was sponsored by the New York Academy of Science.

1993 Research Fellowship awarded by Alexander von Humboldt Foundation, Germany 1992 Co-chair of the Symposium entitled "Cytokines, Hormones and Receptors" during IVth PASPCR meeting in Cincinnati, OH. 1986-1989 National Research Service Award (Postdoctoral Training in Dermatology with Drs Aaron Lerner and John Pawelek , Yale University School of Medicine) 1985-1986 Lawrence M. Gelb Research Fellowship (Postdoctoral Fellowship with Dr. John Pawelek, Yale University School of Medicine) SOCIETY MEMBERSHIPS:

American Association for Cancer Research American Society of Dermatopathology American Physiological Society College of American Pathologists Endocrine Society International Pigment Cell Society International Society of Dermatopathology Panamerican Society for Pigment Cell Research Society for Investigative Dermatology

INVITED LECTURES: 2019 Lecture “"Novel Pathways of Vitamin D and Lumisterol Activation and Their Role in the

Epidermis Functions" during Gordon Research Conference on the Barrier Function of Mammalian Skin, August 11-16, 2019, Waterville Valley, NH, USA

2019 Plenary lectures (2): “New Vitamin D Metabolites In the Skin”, “On the Regulation of the Brain and Neuroendocrine Systems by Ultraviolet Radiation: Special Focus on HPA Axis”, and regular lecture “Vitamin D and Melanoma” during Joint International Symposium on Vitamin D in Prevention and Therapy & Biologic Effects of Light. June 5-7, 2019, Schlossberg, Homburg, Germany

2019 Two presentations: “Melatonin: A Cutaneous Perspective On Its Production, Metabolism and Function” and “Skin Stress Response System: The Keystone” during Congresso Di Mediciena Rigenerativva Estetica, Janury 18-20, 2019, Rome, Italy

2018 Presentation “'Solar exposure-induced modulation of skin endocrine function” During 2018 ASP Biennial Meeting: 12-15 May 2018, Tampa Marriott Waterside Hotel & Marina

2017 Presentation “Vitamin D and Melanoma: What is New Under the Sun” during concurrent session UV Signaling in Melanocytes and Melanoma of the International Pigment Cell Conference, Denver, CO, August 27-30, 2017

2016 Presentation “Discovery of new pathway activating lumisterol in vivo to biologically active molecules” During concurrent session at the Society for Investigative Dermatology 2016 Annual Meeting, May 11-14, 2016, Scottsdale, AZ

2016 Oral presentation” RORα AND RORγ as alternative receptors for nonclassical vitamin D hydroxymetabolites” during 19th Vitamin D Workshop, Boston, March 29-31, 2016

2015 Invited presentation “Neuroendocrinology of the skin” during 19th meeting of the Panamerican Society for Pigment Cell Research, Irvine, CA, September 27-30, 2015

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2015 Speaker for the GRC on Barrier Function of Mammalian Skin to be held August 16-21, 2015 at Waterville Valley, NH: “Cutaneous melatoninergic and secosteroidogenic systems as protectors of epidermal integrity.”

2015 Distinguished Scientist Leadership Society Speaker Series, Amway, Grand Rapids, May 28, 2015: “Ultraviolet, vitamin D, melanin and the skin: What’s new under the sun?

2014 “New Pathways of Vitamin D activation and Their Biological Role”, October, 2014, Jagiellonian University Krakow, and Polish Academy of Science, Warszawa, Poland

2014 “Sensing the environment: Regulation of body homeostasis by the pigmentary system”. XXII International Pigment Cell Conference (IPCC 2014), September 2014, Singapore

2013 “New secosteroidogenic pathway and its clinical implication”. INRS-Institut Armand-Frappier, University of Quebec, July 19, 2013

2013 Presentation on “The physiologic role of CYP11A1 vitamin D regulation of epidermal functions” 16tht Vitamin D Workshop, June 11-14, 2013, San Francisco, CA.

2013 Presentation on “Cutaneous steroidogenesis: implications for local immune functions.” Satellite Symposium Dermatoendocrinology, May 7, 2013, to the IID tricontinental meeting, Edinburgh, Scotland, May 7-11.

2013 Presentation on “Steroidogenesis in the skin: implications for local immune functions.” 2nd Congress on Steroid Research, March 10-12, 2013, Chicago

2012 Presentation on “Melanin and its biosynthesis- a double-edged sword. Does melanin and its precursors play a role in the initiation and promotion of melanoma?” During International Society of Dermatopathology 15th Joint Meeting. March 14-15, 2012, San Diego, CA

2011 Presentation on “Melanogenesis in melanomas: therapeutic and metabolic implications . During 8th International Congress of the Society for Melanoma Research

November 9 – 11, 2011, Tampa, FL 2011 Presentation on: “Introduction to the neuroendocrinology of the pigmentary system” During XXI

International Pigment Cell Conference (IPCC).. 9/20-24, 2011Bordeaux, France. 2011 Lecture on “Neuroendocrinology of the skin” during Gordon Conference; Conference: Barrier

Function of Mammalian Skin, 08/07/2011 - 08/12/2011, NH 2011 Guest lecture “Neuroendocrinology of the skin – How it all began” during meeting of Treffen

der Arbeitsgruppe Dermato-Endokrinologie (ADE) “10 Years Dermato-Endocrinology”, Tubingen, Germany, February 16, 2011

2010 Invited presentation “Neuroendocrinology of the skin” during 13th meeting of International Society of Dermatopathology, March 3-4,2010

2009 Invited presentation “Melanin and epidermal cell homeostasis” during 15th meeting of the European Society for Pigment Cell Research, Munster, Germany, September 21-23, 2009

2009 Keynote lecture “Neuroendocrinology of the Melanin Pigmentary System” during the 15th Annual Meeting of the Panamerican Pigment Cell Society, “ The Pigmentary System: Securing a Place Under the Sun”, September 4-7, 2009, Memphis, TN, USA

2009 Invited Speaker : "Neuroendocrine functions of the skin" of the 2009 US Technical Symposium of The International Society for Bioengineering and Skin Imaging (ISBS), March 19, 2009, Dallas, TX.

2009 Invited Speaker: “Neuroendocrinology of the pigmentary system”, February 25, 2009. Dowling Club Lectures, University of California, Irvine

2008 Invited presentation “Sensing the environment: Regulation of local and global homeostasis by the skin neuroendocrine system. XIII International Congress of Immunocytochemistry and Histochemistry, August 23-27, 2008, Gdank, Poland.

2008 Invited presentation “Novel secosteroidogenic pathway and the skin”. The 34th Meeting of the American Society for Photobiology, June 20-25, 2008, San Francisco, CA

2008 Invited presentations:1) “Neuroendocrine activity of the melanocyte“; 2) “Melatonin in the skin: protection against the oxidative stress”; 3) “Melanogenesis and its hormonal regulation: evolution and biological implications of the pigmentary system.” XXth International Pigment Cell Conference (IPCC) and Vth International Melanoma Research Congress (IMRC), May 7-12, 2008, Sapporo, Japan.

2007 Invited presentation “Role of CRF in the mammalian pigmentary system” The 14th Annual Pan American Society for Pigment Cell Research, September 12-16, 2007, Chicago, IL.

2007 Invited presentation “CRF system of the skin: implications” The Hans Seyle Centennial

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Symposium on Stress: Basic Mechanisms and Clinical Implications, July 11-14, 2007, Montreal Canada

2006 Invited presentation “Corticotropin releasing hormone signaling system in melanocytes: An overview” The 13th Annual Pan American Society for Pigment Cell Research, September 7-10, 2006, Cincinnati, PA.

2006 Invited presentation “Differential regulation of an HPA axis homolog in the skin” XII Adrenal Cortex and V Molecular Steroidogenesis Conference, June 20-23, 2006, Boston

2006 Invited presentation “The non-neuronal serotonin/melatonin pathway in the skin – what is new?” during Conference “The non-neuronal axis in the skin”, April 6-8, 2006, Bradford, England

2005 Invited presentation “Melanin synthesis in melanoma: clinical implications” 6th World Congress on Melanoma, September 6-10, 2005, Vancouver, Canada

2004 Invited presentation "Potential role of corticotropin releasing hormone in skin physiology and pathology" during Conference “Neurobiology of the Skin”, February 13-15, 2004, Munster, Germany.

2003 Invited lecture "Neuroendocrinology of the skin", Johnson and Johnson Consumer Companies (November 14, 2003).

2003 Invited presentation “Cutaneous serotoninergic and melatoninergic systems” during Conference “Frontiers of Cutaneous Biology”, September 3-6, 2003, Bradford, England

2003 Invited presentation “Endocrinology of the skin” during 21st Summer Seminar of Endocrinology and Metabolism, July 24-26, 2003, Hakone, Japan

2003 Invited presentation “Role of CRH in skin physiology and pathology” at Nippon Medical School, Tokyo, Japan, July 22, 2003

2003 “Role of CRH in skin physiology and pathology”, Department of Pathology, UTHSC 2002 Invited lecture "Neuroendocrinology of the skin", Boston University (December 16, 2002). 2002 “Neuroendocrinology of the skin”, Molecular Science Department (December, 2002) 2002 “Neuroendocrinology of the skin”, The Estee Lauder Companies (November, 2002) 2002 Invited presentation “Corticotropin-releasing hormone (CRH) and proopiomelanocortin

involvement in the cutaneous response to stress.” 20th International World Congress of Dermatology, July 1-5, 2002, Paris, France

2001 Invited lecture “Neuroendocrinology of the Skin.” Skin Diseases Research Center, Vanderbilt Medical Center (October 12, 2001)

2001 Seminar “Role of CRH receptors in skin physiology and pathology” Neurobiological Technologies, Inc, CA (September 18, 2001)

2000 Invited presentation during session “Skin as a Neuroendocrine Organ.” XIth International Congress of Histochemistry and Cytochemistry, September 3-8, 2000, University of York, United Kingdom

2000 Presentation at the concurrent Minisymposium 5: “Human Skin is Both a Site of Production and a Target for CRH-related Peptides,” 61st Annual Meeting of the Society for Investigative Dermatology, May 10-14, Chicago, IL

1999 Presentation: “Molecular Pathology of Melanoma.” Institute of Molecular Biology, Jagiellonian University, Cracow, Poland

1999 Presentation: “Skin as a Stress Organ.” Medical University of Gdansk, Gdansk, Poland 1998 Platform Presentation “Diagnosis of Melanoma - New Molecular and Cellular Markers” during the “Cutaneous Oncology Symposium, December 11 & 12, LUMC, Maywood, IL 1998 Co-Chairmen of the Conference “Cutaneous Neuromodulation: the Proopiomelanocortin

System” (Chairs: Luger TA, Paus R, Lipton J, Slominski A), September 11-13, 1998, Munster, Germany. The conference was sponsored by the New York Academy of Science.

1998 Platform Presentation entitled “Cutaneous expression of CRH and CRH-R: is there a “skin stress system?” during the Conference “Cutaneous Neuromodulation: the Proopiomelanocortin System,” September 11-13, Munster, Germany.

1992 Co-chair of the Symposium entitled "Cytokines, Hormones and Receptors" during IVth PASPCR meeting in Cincinnati, OH. 1992 Platform presentation entitled "Melanogenesis is coupled to murine anagen" during Annual Symposium on the Biology of the Skin, "Fundamentals of Hair Biology.” 1990 Alberta Heritage Foundation for Medical Research Invited presentation in the University of Alberta, Edmonton, Canada "L-tyrosine and L-DOPA as positive regulators.”

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EDITORIAL APPOINTMENTS: Journals 1. Editorial Board Member 2007-present Experimental Dermatology 2007-present Journal of Pineal Research 2009-present Open Endocrinology 2011-present Polish Annals of Medicine. 2011-present PLOS ONE 2013 Expert Review of Dermatology 2013-present Melanoma Management 2014-present International Journal of Molecular Sciences 2018 International Journal of Oncology 2014-present Polish Journal of Pathology 2016-present Scientific Reports 2016-present Anticancer Research 2. Reviewer Acta Anatomica, American Journal of Pathology, American Journal of Physiology, Analytical Biochemistry, Archives of Dermatology, Archives of Pathology and Laboratory Medicine, Biochimica et Biophysica Acta, British Journal of Dermatology , British Journal of Pharmacology, Cancer, Cell Differentiation, Comparative Biochemistry and Physiology, Endocrinology, Experimental Cell Research, Experimental Dermatology, FASEB Journal, Gene, International Journal of Biochemistry and Cell Biology, International Journal of Cancer, Journal of Clinical Investigation, In Vitro Cellular & Developmental Biology, Journal of Investigative Dermatology, Journal of Clinical Endocrinology and Metabolism, Journal of the National Cancer Institute, Laboratory Investigation, Life Sciences, Melanoma Research, Nature, Neuropeptides, Peptides, Pigment Cell Research, Proceeding of the National Academy of Science USA, Stress, Trends in Pharmacological Sciences Foundations –reviewer National Science Foundation (NSF), USA The Wellcome Trust Foundation, England Israel Science Foundation, Israel Austrian Science Foundation (AWF), Austria Philip Morris External Research Program, USA INSERM proposals on rare diseases, France The French National Cancer Institute (INCa) Swiss National Science Foundation, Switzerland Health Research Board, Ireland Department of Defense (DOD), USA, December 2010 Review Committees; VA Merit Review Panel 12/4/ 2009, USA Ad Hoc Reviewer for NIDDKD special emphasis panel of NIH (December 17, 2002) Chairman of the Special Review Committee of NIAMSD of NIH (March, 2003) Member the Special Review Committee of NIAMSD of NIH (October, 2003) Member the Special Review Committee of NIAMSD of NIH (June 2004) “High Risk Rheumatologic and Musculoskeletal and Skin Diseases Research." Member the NIDDK Special Emphasis Panel (SEP) ZDK1-GRB-7 (J2) (November 30, 2004) Member the NIH Skin and Rheumatology Review Committee (November 11, 2004) Council ZRG1 MOSS-D 02 and (March 1, 2005), Council AMS (7/11/06). Member the NIH ACTS (9/17-18/2007), AMS 1( 10/25-26//2007), ZAR1 MLB-G (M1) (06/24/2008-06/25/2008), ZAR1 M-D M1 (11/20-21/08), MOSS G 96 (vice-Chair; 713-7/14/09), NIDDK Special Review Panel, Biology of Neuroendocrine Peptides, 12/2009; ZRG1 MOSS-G, 2/11,2010, ZRG1 MOSS-A (02) , 7/7/10, ZRG1-MOSS-C05, 11/09/10; 2011/10 ZRG1 MOSS-C (05), mail reviewer for 5/13/11; SEPS 2012/10 ZCA1 RPRB-O (O1) for 05/30/2012-05/31/2012; 02/06-02/07/2013 ZCA1 RPRB-M (M1) P; 6/27/2014 ZRG1 MOSS-T12; 7/14/2014 ZR1 !PPMOSS [ F10B ], 2/2015 ZRG1 MOSS T12 and ZAT1 HS-19; 11/29/17 ZRG1 MOSS-C12 COMMITTEES AND OFFICES HELD

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2015-2018 Continuing Education and Research Committee, American Society of Dermatopathology 2016-2018 Council Member of the Panamerican Society for Pigment Cell Research 2007, 2014-2015 Council Member of the Panamerican Society for Pigment Cell Research 2011-2014 Elected Secretary of the International Federation of Pigment Cell Societies 2008- 2014 Elected Secretary-Treasurer of the Panamerican Society for Pigment Cell Research 2006-2010 Member of Steering Committee of Melanoma Research Society 2003-2014 Director of Dermatopathology Fellowship Program 2001-present Member of Southwest Oncology Group, National Clinical Research Group, San Antonio, Texas 2001-2004 Member of Credentialing Committee, University of Tennessee Medical Group 2001 Member of the Scientific Review Board “New Melanoma Treatment?” Neurobiological

Technologies, Inc, CA 1998-2000 Director of Dermatopathology Service, Loyola University Medical Center, Maywood, IL 1998-2000 Member of Melanoma Multidisciplinary Clinic, Cardinal Bernardin Cancer Center, Maywood, IL 1998 Co-Chairmen of the Conference “Cutaneous Neuromodulation: the Proopiomelanocortin

System” (Chairs: Luger TA, Paus R, Lipton J, Slominski A), September 11-13, 1998, Munster, Germany. The conference was sponsored by the New York Academy of Science.

1992 Co-chair of the Symposium entitled "Cytokines, Hormones and Receptors" during IVth PASPCR meeting in Cincinnati, OH

FELLOWS/GRADUATE STUDENTS TRAINED 1. Dermatopathology Fellows: Jiang Ping Cai, MD (2004-2005), board certified in DP, 2005 Hong Jiang, MD, PhD (2005-2006), board certified in DP, 2006 Jackie Granese, MD (2007-2009) Radoslaw Bieniek, MD (2009-2011) Blazej Zbytek, MD, PhD (2011-2013) Diane Kovacic, MD (2013-2014) Ashley Tarasen, MD (2015-2016) Cesar E. Gurrero, MD (2016-2017) 2. Postdoctoral Fellows: Gennady Ermak, PhD from University of Minsk, Belarus (1993-1996) Nadem Fazal, MD, PhD from Loyola Medical Center (1997-1999) Birgit Roloff, PhD from Institute of Pharmacology, Berlin Germany (1998-1999) Eugenia Quevedo, MD from Loyola Medical Center (1999-2000) Alexander Pisarchik, PhD from University of Minsk, Belarus (2000-2004)

Blazej Zbytek, MD, from Medical University of Gdansk (2001 – 2004) Igor Semak , PhD from University of Minsk, Belarus (2001-2004 and 2006) Tobias Fischer , MD from University of Jena, Germany (2004) Anna Brozyna, PhD from Copernicus University, Poland (2006-2007) Michal Zmijewski, PhD from University of Gdansk, Poland (2005-2009)

Zorica Janjentovic, MD from University of Tennessee, HSC, (2006-2011) Cezary Skobowiat, DVM, PhD: Univ of Warmia and Mazury, (2009-present) Tae-Kang Kim, PhD from University of Tennessee, HSC, (2006-2013) Wojciech Placha, PhD from Jagiellonian University, Cracow, Poland (2012)

Dr. Sonali Gupta (post-doctoral research trainee), UTHSC, 2013 Dr. B. Brocato (Maternal-Fetal Medicine Fellow), UTHSC, 2013 Dr. M. Brown (Rheumatology Medicine Fellow), UTHSC, 2013-2014 Dr. Anyamanee Chaiprasongsuk (Mahidol University, Thailand), 2018-2019 Dr. Shariq Qayyum, Postdoctoral fellow, 2018-present

2. Graduate Students/Residents Dianne Heasley, DO, resident from Albany Medical College (1996-1997); Mahdu Dahiya, MD, resident from Loyola Medical Center (1998-1999) Jonathan Curry, MD resident from Loyola Medical Center (1998-2000) David Stewart, PhD, University of Mississippi, Oxford (2002-2003)

Jiang-Ping Cai, MD, resident from the University in Tennessee (2003-2004)

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Kempe M, MD, resident from the University in Tennessee (2013) Mary Gupta, MD, resident from the University in Tennessee (2013) Reza Nejati, MD, resident from the University in Tennessee (2012-2014) Guo Zhu, MD, resident from the University in Tennessee (2013-2014) Watts Allison, Dermatology resident at UTHSC (2014) Tao Guo, MD, Pathology resident at the UAB, 2017 Mohammad Rigi, MD, , Pathology resident at the UAB, 2018 Allen Oak, MD, Dermatology resident at the UAB (2018-present)

3. Undergraduate students Jeffrey Howe, summer student at Toolan Institute (1990) Ashkan Gorbani, medical student at AMC (1992) Daniel Pruski, student of Albany School of Pharmacy (1990-1993)

Radomir Slominski, high school student (2003-2005), and student from Emory University (2006)

Jan Kaminski, neuroscience student from Vanderbilt University (2004) Emily Jones, student of Medicine, College of Medicine, UTHSC, supervision

and mentorship of the project funded by NIH Medical Research Fellowship Award in 2006.

Damon DeLeon, student of Medicine, College of Medicine, UTHSC, supervision and mentorship of the project funded by NIH Medical Research Fellowship Award in 2007. Brian E Fuller. student of Medicine, College of Medicine, UTHSC, supervision and mentorship of the project funded by NIH Medical Research Fellowship Award in 2008 Adam C. Wright. student of Medicine, College of Medicine, UTHSC, supervision and mentorship of the project funded by NIH Medical Research Fellowship Award in 2009 Emily D. Escue. student of Medicine, College of Medicine, UTHSC, supervision and mentorship of the project funded by NIH Medical Research Fellowship Award in 2010 Danielle E. Howell, PhD student rotation in 2010 Member of PhD committee for Mekel Richardson from University of Tennessee Cancer Building, UTHSC, 2013 Member of PhD committee for Chikezie Madu from University of Tennessee Cancer Building, UTHSC, 2013 Member of MS committee for Georgina Masoud from University of Tennessee, School of Pharmacy, 2014 Member of PhD committee for Jin Wang from University of Tennessee, UTHSC, College of Pharmacy Supervising in part research of Zongtao Lin from College of Pharmacy Supervising in part research of Qinghui Wang from College of Pharmacy Laura N. Grese. student of Medicine, College of Medicine, UTHSC, supervision and mentorship of the project funded by NIH Medical Research Fellowship Award in 2011. Stanislav N. Tolkachjov. student of Medicine, College of Medicine, UTHSC, supervision and mentorship of the project funded by Dr Slominski in 2011. James S. Riney student of Medicine, College of Medicine, UTHSC, supervision and mentorship of the project funded by Dr Slominski in 2011. Adam C. Wright student of Medicine, College of Medicine, UTHSC supervision and mentorship of the project funded by Dr Slominski in 2011 Alice T. Zhan, high school student, 2012 Maxwell Schwam, college student, 2012 Zane R. Cooke, student of Medicine, College of Medicine, UTHSC, 2012 Jessica L. Baumann, student of Medicine, College of Medicine, UTHSC, 2012 William J. Tidwell, student of Medicine, College of Medicine, UTHSC, 2012 Joseph W. Overman II, Medical student, College of Medicine, UTHSC, 2012

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Adam Seacrest, graduate student, 2012 Zhang Shufeng (undergraduate student) USA, 2013 Logan Williams (Medical Student), UTHSC, 2013 Elizabeth Rutter (Medical Student), UTHSC, 2013 Caitlin Sledge (Medical Student), UTHSC, 2013 Zachary P. Nahmias, student of Medicine, College of Medicine, UTHSC, 2013 Sherie Hanna, college student, 2013 Logan Williams (Medical Student), UTHSC, 2013 Elisabeth Lee (NIH grant recipient), M2 Student, College of Medicine, 2014 Joe Kaminski (Medical Student), UTHSC, 2014 Megan Meadows, College student, 2014 Rubi Aurora, College student, 2014 Katherine Shelton, M2 student, UAB , Summer research, 2016 Allen Oak, MD student (UAB), 2016-2017

Alisa Mobley student (Auburn University Honors College), 2017 Saowanee Jeayeng PhD Student (Mahidol University, Thailand), 2016-2017 Mahmoud M Elsayed MD student (UAB), 2017-2018 Kinya Perkins, CORD project, Summer College student, 2018 Serge Malian, MD student (UAB), Summer 2018 Joshua Alan Wild, MD student (UAB), Summer 2018 Dun My Vo, Undergraduate in biology (UAB), 2018 Ewa Podgorska PhD Student (Jagiellonian University, Poland), 2018-2019

4. Member of PhD or MS Committee Member of PhD committee for Zhao Wang from Department of Pharmaceutical Sciences, UTHSC, defended in 2009 Member of PhD committee for Jianjun Chen from Department of Pharmaceutical Sciences, UTHSC, defended in 2011. Member of PhD committee for Mekel Richardson from University of Tennessee Cancer Building, UTHSC, 2013 Member of PhD committee for Chikezie Madu from University of Tennessee Cancer Building, UTHSC, 2013 Member of MS committee for Georgina Masoud from University of Tennessee, School of Pharmacy, 2014 Member of PhD committee for Jin Wang from University of Tennessee, UTHSC, College of Pharmacy, 2015 Member of PhD committee for Zongtao Lin from University of Tennessee, UTHSC, College of Pharmacy, 2017 Member of PhD committee for Ewa Podgorska from Jagiellonian University, Krakow, Poland, 2019

5. Visiting Scientists Cezary Skobowiat, DMV, PhD, 2017 Ann Brozyna, PhD, 2017 Georgeta Bocheva, MD, Fulbright Fellow, 2018 RESEARCH AND OTHER EXTERNAL SUPPORT: Current Funding 2019-2023 VA Merit 1 I01 BX004293-01A1, Department of Veterans Affairs (Slominski, PI) 3 cal. months

“CYP11A1-derived secosteroids as therapeutic agents in UVB induced skin cancer” 2018-2023 1R01AR073004 - 01A1 NIH/NIAMS (Slominski A, PI) 3.00 cal. months "Mechanism of action and function of novel secosteroid 20(OH)D3 in the skin" 2017-2022 1 RO1 AR071189-01A1 NIH/NIAMS (Slominski, PI) 3.00 cal. months

“Significance of metabolic activation of lumisterol in the skin.”

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2017-2022 PAR-15-023 NIH/NCI (Elmets, PI) Co-I with 0.7 cal. months “RXR Rexinoids for cancer chemoprevention” 2016-2021 1R01ES026219-01A (NIEHS), (Athar, PI); Co-I with 0.6 calendar months

“Chemoprevention of environmental UVB-induced skin cancer in immunosuppressed mice 2016-2020 1I01BX003395-01 VA Merit Department of VA, (Elmets, PI); Co-I with 1.2 calendar months

“Host Defense Mechanisms in Melanoma Pathogenesis”

2015-2018 National Science Centre, Poland (2014/15/B/NZ4/00751) (Brozyna, PI), Co-I

“On the role of melanogenesis in regulation of melanoma behavior: clinical implication in stage 3/4”

Pending: NCI: Efficacy of novel natural analogs of vitamin D in patient derived orthotopic xenografts (PDOXs)

models of metastatic melanoma” NIH: “Defining the nuclear receptor for melatonin for protection against UVB” Previous Funding: 2014-2018 NIH/NIAMS: 1 R21 AR0665051-A1 “Mechanism of action of 20-hydroxyvitamin D3 in dermal

fibroblasts”,Slominski, A, PI, 2011-2018 National Institute of Health (1R01AR056666-01A2); Slominski A, PI Role of exogenous melatonin in skin biology 2012-2016 Veteran Administration (1IP1BX 001607-01) "Program Project for Mechanisms and Treatment of

Arthritis" Program Director: John M. Stuart, MD Project 3"Prevention of Autoimmune Arthritis with 20(OH)D3" Project Leader:Arnold E. Postlethwaite,MD Role on Project: Co-Investigator; budget: $500,000 PPG with $125,00 for project 3

2013-2015 National Institute of Health (2RO1 AR052190-06A2); Slominski A, PI, Postlethwaite A, MPI Novel biosynthetic pathway for secosteroids and the skin (total budget: $300,000) 2014-2015 West Cancer Center Research Support Award; Slominski, A, PI Pre-clinical testing of anti-melanoma activity of 20-hydroxyvitamin D3 (total budget $50,000) 2013-2015 NIH/NIAMS (1R21AR063242-01A1) “Discovery of tissue-selective, nonhypercalcemic VDR

modulators for RA treatment” Wei Li (contact PI), Duane Miller (MPI); Role: Co-investigator, 2% of time commitment (total budget: $405,000)

2012-2015 National Institute of Health/NCI: D. Kaetzel from UM, PI Suppression of Melanoma Initiation and Progression by NM23-H1 Subcontract (2014) to analyze histopathology of mice melanomas (total budget/year : $13,173) 2014-2015 National Institute of Health (1 R01 AR064825-01A1); Kang A, PI,

“20()H)Vit D3, T cells, and Arthritis” (total budget: $1.65 million); Role: Co-investigator, 4.4% of time commitment

2014-2015 UTHSC internal funds; Slominski PI Development of conditional cutaneous CYP11A1 knock-out mice; (budget: $50,000) 2011- 2014 Grant N N402 662840, MNiSW, Poland, Żmijewski (PI), Role: Consultant

„Role of neuropeptides and their receptors in differentiation and growth of epidermal stem cells”. PI 2009-2013 National Science Foundation (IOS-0918934); Slominski A, PI UV-light regulation of skin endocrine functions: POMC system (total budget: $498,424) 2006-2013 National Institute of Health (1RO1 AR052190-01A2); Slominski A, PI Novel biosynthetic pathway for secosteroids and the skin (total budget: $1,994,000) 2012-2013 NIH (1S10OD010678-01) Li (PI); Role-, Co-investigator

“Acquisition of a Q-TOF Mass Spectrometer” Acquisition of a Q-TOF MS to analyze biological samples ($325,000 )

2010 -2013 Grant N405 623238, MNiSW (Poland) Żmijewski (PI), Role: Co-investigator „Analysis of biological activity of novel vitamin D analogs inhibiting growth of skin cancer cell lines”

2009 – 2012 National Institute of Health (1 RC1 AR058723-01) Postlethwaite (PI)

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“Chronic Sleep Restriction Priming of the Immune Response to autoantigen: Role of the SNS” (total budget: $590,362) Co-investigator with 10% of time commitment

2011 Technology Maturation Award (MPI) Wei Li (PI), Slominski (PI) 1/2011-10/2011 University of Tennessee Research Foundation “Preclinical studies of new vitamin D analogs as potential agents for arthritis” 2008-2011 National Cancer Institute (R15CA125623-01A2); Wei Li, PI (2011 non-cost extension) Discovery of novel cytotoxic agents for advanced melanoma (direct budget $150,00) ; role: co-investigator 2009-2010 National Institute of Health (1R13AR057627-01); Slominski A, PI

The pigmentary system: securing a place in the sun; Grant to support 15th Conference of the Pan-America Society for Pigment Cell Research (total budget $22,000)

2007-2009 National Cancer Institute (1R01CA107162), Buolawmini JF, PhD, PI; role Collaborator 2009 National Institute of Health (S-10 Shared Instrumentation Grant, 1S10RR025665-01); Charles Handorf,

PI, Whole Slide Imaging System for Tissue services Core (direct budget: $457,024) Role: Investigator 2006-2007 Department of Energy UTCI Pilot Grant “Inhibition of melanogenesis as an adjuvant strategy in melanoma therapy” 2002-2006 National Institute of Health

“Role of CRH in skin physiology and pathology” 2005-2006 UTHSC Bridge Grant:

“Role of CRH initiated signaling system in skin biology” 2005-2006 ASATONA, Switzerland “Melatonin in the therapy of androgenetic alopecia. Quest for mechanism of action” 2004-2006 Johnson & Johnson Skin Research Center Training Grant for Dr Zbytek (role: mentor)

“Role of corticotropin-releasing hormone in the regulation of keratinocyte functions” 2004-2005 UT Cancer Institute Pilot Project

“Therapeutic and preventive role of melatonin in cutaneous carcinogenesis” 2002-2004 Center of Genomic and Bioinformatics, University of Tennessee Microarrays for the investigation of skin endocrinology” 2002-2003 Center of Excellence for Diseases of Connective Tissue, University of Tennessee “Neuroendocrinology of the skin and connective tissue: Steroidogenesis” 2000-2003 Internal University Funding “Neuroendocrinology of the skin” 2001-2002 Vitiligo Foundation “Melatonin hypothesis of vitiligo” 1996-2001 National Science Foundation "Regulated proopiomelanocortin expression in the skin" 1999-2000 American Cancer Society, IL Division. “Possible role of corticotropin-releasing factor (CRF) in the pathology of melanocytes” 1998-2000 Banes Charitable Foundation "Regulated proopiomelanocortin expression in the skin" 1993-1996 National Science Foundation "Identification of cells expressing POMC in skin" 1995-1996 Dermatology Research Foundation "Melatonin synthesis in the skin" 1990-1993 Lawrence M. Gelb Research Fund (Clairol) "Mechanism regulating hair growth and pigmentation" 1991-1992 NIH Biomed. Res. Support Grant "Melatonin receptors in normal and malignant melanocytes" 1990-1991 American Cancer Society, VT Division "Regulatory mechanism governing melanoma cell differentiation" 1989-1990 Dermatology Research Foundation "Substrates of melanogenesis as regulators of melanoma cell differentiation" PATENTS 1. “Inhibition of Abnormal Cell Growth with Corticotropin-Releasing Hormone Analogs” Edward T. Wei and Andrzej T. Slominski; US 6319900, publication 2001; WO0153777.

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2. “Cloning of splice variants of corticotropin releasing hormone receptor type 1 and therapeutic uses thereof” Alexander Pisarchik and Andrzej Slominski; PCT Int. Appl. (2003), 110 pp. CODEN: PIXXD2 WO 2003024990 A2 20030327 CAN 138:266042 AN 2003:242355 3. “Enzymatic method to produce 7-dehydropregnenolone, vitamin D3-like compounds and derivatives thereof” Andrzej Slominski, Robert Tuckey, Jordan Zjawiony, Jeremy Stewart, Jacobo Wortsman PCT Int. Appl. (2005), 56 pp. CODEN: PIXXD2 WO 2005067673 A2 20050728 CAN 143:171401 AN 2005:673045. 4. “Microarray for evaluation of stress-related genes in skin” Alexander Pisarchik and Andrzej Slominski; U.S. Pat. Appl. Publ. (2007), 191pp. CODEN: USXXCO US 2007059711 A1 20070315 CAN 146:335693 AN 2007:287096 CAPLUS 5. “Hydroxylated forms of ergosterols and ergocalciferols, derivatives thereof, methods of production and uses thereof.” Slominski, Andrzej ; Tuckey, Robert; Li, Wei; Zbytek, Blazej; Zjawiony, Jordan; Wortsman, Jacobo. PCT Int. Appl. (2007), WO 2007006036 A2 20070111 6. “Uses of melatonin in skin” Slominsk Ai, Fischer T, Sweatman T, Semak I. United States Patent 20070218023. 7. Hydroxylated cholecalciferol (vitamin D3) derivatives produced by cytochrome P450scc and uses therefor. Slominski A, Tuckey Robert, Zmijewski Michal, Li Wei, Zjawiony Jordan, Janjentovic Zorica, Zbytek Blazej, Nguyen Minh Ngoc. Provisional patent U.S. Serial No. 61/067,461, filed on February 28, 2008. 8. Inhibition of tyrosinase activity or melanin synthesis as a new method to sensitize malignant melanoma to immunotherapy, chemotherapy, radiotherapy and phototherapy. Andrzej Slominski. Provisional patent filed on April; 25, 2008. 9. Structures and uses of short side 5,7-dienes and UVB conversion products thereof. Andrzej Slominski, Jordan Zjawiony, Michal Zmijewski, Wei Li, Zorica Janjetovic, Trevor Sweatman, Duane Miller. Provisional patent U.S. Serial No. 61/189,798, filed August 22, 2008. 10. Enzymatic production or chemical synthesis and uses for 5,7-dienes and UVB conversion products thereof. Slominski A, Li Wei, Zbytek Blazej, Tuckey Robert, Zjawiony Jordan, Nguyen Minh Ngoc, Janjentovic Zorica, Zmijewski Michal, Miller Duane, Chen Jianjun, Arnold Postlethwaite. Pub #: US2011/0118228A1; Publication Date: May 19, 2011. PCT/US2009/001324; WO/2009/108388 PUBLICATIONS Peer-Reviewed Journal Articles 1. Slominski A, Kobzdej D (1983) Transplantability of Bomirski melanomas in Syrian hamsters. Neoplasma 30, 51-56. 2. Scislowski PWD, Slominski A (1983) The role of NADP-dependent dehydrogenases in hydroxylation of tyrosine in hamster melanoma. Neoplasma 30, 239-243. 3. Slominski A (1983) Rapid melanization of Bomirski amelanotic melanoma in cell culture. Biosci Rep 3, 189-194. 4. Slominski A, Scislowski PWD, Bomirski A (1983) Tyrosinase activity in primary cell culture of amelanotic melanoma cells. Biosci Rep 3, 1027-1034. 5. Slominski A, Scislowski PWD, Bomirski A (1984) Biochemical characterization of three hamster melanoma variants. I. Tyrosinase activity and melanin content. Int J Biochem 16, 323-326. 6. Scislowski PWD, Slominski A, Bomirski A (1984) Biochemical characterization of three hamster melanoma variants. II. Glycolysis and oxygen consumption. Int J Biochem 16, 327-331. 7. Slominski A, Bomirski A, Scislowski PWD, Arendarczyk M (1984) Effect of tissue selection on melanization of MI melanoma. Neoplasma 31, 551-556. 8. Slominski A, Bomirski A, Scislowski PWD, Zolnierowicz S (1984) Effects of actinomycin D and cycloheximide on the increase of tyrosinase activity of hamster melanoma cells in vitro. Biosci Rep 4, 1059-1064. 9. Slominski A (1985) Some properties of Bomirski Ab amelanotic melanoma cells, which underwent spontaneous

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melanization in primary cell culture. Growth kinetics, cell morphology, melanin content and tumorogenicity. J Cancer Res Clin Oncol 109, 29- 37. 10. Slominski A, Bomirski A (1985) Phenotypic changes of Ab hamster melanoma during long-term culture. Anticancer Res 5, 403-410. 11. Scislowski PWD, Slominski A, Bomirski A, Zydowo M (1985) Metabolic characterization of three hamster melanoma variants. Neoplasma 32, 593-598. 12. Bomirski A, Slominski A (1986) Ultrastructural aspects of melanization of hamster Ab amelanotic melanoma in primary cell culture. Acta Derm Venereol (Stockh) 66, 520-528. 13. McNeely T, Slominski A, Bomirski A, Pawelek J (1986) Phosphorylation of protein of approximately 90 K daltons is a factor in the regulation of melanoma cell growth by insulin and the expression of high affinity receptors for insulin. In: Advances in Gene Technology: Molecular Biology of the Endocrine System. PuetD et al. (eds.). ICSU Short Reports 4, p55. Cambridge University Press, Cambridge MA. 14. Bomirski A, Wrzolkowa T, Arendarczyk M, Bomirska M, Kuklinska E, Slominski A, Moellmann G (1987) Pathology and ultrastructural characteristics of a hypomelanotic variant of transplantable hamster melanoma with high tyrosinase activity. J Invest Derm 89, 469-473. 15. Slominski A, Pawelek J (1987) MSH binding in Bomirski amelanotic melanoma cells is stimulated by L-tyrosine. Biosci Rep 7, 949-954. 16. Slominski A, Moellmann G, Kuklinska E, Bomirski A, Pawelek J (1988) Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway: L-tyrosine and L-dopa. J Cell Sci 89, 287-296. 17. Bomirski A, Slominski A, Bigda J (1988) The natural history of a family of transplantable melanomas in hamsters. Cancer Met Rev 7, 95-119. 18. Pawelek J, Bolognia J, McLane J, Murray M, Osber M, Slominski A (1988) A possible role of melanin precursors in regulating both pigmentation and proliferation of melanocytes. Adv Pigment Res Prog Clin Biol Res 256, 143-155. 19. Moellmann G, Slominski A, Kuklinska E, Lerner AB (1988) Regulation of melanogenesis in melanocytes. Pigment Cell Res Suppl 1, 79-871. 20. Slominski A, Moellmann G, Kuklinska E (1989) L-tyrosine, L-dopa and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma. Pigment Cell Res 2. 109-116. 21. Slominski A, Moellmann G, Kuklinska E (1989) MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cAMP levels and tyrosinase activity without inducing melanogenesis. J Cell Sci 92, 551-559. 22. Slominski A (1989) L-tyrosine induces synthesis of melanogenesis related proteins. Life Sci 45, 1799-1803. 23. Slominski A, Jastreboff P, Pawelek J (1989) L-tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells. Biosci Rep 9, 579-587. 24. Ren S, Slominski A, Yu R (1989) Glycosphingolipids in Bomirski transplantable hamster melanomas. Cancer Res 49, 7051-7056. 25. Slominski A, Paus R, Bomirski A (1989) Hypothesis: a possible role of the melatonin receptor in vitiligo. J Royal Soc Med 82, 539-541. 26. Slominski A, Paus R (1990) Are L-tyrosine and L-dopa hormone-like bioregulators. J Theor Biol 143, 123-

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138. 27. Slominski A, Paus R, Costantino R (1991) Differential expression and activity of melanogenesis-related proteins during induced hair growth in mice. J Invest Dermatol 96, 172-179. 28. Howe J, Costantino R, Slominski A.(1991) On the putative mechanism of induction and regulation of melanogenesis by L-tyrosine. Acta Derm Veneorol (Stockh) 71, 15-152. 29. Slominski A, Costantino R (1991). L-tyrosine induces tyrosinase expression via a posttranscriptional mechanism. Experientia 47, 721-725. 30. Slominski A, Costantino R (1991). Molecular mechanism of tyrosinase regulation by L-DOPA. Life Sci 48,2075-2079. 31. Slominski A, Paus R, Wortsman J (1991). Can some melanotropins modulate keratinocyte proliferation? J Invest Derm 97, 747. 32. Slominski A, Costantino R, Howe J, Moellmann G (1991). Molecular mechanism governing melanogenesis in hamster melanomas: Relative abundance of tyrosinase and catalase-B (gp 75). Anticancer Res 11, 257-263. 33. Slominski A (1991). POMC gene expression in hamster and mouse melanoma cells. FEBS Lett 291, 165-168. 34. Slominski A (1991). L-tyrosine binding proteins on melanoma cells. In Vitro Cell Dev Biol 27A, 735-738. 35. Slominski A, Paus R, Mazurkiewicz J (1991). Proopiomelanocortin expression and potential function of proopiomelanocortin products during induced hair growth in C57 Bl-6 mouse. Ann NY Acad Sci 642, 459-462. 36. Slominski A, Paus R, Mazurkiewicz J (1992). Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia 48, 50-54. 37. Slominski A, Costantino R, Wortsman J, Paus R, Ling N (1992) Melanotropic activity of gamma MSH peptides in melanoma cells. Life Sci 50, 1103-1108. 38. Slominski A, Goodman-Snitkoff G (1992). DOPA inhibits induced proliferative activity of murine and human lymphocytes. Anticancer Res 12, 753-756. 39. Slominski A, McNeely T, Pawelek J (1992). Insulin receptor proteolysis in insulin resistant variants of Cloudman S91 melanoma cells. Melanoma Res 2,115-122. 40. Slominski A, Pruski D (1992). L-DOPA binding sites in rodent melanoma cells. Biochim Biophys Acta 1139, 324-328. 41. Slominski A, Friedrich T (1992) L-DOPA inhibits in vitro phosphorylation of melanoma glycoproteins. Pigment Cell Res 5, 396-400. 42. Li L, Paus R, Slominski A, Hoffman R (1992). Skin histoculture assay for studying the hair cycle. In Vitro Cell Dev Biol 28A 695-698. 43. Slominsk A, Pruski D (1993) Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells. Exp Cell Res 206, 189-294. 44. Ren SL, Ariga T, Scarsdale JN, Zhang Y, Slominski A, Livingston PO, Ritter G, Kushi Y, Yu RK (1993). Characterization of a hamster melanoma associated ganglioside antigen as 7-0-acetylated disialoglangloside GD3. J Lipid Res 34, 1565-1572. 45. Gaudet S, Slominski A, Etminan M, Pruski D, Paus R, Namboodiri MAA (1993). Identification and characterization of two isozymic forms of arylamine N-acetyltransferase in Syrian hamster skin. J Invest Dermatol

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101, 650-656. 46. Slominski A, Wortsman J, Mazurkiewicz J, Matsuoka L, Lawrence K, Gorbani A, Paus R (1993). Detection of the proopiomelanocortin-derived antigens in normal and pathologic human skin. J Lab Clin Med 122, 658-666. 47. Slominski A, Paus R, Schaderdorf D (1993). Melanocytes are sensory and regulatory cells of epidermis. J Theor Biol 164, 103-120. 48. Slominski A, Paus R, Wortsman J (1993) On the potential role of proopiomelanocortin in skin physiology and pathology. Mol Cell Endocrinol 93, C1-C6. 49. Slominski A, Paus R (1993) Bomirski melanomas: A versatile and powerful model for pigment cell and melanoma research. Int J Oncology 2, 221-228. 50. Slominski A, Paus R (1993). Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth. J Invest Dermatol 101 , 90S-97S. 51. Slominski A, Paus R. (1994) Towards defining receptors for L-tyrosine and L-DOPA. Mol Cell Endocrinol 99, C7-C11. 52. Slominski A, Chassalerris N, Mazurkiewicz J, Paus R (1994). Murine skin as a target for melatonin bioregulation. Exp Dermatol 3, 45-40. 53. Paus R, Maurer M, Slominski A, Czarnetzki B (1994) Mast cell involvement in murine hair growth. Developmental Biol 163, 230-240. 54. Slominski A, Paus R, Plonka P, Maurer M, Chakraborty A, Pruski D, Lukiewicz S. (1994) Melanogenesis during the anagen-catagen-telogen transformation of the murine hair cycle. J Invest Dermatol 102, 862-869. 55. Paus R, Slominski A, Czarnetzki B (1995). Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb? Yale J Biol Med 66, 541-554. 56. Slominski A, Ross J, Mihm, MC (1995) Cutaneous melanoma: pathology, relevant prognostic indicators and progression. British Medical Bulletin 51, 548-569. 57. Chakraborty A, Slominski A, Ermak G, Hwang J, Pawelek J (1995) Ultraviolet and melanocyte-stimulating hormone (MSH) stimulate mRNA production of α-MSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes. J Invest Dermatol 105, 655-659. 58. Slominski A, Ermak, Hwang J,Chakraborty A, Mazurkiewicz J, Mihm M (1995) Proopiomelanocortin, corticotropin releasing hormone and corticotropin releasing hormone receptor genes are expressed in human skin. FEBS Lett 374, 113-116. 59. Slominski A, Ermak, Hwang J, Mazurkiewicz J, Corliss, Eastman A (1996) The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin. Biochim Biophys Acta 1289, 247-251. 60. Slominski A, Paus R, Plonka P, Handjinski B, Maurer M, Chakraborty A, Mihm M (1996) Pharmacological disruption of hair follicle pigmentation as a model for studying the melanocyte response to and recovery from cytotoxic damage in situ. J Invest Dermatol 106, 1203-1211. 61. Slominski A, Mihm MC (1996) Potential mechanism of skin response to stress. Int J Dermatol 35, 849-851. 62. Chakraborty A, Funasaka Y, Slominski A, Ermak G, Hwang J, Pawelek J, Ichihashi M (1996) Production an release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture:

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Regulation by UVB. Biochim Biophys Acta 1313, 130-138. 63. Pajak S, Cieszka K, Plonka P, Lukiewicz S, Mihm M, Slominski A (1996) Transplantable melanomas in gerbils (meriones unguiculatus). I. Origin, morphology and growth rate. Anticancer Res 16, 1203-1208. 64. Slominski A, Baker J, Rosano T, Guisti LW, Ermak G, Grande M, Gaudet SJ (1996) Metabolism of serotonin to N-acetylserotonin, melatonin and 5-hydroxytryptamine in hamster skin culture. J Biol Chem 271, 12281-12286. 65. Slominski A, Ermak G, Mihm MC (1996) ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin. J Clin Endocrinol Met 81, 2746-2749. 66. Slominski A, Baker J, Ermak G, Chakraborty A, Pawelek J (1996) UVB stimulates production of corticotropin releasing factor (CRF) by human melanocytes. FEBS Lett 399, 175-176. 67. Ermak G, Slominski A (1997) Production of POMC, CRH-, ACTH- and α-MSH- receptor mRNA and expression of tyrosinase gene in relation to hair cycle and dexamethasone treatment in the C57BL/6 mouse skin. J Invest Dermatol 108, 160-167. 68. Slominski A, Goodman-Snitkoff G, Maurer M, Paus R (1997) Hair cycle associated changes in splenocyte proliferation. In Vivo 11, 101-102. 69. Furkert J, Klug U, Slominski A, Eichmuller S, Mehlis B, Kertscher U, Paus R (1997) Identification and measurement of β-endorphin levels in the skin during induced hair growth in mice. Biochim Biophys Acta 1336, 315-322. 70. Luger TA. Scholzen T, Brzoska T, Becher E, Slominski A, Paus R (1998) Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone. Ann NY Acad Sci 840, 381-394. 71. Slominski A, Pawelek J (1998) Animals Under the Sun: Effects of UV Radiation on Mammalian Skin. Clin Dermatol 16, 503-515. 72. Slominski A, Paus R, Mihm M (1998). Inhibition of melanogenesis as an adjuvant strategy for the treatment of melanotic melanomas. Selective review and hypothesis. Anticancer Res 18, 3709-3716 73. Schallreuter K, Slominski A, Pawelek J, Jimbow K, Gilchrest B (1998) What control melanogenesis? Exp Dermatol 7, 143-150. 74. Slominski A, Wortsman J, Nickoloff B, McClatchey K, Mihm, MC , Ross J (1998) Molecular pathology of melanoma. Am J Clin Pathol 110, 788-794. 75. Roloff B, Fechner K, Slominski A, Furkert J, Botchkarev VA, Bulfone-Paus S, Zipper J, Krause K, Paus R (1998) Hair Cycle-Dependent Expression of Corticotropin Releasing Hormone (CRH) and CRH Receptors (CRH-R) in Murine Skin. FASEB J 12, 287-297. 76. Slominski A, Ermak G, Mazurkiewicz JE, Baker J, Wortsman J (1998) Characterization of corticotropin releasing hormone (CRH) in human skin. J Clin Endocrinol Metab 83, 1020-1024. 77. Slominski A, Botchkarev V, Botchkarev N, Chakraborty A, Luger T, Uenalan M, Paus R (1998) Hair cycle dependent production of ACTH in mouse skin. Biochim. Biophys. Acta 1448, 147-152. 78. Fazal N, Slominski A, Choudhry MA, Wei ET, Sayeed MM (1998) Effect of CRF and related peptides on calcium signalling in human and rodent melanoma cells. FEBS Lett 435, 187-190. 79. Slominski A (1998) Identification of β-endorphin, α-MSH and ACTH peptides in cultured human melanocytes, melanoma and squamous cell carcinoma cells. Exp Dermatol 7, 213-216

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80. Slominski A, Heasley D, Ermak G, Mazurkiewicz JE, Baker J, Carlson A (1999) Expression of proopiomelanocortin (POMC) derived melanocyte stimulating hormone (MSH) and ACTH peptides in skin of basal cell carcinoma patients. Human Pathology 30, 208-215. 81. Wood JM, Jimbow K, Boissy RE, Slominski A, Plonka P, Slawinski J, Wortsman J, Tosk J (1999) What’s the use of generating melanin? Exp Dermatol 8, 153-164. 82. Birkle S, Ren S, Slominski A, Zeng G, Gao L, Kasama T, Yu R K. (1999) Down regulation of the expression of O-acetyl-GD3 by the O-acetylesterase gene in hamster melanoma cells: effects on cellular proliferation, differentiation, and melanogenesis. J Neurochem 72, 954-961. 83. Slominski A, Gomez-Sanchez Celso, Foecking MF, Wortsman J (1999) Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells. FEBS Lett 445, 364-366. 84. Slominski A, Ermak G, Wortsman J (1999) Modification of melanogenesis in cultured human melanoma cells. In Vitro Cell Develop Biol 35, 564-565. 85. Slominski A, Botchkarev V, Choudhry M, Fazal, N, Fechner, K, Furkert, J, Krause, E, Roloff, B.; Sayeed, M.; Wei, E.; Zbytek, B.; Zipper, J.; Wortsman, J.; Paus, R. (1999) Cutaneous expression of CRH and CRH-R: is there a “skin stress system”? Ann NY Acad Sci 885, 287-311. 86. Paus R, Botchkarev VA, Botchkareva NV, Fechner K, Furkert J, Roloff B, Slominski A (1999) The skin POMC system (SPS): leads and lessons from the hair follicle.” Ann NY Acad Sci 885, 350-363. 87. Chakraborty A, Pawelek JM, Bolognia J, Funasaka Y, Slominski A (1999) UV light and MSH receptors. Ann NY Acad Sci 885, 100-116. 88. Botchkarev VA, Slominski A, Botchkareva NV, Roloff B, Luger T, Paus R (1999) Developmentally regulated expression of α-MSH and MC-1 receptor in C57BL/6 mouse skin suggests functions beyond pigmentation. Ann NY Acad Sci 885, 433-439. 89. Mazurkiewicz JE, Corliss D, Slominski A (1999) Differential temporal and spatial expression of POMC mRNA and of the production of POMC peptides during the murine hair cycle. Ann NY Acad Sci 885, 427-429. 90. Slominski A, Botchkarev V, Botchkarev N, Chakraborty A, Luger T, Uenalan M, Paus R (1999) ACTH production in C57BL/6 mouse skin. Ann NY Acad Sci 885, 448-450. 91. Slominski A, Wortsman J, Carlson A, Nickoloff B, McClatchey K (1999) Molecular pathology of soft tissue and bone tumors. A review. Arch Pathol Lab Med 123, 146-1259. 92. Tobin DJ, Slominski A, Botchkarev V, Paus R (1999) The fate of hair follicle melanocytes during the hair growth in mice. J Invest Dermatol Symp Proc 4, 323-332. 93. Cieszka K, Romanowska B, Elas, M, Pajak S, Paziewski E, Bryk J, Kukielczak B, Slominski A, Zygulska- Mach H, Lukiewicz S (2000) Experimetal ruthenium plaque therapy of amelanotic and melanotic melanomas growing in hamster eye. Melanoma Res 10, 26-35. 94. Slominski A, Roloff B, Zbytek B, Wei ET, Fechner K, Curry J, Wortsman J (2000) Corticotropin releasing hormone (CRH) and related peptides can act as bioregulatory factors in human keratinocytes. In Vitro Cell Develop Biol 36, 211-216. 95. Slominski A, Roloff B, Curry J, Dahiya M, Szczesniewski A, Wortsman J (2000) The skin produces urocortin. J Clin Endocrinol Metab 85, 815-823 96. Slominski A, Gomez-Sanchez Celso, Foecking MF, Wortsman J (2000) Active steroidogenesis in the normal rat skin. Biochim Biophys Acta 1474, 1-4.

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97. Slominski A, Wortsman J, Luger T, Paus R, Salomon S (2000) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 80, 979-1020. 98. Slominski A, Wortsman J (2000) Neuroendocrinology of the skin. Endocrine Rev 21, 457-487.

99. Mazurkiewicz JE, Corliss D, Slominski A (2000) Spatiotemporal expression, distribution, and processing of POMC and POMC-derived peptides in murine skin. J Histochem Cytochem 48, 905-914. 100. Slominski A, Wortsman J, Szczesniewski A (2000) Liquid chromatography-mass spectrometry detection of corticotropin-releasing hormone and proopiomelanocortin-derived peptides in human skin. J Clin Endocrinol Metab 85, 3575-3581. 101. Slominski A, Malarkey WB, Wortsman J, Asa S, Carlson A (2000) Human skin expresses growth hormone (GH), but not the prolactin (PRL) gene. J Lab Clin Med 136, 476-481. 102. Cascinelli N, Heerlyn M, Schneeberger A, Kuwert C, Slominski A, Armstrong C,Belli F, Lukiewicz S, Maurer D, Ansel J, Stingl G, Saida T (2000) What is the most promising strategy for the treatment of metastasizing melanoma? Exp Dermatol 9, 439-451. 103. Slominski A, Carlson A, Wortsman J, Mihm M (2001) The role of molecular biology in diagnostic pathology of melanoma. Meth Mol Medicine 61, 123-163 104. Quevedo MA, Slominski A, Pinto W, Wei E, Wortsman J (2001). Pleiotropic effects of corticotropin releasing hormone (CRH) on normal human keratinocytes. In Vitro Cell Develop Biol 37A, 50-54. 105. Curry JL, Pinto W, Nickoloff BJ, Slominski AT (2001). Human keratinocytes express functional α-MSH (MC1-R) Receptors. In Vitro Cell Develop Biol 37,234-236. 106. Carlson KT, Stair Navy S, Wei ET, Sadie W, Filov VA, Rezsova VV, Slominski A, Quillan JM (2001) Inhibition of mouse melanoma cell proliferation by corticotropin releasing hormone and its analogs. Anticancer Res 21, 1173-1180. 107. Roloff D, Gomez-Sanchez CE, Foecking MF, Wortsman J, Slominski A (2001) Steroidogenesis in the human skin: 21-hydroxylation in cultured keratinocytes. J Steroid Biochem Mol Biol 78, 77-81. 108. Slominski A, Wortsman J, Carlson A, Matsuoka L, CM Balch, Mihm M (2001) Malignant melanoma: An update. Arch Pathol Lab Med 125, 1295-1306. 109. Slominski A, Wortsman J, Pisarchik A, Zbytek A, Linton EA, Mazurkiewicz J, Wei ET (2001) Cutaneous expression of corticotropin releasing hormone (CRH), urocortin and CRH receptors. FASEB J 15, 1678-1693. 110. Mahuren JD, Coburn SP, Slominski A, Wortsman J (2001) Microphosphate determination provides a general method for measuring the activity of phosphatases using physiological, nonchromogenic substrates such as lysophosphatidic acid. Anal Biochem 298, 241-245. 111. Pisarchik A, Slominski A (2001) Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. FASEB J 15, 2754-2756; full text FASEB J (October 15, 2001) 10.1096/fj.01-0487fje. 112. Carlson JA, Mu XC, Slominski A, Weismann K, Crowson AN, Malfetano J,Prieto VG, Mihm MC (2002) Melanocytic proliferations associated with lichen sclerosus. Arch Dermatol 138, 77-87. 113. Zbytek B, Mysliwski A, Slominski A, Wortsman J, Wei E, Mysliwska J (2002) Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes. Life Sci 70, 1013-1021.

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114. Slominski A, Wortsman J, Foecking M, Shackleton C, Gomez-Sanchez C, Szczesniewski A. (2002) Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes, J Invest Dermatol 118, 310-315. 115. Pisarchik A, Slominski A (2002) Corticotropin releasing hormone receptor type 1: molecular cloning and investigation of alternative splicing in the hamster skin. J Invest Dermatol 118, 1065-1072. 116. Slominski A, Semak I, Pisarchi A, , Sweatman T, Szczesniewski A, Wortsman J (2002) Conversion of L-tryptophan to serotonin and melatonin in melanoma cells. FEBS Lett 511, 102-106. 117. Carlson A, Grabowski R, Mu XC, Del Rosario A, Malfetano J, Slominski A (2002) Possible mechanisms of hypopigmentation in lichen slerosus. Am J Dermatopathol 24, 97-107. 118. Slominski A, Pisarchik A, Semak I, Sweatman T, Wortsman J, Szczesniewski A, Slugocki G, McNulty J, Kauser S, Tobin DJ, Jing C, Johansson O (2002) Serotoninergic and melatoninergic systems are fully expressed in human skin. FASEB J 16, 896-898; full text FASEB J (April 23, 2002) 10.1096/fj.0.1-0952fje. 119. Slominski A (2002). Coming of age of melanogenesis related proteins. Arch Path Lab Med 126, 775-777. 120. Slominski A, Pisarchik A, Semak I, Sweatman T, Szczesniewski A, Wortsman J (2002) Serotoninergic system in hamster skin. J Invest Dermatol 119, 934-942. 121. Slominski A, Wortsman J, Kohn L, Ain KB, Venkataraman GM, Pisarchik A,Chung JH, Giuliani C, Thornton M, Slugocki G,. Tobin DJ (2002) Expression of hypothalamo-pituitary-thyroid axis related genes in the human skin. J Invest Dermatol 119, 1449-1455. 122. Slominski A, Wortsman J (2003) Self-regulated endocrine system in the skin. Minerva Endocrinologica, 28, 135-143. 123. Plonka P, Slominski A, Pajak S, Urbanska K (2003) Transplantable Melanomas in Gerbils (Meriones unguiculatus). II – Melanogenesis. Exp Dermatol 12, 356-364. 124. Coburn SP, Slominski A, Mahuren JD, Wortsman J, Hessle L, Millan JL (2003) Cutaneous metabolism of vitamin B-6. J Invest Dermatol 120, 292-300. 125. Wiesner B, B Roloff, Fechner K, Slominski A (2003) Intracellular calcium measurements of single human skin cells after stimulation with corticotropin-releasing factor and urocortin using confocal laser scanning microscopy. J Cell Sci 116, 1261-1268. 126. Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J (2003) Functional activity of serotoninergic and melatoninergic systems expressed in the skin. J Cell Physiol 196, 144-153. 127. Carlson JA, Slominski A, Linette G, Mihm CM, Jr., Ross JS (2003) Biomarkers in melanoma. Part 1. Predispostion, screening and diagnosis. Exp Rev Mol Diagn 3, 163-184. 128. Carlson JA, Slominski A, Linette G, Mihm CM, Jr., Ross JS (2003) Biomarkers in melanoma. Part II. Staging, prognoses and detection of early metastases. Exp Rev Mol Diagn 3, 303-330. 129. Slominski A (2003) β-endorphin/µ-opiate receptor system in the skin (Commentary). J Invest Dermatol 120, xii-xiii. 130. Slominski A, Pisarchik A, Semak I, Sweatman T, Wortsman J (2003) Characterization of the serotoninergic system in C57BL/6 mouse skin. Eur J Biochem 270, 3335-3344. 131. Slominski A, Wortsman J, Linton E, Pisarchik A, Zbytek B (2003) The skin as a model for the immunodulatory effects of corticotropin-releasing hormone. In “Mind over Matter – Regulation of Peripheral

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Inflammation by the CNS“, M Schaffer, C Stein, editors (Progress in Inflammation Research; M. J. Parnham, series editor), pp149-176, 2003, Birkahauser Verlag, Basel. 132. Slominski A, Pisarchik A, Johansson O, Jing C, Semak I, Slugocki G, Wortsman J, (2003) Tryptophan hydroxylase (TPH) expression in human skin cells. Biochim Biophys Acta 1639, 80-86. 133. Zbytek B, Pfeffer L, Slominski A (2003) CRH inhibits NF-κB pathway in human HaCaT keratinocytes. J Invest Dermatol 121, 1496-1499. 134. Semak, I. V.; Korik, E. O.; Naumova, M. V, Slominski, A (2003) Interaction of products of peroxidase oxidation of mono-, di-, and trihydroxyflavones with glutathione. Vestsi Natsyyanal'nai Akademii Navuk Belarusi, Seryya Medyka-Biyalagichnykh Navuk (2003), (4), 50-56. 135. Korik, E. O.; Naumova, M. V.; Slominski, A.; Semak, I. V. (2003) Probable mechanisms of formation of glutathione conjugates of quercetin and rutin. Vestsi Natsyyanal'nai Akademii Navuk Belarusi, Seryya Medyka-Biyalagichnykh Navuk (2003), (4), 62-67. 136. Semak I, Korik E, Naumova M, Wortsman J, Slominski A (2004) Serotonin metabolism in rat skin: characterization by liquid chromatography – mass spectrometry. Arch Biochem Biophys 421, 61-66. 137. Slominski A, Pisarchik A, Tobin DJ, Mazurkiewicz JE, Wortsman J (2004) Differential expression of cutaneous corticotropin releasing hormone system. Endocrinology 145, 941-950. 138. Slominski A, Tobin DJ, Shibahara S, Wortsman J (2004) Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 84, 1155-1228. 139. Zbytek B, Pffefer L, Slominski A (2004) Corticotropin-releasing hormone stimulates NF-kappaB in human epidermal keratinocytes. J Endocrinol 181, R1-R7. 140. Pisarchik A, Slominski A (2004) Molecular and functional characterization of novel CRFR1 isoforms identified in the skin. Eur J Biochem 271, 2821-2830. 141. Grabacka M, Placha W, Plonka PM, Pajak S, Urbanska K, Laidler P, Slominski A (2004) Inhibition of melanoma metastases by fenofibrate Arch Derm Res 296, 54-58. 142. Pisarchik A, Wortsman J, Slominski A (2004) A novel microarray to evaluate stress-related genes in skin: Effect of ultraviolet light radiation. Gene 341, 199-207. 143. Slominski A, Pisarchik A, Wortsman J (2004) Expression of genes coding melatonin and serotonin receptors in rodent skin. Biochim Biophys Acta 1680, 67-70. 144. Slominski A, Zjawiony J, Wortsman J, Semak I, Stewart J, Pisarchik A, Sweatman T, Marcos J, Dunbar C, Tuckey RT (2004) A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Europ J Biochem 271, 4178-4188 145. Semak, I. V.; Korik, E. O.; Naumova, M. V.; Slominski, A (2004) New method for determination of arylalkylamine N-acetyltransferase activity by high pressure liquid chromatography and mass spectrometry. Vestsi Natsyyanal'nai Akademii Navuk Belarusi, Seryya Biyalagichnykh Navuk (2004), (4), 69-73. 146. Zbytek B, Pikula M, Slominski RM, Mysliwski A,Wei E, Wortsman J, Slominski AT (2005) CRH triggers differentiation in HaCaT keratinocytes. British J Dermatol 152,474-480. 147. Slominski A, Wortsman J, Plonka PM, Schallreuter KU, Paus R, Tobin DJ (2005) Hair follicle pigmentation. J Invest Dermatol 124: 13-21.

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148. Zbytek B, Slominski A (2005) CRH induces differentiation program in human adult epidermal keratinocytes. J Cell Physiol 203:118–126 149. Carlson JA, Ross JS, Slominski A, Linette G, Mysliborski J, Hill J, Mihm MJr. (2005) Molecular markers in melanoma. J Amer Acad Dermatol 52:743-75 150. Slominski A, Plonka PM, Pisarchik A, Smart JL, Tolle V, Wortsman J, Low MJ (2005) Preservation of eumelanin hair pigmentation in Pomc-gene knockout mice on a non-agouti (a/a) genetic background. Endocrinology 146, 1245–1253 151. Slominski A, Wortsman J, Tobin DJ (2005) The cutaneous serotoninergic/melatoninergic system: securing a place under the sun. FASEB J 19, 176-194. 152. Slominski A, Zbytek B, Szczesniewski A, Semak I , Kaminski J, Sweatman T, Wortsman J (2005) CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH. Am J Physiol Endocrinol Metab 288, E701–E706 153. Slominski A (2005) Neuroendocrine system of the skin (William J Cunliffe Scientific Award lecture). Dermatology 211, 199-208 154. Slominski A, Zbytek B, Semak I , Sweatman T, Wortsman J (2005) CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol 162, 97– 102 155. Linette G, Carlson JA, Slominski A, Mihm MJr, Ross JS, (2005) Biomarkers in melanoma: Stage III and IV disease. Expert Rev. Mol. Diagn. 5, 65-74. 156. Slominski A, Semak I , Zjawiony J, Wortsman J, Li W, Szczesniewski A, Tuckey RT (2005) The cytochrome P450scc system opens an alternate pathway of vitamin D3metabolism. FEBS Journal 272, 480-4090. 157. Semak I; Naumova M; Korik E; Terekhovich V; Wortsman J; Slominski A (2005). A Novel Metabolic Pathway of Melatonin: Oxidation by Cytochrome c. Biochemistry 44, 9300-9307. 158. Plonka PM, Michalczyk D, Popik M, Handjiski B, Slominski A, Paus R (2005) Splenic eumelanin differs from hair eumelanin in C57BL/6 mice. Acta Biochim Pol. 52, 433-441. 159. Slominski A, Semak I , Zjawiony J, Wortsman J, Gandy MN, Li J, Zbytek B, Li W, Tuckey RT (2005) Enzymatic metabolism of ergosterol by cytochrome P450scc (CYP11A1) to biologically active 17α,24-dihydroxyergosterol. Chemistry & Biology 12, 931-939 160. Slominski A, Fischer T, Zmijewski MA, Wortsman J, Semak I , Zbytek B, Slominski RM, Tobin DJ (2005) On the role of melatonin in skin physiology and pathology. Endocrine 27,137-48 161. Arck PC, Slominski A, Theoharides TC, Peters EMJ, Paus R (2006) Neuroimmunology of stress: skin takes center stage. J Invest Dermatol 126:1697-704.

162. Slominski A., Zbytek, B., Pisarchik, A., Slominski, R.M., Wortsman, J. (2006) CRH functions as a growth factor/cytokine in the skin. J Cell Physiol 206, 780-791 163. Fischer T, Zbytek B, Sayre RM, Apostolov EO, Basnakian AG, Sweatman TM, Wortsman J, Elsner P, Slominski A (2006) Melatonin increases survival of HaCaT keratinocytes by suppressing UV-induced apoptosis. J Pineal Res 40, 18-26. 164. Slominski A, Zbytek B, Zmijewski M, Slominski RM, S Kauser, Wortsman J, DJ Tobin (2006) Corticotropin releasing hormone and the skin Front Biosci 11, 2230-2248. 165. Slominski A., Zbytek B., Szczesniewski A., Wortsman J (2006) Cultured human dermal fibroblasts do

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produce cortisol. J Invest Dermatol 126, 1177-1178. 166. Fischer T, Sweatman TM, Semak I, Sayre RM, Wortsman J, Slominski A (2006) Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems. FASEB J 20, 1564-1566 167. Kauser S, Slominski A, Wei E, Tobin DJ (2006) Modulation of the human hair follicle pigmentary unit by CRH and urocortin peptides. FASEB J 20, 882-895. 168. Zbytek B, Pfeffer L, Slominski A (2006) CRH inhibits NF-κB activity in melanocyte via POMC signaling. Peptides 27, 3276-3283. 169. Zbytek B, Wortsman J, Slominski A. (2006) Mechanisms of UVB stimulated corticotropin-releasing hormone and proopiomelanocortin production in the human melanocytes. Mol Endocrinol 20, 2539-2547. 170. Slominski A (2006) Proopiomelanocortin (POMC) signaling system is operating in mast cells. J Invest Dermatol 126, 1934-1936. 171. Slominski A, Semak I, Wortsman J, Zjawiony J, Li W, Zbytek B, Tuckey T (2006) An alternate pathway of vitamin D2 metabolism: Cytochrome P450scc (CYP11A1) mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2. FEBS J 273, 2891-901. 172. Fisher T,Zmijewski M, Zbytek B, Sweatman TW, Slominski RM, Wortsman J, Slominski A (2006) Oncostatic effects of indole melatonin and expression of its cytosolic and nuclear receptor in cultured human melanoma cell lines. Int J Oncol 29, 665-672. 173. Jiang H, Wortsman J, Matsuoka L, Granese J, Carlson JA, Mihm M, Slominski A (2006) Molecular Spectrum of Pigmented Skin Lesions: From Nevus to Melanoma. Expert Rev Dermatol 1, 679-700. 174. Zbytek B, Slominski A (2007) CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes. J Invest Dermatol 127, 730–732. 175. Slominski A, Wortsman J, RC Tuckey, Paus R (2007) Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol 265-266, 143-149. 176. Slominski A, Zmijewski M, Pisarchik A, Wortsman J (2007) Molecular cloning and initial characterization of african green monkey (Cercopithecus aethiops) corticotropin releasing hormone receptor type 1 (CRF1) from COS-7 cells. Gene 389, 154-162. 177. Rohwedder A, Slominski A, Wolff M, Kredentser D, Carlson AJ (2007) Epidermodysplasia verruciformis and cutaneous human papillomavirus dna, but not genital human papillomavirus DNAs, are frequently detected in vulvar and vaginal melanoma. Am J Dermatopathol 29:13–17 178. Rousseau K, Kauser S, Pritchard LE, Warhurst A, Oliver RL, Slominski A, Wei ET, Thody AJ, Tobin DJ, White A (2007) Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J 21, 1844-1856. 179. Zmijewski M, Sharma R, Slominski A (2007) Expression of an equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium. J Endocrinol, 193, 157–169. 180. Li W, Wang Z, Gududuru V, Zbytek B, Slominski AT, Dalton JT and Miller DD (2007) Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma. Anticancer Res 27, 883-888. 181. Paus R, Klein J, Permana PA, Owecki M, Chaldakov GN, Bohm M, Hausman G, Lapiere CM, Atanassova P, Sowinski J, Fasshauer M, Hausman DB, Maquoi E, Tonchev AB, Peneva VN, Vlachanov KP, Fiore M, Aloe L,

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Slominski A, Reardon CL, Ryan, TJ, Pond CM (2007) What are subcutaneous adipocytes really good for…? Exp Dermatol 16, 45–70. 182. Brozyna A, Zbytek B, Granese J, Ross J, Carlson JA, Slominski A (2007) Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma. Expert Rev Dermatol 2, 451-469. 183. Slominski A (2007) A nervous breakdown in the skin: Stress and the epidermal barrier. J Clin Invest 117, 3166-3169. 184. Nordlind K, EC Azmitia, Slominski A (2008) The skin as a mirror of the soul: Exploring the possible roles of serotonin. Exp Dermatol 17, 301-311. 185. Carlson J.A., Linette G.P., Aplin A., Ng B., Slominski A. (2007) Melanocyte receptors: Clinical implications and therapeutic relevance. Dermatol Clin 25, 541-557. 186. Fischer T, Zmijewski M, Zbytek B, Wortsman J, Slominski A (2008) Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-8/casp-9) and effector caspases (casp-3/casp7) and PARP in UVR-exposed keratinocytes. J Pineal Res 44, 397–407. 187. Fischer T, Slominski A, Tobin DJ, Paus R (2008) Melatonin and the hair follicle. J Pineal Res 44, 1-15. 188. Slominski A, Tobin DJ, Zmijewski M, Wortsman J, Paus R (2008) Cutaneous melatonin: production, metabolism and phenotypic effects. Trends Endo Metab 19, 17-24. 189. Schallreuter K.U., Bahadoran P., Picardo M., Slominski A., Elassiuty Y.E., Kemp E.H., Giachino C., Liu J.B., Luiten R.M., Lambe T., Le Poole I.C., Dammak I., Onay H., Zmijewski M.A., Dell’Anna M.L., Zeegers M.P., Cornall R.J., Paus R., Ortonne J.P., Westerhof W. (2008) Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Derm 17, 139-160 190. Slominski A, Wortsman J, Paus, R, Elias PM, Tobin DJ, Feingold K (2008) Skin as an endocrine organ: implications for its function. Drug Discovery Today: Dis Mech 5: e137-e144

191. Fischer T, Slominski A, Zmijewski M, Reiter RJ, Paus R (2008) Melatonin as a major skin protectant: From free radical scavenging to DNA damage repair. Exp Derm 17: 713-730. 192. Zbytek B, Janjetovic Z, Tuckey RC, Zmijewski MA, Sweatman TW, Jones E, Nguyen MN, Slominski AT. (2008) 20-Hydroxyvitamin D3, a Product of Vitamin D3 Hydroxylation by Cytochrome P450scc, Stimulates Keratinocyte Differentiation. J Invest Dermatol 128, 2271-2280. 193. Brozyna A, VanMiddlesworth L, Slominski A (2008) Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy. Int J Cancer 123, 1448-1456. 194. Tuckey RC, Li W, Zjawiony JK, Zmijewski MA, Nguyen MN, Sweatman T, Miller D, Slominski A. (2008) Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. FEBS J 275, 2585-2596. 195. Tuckey RC, Nguyen MN, Slominski A. (2008) Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin. Int J Biochem Cell Biol 40, 2619-2626. 196. Slominski A (2008) Cooling skin cancer: Menthol inhibits melanoma growth. Am J Physiol: Cell Physiol 295, C293-C295. 197. Blossom J, Altmayer S, Jones DM, Slominski A, Carlson J.A (2008) Volar melanotic macules in a gardener: A case report and review of the literature. Am J Dermatopathol 30, 612–619. 198. Semak I, Korik E , Antonova M, Wortsman J, Slominski A (2008) Metabolism of melatonin by cytochrome P-450s in rat liver mitochondria and microsomes. J Pineal Res 45, 515-523.

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199. Van Beek E, Bodo E, Kromminga A, Gaspar E, Meyer K, Zmijewski M, Slominski A, Wenzel BE, Paus R (2008) Thyroid hormones directly alter human hair follicle functions: Anagen prolongation, and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab 93, 4381-4388 200. Zmijewski MA, Li W, Zjawiony JK, Sweatman TW, Chen J, Miller DD, Slominski AT (2008) Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives. Photochem Photobiol Sci 7, 1570-1576. 201. Zbytek B, Carlson JA, Granese J, Ross J, Mihm M, Slominski A (2008) Current concepts of metastasis in melanoma. Expert Rev Dermatol 3, 569-585. 202. Bodo E, Kromminga A, Biro T, Istvan B, Gaspar E, Zmijewski M, van Beek E, Langein L, Slominski A, Paus R (2008) Human female hair follicles are a direct, non-classical target for thyroid-stimulating hormone (TSH). J Invest Dermatol, 129, 1126-1139. 203. Slominski A, Zbytek B, Slominski R (2009) Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells. Int J Cancer 124, 1470-1477. 204. Slominski A (2009) On a role of the CRF signaling system in the etiology of inflammatory skin disorders. Brit J Dermatol 160:229–232 205. Tuckey RC, Janjetovic,Z, Li W, Nguyen MN, Zmijewski MA, Zjawiony JK, Slominski A. (2008) Metabolism of 1α-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1α,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol, 112(4-5):213-9 206. Zmijewski MA, Li W, Zjawiony JK, Sweatman TW, Chen J, Miller DD, Slominski AT (2009) Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3β,17α,20-triol and their bioactivity in melanoma cells. Steroids 74, 218-228. 207. Slominski A, Zmijewski MA, Semak I, Sweatman T, Janjetovic Z, Li W, Zjawiony JK, Tuckey RC (2009) Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. PLoSONE 4(2), e4309-e. 208. Li W, Slominski, R, Slominski A (2009) HRMAS NMR analysis of metabolic changes in melanoma cells after induction of melanogenesis. Anal Biochem 386:282-284 209. Zmijewski M, Slominski A (2009) CRF1 receptor splicing in epidermal keratinocytes: Potential biological role and environmental regulations. J Cell Physiol 218: 593–602. 210. Nguyen MN, Slominski A, Li W, Ng WR, Tuckey RC . (2009) Metabolism of vitamin D2 to 17,20,24-trihydroxyvitamin D2 by cytochrome P450scc (CYP11A1). Drug Metab Dispos. 37:761–767 211. Slominski A (2009) Neuroendocrine activity of the melanocyte. Exp Dermatol, 18: 760-763 212. Zmijewski M, Sweatman T, Slominski A (2009) The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19). Mol Cell Endocrinol 307:211-216. 213. Slominski A (2009) Are suberythemal doses of ultraviolet B good for your skin? Pigment Cell Melanoma Res 22, 154-155 214. Carlson JA, Ross J, Slominski A (2009) New techniques in dermatopathology that help to diagnose and prognosticate melanoma. Clin Dermatol 27, 75-102 214. Lu S, Slominski A, Yang SE, Sheehan C, Ross J, Carlson JA, (2010) The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia associated transcription factor (MITF) and other

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melanogenesis related proteins in normal and pathological skin, hair follicles, and melanocytic nevi. J Cut Pathol, 37 (Suppl. 1): 26–40. 215. Janjentovic Z, Zmijewski M, Tuckey RT, DeLeon DA, Nguyen MN, Pfeffer L, Slominski A (2009) 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-κB activity by increasing IκBα levels in human keratinocytes. PLoSOne 4(6), e5988. 216. Schwartz AL, Malgor R, Dickerson E, Weeraratna AT, Slominski A, Wortsman J, Harii N, Kohn AD, Moon RT, Schwartz FL, Goetz DJ, Kohn LD, McCall KD (2009) Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res 15:4114-4122. 217. P. M. Plonka, T. Passeron, M. Brenner, D. J. Tobin, S. Shibahara, A. Thomas, A. Slominski, A. L. Kadekaro, D. Hershkovitz, E. Peters, J. J. Nordlund, Z. Abdel-Malek, K. Takeda, R. Paus, J. P. Ortonne, V. J. Hearing, K. U. Schallreuter (2009) What are melanocytes really doing all day long…? Exp Dermatol 18, 799-819 218. Janjentovic Z, Tuckey RT, Nguyen MN, Thorpe E, Slominski A (2010) 20,23-Dihydroxyvitamin D3, Novel P450scc product, stimulates differentiation and inhibits proliferation and NF-κB activity in human keratinocytes. J Cell Physiol 223, 36-48. 219. Zmijewski M, Slominski A (2009) Modulation of CRF signaling through receptor splicing in mouse pituitary cell line AtT-20 - Emerging role of soluble isoforms. J Physiol Pharmacol 60, Suppl 4, 39-46 220. Hang CH, Fan M, Slominski A, Yue J, Pfeffer L (2010) The role of constitutively activated STAT3 in B16 melanoma. Inter J Interferon, Cytokine Mediator Res 2,1-7. 221. Kim T-K., Chen J., Li W., Zjawiony J., Miller D., Janjetovic Z., Tuckey R.C., Slominski A. (2010) A new steroidal 5,7-diene derivative, 3β-hydroxyandrosta-5,7-diene-17β-carboxylic acid, shows potent anti-proliferative activity. Steroids 75, 230-239 222. Zmijewski M, Slominski A (2010) Emerging role of alternative splicing of CRF1 receptor in CRF signaling . Acta Biochim Pol 57, 1-13, 2010. 223. Slominski AT, Janjetovic Z, Fuller BE, Zmijewski MA, Tuckey RC, et al. (2010) Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity. PLoS ONE 5(3): e9907. 224. Zmijewski MA, Li W, Chen Jianjun, Kim Tae-Kang, Zjawiony JK, Sweatman TW, Miller DD, Slominski AT (2011) Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity. Steroids 76, 193–203. 225. Li W, Chen J, Janjetovic Z, Kim T-K., Sweatman T, Zjawiony J, Tuckey R.C., Miller, D., Slominski A. (2010) Chemical synthesis of 20S-hydroxyvitamin D3, which shows anti-proliferative activity. Steroids 75:926-35. 226. Tang EKY, Li W, Janjetovic Z, Nguyen MN, Wang Z, Slominski A, Tuckey RC (2010) Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3 producing 1α,20,23-trihydroxyvitamin D3 which has altered biological activity. Drug Metab Dispos 38: 1553-1559. 227. Seiberg M, Lin CB, Hu Y, Rossetti D, Chen N, Cassarino D, Slominski A (2010) Immuno-histochemical evaluation of solar lentigines: the association of KGF/KGFR and other factors with lesion development. J Dermatol Sci 59:91-97. 228. Pinczewski J, Slominski A (2010) The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms. Exp Dermatol 19, 860-864.

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229. Rech A, Wojcik-Maciejewicz A, Slominski AT (2010) Stress and the skin. Giornale Italiano di Dermatologia e Venereologia 145,213-220

230. Slominski A (2010) Nicotinic receptor signaling in non-excitable epithelial cells: paradigm shifting from ion current to kinase cascade. Am J Physiol: Cell Physiol, (August 25, 2010). doi:10.1152/ajpcell.00324.2010 231. Slominski A, Zmijewski MA, Zbytek B, Brozyna A, Granese J, Pisarchik A, Szczesniewski A, Tobin DJ (2011) Regulated proenkephalin expression in human skin and cultured skin cells. J Invest Dermatol 131: 613-622 232. Slominski AT, Kim T-K., Janjetovic Z, Tuckey RC, Bieniek, R, Yue Y, Li W, Chen J, Miller D, Chen T, Holick M (2011) 20-hydroxyvitamin D2 is a non-calcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells. Am J Physiol: Cell Physiol 300:C526-C541. 233. Brozyna A, Jozwicki W, Janjetovic Z, Slominski AT (2011) Expression of vitamin D receptor (VDR) decreases during progression of pigmented skin lesions. Human Pathology42, 618–631 234. Slominski AT, Li W, Bhattacharya SK, Smith RA, Johnson PL, Chen J, Nelson KE, Tuckey RC, Miller D, Jiao Y, Gu W, .Postlethwaite A (2011) Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity. J Invest Dermatol 131, 1167-1169 235. Li L, Slominski A, Qian J, Carlson JA. (2011) Acquired primary cutaneous ganglioneuroma with adipocytic metaplasia: "An end point of melanocytic 'maturation'?" a case report and meta-analysis with comparison to a cross-sectional study of neurotized melanocytic nevi. Am J Dermatopathol. 33, 17-26. 236. Linos K, Slominski A, Ross J, and Carlson JA (2011). Melanoma update: diagnostic and prognosticate factors that can effectively shape and personalize management. Biomarkers Med, 5 (3), 333–360. 237. Tuckey RC, Li W, Shehabi HZ, Janjetovic Z, Nguyen MN, Kim T-K, Chen J,. Howell DE, Benson HAE, Sweatman T, Baldisseri DM, Slominski A. Production of 22-hydroxy-metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and analysis of their biological activities on skin cells. Drug Metab Dispos 39, 1577–1588. 238. Skobowiat C, Dowdy JD, Sayre RM, Tuckey RC, Slominski A (2011). Cutaneous hypothalamic pituitary adrenal (HPA) axis homologue - Regulation by ultraviolet radiation. Amer J Physiol Endocrinol Metab 301:E484-E493. 2389 Vessels C, Patel TS, Greenhaw B, Shimek C, Randall MB, Slominski A, Skinner RB (2011) Scalp nodule in a middle aged female. Clin Exp Dermatol 36, 818-819. 240. Janjetovic Z, Brozyna A, Tuckey RC, Kim T-K, Nguyen, MN, Jozwicki W. Pfeffer SR, Pfeffer LM, Slominski AT (2011) High basal NF-kB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives. Brit J Cancer 105, 1874 – 1884. 241. Slominski A, Zmijewski, M, Pawelek J (2012) L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions. Pigment Cell Melanoma Res 25, 14-27 242. Sharpley CF, McFarlane JR, Slominski A (2012) Stress-Linked Cortisol Concentrations in Hair: What We Know and What We Need to Know? Rev Neurosci 23, 111–121 243. Tuckey RC, Nguyen MN, Chen J, Slominski A, Baldisseri DM, Tieu EW, Li W (2012) Human cytochrome P450scc (CYP11A1) catalyses epoxide formation with ergosterol. Drug Metab Dispos 40, 436-444. 244. Tieu EW, Li W, Chen J, Baldisseri DM, Slominski AT, Tuckey RC (2012) Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1. J Steroid Biochem Mol Biol 129, 163– 171.

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245. Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT (2012). Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol Cell Endocrinol 351:152-66 246. Lu Y, Chen J, Janjetovic J, Michaels P, Tang K Y, Wang J, Tuckey RC, Slominski AT, Li W, Miller DD (2012) Design, Synthesis and Biological Action of 20R-Hydroxyvitamin D. J Med Chem 55: 3573-3577 247. Wang J, Slominski AT, Tuckey RC, Janjetovic Z, Kulkarni A, Chen J, Postlethwaite A, Miller D, Li W (2012) 20-Hydroxylvitamin D3 possesses high efficacy against proliferation of cancer cells while being non-toxic. Anticancer Res 32: 739-746 248. Brozyna A, Jozwicki W, Janjetovic Z, Slominski AT (2013) Expression of vitamin D activating enzyme 1-alpha-hydroxylase (CYP27B1) decreases during melanoma progression. Human Pathol 44, 374-387 249. Kim T-K, Wang J, Janjetovic Z, Chen J, Robert C. Tuckey RC, Nguyen MN, Tang EKY, Miller D, Li W, Slominski A (2012) Correlation between secosteroid induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength. Mol Cell Endocrinol 361: 143-152 250. Slominski A, Zmijewski MA, Skobowiat C, Zbytek B, Slominski RM, and Steketee JD (2012). Sensing the environment: Regulation of local and global homeostasis by the skin neuroendocrine system. Adv Anat, Embryol Cell Biol 212: 1-115. 251. Bohm M, Zmijewski MA, Wasiewicz T, Straub RT, Raap U, LugerTA, Slominski A (2012) KU812 basophils express urocortin, CRH-R, MC1R and steroidogenic enzymes and secrete progesterone. Exp Derm 21, 535–561 252. Slominski, A. T., Kim, T.-K., Shehabi, H. Z., Semak, I., Tang, E. K. Y., Nguyen, M. N., Benson, H. A. E. Korik, E., Janjetovic, Z., Chen, J., Yates, C. R., Postlethwaite, A., Li, W. & Tuckey, R. C. (2012). In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1. FASEB J 26, 3901–3915. 253. Slominski, A. T., Kim, T.-K., Chen J.J., Nguyen, M. N., Li W., Yates, C. R., Sweatman, T, Janjetovic, Z., Tuckey, R. C. (2012) Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes. Int J Biochem Cell Biol 44, 2003– 2018. 254.Szyszka P, Zmijewski MA, Slominski AT (2012) New vitamin D analogs as potential therapeutics in melanoma. Expert Rev Anticancer Ther 12, 585–599. 255. Slominski A, Janjetovic Z, Kim TK, Wright AC, Greese LN, Riney SJ, Nguyen MN, and Tuckey R (2012) Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes. Anticancer Res 32, 3733-3742. 256. Jarrett SG, Novak M, Dabernat S, Daniel JY, Mellon I, Zhang Q, Harris N, Ciesielski MJ, Fenstermaker RA, Kovacic D, Slominski A, and Kaetzel DM(2012) Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis. Cancer Res 72: 133-143. 257. Guo H, Carlson AJ, Slominski A (2012) Role of TRPM in melanocytes and melanoma. Exp Dermatol 21, 650-654 258. Jarrett SG, Novak M, Harris N, Merlino G, Slominski A, and Kaetzel DM (2013) NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma. Clin Exp Met 30, 25-36. 259. Zbytek B, Peackock DL, Seagrove TN, Slominski A (2013) Putative role of HIF transcriptional activity in melanocytes and melanoma biology. Dermato-Endocrinology 4, 1-13.

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260. Slominski A, Zbytek B, Nikolakis G, Manna P, Skobowiat C, Zmijewski M, Li W, Janjetovic Z, Postlethwaite A, Zouboulis CC, Tuckey RC (2013) Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol 137, 107-123 261. Tang EKY, Chen J, Janjetovic Z, Tieu EW, Slominski AT, Li W, Tuckey, RC (2013) Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1. Drug Metab Dispos 41(5):1112-1124 (http://dx.doi.org/10.1124/dmd.113.050955). 262. Slominski A, Janjetovic Z, Tuckey RC, Nguyen MN, Bhattacharya KG, Wang J, Li W, Jiao Y, Gu W, Brown M, Postlethwaite AE (2013) 20-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo. J Clin Endocrinol Metab 98, E298-E303. 263. Zmijewski M, Slominski A (2013) Is Mc1r an important regulator of non-pigmentary responses to UV radiation? Exp Derm 22, 790-791. 264. Slominski A, Kim T-K, Zmijewski M, Janjetovic Z, Li W, Chen JJ, Kusniatsova EI, Semak I, Postlethwaite A, Miller D, Zjawiony J, Tuckey RC (2013) Novel vitamin D photoproducts and their precursors in the skin. Dermato-Endocrinology 5:1, 7-19. 265. Kleszczynski K, Slominski A (2013) Targeting ALDH1A1 to treat pigmentary disorders. Exp Derm 22, 316-317. 266. Chen JJ, Slominski A, Miller D, Li W (2013) Effects of side chain length and composition on the kinetic conversion and product distribution of vitamin D analogs determined by real-time NMR Dermato-Endocrinology, 5, 142-149. 267. Skobowiat C. Sayre R, Dowdy J, Slominski A (2013). Ultraviolet radiation regulates cortisol activity in a waveband dependent manner in human skin ex-vivo. Brit J Dermatol 168, 595-601 268. Kovacic, D, Carlson AJ, Slominski A (2013) Targeted chemotherapy of metastatic melanoma: the impact of tumor cell heterogeneity. Expert Rev Dermatol 8, No. 2 , Pages 131-134 (doi: 10.1586/edm.13.3) 269. Kim TK, Kleszczynski, Janjetovic Z, Sweatman T, Lin Z, Li W, Reiter R, Fischer T, Slominski AT (2013) Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells. FASEB J 27, 2742–2755: doi: 10.1096/fj.12-224691 270. Slominski A, Zmijewski M, Zbytek B, Pisarchik A, Li W, Zjawiony J, Tuckey RC (2014) Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways. Anticancer Agents Med Chem 14, 77-98; PMCID: PMC3740756 271. Brożyna AA, Jóźwicki W, Carlson JA, Slominski AT (2013) Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanoma. Human Pathol 44, 2071-2074. 272. Slominski A, Zmijewski M, Zbytek B, Tobin D, Tobin DJ, Theoharides TC, Rivier J. (2013) Key Role of CRF in the Skin Stress Response System. Endocrine Rev 34:827-884. 273. Nejati R, Skobowiat C, Slominski A (2013) Commentary on the practical guide for the study of sebaceous glands. Exp Dermatol 22, 629-630. 274. Skobowiat C, Nejati R, Lu L, Williams R, Slominski A (2013) Genetic variation of the cutaneous HPA axis: An analysis of UVB-induced differential responses. Gene 530, 1-7. 275. Nejati R, Kovacic D, Slominski A (2013) Neuro-immune-endocrine functions of the skin: an overview Expert Rev Dermatol 8(6), 581-583.

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276. Slominski A, Kim TK, Li W, Yi AK, Postlethwaite A, Tuckey RC (2014) The physiological role of CYP11A1 in vitamin D regulation of epidermal functions. J Steroid Biochem Mol Biol 144PA, 28-39. http://dx.doi.org/10.1016/j.jsbmb.2013.10.012 277. Zhu G, Janjetovic Z, Slominski A (2014) On the role of environmental humidity on cortisol production by epidermal keratinocytes . Exp Dermatol 23, 15-17. 278. Manna PR, Slominski AT, King SR, Stetson CL, Stocco DM (2014) Synergistic activation of steroidogenic acute regulatory protein expression and steroid biosynthesis by retinoids: involvement of cAMP/PKA signaling. Endocrinology 155, 576-591. 279. B. Brocato, A.A. Zoerner, Z. Janjetovic, C. Skobowiat, S. Gupta, B.M. Moore II, A. Slominski, J. Zhang, M. Schenone, R. Phinehas, R.J. Ferry Jr., E. Dick Jr., G.B. Hubbard, G. Mari, N. Schlabritz-Loutsevitch (2013) Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. Placenta 34:983-989 280. Slominski, A.T., Kim, T-K., Shehabi, H.S., Tang, E., Benson, H.A.E., Semak, I., Lin, Z., Yates, C.R., Wang, J., Li, W., Tuckey, R.C. (2014) In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. Mol Cellular Endocrinol 383, 181-192. 281. Slominski, A. T. and A. J. Carlson (2014). Melanoma resistance: bright future for academicians and challenge for patient advocates. Mayo Clin Proc 89, 429-433 282. Slominski, A. , K. T-K, Y. Takeda, Z. Janjetovic, A. Brozyna, C. Skobowiate, J. Wang, A. Postlethawite, W. Li, R. Tuckey and A. Jetten (2014). RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxy-vitamin D. FASEB J 28:2775-2789. 283. Chen, J., J. Wang, T. Kim, E. Tieu, E. Tamg, Lin Z, D. Kovacic, D. Miller, A. Postlethwaite, R. Tuckey, A. Slominski and W. Li (2014). Novel Vitamin D Analogs as Potential Therapeutics: The Metabolism, Toxicity Profiling, and Antiproliferative Activity. Anticancer Res 34: 2153-2163. 284. Janjetovic Z, Nahmias ZP, Hanna S, Jarrett SG, Kim TK, Reiter RJ, Slominski AT (2014) Melatonin and its metabolites ameliorate UVB-induced damages in human epidermal keratinocytes. J Pineal Res 57, 90-102. 285. Mari, G., Deprest, J., Schenone, M., Jackson, S., Samson, J., Brocato, B., Tate, D., Sullivan, R., White, G., Dhanireddy, R., Mandrell, T., Gupta, S., Skobowjat, C., Slominski, A., Cohen, H. L., Schlabritz-Loutsevitch, N. (2014) A novel translational model of percutaneous fetoscopic endoluminal tracheal occlusion - baboons (Papio spp.). Fetal Diagn Ther 35, 92-100. 286. Brożyna AA, Jóźwicki W and Slominski AT (2014) Decreased VDR Expression in Cutaneous Melanomas as Marker of Tumor Progression: New Data and Analyses. Anticancer Res 34, 2735-2743. 287. Slominski A, Manna RP, Tuckey RC (2014) Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity. Exp Derm 23, 369-374. 288. Muenyi CS, Carrion S, Jones LA, Kennedy LH, Slominski AT, Sutter CH, Sutter TR (2014) Effects of in Utero Exposure of C57BL/6J Mice to 2,3,7,8- Tetrachlorodibenzo-p-dioxin on Epidermal Permeability Barrier Development and Function. Environ Health Perspect 122: 1052-1058 289. Slominski A, Kim TK, Brozyna AA, Janjetovic Z, Brooks DL, Schwab LP, Skobowiat C, Jozwicki W, Seagroves TN (2014) The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways. Arch Biochem Biophys 563:79-93.

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290. Cheng CYS, Slominski AT, Tuckey RC (2014) Metabolism of 20-hydroxyvitamin D3 by mouse liver microsomes. J Steroid Biochem Mol Biol 144, 286-293. 291. Tuckey RC, Slominski AT, Cheng CYS, Chen J, Kim TK, Xiao M, Li W (2014) Lumisterol is metabolized by CYP11A1: Discovery of a new pathway. Int J Biochem Cell Biol 55, 24-34 292. Kim TK, Lin Z, Tidwell W J, Li W, Slominski AT (2015) Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro. Mol Cell Endocrinol 404, 1-8. 293. Slominski A, Kleszczynski K, Semak I, Janjetovic Z, Zmijewski MA, Kim TK, Slominski RM, Reiter RJ, Fischer TW (2014) Local melatoninergic system as the protector of skin integrity. Int J Mol Sci 15, 17705-17732. 294. Skobowiat C, Slominski A (2015) Ultraviolet B (UVB) activates hypothalamic-pituitary-adrenal (HPA) axis in C57BL/6 mice. J Invest Dermatol, 135:1638-48. 295. Brozyna, Jochymski C, Janjetovic Z, Jozwicki W, Tuckey RC, Slominski A (2014) CYP24A1 Expression Inversely Correlates with Melanoma Progression: Clinic-Pathological Studies. Int J Mol Sci 15, 19000-19017. 296. Slominski A (2015) On the role of endogenous opioid system in the regulation of epidermal homeostasis. J Invest Dermatol 135:333-4. 297. Brozyna AA, Jozwicki W, Jochymski C, Slominski AT (2015). Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas. Oncol Rep 33:599-606 298. Slominski A, Haderland R, Reiter R (2015) When the circadian clock meets the melanin pigmentary system. J Investigative Dermatol 135(4):943-5 299. Slominski A, Postlethwaite A (2015). Skin under the sun: when melanin pigment meets vitamin D. Endocrinology 156: 1-4. 300. Slominski RM, Zmijewski M, Slominski A (2015) On the role of melanin pigment in melanoma. Exp Dermatol 24: 258-259. 301. Slominski AT, Li W, Kim T, Semak I, Wang J, Zjawiony J, Tuckey RC (2015) Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol 151,25-37. 302. Slominski A (2015) Ultraviolet radiation (UVR) activates central neuro-endocrine-immune system. Photodermatology, Photoimmunology & Photomedicine 31:121-123 303. Slominski AT, Janjetovic Z, Kim T-K, Wasilewski P, Rossa S, Hanna S, Sayre RM, Dowdy JC, Li W, Tuckey RC (2015) Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J Steroid Biochem Mol Biol 148: 52-60. 304. Jozwicki W, Brozyna AA, Siekiera J, Slominski AT (2015) Expression of RCAS1 Correlates with Urothelial Bladder Cancer Malignancy. Int J Mol Sci 16, 3783-3803. 305. Kim TK, Lin Z, J, Li W, Reiter RJ, Slominski AT (2015) N1-acetyl-5-methoxykynuramine (AMK) is produced in the human epidermis and shows anti-proliferative effects. Endocrinology 156: 1630–1636. 306. Slominski AT, Manna PR, Tuckey RC (2015) On the role of skin in the regulation of local and systemic steroidogenic activities. Steroids 103, 72-78. 307. Wasiewicz T, Szyszka P, Cichoreck M, Janjetovic Z, Tuckey RC, Slominski A, Zmijewski M (2015) Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation. In J Mol Sci 24;16:6645-67.

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308. Slominski AT, Brozyna A, Jozwicki W, Tuckey RC (2015) Vitamin D as an adjuvant in melanoma therapy. Melanoma Manag. 2:1-4. 309. Zabul P, Wozniak M, Slominski AT, Preis K, Gorska M, Korozan M, Wieruszewski J, Zmijewski MA, Zabul E, Tuckey R, Kuban-Jankowska A, Mickiewicz W, Knap N (2015) A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia. Int J Mol Sci. 16:13043-64 310. Manna PR, Sennoune SR, Martinez-Zaguilan R, Slominski AT, Pruitt K (2015) Regulation of retinoid mediated cholesterol efflux involves liver X receptor activation in mouse macrophages. Biochem Biophys Res Commun. 464:312-7. 311. Wierzbicka JM, Binek A, Ahrends T, Nowacka JD, Szydłowska A, Turczyk Ł, Wąsiewicz T, Wierzbicki PM, Sądej R, Tuckey RC, Slominski AT, Chybicki J, Adrych K, Kmieć Z, Żmijewski MA (2015) Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture. Int J Oncol. 4:1084-96. 312. Manna PR, Stetson CL, Daugherty C, Shimizu I, Syapin PJ, Garrel G, Cohen-Tannoudji J, Huhtaniemi I, Slominski AT, Pruitt K, Stocco DM (2015) Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging. Mech Ageing Dev 150: 74-82. 313. Tieu EW, Li W, Chen J, Kim TK, Ma D, Slominski AT, Tuckey RC (2015) Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1. J Steroid Biochem Mol Biol. 149:153-65. 314. Lin Z, Marepally S, Ma D, Myers L, Postlthwaite A, Tuckey RC, ChengC, Kim TK Yue J, Slominski A, Miller D, Li W (2015) Chemical synthesis and biological activities of 20S,24S/R-dihydroxyvitamin D3 epimers and their 1α-hydroxyl derivatives. J Med Chem 58:7881-7887. 315. Slominski AT, Kim TK, Li W, Postlethwaite A, Thieu EW, Thang EKY, Tuckey RC (2015) Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland. Sci. Rep. 5, 14875; doi: 10.1038/srep14875 (2015). 315. Jozwicki W, Brozyna A, Siekiera J, Slominski AT (2015) Expression of Vitamin D Receptor (VDR) Positively Correlates with Survival of Urothelial Bladder Cancer Patients. Int J Mol Sci 16:24369-86. 316. Wang Q, Lin Z, Kim TK, Slominski AT, Milled DD, Li W (2015) Total synthesis of biologically active 20S-hydroxyvitamin D3. Steroids 104:153-62. 317. Manna PR, Stetson CL, Slominski AT, Pruitt K (2016) Role of the steroidogenic acute regulatory protein in health and disease. Endocrine 51: 7-21. 318. Slominski AT, Kim TK, Li W, Tuckey RC (2016) Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts Exp Dermatol 25:231-232. 319. Skobowiat C, Slominski A (2016) Ultraviolet B stimulates POMC signaling in the arcuate nucleus of the hypothalamus in mice. Exp Dermatol 25:120-3. 320. Schlabritz-Loutsevitch NE, Comuzzie AG, Mahaney MM, Hubbard GB, Dick EJ, Kocak M, Gupta S, Carrillo M, Schenone M, Postlethwaite A, Slominski A (2016). Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity. Comp Med. 66:137-42. 321. Lin Z, Marepally SR, Kim TK, Janjetovic Z, Oak AS, Postlethwaite AE, Myers LK, Tuckey RC, Slominski AT, Miller DD, Li W (2016). Design, Synthesis and Biological Activities of Novel Gemini 20S-Hydroxyvitamin D3 Analogs. Anticancer Res. 2016;36(3):877-86. PubMed PMID: 26976974.

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322. Cheng CY, Slominski AT, Tuckey RC (2016) Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4. J Steroid Biochem Mol Biol. 159:131-41. 323. Jozwicki W, Brozyna AA, Siekiera J, Slominski AT (2016) Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study. Int J Mol Sci. 2016;17(3) 285. doi: 10.3390/ijms17030285. PubMed PMID: 26927070; PMCID: PMC4813149. 324. Jozwicki W, Brozyna AA, Siekiera J, Slominski AT (2016) Frequency of CD4+CD25+Foxp3+ cells in peripheral blood in relation to urinary bladder cancer malignancy indicators before and after surgical removal. Oncotarget 10, 11450-62. doi: 10.18632/oncotarget.7199. PubMed PMID: 26862849. 325. Lin Z, Marepally SR, Ma D, Kim TK, Oak AS, Myers LK, Tuckey RC, Slominski AT, Miller DD, Li W (2016) Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer. J Med Chem. 59:5102-5108. doi: 10.1021/acs.jmedchem.6b00182. PubMed PMID: 27070779. 326. Slominski AT, Semak I, Fischer TW, Kim TK, Kleszczynski K, Hardeland R, Reiter RJ (2017). Metabolism of melatonin in the skin: why is it important? Exp Dermatol 26:563–568, doi: 10.1111/exd.13208. PubMed PMID: 27619234. 327. Brozyna A, Jozwicki W, Roszkowski K, Filipiak J, Slominski AT (2016) Melanin content in melanoma metastases affects the outcome of radiotherapy. Oncotarget 20:17844-1785 2016 Feb 3. doi: 10.18632/oncotarget.7528. PubMed PMID: 26910282. 328. Piotrowska A, Wierzbicka J, Ślebioda T, Woźniak M, Tuckey RC, Slominski AT, Żmijewski M A. (2016) Vitamin D derivatives enhance cytotoxic effects of H2O2 on human keratinocytes: Quest for improvement of anticancer drug activity. Steroids 110:49-61. doi: 10.1016/j.steroids.2016.04.002. PubMed PMID: 27083311; PMCID: PMC4853285. 329. Skobowiat C, Slominski AT (2016) Sun-derived infrared A (IRA) and ultraviolet B (UVB) radiation: Allies or enemies in melanomagenesis? Exp Derm 25(10):760-762. doi: 10.1111/exd.13129. PubMed PMID: 27315042; PMCID: PMC5042839. 330. Slominski AT, Kim TK, Hobrath JV, Oak AS, Tang EK, Tieu EW, Li W, Tuckey RC, Jetten AM. (2017) Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORalpha and RORgamma. J Steroid Biochem Mol Biol. 173, 42-56. doi: 10.1016/j.jsbmb.2016.09.024. PubMed PMID: 27693422. 331. Wierzbicka JM, Zmijewski MA, Piotrowska A, Nedoszytko B, Lange M, Tuckey RC, Slominski AT. (2016) Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes. Mol Cell Endocrinol. 437:312-322. doi: 10.1016/j.mce.2016.08.006. PubMed PMID: 27524410. 332. Brozyna AA, Jozwicki W, Skobowiat C, Jetten A, Slominski AT (2016) RORalpha and RORgamma expression inversely correlates with human melanoma progression. Oncotarget 20:17844-17853, 2016. doi: 10.18632/oncotarget.11211. PubMed PMID: 27542227. 333 Plonka PM, Picardo M, Slominski AT. Does melanin matter in the dark? (2017) Exp Dermatol. 26:595–597, 2016. doi: 10.1111/exd.13171. PubMed PMID: 27541811 334. Schlabritz-Loutsevitch N, Apostolakis-Kyrus K, Krutilina R, Hubbard G, Kocak M, Janjetovic Z, Sathanandam S, Slominski AT, Mari G, Dick E, Jr (2016) Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity. J Med Primatol 45, 297–303. PubMed PMID: 27627870. 335. Slominski A, Zmijewski M, Jetten A (2016) RORα is not a receptor for melatonin (Response to DOI 10.1002/bies.201600018). BioEssays 38, 1193-1194.

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336. Skobowiat C, Postlethwaite AE, Slominski AT (2017). Skin Exposure to Ultraviolet B Rapidly Activates Systemic Neuroendocrine and Immunosuppressive Responses. Photochem Photobiol. 93:1008–1015, 2017. doi: 10.1111/php.12642. PubMed PMID: 27716949. 337. Wierzbicka JM, Zmijewski MA, Antoniewicz J, Sobjanek M, Slominski AT (2017) Differentiation of Keratinocytes Modulates Expression of Epidermal Elements of the Cutaneous Analog of Hypothalamus-Pituitary-Adrenal Axis. J Cell Physiol 232(1):154-166. doi: 10.1002/jcp.25400. PubMed PMID: 27061711. 338. Slominski A, Zmijewski M (2017) Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action. J Invest Dermatol 137, 1012–1014. 339. Jeayeng S, Wongkajornsilp A, Slominski AT, Jirawatnotai S, Sampattavanich S, Panich U (2017) Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling. Free Rad Biol Med 108, 918–928. 340. Abyaneh, M.A.Y., Engel P, Slominski A., Rgasdale B., Agag R., Cramer D., Carlson J.A. (2017) Giant Basal Cell Carcinomas Express Neuroactive Mediators and Show a High Growth Rate: A Case-Control Study and Meta-Analysis of Etiopathogenic and Prognostic Factors. Amer J Dermatopathol 39:189–194. 341. Janjetovic Z, Jarrett SG, Lee EF, Duprey C, Reiter RJ, Slominski AT. (2017) Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways. Sci Rep 2017;7(1):1274. 342. Slominski A.T. , Brożyna AA, Zmijewski MA, Jóźwicki W, Jetten AM, Mason RS, Tuckey RC and Elmets CA (2017) Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management. Lab Invest 97, 706-724 (June 2017) | doi:10.1038/labinvest.2017.3 343. Skobowiat C, Oak ASW, Kim T-K, Yang CH, Pfeffer LM, Tuckey RC, Slominski AT (2017) Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models. Oncotarget 8:9823-9834. https://doi.org/10.18632/oncotarget.14193 344. Brożyna AA , Guo H , Yang S-E , Cornelius L , Linette G , Murphy M , Sheehan C , Ross J , Slominski A , Carlson JA .TRPM1 (melastatin) expression is an independent predictor of overall survival in clinical AJCC stage I and II melanoma patients. J Cutan Pathol. 2017;44:328–337. https://doi.org/10.1111/cup.12872 345. Slominski AT, Brozyna AA, Skobowiat C, Zmijewski MA, Kim T-K, Janjetovic Z, Oak AS, Jozwicki W, Jetten AM, Mason RS, Elmets C, Li W, Hoffman1RM, Tuckey RC (2018) On the role of classical and novel forms of vitamin D in melanoma progression and management. J Steroid Biochem Mol Biol 177:159-170. http://dx.doi.org/10.1016/j.jsbmb.2017.06.013 346. Cheng CYS, Tae-Kang Kim , Saowanee Jeayeng , Slominski AT, Tuckey RC (2018) Purified CYP2R1 in a in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3. J Steroid Biochem Mol Biol 177, 59-69. 347. Slominski AT, Zmijewski M, Semak I, Kim T-K, Janjetovic Z, Slominski RM, Zmijewski J (2017) Melatonin, mitochondria and the skin. Cell Mol Life Sci 74(21), 3913-3925. 348. Slominski AT, Brozyna AA, Tuckey RC (2017) Cutaneous glucocorticoidogenesis and cortisol signaling are defective in psoriasis. J Invest Dermatol 137, 1609-1611. 349. Lin Z, Chen H, Belorusova A, Bollinger JC, Tang EKY, Janjetovic Z, Kim TK, Wu Z, Miller DD, Slominski AT, Postlethwaite A, Tuckey RC, Rochel N, Li W (2017) 1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis. Sci Rep 7:10193; DOI:10.1038/s41598-017-10917-7

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350. Tarasen A, Carlson JA, Leonard MK, Merlino G, Kaetzel D, Slominski AT (2017) Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus. In J Mol Sci 18, 1769; doi:10.3390/ijms18081769 351. Leonard MK, Pamidimukkala N, Puts G, Snyder DE, Slominski AT, Kaetzel D (2017) The HGF/SF Mouse Model of UV-Induced Melanoma as an In Vivo Sensor for Metastasis-Regulating Gene. Int. J. Mol. Sci. 2017, 18, 1647; doi:10.3390/ijms18081647. 352. Slominski AT, Kim TK, Hobrath JV, Janjetovic Z, Oak ASW, Postlethwaite A, Lin Z, Li W, Takeda Y, Jetten AM, Tuckey RC (2017) Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols. Sci Rep 2017; 7:11434 353. Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R (2018) Melatonin: A cutaneous perspective on its production, metabolism and functions. J Invest Dermatol 138:490-499. 354. Lin Z, Marepally SR, Goh SY, Cheng CYC, Janjetovic Z, Kim TK, Miller DD, Postlethwaite AT, Slominski

AT, Tuckey RC, Peluso-Iltis C, Rochel N, Li W (2018) Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities. Sci Rep. 2018 Jan 24;8(1):1478. doi: 10.1038/s41598-018-19183-7. 355. Jetten MA, Takeda Y, Slominski A, Kang HS (2018) Retinoic acid-related Orphan Receptors (RORs): connecting sterol metabolism to regulation of immunity and disease. Current Opinion in Toxicology 8:66–80. 356. Brożyna AA, Aplin A, Cohen C, Carlson G, Page AJ, Murphy M, Slominski AT, Carlson JA (2018) CS1 expression in melanocytic nevi and melanoma. Oncotarget. 2018; 9:4173-4187. 357. Tuckey RC, Li W, Ma D, Cheng CYS, Wang KM, Kim TK, Jeayeng S, Slominski AT (2018) CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites J Steroid Biochem Mol Biol 177, 59-69. 358. Slominski AT, Zmijewski AM, Plonka P, Szaflarski J, Paus R (2018) How ultraviolet light touches the brain and endocrine system through skin, and why. Endocrinology 159(5), 1992-2007. 359. Skobowiat C, Brozyna A, Janjetovic Z, Saowanee J, Oak, ASW, Kim TK, Panich U, Reiter RJ, Slominski AT (2018) Melatonin and its derivatives counteract the ultraviolet B radiation-induced damage in human and porcine skin ex vivo. J Pineal Res 65(2):e12501. doi: 10.1111/jpi.12501. 360. Sniegocka M, Podgorska E, Plonka PM, Elas M, Romanowska-Dixon B, Szczygiel M, Zmijewski M, Cichorek M, Markiewicz A, Brozyna A, Slominski AT, Urbanska K (2018) Transplantable melanomas in hamsters and gerbils as models for human melanoma. Sensitization in melanoma radiotherapy: from animal models to clinical trials. Int J Mol Sci 19(4), 1048; https://doi.org/10.3390/ijms19041048. 361. Singh B, Schoeb TR, Baipi P Slominski AT, Singh KK (2018) Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function Cell Death & Disease Jul 20;9(7):735.

362. Podgorska E, Drzal A, Matuszak Z, Swakon J, Slominski AT, Elas M, Urbanska K (2018) Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Low⁻LET Proton Beam Irradiation. Int J Mol Sci 2018 Jul 31;19(8). pii: E2236. doi: 10.3390/ijms19082236. 363. Podgorska E, Sniegocka M, Mycinska M, Trybus W, Trybus E, Kopacz-Bednarska A, Wiechec O, Krzykawska-Serda M, Elas M, Krol T, Urbanska K, Slominski AT (2018) Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus). Acta Biochim Pol 65, 351-358.

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364. Wasiewicz T, Piotrowska A, Wierzbicka J, Slominski AT, Zmijewski MA (2018) Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors. In J Mol Sci 2018, 19(9), 2583; https://doi.org/10.3390/ijms19092583 365. Slominski A T, Kim TK, Janjetovic Z, Brozyna AA, Zmijewski MA, Xu H, Sutter TR, Tuckey RC, Jetten AM, Crossman DK (2018) Differential and Overlapping Effects of 20,23(OH)(2)D3 and 1,25(OH)(2)D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)(2)D3. In J Mol Sci 2018, 19 (10), 3072; https://doi.org/10.3390/ijms19103072 366. Tuckey RC, Cheng CYS and Slominski AT (2019). The serum vitamin D metabolome: What we know and what is still to discover. J Steroid Biochem Mol Biol 186, 4-21. 367. Chaiprasongsuk A, Janjetovic Z, Kim TK, Jarrett SG, D'Orazio JA, Holick MF, Tang EKY, RC Tuckey RC, Panich U, Li W, Slominski AT (2019) Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms. Redox Biology 24, June 2019, 101206 https://doi.org/10.1016/j.redox.2019.101206 368. Markiewicz A, Brożyna AA, Podgórska E, Elas M, Urbańska K, Jetten AM, Słominski AT, Jóźwicki W, Orłowska-Heitzman J, Dyduch G, Romanowska-Dixon B (2019) Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels. Sci Rep (2019) 9:9142 | https://doi.org/10.1038/s41598-019-45161-8 368. Bocheva G, Slominski RM, Slominski AT (2019) Neuroendocrine aspects of skin aging. Int J Mol Sci. 2019 Jun 7;20(11). pii: E2798. doi: 10.3390/ijms20112798. 369. Manna PR, Ahmed AU, Yang S, Narasimhan M, Cohen-Tannoudji J, Slominski AT, Pruitt K (2019) Genomic profiling of the steroidogenic acute regulatory protein in cancer: in silico assessment and mechanistic perspective. Cancers (Basel). 2019 May 4;11(5). pii: E623. doi: 10.3390/cancers11050623. 370. Culter-Peck CM, Dryden SC, Fowler BT, Kovacic D, Slominski A, Fleming JC (2019) Essential skin shrinkage: cicatricial ectropion, a histopathologic evaluation and clinical analysis. Orbit. 2019 May 20:1-5. doi: 10.1080/01676830.2019.1600152. [Epub ahead of print] 371. Brozyna A, Jozwicki W, Jetten AM, Slominski A (2019) On the relationship between VDR, RORα and RORγ receptors expression and HIF1-α levels in human melanomas. Exp Dermatol, doi: 10.1111/exd.14002. 372. Slominski RM, Tuckey RC, Mana P, Jetten A, Postlethwaite A, Raman C, Slominski AT. Extra-adrenal glucocorticosteroidogenesis: Implications for autoimmune and inflammatory disorders. Genes & Immunity, in preparation, an invited review.

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Books/Books Chapters/Journal Special Issues 1. Luger TA, Paus R, Lipton JM, Slominski A (eds) Cutaneous Neuromodulation” The Proopiomelanocortin

System. Ann NY Acad Sci, Vol 885, 1999 2. Slominski, R., Slominski. A. Synthesis and metabolism of melatonin in the skin and retinal pigment

epithelium. In Melatonin in the Promotion of Health, 2nd ed., R.R. Watson (ed), pp. 69-80, 2011. CRC Press: Boca Raton, FL.

3. Carlson JA, Murphy M, Slominski A, Wilson VL. Evidence of Skin Field Cancerization. In: Dakubo G, editor. Field Cancerization: Basic Science and Clinical Applications. Hauppauge, New York: Nova Science Publishers; 2011.

Book Reviews, Letters to Editor, Case Reports 1. Slominski A, Paus R (1995). Inhibition of melanogenesis for melanoma therapy? Letter to edtitor. J Invest Dermatol 103, 742. 2. Chhieng DC, Jennings T, Slominski A, Mihm MC (1995) Choriocarcinoma presenting as a cutaneous metastasis. J Cut Pathol 22, 347-377. 3. Slominski A (1996) Correspondence re: G.P. Studzinski and D.C. Moore, Sunlight-can it prevent as well as cause cancer? Cancer Res 56, 925. 4. Carlson JA, Slominski A, Mihm MC (1998) Inductive epidermal hyperplasias are inversely related to the distance from dermatofibromas and dermatofibrosarcomas protuberans. Am J Dermatopath 20, 428-430. 5. Carlson JA, Healy K, Slominski A, Mihm MC (1999). Melanocytic matricoma: a report of 2 cases of a new entity. Am J Dermatopath 21, 344-349. 6. Izban KF, Slominski A, Reddy VR (2000) Eccrine porocarcinoma. ASCP Check Sample SPII00-3. 7. Slominski A (2000). Review of the book “Essential skin pathology”, McKee PH, ed. Arch Pathol Lab Med 124, 640. 8. Slominski A (2000). Review of the book “Vitiligo”, Hann S-K and Bordlund JJ, eds. New Engl J Med 343, 976-977. 9. Slominski A (2003) β-endorphin/µ-opiate receptor system in the skin (Commentary). J Invest Dermatol 120, xii-xiii. 10. Slominski, A, Tobin DJ, Paus R (2007) Does p53 regulate skin pigmentation by controlling proopiomelanocortin gene transcription? Pigment Cell Res 20, 307-308. 11. Blackmon JT, Stratton MS, Young Kwak Y, Pavlidakey PG, Slominski AT, McKee SB, Viator TM, Kim JY, Huang CC, Conry RM (2017) Inflammatory melanoma in transit metastases with complete response to talimogene laherparepvec. JAAD Case Reports 3, 280-283. 12./ Soni A, Guerrero C, Tarasen A, Canavan T, Elewski B, Elmets C, Carlson JA, Slominski A (2017) Solar keratosis of the nail bed with progression to squamous cell carcinoma. ASCP Case Reports 12. Picardo M, Slominski AT (2017) Melanin pigmentation and melanoma. Exp Derm 26:555–556. .

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Abstracts 1. McNeely T, Slominski A, Pawelek J (1986) Phophorylation of 90 K daltons is a factor in the regulation of melanoma growth by insulin. J Invest Derm 86, 494. 2. Slominski A, Moellmann G, Kuklinska E, Pawelek J (1987) Positive regulation of melanogenesis by L-tyrosine and L-dopa. J Invest Derm 88, 519. 3. Slominski A, Moellman G, Kuklinska E, Pawelek J (1987) Positive regulation of the pigmentary system by L-tyrosine and L-dopa: Requirement of active tyrosinase for augmentation of tyrosinase activity. J Cell Biol 105, 157. 4. Moellmann G, Slominski A, Kuklinska E, Bomirski A, Pawelek J (1987) Ultrastructural histochemical aspects of post-Golgi translocation of tyrosinase in Bomirski's amelanotic hamster melanoma. First Meeting of the European Society for Pigment Cell Research. Sorrento (Naples), Italy, October 11-14. Program and Abstracts, p. 42. 5. Kuklinska E, Slominski A, Moellmann G, Lerner A (1988) Observation on aged vitiligo mice: the development of alopecia areata and a transplantable tumor of neuroectodermal origin. J Invest Derm 90, 578. 6. Moellmann G, Kuklinska E, Slominski A, Lerner A (1988) Studies on the mechanism of action of MSH in pigmentation: acidification of melanosomes. J Invest Derm, 589. 7. Slominski A, Moellmann G, Kuklinska E, Lerner A (1988) Melanotropin (MSH) inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cAMP levels and tyrosinase activity without inducing melanogenesis. J Cell Biol 107, 483. 8. Slominski A, Moellmann G, Kuklinska E, Pawelek J (1989) MSH receptor system in Bomirski amelanotic hamster melanoma cells. Pigment Cell Res 2, 147. 9. Ren S, Slominski A, Yu R (1989) Glycosphingolipids in Bomirski melanomas: A correlation between glycolipid composition and degree of cell differentiation and malignancy. Pigment Cell Res 2, 448. 10. Moellmann G, Kuklinska E, Slominski A (1989) Studies on the role of melanosomal pH in the control of melanogenesis. Pigment Cell Res 2, 449. 11. Slominski A, Moellmann G (1989) On the role of L-tyrosine in the induction of melanogenesis in hamster amelanotic melanoma cells. Pigment Cell Res 2, 450. 12. Slominski A, McNeely T, Pawelek J (1989) Insulin receptor proteolysis in insulin-resistant variants of Cloudman S91 mouse melanoma cells. J Cell Biol 109, 333. 13. Slominski A, Paus R, Constantino R (1990) Differential transcription, translation and activity of tyrosinase during induced hair growth in mice,J. Invest Dermatol 94, 579. 14. Slominski A, Costantino R, Howe J. Molecular mechanism of the regulation of tyrosinase activity by L-tyrosine and L-dopa. XIV IPCC, Kobe, Japan, October 31-November 4, 1990. 15. Slominski A, Costantino R, Howe J, Moellmann G. Molecular mechanism governing melanogenesis in Bomirski hamster melanomas: Relative abundance of tyrosinase and catalase-B (gp 75). XIV IPCC, Kobe, Japan, October 31-November 4, 1990. 16. Slominski A, Paus R, Mazurkiewicz J (1991). Proopiomelanocortin expression and potential function of POMC products during induced hair growth in C57 Bl-6 mouse. J. Invest Dermatol 96, 623. 17. Slominski A (1991). POMC gene expression in hamster and mouse melanoma cells. Proc Amer Assoc Cancer Res 32, 212

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18. Slominski A, Goodman-Snitkoff G (1992). L-DOPA inhibits proliferative activity of murine and human lymphocytes. J Invest Dermatol 98, 824. 19. Slominski A, Mazurkiewicz J, Matsuoka L, Wortsman J, Paus R, Ambros R, Lawrence K (1992). Immunocytochemical studies on the proopiomelanocortin (POMC) expression in the human skin. J Invest Dermatol 98, 588. 20. Li L, Slominski A, Paus R, Hoffman R (1992). In vitro hair growth is coordinated with melanin production in histocultured skin of the C57 BL-6 mouse. J Invest Dermatol 98 , 644. 21. Maurer M, Paus R, Daum S, Luftl M, Heinzelmann T, Slominski A, Czarnetzki BM (1992). Do mast cells play a role in hair growth regulation?. J Invest Dermatol 98, 522. 22. Slominski A (1992). L-DOPA binding sites in rodent melanoma cells. Pigment Cell Res 5, 94. 23. Gaudet S, Slominski A, Etminan M, Pruski D, Paus R, Namboodiri MAA (1993). Identification and characterization of two isozymic forms of arylamine N-acetyltransferase in Syrian hamster skin. J Invest Dermatol 100, 537. 24. Slominski A, Plonka P, Chakraborty A, Pruski D, Lukiewicz S, Czarnetzki B, Paus R (1993). Melanogenesis during the anagen-catagen-telogen transition of the murine hair cycle. J Invest Dermatol 101, 436. 25. Slominski A, Chassalerris N, Mazurkiewicz J, Paus R (1994). Keratinocytes as a target for melatonin bioregulation in murine skin. Arch Dermatol Res. 26. Slominski A, Paus R, Plonka P, Handjinski B, Maurer M, Chakraborty A, Mihm M (1995) Pharmacologically induced disorders of hair follicle pigmentation as a model for melanocyte response to cytotoxic drug damage in situ. J Invest Dermatol 104, 616. 27. Mazurkiewicz, JE, Ermak G, Hwang J, Chhiap V, Corliss D, Slominski A (1995) Towards identification of cells expressing POMC in the skin. J Invest Dermatol 104, 636. 28. Mazurkiewicz, Corliss D, JE, Ermak G, Slominski A (1996) Differential expression of POMC mRNA and POMC peptides during the hair cycle in mouse. J Histochem Cytochem 44, 784. 29. Roloff B, Fechner K, Slominski A, Furkert J, Botchkarev VA, Zipper J, Krause K, Paus R. (1997) Hair Cycle-Dependent Expression of Corticotropin Releasing Hormone (CRH) and CRH Receptors (CRH-R) in Murine Skin. J. Invest Dermatol 108, 654. 30. BirkleS, Gao L, Zeng G, Slominski A, Yu RK (1997) Expression of O-acetylesterase gene in hamster melanoma cells stimulates dendrite formation Mol Biol Cell, 8: 334. 31. Roloff B, Botchkarev V, Slominski A, Luger T, Paus R (1998) Is α-melanocyte stimulating hormone (α-MSH) involved in hair growth control? J Invest Dermatol 110, 533. 32. Birkle S, Ren S, Slominski A, Zeng G, Gao L, Yu RK (1998 ) Expression of O-acetyl esterase gene in hamster melanoma cells inhibits cell proliferation and stimulates dendrite formation. J. Neurochem, 70 (suppl 1): S35C. 33. Slominski A (1998) Cutaneous expression of CRH and CRH-R: is there a “skin stress system”? Exp Dermatol 7, 230. 34. Botchkarev VA, Slominski A, Botchkareva NV, Roloff B, Luger T, Paus R (1998) Developmentally regulated expression of α-MSH and MC-1 receptor in C57BL/6 mouse skin suggests functions beyond pigmentation. Exp Dermatol 7, 221. 35. Chakraborty A, Pawelek JM, Bolognia J, Funasaka Y, Slominski A (1998) UV light and MSH receptors. Exp

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Dermatol 7, 222. 36. Paus R, Botchkarev VA, Botchkareva NV, Fechner K, Furkert J, Roloff B, Slominski A (1998) The skin POMC system (SPS): leads and lessons from the hair follicle.” Exp Dermatol 7, 228. 37. Dahiya M, Slominski A, Carlson A, Wojcik EM, Wharton J, Bakhos R, Nickoloff B (1999) Desmoplastic malignant melanoma: expression of POMC derived antigens, tyrosinase and DNA content. Lab. Invest. 38. Berrutti LE, Mu XC, Jones DM, Tran TA, Slominski A, Carlson JA (1999) Are melanoma cells hybrid? Expression of the macrophage marker CD68 in melanocytic lesions. Am J Dermatopathol 21, 600. 39. Curry JL, Pinto W, Nickoloff B, Slominski A (2000) Expression of functional MC1 receptor on human keratinocytes. 89th Annual Meeting of the United States and Canadian Academy of Pathology, March 25-31, 2000, New Orleans, LA. 40. Buchli R, Ndoye A, Slominski A, Grando SA (2000) Cholinergic control of melanogenesis. J Invest Dermatol 114, 859. 41. Slominski A, Wortsman J, Roloff B, Curry J, Dahiya M, Szczesniewski A, Quevedo M, Wei E (2000) Human skin is both a site of production and a target for CRH-related peptides. J Invest Dermatol 114, 799. 42. Slominski A, Wortsman J, Mazurkiewicz JE, Wei E (2000) Cutaneous expression of corticotropin releasing hormone (CRH) and CRH receptors. Abstract booklet of ICHC 2000, University of York, UK; XIth International Congress of Histochemistry and Cytochemistry; Cell Biology and Imaging Tools for New Century. p32. 43. Slominski A, Wortsman J, Carlson A, Herlyn M, Wei E. (2001) On the linkage between cutaneous proopiomelanocortin/MC- receptor system and melanoma development and progression. Melanoma Res 11, Supplement 1, S117-118. 44. Wei ET, Slominski A, Quillan JM, Carlson KW (2001) Abstracts of the Western Pharmacology Society Meeting, Vancouver, BC Canada, March 25 to March 29, 2001. 45. Zbytek B, Mysliwski A, Slominski A, Szmit E, Trzonkowski P: Corticotropin-releasing hormone modulates inflammatory cytokine production by keratinocytes. Scandinavian Journal of Immunology, 54(S.1):110, 2001, 11th International Congress of Immunology, Stockholm, Sweden, 22-27 July 2001 46. Slominski A, Wortsman J, Wei E (2002) Corticotropin-releasing hormone (CRH) and proopiomelanocortin involvement in the cutaneous response to stress. 20th International World Congress of Dermatology, July 1-5, 2002, Paris, France. 45. Coburn SP, Mahuren JD, Slominski A, Wortsman J, Hessle L, Millan JL (2003) Properties of pyridoxal (pyridoxine) phosphate hydrolase in human skin, SKMEL 188, HaCaT, and Cl-4 cells. FASEB J17:717. 46. Slominski A, Pisarchik A, Zbytek B, Wortsman J (2003) Serotoninergic and melatoninergic systems expressed in the skin. J Invest Dermatol 121, 0753. 47. Slominski A, Wortsman J , Semak I, Zbytek B, (2004) Novel serotoninergic/melatoninergic system(s) in mammalian skin. Pigment Cell Res 17, 452. 48. Slominski A, Zbytek B, Kaminski J, Wortsman J (2005) Specificity for cell type in the expression of functional HPA axis in human skin. J Invest Dermatol 124 (4): A90 49. Zbytek B, Pfeffer L, Slominski A, (2005) Differential regulation of NF-ΚΒ by CRH in the human epidermis. J Invest Dermatol 124 (4): A90

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50. Fisher T, Zbytek B, Sayre R, Apostolov EO, Basnakian AG, Sweatman TW, Elsner P, Slominski A (2005) Melatonin increases survival and suppresses apoptosis in UV light exposed keratinocytes. J Invest Dermatol 124 (4): A129 51. Slominski A, Zbytek B, Zmijewski M, Wortsman J (2005) Functional HPA axis homolog is expressed by melanocytes. Pigment Cell Res 18, 20. 52. Zbytek B, Slominski A (2005) UVB triggers POMC production via CRH/CRH-R1 signaling system. Pigment Cell Res 18, 20. 53. Zmijewski M, Fisher T, Zbytek B, Sweatman TW, Slominski RM, Wortsman J, Slominski A (2006) Characterization of melatonin oncostatic effect and cytosoloic and nuclear receptor expression in growth stage-defined human melanoma cell lines. J Invest Dermatol 126, 149. 54. Fischer T, Sweatman TM, Semak I, Sayre RM, Wortsman J, Slominski A (2006) Constitutive melatonin metabolism in keratinocytes and its UV radiation dependent stimulation . J Invest Dermatol 126, 137. 55. Slominski A, Zbytek B, Zmijewski M, Slominski RM, Wortsman J (2006) On the biological role and organization of the corticotropin releasing hormone (CRH) signaling system of the skin. J Invest Dermatol 126, 91. 56. Zbytek B, Slominski A (2006) Mechanism of UVB stimulated corticotropin releasing hormone and proopiomelanocortin production in the human epidermis. J Invest Dermatol 126, 137. 57. Zmijewski M, Sharma RK, Slominski A (2006) Expression of an equivalent of hypothalamic-pituitary-adrenal axis in retinal pigment epithelium. Pigment Cell Res, in press. 58. Slominski A, Zbytek B, Zmijewski, Wortsman J (2006) Corticotropin releasing hormone signaling system in melanocytes: an overview. Pigment Cell Res, in press. 59. Z. Janjetovic, B. Zbytek, M.A. Zmijewski, E. H. Jones, T. Sweatman, I. Semak, J. Wortsman, R.C. Tuckey, A. Slominski (2007) Vitamin D3 hydroxylation by P450-scc originates 20-hydroxycholecalciferol that stimulates keratinocytes differentiation. J Invest Dermatol 127, S74 60. T.W. Fischer, M.A. Zmijewski, J. Wortsman A. Slominski (2007) Melatonin attenuates the apoptotic pathway in UV-irradiated human keratinocytes . J Invest Dermatol 127, S142. 61. A. Slominski, I. Semak, M.A. Zmijewski, T. Sweatman, Z. Janjetovic, J. Wortsman, R.C. Tuckey (2007) Sequential metabolism of provitamin D3 (7-dehydrocholesterol) to 5,7-diene products in the adrenal gland . J Invest Dermatol 127, S74. 62. MA. Zmijewski, AT. Slominski (2007) Global regulation of CRF signaling through CRFR1 receptor splicing. J Invest Dermatol 127, S96. 63. Z Wang, Y Lu, V Gududuru, B Zbytek, M A Zmijewsk, AT Slominski, JT Dalton, DD Miller, W Li (2007) Synthesis and SAR Studies of novel thiazolidine analogs for melanoma. American Association for Cancer Research Annual Meeting: Proceedings; 2007 Apr 14-18; Los Angeles, CA. Philadelphia (PA): AACR; 2007. Abstract nr 3963 . 64. Slominski A (2007) Role of CRH in the mammalian pigmentary system. Pigment Cell Res 20, 327 65. Zmijewski MA, Slominski A (2007) Melatoninergic system is fully expressed in retinal pigment epithelium. Pigment Cell Res 20, 327. 66.Slominski A, Zbytek B, Brozyna A, Slominski RM, Urbanska K, Calrson A, Mihm M (2007) Melanogenesis and melanoma: experimental and clinical implications. Pigment Cell Res 20, 552.

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67. Wei Li, Radomir Slominski, Andrzej T. Slominski, “HRMAS NMR monitoring of changes in metabolic profile of melanoma cells after induction of melanin synthesis”, 2007, 48th Experimental NMR Conference, April 22-27, Daytona Beach, FL. Poster #190 68. Janjentovic Z, Zmijewski M, Tuckey RT, Nguyen MN, Slominski A (2008) 20-hydroxychoecalciferol and 20, 23-dihydroxychoecalciferol products of vitamin D3 hydroxylation by P450scc, decrease NFκΒ activity by increasing IκΒα levels in normal and HaCaT keratinocytes. J Invest Dermatol 128:S20. 69. Zmijewski M, Fischer T, Slominski A (2008) Melatonin regulates expression and activity of androgen related genes in human skin cells. J Invest Dermatol 128: S149. 70. Tobin D, Rousseau K, Kauser S, Pritchard LE, Warhurst A, Oliver RL, Slominski A, Wei ET, Thody AJ, Tobin

DJ, White A (2007) Proopiomelanocortin (POMC), the melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. J Invest Dermatol 128: S221. 71. Bodó E, Kromminga A, Gáspár E, Zmijewski MA, van Beek N, Langbein L, Wenzel BE, Slominski A, Paus R (2008) Human hair follicles are a direct, non-classical target for thyroid stimulatinghormone (TSH). J Invest Dermatol 128: S155. 72. van Beek N, Bodó E, Kromminga A, Gáspár E, Meyer K, Zmijewski MA, Slominski A, Wenzel BE, Paus R (2008) Human hair follicles are a direct targets for thyroids hormones: involvement in anagen prolongation, hair matrix proliferation, hair pigmentation and metabolism. J Invest Dermatol 128: S156. 73. Granese J, Tobin D, Brozyna A, Zmijewski MA, Zbytek B, Slominski A (2008) Proenkefalin expression in normal and diseased skin. J Cutan Pathol 35: 120. 74. Granese J, Mullins A, Skinner R, Slominski A (2008) Pilar neurocristic hamartoma. J Cutan Pathol 35: 133. 75. Slominski A, Paus R, Fischer T, Reiter R (2008) Melatonin in the skin: protection against the oxidative stress. Pigment Cell Res 21, 292. 76. Slominski A (2008) Melanogenesis and its hormonal regulation: evolution and biological implications of the pigmentary systems. Pigment Cell Res 21, 289. 77. Slominski A (2008) Neuroendocrine activity of the melanocyte. Pigment Cell Res 21, 248. 78. Zorica Janjetovic, Lawrence M. Pfeffer, and Andrzej T. Slominski. Induction of pigmentation in human melanoma cells stimulates NFkB activity and affects the responsiveness to vitamin D3 derivatives. SID meeting, Montreal, Quebec, Canada, May 2009. Society for Investigative Dermatology Conference. Montreal, Quebec Canada, May 2009. Journal of Investigative Dermatology. 69th Meeting of the Society for Investigative Dermatology (2009). Vol 129 Supplement 1 pg S141. 79. Andrzej Slominski, Blazej Zbytek, Zorica Janjetovic, Weil Li, Anna Brozyna, Radomir Slominski, Robert C. Tuckey, Michael F. Holick, Martin Mih. Melanogenesis defines metabolism and behavior of melanoma cells as well as responsiveness to the therapy. Melanoma International Cell Conference, Boston, MA, November, 2009. 80. Zorica Janjetovic, Robert C. Tuckey, Minh N. Nguyen,Tai C. Cheng, Michael F. Holick, Andrzej T. Slominski. The biological activity of vitamin D3 hydroxyderivatives and expression of vitamin D receptor are attenuated after induction of melanin synthesis in melanoma cells. PanAmerican Society for Pigment Cell Research Meeting (PASPCR), Memphis, TN. September, 2009. 81. Zoran Pavicevic, Slominski A., Janjetovic Z., Ignatova, T.N., Duntsch, C.D., Kukekov, V.G. Expression of GFP Reporter Driven by Human Oct-4 Promoter in SK Mel 188 Nonpigmented Cell Line Identifies the Most Agressive Melanoma Cancer Stem Cells in Melanoma Progression. PanAmerican Society for Pigment Cell Research Meeting (PASPCR), Memphis, TN. September, 2009.

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82. Andrzej Slominski, Michal A. Zmijewski, Blazej Zbytek, Anna A. Brozyna, Jacqueline Granese, Zorica Janjetovic, Andre Szczesniewski, and Desmond J. Tobin. Regulated proenkephalin expression in human skin and cultured skin cells. SID meeting, Montreal, Quebec, Canada, May 2009. Society for Investigative Dermatology Conference. Montreal, Quebec Canada, May 2009. Journal of Investigative Dermatology. 69th Meeting of the Society for Investigative Dermatology (2009). Vol 129 Supplement 1 pg S116. 83. Andrzej Slominski, Zorica Janjetovic, Brian E. Fuller, Michal A. Zmijewski, Robert C. Tuckey, Minh N. Nguyen, Trevor Sweatman, Weil Li, Jordan Zjawiony, Duane Miller, Tai C. Chen, Michael F. Holick. Novel products of vitamin D3 metabolism by cytochrome P450scc inhibit proliferation and stimulate differentiation of leukemia cells, have very low or absent calcemic activity and show anti-tumor effect in other cancer lines Endocrinology Meeting, Washington DC, WA June, 2009. 84. Wei Li , Michal A. Zmijewski, Janjun Chen, Zorica Janjetovic, Jordan K. Zjawiony, Trevor W. Sweatman, Duane D. Miller, and Andrzej T. Slominski. Synthesis and biological evaluation of novel vitamin D3 derivative. ACS National meeting, Salt Lake City, UT, May 2009. 85. Zorica Janjetovic, Robert C. Tuckey, Minh N. Nguyen, Lawrence M. Pfeffer and Andrzej T. Slominski. 20(OH)D3, the novel vitamin D3 derivative, inhibits NF-κB activity in melanoma cells with low melanin content. The Pigmentation and Melanoma Research Society Congres. Vancouver, Canada, September 2010. XVIth Annual Meeting of Pan American Society for Pigment Cell Research Vancouver Pigmentation and Melanoma Research Conference “The latest developments in the research and treatment of pigmentation conditions and melanoma”. Pigment Cell & Melanoma Research Volume 23, Issue 5, pages 695–721, October 2010. DOI: 10.1111/j.1755-148X.2010.00747.x 86. Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Radoslaw Bieniek, Junming Yue, Wei Li, Jianjun Chen, Minh N. Nguyen, Duane Miller, Tai C. Chen, Michael Holick, Andrzej T Slominski. 20-hydroxyvitamin D2, a product of cytochrome P450scc hydroxylation, inhibits proliferation of melanoma and melanocytes through vitamin D receptor. The Pigmentation and Melanoma Research Society Congres. Vancouver, Canada, September 2010. XVIth Annual Meeting of Pan American Society for Pigment Cell Research Vancouver Pigmentation and Melanoma Research Conference “The latest developments in the research and treatment of pigmentation conditions and melanoma”. Pigment Cell & Melanoma Research, Volume 23, Issue 5, pages 695–721, October 2010. 87. Zorica Janjetovic, Adam C. Wright, Blazej Zbytek, Robert C. Tuckey, Minh N. Nguyen, Andrzej T. Slominski.. New vitamin D3 derivatives: 20-hydroxy- and 20, 23-dihydroxyvitamin D3 inhibit growth and induce apoptosis in vertical growth phase and metastatic human melanoma lines. Endocrinology Society meeting, San Diego, CA, June 2010. The 92nd annual meeting & Expo Guide, The Endocrine Society, pg 65. 88. Wei Li, Jianjun Chen, Zorica Janjetovic, Tae-Kang Kim, Trevor Sweatman, Yan Lu, Jordan Zjawiony, Robert C Tuckey, Duane Miller, Andrzej Slominski. Chemical Synthesis of 20S-hydroxyvitamin D3, which shows anti-proliferative activity Endocrinology Society meeting, San Diego, CA, June 2010. Endocrinology Society meeting, San Diego, CA, June 2010. The 92nd annual meeting & Expo Guide, The Endocrine Society, pg 120. 89. AT Slominski, RC Tuckey, A Postethwaite, W Li, Z Janjetovic, T-K Kim, M Zmijewski, T Sweatman, J Chen, J Zjawiony, T Chen, MF Holick, D Miller. Novel secosteroidogenica pathway initiated by CYP11A1 produces biological active intermediates. International Adrenal Cortex Conference. San Diego, CA, June 2010. 90. AT Slominski, Janjetovic, T-K Kim, M Zmijewski RC Tuckey, T Sweatman, W Li, J Zjawiony, J Chen, D Miller, Radoslaw Bieniek, Minh N. Nguyen, T Chen, MF Holick Novel 5,7-unsaturate steroidal and secosteroidal products of cytochrome P450scc show antimelanoma activity. Society for Investigative Dermatology Conference. Atlanta, GA, May, 2010. Journal of Investigative Dermatology (2010), Vol 130, pg S142. 91. Skobowiat C, Dowdy J.C., Sayre, R.M., Slominski A. (2010) The influence of Ultraviolet A, B and C on HPA axis expression in human skin ex-vivo and keratinocyte/melanocyte co-culture. XVIth Annual Meeting of PASPCR, “The latest developments in the research and treatment of pigmentation conditions and melanoma”, Vancouver 09,29-10,03,2010. Pigment Cell & Melanoma Research Vol.23 :713, 2010

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92. Pinczewski J, Skinner R, Slominski A. Acquired reactive perforating collagenosis in the setting of HIV. College of American Pathologists Annual Meeting, Chicago, 2010. Arch Pathol Lab Med. 134:1376, 2010 93. Zhang J., Kulkarni A., Skinner A., Stanton C., Handorf C., Slominski A., (2010) "Virtual Signout" platform - Tool for Dermatopathology Training. American Society of Dermatopathology Annual Meeting. Atlanta, October 2010 (oral presentation). 94. Dianne Kovacic, MD, Amanda Mullins, MD, Francisco Vieira, MD, Andrzej Slominski, MD, PhD, Vickie Baselski, PhD, Jie Zhang, MD. Eumycotic Mycetoma of the Scalp. 47th Meeting of American Society of Dermatopathology, Atlanta, GA, 2010, Journal of Cutaneous Pathology, 38(1):97, 2011. 95. Dianne Kovacic, MD, Amanda Mullins,MD, Robert Skinner, MD, Andrzej Slominski, MD, PhD, and Jie Zhang, MD. Neutrophilic Sebaceous Adenitis in an HIV Positive Patient. 47th Meeting of American Society of Dermatopathology, Atlanta, GA, 2010, Journal of Cutaneous Pathology, 38(1):100, 2011

96. Zbytek B, Slominski A. D-penicillamine is a potential adjuvant treatment in melanoma therapy, 47th Meeting of American Society of Dermatopathology, Atlanta, GA, 2010, Journal of Cutaneous Pathology, 38(1):111, 2011. 97. Skobowiat C, Dowdy JC, Sayre RM, Tuckey RC, Slominski A. Ultraviolet as a regulator of stress system in the human skin. Society for Investigative Dermatology 71st Annual Meeting May 4-7, 2011 Phoenix, Arizona. Published in J. Invest. Dermatol. 131, Suppl. 1:S117, 2011 98. Tuckey RC, Li W., Shehabi H, Janjetovic Z, Nguyen MN, Kim TK, Howell DE, Chen J, Sweatman T, Miller DD, Slominski AT. Production of 22-hydroxi metabolites of vitamin D3 by cytochrome P450 scc (CYP11A1) and analysis of their biological activities on keratinocytes. The Endocrine Society's Meeting, Boston MA, 2011. 93rd Meeting and Expo Guide, p.27. 99. Janjetovic Z, Pfeffer ML, Escue E, Wright AC, Tuckey RC, Pfeffer S, Slominski AT. New vitamin D3 derivatives: 20-hydroxi and 20,23-dihydroxivitamin D3 target NF-kB in melanoma cells. The Endocrine Society's Meeting, Boston MA, 2011. 93rd Meeting and Expo Guide, p.27. 100. Slominski A, Janjetovic Z, Janjetovic Z, Li W, Kim T-K, Postlethwaite A, M Zmijewski, T Sweatman, J Chen, J Zjawiony, MN Nguyen, T Chen, MF Holick, D Miller. Novel secosteroids regulate melanocytic activity. Society for Investigative Dermatology 71st Annual Meeting May 4-7, 2011 Phoenix, Arizona. Published in J. Invest. Dermatol. 131, Suppl. 1: p.S123, 2011. 101. Postlethwaite A, Li W, J Chen, D Miller, Gu W, Jiao Y, Slominski A. Non-calcemic natural vitamin D analogue, 20(OH)D3, protects mice from bleomycin induced scleroderma. Society for Investigative Dermatology 71st Annual Meeting May 4-7, 2011 Phoenix, Arizona. Published in J. Invest. Dermatol. 131, Suppl. 1: p.S123, 2011. 102. Brozyna A, Jozwicki W, Slominski A. Alternation of CYP27b1 expression during progression of pigmented lesions in the skin. Society for Investigative Dermatology 71st Annual Meeting May 4-7, 2011 Phoenix, Arizona. Published in J. Invest. Dermatol. 131, Suppl. 1: p.S126, 2011. 103. Dianne Kovacic, Andrzej Slominski, Jie Zhang. “Cutaneous Pilar Leiomyoma: A case report” (2011, September) Presentation: 48th Annual Meeting for the American Society of Dermatopathology, Seattle, WA, 2011. 104. Dianne Kovacic, Sohail Qayyum, Anand Kulkarni, Andrzej Slominski. “Melanoma Case of Medicolegal Importance- Digital Archiving” (2011, September) Poster Presentation: 48th Annual Meeting for the American Society of Dermatopathology, Seattle, WA, 2011. 105. Dianne Kovacic, Teresa Santiago, Andrzej Slominski, Jie Zhang. “Pedunculated angiolipofibroma of the axilla” (2011, September) Poster Presentation: 48th Annual Meeting for the American Society of Dermatopathology, Seattle, WA, 2011.

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106. Dianne Kovacic, Jie Zhang, Andrzej Slominski. “Desmoplastic Nevus; a unique acquired melanocytic nevus” (2011, September) Poster Presentation: 48th Annual Meeting for the American Society of Dermatopathology, Seattle, WA, 2011. J Cutaneous Pathol 39, 120, 2012 107. Zbytek B, Kovacic D, Bieniek R, Janjetovic Z, Brozyna AA, Zhang J, Jozwicki W, Slominski AT (2012) Vitamin D and Vitamin D receptor system in human melanocytes and melanoma: immunohistochemistry and cell culture study, abstract, Journal of Cutaneous Pathology, 39: 126. 108 Zbytek B, Slominski AT (2012) Role of corticotropin-releasing hormone and its receptor in the development of dermatofibroma, abstract, Journal of Cutaneous Pathology, 39: 101. 109. Kim TK, Janjetovic Z, Li W, Fischer T, Slominski AT (2012) Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in skin cells. Pigment Cell & Melanoma Research. Volume 25, Issue 5. 683.

110. Kim TK, Wang J, Janjetovic Z, Chen J, Tuckey RC, Nguyen MN, Tang EKY, Miller D, Li W, Slominski AT. Secosteroids with a long side chain interact more strongly with the vitamin D receptor (VDR) than those with a shorter side chain. SID 2012, Raleigh, NC. 2012. 111. Slominski AT, Kim TK, Shehabi HZ, Semak I, Tang EKY, Nguyen MN, Benson HAE, Korik E, Janjetovic Z, Chen J, Yates CR, Postlethwaite A, Li W, Tuckey RC. In vivo evidence for novel pathway of vitamin D3 metabolism initiated by P450scc. Endo 2012, Houston, TX. 2012. 112. B. Brocato, C. Skobowiat, A.Slominski, G. Mari, P. W.Nathanielsz, A. Kulkarni , G. B. Hubbard, E. J. Dick and N. Schlabritz-Loutsevitch. Maternal IL -8 Concentration and the Key Molecule of Placental Endocannabinoid system. 2012, SGI 113. Slominski, A. T., Kim, T.-K., Shehabi, H. Z., Semak, I., Tang, E. K. Y., Nguyen, M. N., Benson, H. A. E. Korik, E., Janjetovic, Z., Chen, J., Yates, C. R., Postlethwaite, A., Li, W. & Tuckey, R. C. (2012). In Vivo Evidence for Novel Pathway of Vitamin D3 Metabolism Initiated by P450scc. Endocr Rev 33: OR15-2 114. Natalia Schlabritz-Loutsevitch, Brian Brocato, Zorica Janjetovic, Cezary Skobowiat, Andrzej Slominski, Sara Rutter, Iram Rodríguez-Sánchez, Robert Ferry, Edward Dick, Gene Hubbard, Giancarlo Mari. Placental endocannabinoid system as a pharmacological target to improve fetal growth. American Journal of Obstetrics and Gynecology, Volume 208, Issue 1, Supplement, January 2013, Pages S191-S192

115. Brian Brocato , Zorica Janjetovich , Andrzej Slominski , Mari Giancarlo , Gene Hubbard , Edward Dick and Natalia Schlabritz-Loutsevitch. Critical enzymes for endocannabinoid metabolism in a baboon model of maternal obesity. American Journal of Obstetrics and Gynecology, Volume 208, Issue 1, Supplement, January 2013, Page S193, Erratum April 2013 116. Natalia Schlabritz-Loutsevitch, Brian Brocato, Giancarlo Mari, Andrzej Slominski and Arnold Postlethwaite. Vitamin D metabolism in pregnancy: Effects of UV-B exposure and obesity in a non-human primate model (Papio spp.). 2013, Reproductive sciences. Vol 20, N3, supplement, p168A 117. Zbytek, B, Skobowiat C, Gupta M, Kempe M, Seagroves T, Slominski A (2013) Enhanced expression of HIF-1alpha in malignant melanomas vs bening nevi. J Cutaneous Pathol 40, 143. 118. Kempe M, Zbytek B, Burruss G, Slominski A , Chesney T (2013) Mast cell sarcoma: report of rare case and review of the literature. J Cutaneous Pathol 40, 149. 119. Kovacic D, Kempe M, Carlson JA, Slominski A (2013) Spindle cell hemangioma of the scrotum: a case report. J Cutaneous Pathol 40, 196.

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120. Z. Janjetovic, S. Gupta, Iram P. Rodríguez-Sánchez, J. Samson B. Brocato, M. Schenone, D. Tate, N. Meyer, A. Slominski, B. Moore, G. Mari and N. Schlabritz-Loutsevitch. Placental key enzymes of the endocannabinoid system in maternal obesity: from primate to primate. 2013. Placenta. Volume 34, Issue 9, p A80, P 2-71

121. M. Schenone, Z. Janjetovic, R. Phineas, B. Brocato, G. Mari, R. Ahokas, A. Slominski and N. Schlabritz-Loutsevitch Reduced uterine perfusion pressure does not influence the endocannabinoid system (ecbs) transcripts in the rat model. (2013), Volume 4, Issue 9, page A27, P1.46 122. Kim TK, Lin Z, Tuckey RC, Tang EK, Li W and Slominski AT. Novel metabolism of vitamin D in human epidermal keratinocytes and epithelial colon cells. IID 2013, Edinburgh, UK, May, 2013. 123. Kim TK, Janjetovic Z, Lin Z, Tidwell WJ, Slominski AT. Melatonin and its metabolites show anti-proliferative and cell protective effects in human epidermal melanocytes and keratinocytes. PASPCR Conference (PanAmerican Society for Pigment Cell Research), Madison, WI, September 2013. 124. Zorica Janjetovic and Andrzej T. Slominski. Melatonin and its metabolites protect human melanocytes against UVB induced damage. 18th PanAmerican Pigment Cell Society Meeting, Madison, WI, September 2013. XVIII PASPCR 2013: Advances in Melanoma Biology, pg 63. 125. Katherine Apostolakis-Kyrus, Raya Krutilina, Logan K. Williams, Shufeng Zhang, Zorica Janjetovic, Andrzej T. Slominski, Edward Dick , Gene Hubbard, Giancarlo Mari, Natalia E. Schlabritz-Loutsevitch. Obesity alters pregnancy-related maternal cardiovascular remodeling through a miR-29 related mechanism. 2014 American Journal of Obstetrics and Gynecology, Supplement to Vol. 210, N1,S44 126. Natalia Schlabritz-Loutsevitch, Jacques Samson, Sonali Gupta, Mauro Schenone, Brian Brocato, Danielle Tate, Raisa Krutilina, Cezary Skobowiat, Andrzej Slominski, Bob Moore, Giancarlo Mari. Fetal Gender-Specific Placental “Endocannabinoidome” in Maternal Obesity. 2014 American Journal of Obstetrics and Gynecology, Supplement to Vol. 210, N1,S. 94. 127. Kim TK, Lin Z, Tidwell WJ, Li W, Slominski AT. The roles of endogenously produced melatonin and its metabolites in pigmentary system. SID 2014, Albuquerque, NM. 2014. 128. Zorica Janjetovic, Sherie Hanna, Zachary P. Nahmias, Stewart G. Jarrett, Tae-Kang Kim, and Andrzej T. Slominski. Melatonin and its metabolites protect human keratinocytes against UVB-induced oxidative stress, increase p53, and induce DNA repair in UVB damaged cells. Society for Investigative Dermatology Conference. Albuquerque, NM, May 7-10, 2014. Journal of Investigative Dermatology (2014). 129. Andrzej T. Slominski, Tae-Kang Kim, Yukisama Takeda, Zorica Janjetovic, Anna Brozyna, Cezary Skobowiat, Jin Wang, Arnold Postlethwaite, Wei Li, Robert C. Tuckey, Anton Jetten. RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxy-vitamin D. Endocrinology Society meeting, Chicago, IL, June 21-24, 2014. The 96nd annual meeting & Expo Guide, The Endocrine Society 130. Brozyna AA, Jochymski C, Juzwicki W, Slominski AT (2014) Elevated expression of CYP24A1 in nevi and early-stage skin melanomas. J Invest Dermatol 134, Supplement 1: S123 131. Soni A, Wei S, McKay K, Slominski, A. Cutaneous presentation of desmoplastic epitheliod hemangioendotheliom. American Society of Dermatopathology Annual Meeting. October 9-10, 2015; San Francisco, CA; Poster 189. 132. PIGMENTED EPITHELIOID MELANOCYTOMA (PEM)/ANIMAL TYPE MELANOMA (ATM); REPORT OF AN UNUSUAL CASE WITH FOLLICULAR ORIGIN. A Tarasen, P Pavlidakey, JA Carlson, A Slominski. Presented during the poster session at the American Society of Dermatopathology (ASDP) 2015 annual meeting, October, 2015, San Fransisco, Ca.

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133. LYMPHOCYTIC VASCULITIS IN A PATIENT WITH MULTICENTRIC CASTLEMAN’S DISEASE AND POEMS SYNDROME. A Tarasen, M Hurst, JA Carlson, N Sami, P Pavlidakey, A Slominski. Presented during the poster session at the American Society of Dermatopathology (ASDP) 2015 annual meeting, October, 2015, San Fransisco, Ca. 134. A CASE OF LICHEN SCLEROSIS EXHIBITING LYMPHEDEMA WITH BASAL KERATINOCYTE EXPRESSION OF D2-40, A CASE STUDY. A Tarasen, A. Soni, M Stratton, JA Carlson, A Slominski, M Jacobs. The 19th Joint Meeting of the International Society of Dermatopathology (ISDP), March, 2016, Washington DC, poster session. 135. Brożyna A.A., W. Jóźwicki, A.T. Slominski: The relationship between pigmentation level and CD4+, CD8+ and CD20+ lymphocytes in primary cutaneous melanomas. J. Invest. Dermatol. 2015 : Vol. 135 vol 8, s. s6. (2015 Annual Meeting of the Society for Investigative Dermatology, Atlanta, Georgia, USA, 6-9.V.2015, poster LB768) 136. SOLAR KERATOSIS OF THE NAIL BED WITH PROGRESSION TO SQUAMOUS CELL CARCINOMA. A Soni, A Tarasen, T Canavan, B Elewski, C Elmets, JA Carlson, A Slominski. The 19th Joint Meeting of the International Society of Dermatopathology, March, 2016. Washington DC, platform presentation. 137. Andrzej T Slominski, Tae-Kang Kim, Judith V Hobrath, Zorica Janjetovic, Allen SW Oak, Arnold Postlethwaite, Wei Li, Anton M Jetten, Robert C Tuckey (2016) Discovery of new pathway activating lumisterol in vivo to biologically active molecules. J Invest Dermatol 136, Suppl1, Page S105. 138. A.S. Oak, R. Shafi, S. Katiyar, A.T. Slominski, W. Cantrell, C. Wang, R.K. Srivastava, C. Li, M. Athar, C. Elmets (2016) Oral administration of table grapes has a photoprotective effect on the sunburn response and on cyclobutane pyrimidine dimers in humans in vivo. J Invest Dermatol Volume 136, Issue 5, Supplement 1, Page S51 139. Anna A. Brożyna, Wojciech Jóźwicki, M. Pawlikowska, Ewelina Wędrowska, A. Słomiński. Expression of retinoic acid receptor-related orphan receptors (ROR) α and γ correlates with hypoxia in cutaneous melanomas. J. Invest. Dermatol. 2016 : Vol. 136, suppl. 2, s. 241. 46th Annual ESDR Meeting. Munich,Germany, 7-10 IX 2016 140. J.M. Wierzbicka, A. Piotrowska, A. Slominski, M.A. Zmijewski (2016) Vitamin D enhances skin HPA signalling. Journal of Investigative Dermatology, Vol. 136, Issue 9, S181 141. AS Oak, C Skobowiat, T Kim and A Slominski (2016) Anti-melanoma activity of 20(OH)vitamin D3. J Invest Dermatol 136, Suppl1, Page S237. 142. Kim TK, Oak AS, Skobowiat C, Pfeffer L, Tuckey RC, Slominski AT. Endogenously produced 20-hydroxyvitamin D3 is non-calcemic and inhibits human melanoma in vitro and in vivo. UAB Comprehensive Cancer Center 18th Annual Research Retreat. Birmingham, AL. October 17, 2016 143. Zorica Janjetovic, Elisabeth F. Lee, Corey Duprey, Taban Ghaffari, Adrzej T. Slominski. NRF2 is an important target for the protective action of melatonin and its metabolites against UVB-induced damage in human melanocytes. PASPCR 2016 Conference, October 5-8, 2016, Baltimore, MD. 144. Andrzej T. Slominski, Tae-Kang Kim, Judith V. Hobrath, Allen S.W. Oak, Edith K. Y. Tang, Elaine W. Tieu, Wei Li, Robert C. Tuckey, Anton M. Jetten RORα AND RORγ AS ALTERNATIVE RECEPTORS FOR NONCLASSICAL VITAMIN D HYDROXY-METABOLITES. The 19th Workshop on Vitamin D Boston, MA, USA, March 29-31, 2016 145. Slominski AT, Brozyna AB, Skobowiat C, Zmijewski MA, Kim T, Janjetovic Z, Oak AS, Jozwicki W, Jetten AM, Mason RS, Elmets C, Tuckey (2017) ON THE ROLE OF CLASSICAL AND NOVEL FORMS OF VITAMIN D IN MELANOMA PROGRESSION AND MANAGEMENT. 20TH WORKSHOP ON VITAMIN D, Orlando, FL, March 28-31.

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146. Tuckey RC, Li W, Ma D, Cheng CYS, Wang KM, Jeayeng S, Kim T and Slominski AT.(2017) METABOLISM OF LUMISTEROL BY CYP27A1. 20TH WORKSHOP ON VITAMIN D, Orlando, FL, March 28-31. 147. A. Slominski, T. Kim, I. Semak, T. Sweatman, C. Skobowiat, J. Steketee, Z. Lin, A. Postlethwaite, W Li, D Tobin (2017) Production of Serotonin and N-acetylserotonin in the human skin in vivo. J Invest Dermatol Volume 137, Issue 5, Supplement 1, Page S79. 148. Zorica Janjetovic, Stuart G. Jarrett, Elizabeth F. Lee, Cory Duprey, Russel J. Reiter, Andrzej T. Slominski. Melatonin and its metabolites enhance the DNA repair in human melanocytes exposed to UVB 23rd IPCC meeting, . Denver, CO. August 26 – 30, 2017. 149. Kim TK, Oak ASW, Lin Z, Li W, Tuckey RC, Slominski AT. Endogenously producing Lumisterol derivatives have anti-proliferative effects on human melanoma and epidermal melanocytes. IPCC 2017. Denver, CO. August 26 – 30, 2017. 150. Andrzej T. Slominski, Anna A Brozyna, Cezary Skobowiat, Michal A. Zmijewski, Tae-Kang Kim, Zorica Janjetovic, Allen S. Oak, Wojciech Jozwicki, Anton M. Jetten, Rebecca S. Mason, We Li, Robert M. Hoffman, . Robert C. Tuckey. Vitamin D and Melanoma: What is New Under the Sun. 23rd IPCC meeting, Denver, CO. August 26 – 30, 2017. 151. Guo T, Brozyna AA, Slominski AT (2018) Megalin expression decreases in psoriatic skin. 21st Joint Meeting of the ISDP, San Diego, CA, February 14-15, 2018 152. Mahmoud M Elsayed, Anna A Brozyna, Tae-Kang Kim, Changzhao Li, Zorica Janjetovic, Wei Li, Anton M Jetten, Robert C Tuckey, Craig Elmets, Mohammad Athar, Andrzej T Slominski. . “Vitamin D hydroxyderivatives as therapeutic agents in skin cancer. International Investigative Dermatology Meeting, 16-19 May 2018, Orlando, FL, USA. 153. Anna A Brozyna, Wojciech Jicki, Andrzej T Slominski . E-cadherin expression correlates to nuclear receptors for vitamin D and pigmentation in melanomas. International Investigative Dermatology Meeting, 16-19 May 2018, Orlando, FL, USA. 154. Zorica Janjetovic, Tae-Kang Kim, Arnold Postlethwaite Wei Li, Robert C Tuckey, Anton M Jetten, Andrzej T Slominski . Antifibrogenic activities of novel vitamin D3 analogs are modified by RORγ expression. International Investigative Dermatology Meeting, 16-19 May 2018, Orlando, FL, USA. 155. Andrzej T Slominski. “'Solar exposure-induced modulation of skin endocrine function” 2018 ASP Biennial Meeting: 12-15 May 2018, Tampa Marriott Waterside Hotel & Marina 156. Tuckey RC, Li W,Ma Di, Wang K, CChen C, Jeayeng S, Kim TK, Slominski AT. THE PRE-VITAMIN D3 PHOTOPRODUCT, LUMISTEROL, IS HYDROXYLATED BY CYP27A1 TO BIOLOGICALLY ACTIVE PRODUCTS Conference of IUBMB Seoul 2018, South Korea. 157. Malian, Serge - ACOM; Andrzej Slominski, Preceptor “FGF23 Expression in Skin Cells” ” 2018 UAB student expo, and at Alabama College of Osteopathic Medicine, Dotham, A 158. Wild, Josh - ACOM; Andrzej Slominski, Preceptor“Presence of receptor target proteins for D3-hydroxyderivatives in various cancer cell lines” 2018 UAB student expo, and at Alabama College of Osteopathic Medicine, Dotham, AL 159 Andrzej T. Slominski, Przemyslaw Plonka, Ralf Paus “Neuro-immuno-endocrinology of the skin: Moving the pigmentary system into center stage” Montagna Symposium on the Biology of Skin/PASPCR Annual Meeting 2018, October 17 – 22, 2018, Salishan Resort, Gleneden Beach, Ore., U.S.A.

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160. Tae-Kang Kim, Ewa Podgorska, Robert C. Tuckey, Junming Yue, Andrzej T. Slominski Vitamin D receptor silencing in WM164 melanoma cells affects their behavior and responsiveness to vitamin D3 . Montagna Symposium on the Biology of Skin/PASPCR Annual Meeting 2018, October 17 – 22, 2018, Salishan Resort, Gleneden Beach, OR, U.S.A